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Q6RY98

- SRTXL_ATRMM

UniProt

Q6RY98 - SRTXL_ATRMM

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Protein

Long-sarafotoxin

Gene
N/A
Organism
Atractaspis microlepidota microlepidota
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Vasoconstrictor activity. These toxins cause cardiac arrest probably as a result of coronary vasospasm. The major effects of sarafotoxin-m are a progressive decrease in heart rate (bradycardia) that turns into an arrhythmic phase that is followed by an A-V block.1 Publication
Sarafotoxin-m: vasoconstrictor activity. Causes cardiac arrest probably as a result of coronary vasospasm By similarity. Displays low agonistic activities towards endothelin-2 receptor (EDNRB) (displays affinity in the micromolar range) (1 Publication).1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei2 – 21Endothelin-receptor binding site By similarity
Sitei50 – 501Endothelin-receptor binding site By similarity
Sitei98 – 981Endothelin-receptor binding site By similarity
Sitei146 – 1461Endothelin-receptor binding site By similarity
Sitei194 – 1941Endothelin-receptor binding site By similarity
Sitei242 – 2421Endothelin-receptor binding site By similarity
Sitei290 – 2901Endothelin-receptor binding site By similarity
Sitei338 – 3381Endothelin-receptor binding site By similarity

GO - Biological processi

  1. regulation of vasoconstriction Source: InterPro
  2. vasoconstriction Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Cardiotoxin, G-protein coupled receptor impairing toxin, Toxin, Vasoactive, Vasoconstrictor

Names & Taxonomyi

Protein namesi
Recommended name:
Long-sarafotoxin
Short name:
L-SRTX
Cleaved into the following 6 chains:
Sarafotoxin-m
Short name:
SRTX-m
Sarafotoxin-m1
Short name:
SRTX-m1
Sarafotoxin-m2
Short name:
SRTX-m2
Sarafotoxin-m3
Short name:
SRTX-m3
Sarafotoxin-m4
Short name:
SRTX-m4
Sarafotoxin-m5
Short name:
SRTX-m5
OrganismiAtractaspis microlepidota microlepidota
Taxonomic identifieri172021 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaAtractaspididaeAtractaspis

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Toxic dosei

Sarafotoxin-m: LD50 is 27-37 µg/kg by intravenous injection into mice.1 Publication

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi51 – 533Missing: Drastic 4-orders or magnitude increase in affinity for ET-B receptors. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Peptidei‹1 – 5›5Sarafotoxin-m5PRO_0000315373
Propeptidei6 – 2924PRO_0000315374Add
BLAST
Peptidei30 – 5324Sarafotoxin-m1 PublicationPRO_5000092481Add
BLAST
Propeptidei54 – 7724PRO_0000315375Add
BLAST
Peptidei78 – 10124Sarafotoxin-m1PRO_5000092482Add
BLAST
Propeptidei102 – 12524PRO_0000315376Add
BLAST
Peptidei126 – 14924Sarafotoxin-m3PRO_5000092483Add
BLAST
Propeptidei150 – 17324PRO_0000315377Add
BLAST
Peptidei174 – 19724Sarafotoxin-m2PRO_5000092484Add
BLAST
Propeptidei198 – 22124PRO_0000315378Add
BLAST
Peptidei222 – 24524Sarafotoxin-m2PRO_5000092485Add
BLAST
Propeptidei246 – 26924PRO_0000315379Add
BLAST
Peptidei270 – 29324Sarafotoxin-mPRO_5000092486Add
BLAST
Propeptidei294 – 31724PRO_0000315380Add
BLAST
Peptidei318 – 34124Sarafotoxin-m4PRO_5000092487Add
BLAST
Propeptidei342 – 35110PRO_0000315381

