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Protein

Sodium/potassium-transporting ATPase subunit alpha

Gene
N/A
Organism
Taenia solium (Pork tapeworm)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients (By similarity).By similarity

Catalytic activityi

ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei368 – 36814-aspartylphosphate intermediateBy similarity
Metal bindingi708 – 7081MagnesiumBy similarity
Metal bindingi712 – 7121MagnesiumBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alpha (EC:3.6.3.9)
Short name:
Na(+)/K(+) ATPase alpha subunit
Alternative name(s):
Sodium pump subunit alpha
TNaK1-alpha
OrganismiTaenia solium (Pork tapeworm)
Taxonomic identifieri6204 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesCestodaEucestodaCyclophyllideaTaeniidaeTaenia

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei124 – 14421HelicalSequence AnalysisAdd
BLAST
Transmembranei281 – 30020HelicalSequence AnalysisAdd
BLAST
Transmembranei313 – 33018HelicalSequence AnalysisAdd
BLAST
Transmembranei764 – 78320HelicalSequence AnalysisAdd
BLAST
Transmembranei794 – 81421HelicalSequence AnalysisAdd
BLAST
Transmembranei834 – 85623HelicalSequence AnalysisAdd
BLAST
Transmembranei909 – 92820HelicalSequence AnalysisAdd
BLAST
Transmembranei942 – 96019HelicalSequence AnalysisAdd
BLAST
Transmembranei976 – 99621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10141014Sodium/potassium-transporting ATPase subunit alphaPRO_0000291569Add
BLAST

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ6RWA9.

Expressioni

Tissue specificityi

Preferentially localized in muscle cells and protonephridial ducts, and in small quantities in the tegument of cysticerci.1 Publication

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6RWA9.
SMRiQ6RWA9. Positions 20-1014.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005775. P-type_ATPase_IIC.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6RWA9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKSRGDKYR DATDGKKDAK KDLNELKQEL AMDEHQISLD ELYARLGTNP
60 70 80 90 100
DTGLTSEQAK TRLDRDGPNA LTPPKTTPEW VKFCKNMFGG FSLLLWIGAV
110 120 130 140 150
LCFIAHGIPC WCAGEPYLYD NLYLGIVLAA VVVITGCFSY YQESKSSKIM
160 170 180 190 200
ESFAKLVPQY AVVIRGGQRI DAPAEALVVG DIIDVKFGDR VPADIRVIKA
210 220 230 240 250
SSFKVDNSAL TGESEPQTRT AEYTNENPLE TKNLAFFSTN AVEGTCRGVV
260 270 280 290 300
VATGDRTVMG RIANLASGLE MGATPIAREI AHFIHIITGV AVFLGVTFFI
310 320 330 340 350
IAFILGYYWL DAVIFLIGII VANVPEGLLA TVTVCLTLTA KRMASKNCLV
360 370 380 390 400
KNLEAVETLG STSTICSDKT GTLTQNRMTV AHMWFDNKIF EADTSDDQST
410 420 430 440 450
ANYSRASSTW MALSRIAMLC NRAEFKPGEE TNPVLKRECN GDASESALLK
460 470 480 490 500
CVGLSIGGVT GYRTDKPKVA EIPFNSTNKY QVSVHQTDDG DERYLVVMKG
510 520 530 540 550
APERILDRCS TVLMEGQELH MDDQWRESFN NAYLELGGIG ERVLGFCDLR
560 570 580 590 600
LPADKFPRGF KFDIDEPNFP IEGMPFVGLM SMIDPPRAAV PDAVSKCRSA
610 620 630 640 650
GIKVVMVTGD HPITAKAIAK GVGIISDGNK TVEDIAAERG VPVSQVNPRE
660 670 680 690 700
ASACVVHGSD LRDMTPAQID EILENHSEIV FARTSPQQKL IIVEGIQRMG
710 720 730 740 750
AIVAVTGDGV NDSPALKKAD IGVAMGITGS DVSKQAADMI LLDDNFASIV
760 770 780 790 800
TGVEEGRIIF DNLKKSIAYT LTSNIPEITP FLIFILADVP LPLGTITILC
810 820 830 840 850
IDLGTDMVPA ISLAYEEAED IMKRMPRDPF RDKLVNERLI SMAYGQIGMI
860 870 880 890 900
QASGGFFVYF VIMAENGFWP SRLLGLRKQW DSPAINDVAD SYGQEWTYTQ
910 920 930 940 950
RKRLEYTCHT AFFASIVIVQ WTDLLICKTR KNSIYQQGMW NHHLTFGLFF
960 970 980 990 1000
ETTLAIFLSY CPGLEHGLRM MPLRWTWWLP VLPFSVSIFI FDEVRKKFLR
1010
TLPPGNWVER ETNY
Length:1,014
Mass (Da):111,990
Last modified:July 5, 2004 - v1
Checksum:i595741648A93D5D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY487828 mRNA. Translation: AAS59168.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY487828 mRNA. Translation: AAS59168.1.

3D structure databases

ProteinModelPortaliQ6RWA9.
SMRiQ6RWA9. Positions 20-1014.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiQ6RWA9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR005775. P-type_ATPase_IIC.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Cloning and expression of a Na(+), K(+)-ATPase alpha-subunit from Taenia solium (TNaK1alpha)."
    Willms K., Shoemaker C.B., Skelly P.J., Landa A.
    Mol. Biochem. Parasitol. 138:79-82(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiAT1A_TAESO
AccessioniPrimary (citable) accession number: Q6RWA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: July 5, 2004
Last modified: March 4, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.