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi30 ↔ 441 Publication
Disulfide bondi32 ↔ 401 Publication
Disulfide bondi78 ↔ 92 By similarity
Disulfide bondi80 ↔ 88 By similarity
Disulfide bondi126 ↔ 140 By similarity
Disulfide bondi128 ↔ 136 By similarity
Disulfide bondi174 ↔ 188 By similarity
Disulfide bondi176 ↔ 184 By similarity
Disulfide bondi222 ↔ 236 By similarity
Disulfide bondi224 ↔ 232 By similarity
Disulfide bondi270 ↔ 284 By similarity
Disulfide bondi272 ↔ 280 By similarity
Disulfide bondi318 ↔ 332 By similarity
Disulfide bondi320 ↔ 328 By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Structurei

Secondary structure

1
351
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi273 – 2753
Helixi277 – 28610

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LDFNMR-A270-293[»]

Miscellaneous databases

EvolutionaryTraceiQ6RY98.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati6 – 53481Add
BLAST
Repeati54 – 101482Add
BLAST
Repeati102 – 149483Add
BLAST
Repeati150 – 197484Add
BLAST
Repeati198 – 245485Add
BLAST
Repeati246 – 293486Add
BLAST
Repeati294 – 341487Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni6 – 3413367 X 48 AA tandem repeatsAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG017852.

Family and domain databases

InterProiIPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view]
PfamiPF00322. Endothelin. 7 hits.
[Graphical view]
PRINTSiPR00365. ENDOTHELIN.
SMARTiSM00272. END. 7 hits.
[Graphical view]
PROSITEiPS00270. ENDOTHELIN. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6RY98-1 [UniParc]FASTAAdd to Basket

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IWDEPVVVSA RDTEEAARVP SPQKRSQPLC SCNDINDKEC MYFCHQDVIW    50
DEPVVVSVRD TEEAARVPSP QKRPQPRCSC NDMNDKECMY FCHQDVIWDE 100
PVVVSVRDTE EAARVPSPQK RSQPRCSCND MNDKECVYFC HLDIIWDEPV 150
VVSVRDTEEA TRVPSPQKRS QPLCSCNDIN DKECMYFCHQ DIIWDEPVVV 200
SVRDTEEAAR VPSPQKRSQP LCSCNDINDK ECMYFCHQDI IWDEPVVVSV 250
RDTEEAARVP SPQKRSQPLC SCNDINDKEC MYFCHQDVIW DEPVVVSVQD 300
TEEAARVPSP QKRSQPLCSC NNMSDKECLN FCNLDIIWEN VDTSADPEFL 350
G 351
Length:351
Mass (Da):40,341
Last modified:July 5, 2004 - v1
Checksum:iF901846C8D6E01CC
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY485934 mRNA. Translation: AAR84382.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY485934 mRNA. Translation: AAR84382.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2LDF NMR - A 270-293 [» ]
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG017852.

Miscellaneous databases

EvolutionaryTracei Q6RY98.

Family and domain databases

InterProi IPR020475. Bibrotoxin/Sarafotoxin-D.
IPR019764. Endothelin_toxin_CS.
IPR001928. Endothln-like_toxin.
[Graphical view ]
Pfami PF00322. Endothelin. 7 hits.
[Graphical view ]
PRINTSi PR00365. ENDOTHELIN.
SMARTi SM00272. END. 7 hits.
[Graphical view ]
PROSITEi PS00270. ENDOTHELIN. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 30-53; 78-101; 126-149; 174-197; 222-245; 270-293 AND 318-341, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, LETHAL DOSE, SYNTHESIS OF SARAFOTOXIN-M, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Venom and Venom gland.
  2. "Pharmacological and structural characterization of long-sarafotoxins, a new family of endothelin-like peptides: role of the C-terminus extension."
    Mourier G., Hajj M., Cordier F., Zorba A., Gao X., Coskun T., Herbet A., Marcon E., Beau F., Delepierre M., Ducancel F., Servent D.
    Biochimie 94:461-470(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF SARAFOTOXIN-M, DISULFIDE BONDS, MUTAGENESIS OF 51-ASP--PRO-53.

Entry informationi

Entry nameiSRTXL_ATRMM
AccessioniPrimary (citable) accession number: Q6RY98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3