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Q6RWA9 (AT1A_TAESO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sodium/potassium-transporting ATPase subunit alpha

Short name=Na(+)/K(+) ATPase alpha subunit
EC=3.6.3.9
Alternative name(s):
Sodium pump subunit alpha
TNaK1-alpha
OrganismTaenia solium (Pork tapeworm)
Taxonomic identifier6204 [NCBI]
Taxonomic lineageEukaryotaMetazoaPlatyhelminthesCestodaEucestodaCyclophyllideaTaeniidaeTaenia

Protein attributes

Sequence length1014 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients By similarity.

Catalytic activity

ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Subunit structure

Composed of three subunits: alpha (catalytic), beta and gamma By similarity.

Subcellular location

Membrane; Multi-pass membrane protein Ref.1.

Tissue specificity

Preferentially localized in muscle cells and protonephridial ducts, and in small quantities in the tegument of cysticerci. Ref.1

Sequence similarities

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily. [View classification]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 10141014Sodium/potassium-transporting ATPase subunit alpha
PRO_0000291569

Regions

Transmembrane124 – 14421Helical; Potential
Transmembrane281 – 30020Helical; Potential
Transmembrane313 – 33018Helical; Potential
Transmembrane764 – 78320Helical; Potential
Transmembrane794 – 81421Helical; Potential
Transmembrane834 – 85623Helical; Potential
Transmembrane909 – 92820Helical; Potential
Transmembrane942 – 96019Helical; Potential
Transmembrane976 – 99621Helical; Potential

Sites

Active site36814-aspartylphosphate intermediate By similarity
Metal binding7081Magnesium By similarity
Metal binding7121Magnesium By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6RWA9 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 595741648A93D5D1

FASTA1,014111,990
        10         20         30         40         50         60 
MGKSRGDKYR DATDGKKDAK KDLNELKQEL AMDEHQISLD ELYARLGTNP DTGLTSEQAK 

        70         80         90        100        110        120 
TRLDRDGPNA LTPPKTTPEW VKFCKNMFGG FSLLLWIGAV LCFIAHGIPC WCAGEPYLYD 

       130        140        150        160        170        180 
NLYLGIVLAA VVVITGCFSY YQESKSSKIM ESFAKLVPQY AVVIRGGQRI DAPAEALVVG 

       190        200        210        220        230        240 
DIIDVKFGDR VPADIRVIKA SSFKVDNSAL TGESEPQTRT AEYTNENPLE TKNLAFFSTN 

       250        260        270        280        290        300 
AVEGTCRGVV VATGDRTVMG RIANLASGLE MGATPIAREI AHFIHIITGV AVFLGVTFFI 

       310        320        330        340        350        360 
IAFILGYYWL DAVIFLIGII VANVPEGLLA TVTVCLTLTA KRMASKNCLV KNLEAVETLG 

       370        380        390        400        410        420 
STSTICSDKT GTLTQNRMTV AHMWFDNKIF EADTSDDQST ANYSRASSTW MALSRIAMLC 

       430        440        450        460        470        480 
NRAEFKPGEE TNPVLKRECN GDASESALLK CVGLSIGGVT GYRTDKPKVA EIPFNSTNKY 

       490        500        510        520        530        540 
QVSVHQTDDG DERYLVVMKG APERILDRCS TVLMEGQELH MDDQWRESFN NAYLELGGIG 

       550        560        570        580        590        600 
ERVLGFCDLR LPADKFPRGF KFDIDEPNFP IEGMPFVGLM SMIDPPRAAV PDAVSKCRSA 

       610        620        630        640        650        660 
GIKVVMVTGD HPITAKAIAK GVGIISDGNK TVEDIAAERG VPVSQVNPRE ASACVVHGSD 

       670        680        690        700        710        720 
LRDMTPAQID EILENHSEIV FARTSPQQKL IIVEGIQRMG AIVAVTGDGV NDSPALKKAD 

       730        740        750        760        770        780 
IGVAMGITGS DVSKQAADMI LLDDNFASIV TGVEEGRIIF DNLKKSIAYT LTSNIPEITP 

       790        800        810        820        830        840 
FLIFILADVP LPLGTITILC IDLGTDMVPA ISLAYEEAED IMKRMPRDPF RDKLVNERLI 

       850        860        870        880        890        900 
SMAYGQIGMI QASGGFFVYF VIMAENGFWP SRLLGLRKQW DSPAINDVAD SYGQEWTYTQ 

       910        920        930        940        950        960 
RKRLEYTCHT AFFASIVIVQ WTDLLICKTR KNSIYQQGMW NHHLTFGLFF ETTLAIFLSY 

       970        980        990       1000       1010 
CPGLEHGLRM MPLRWTWWLP VLPFSVSIFI FDEVRKKFLR TLPPGNWVER ETNY 

« Hide

References

[1]"Cloning and expression of a Na(+), K(+)-ATPase alpha-subunit from Taenia solium (TNaK1alpha)."
Willms K., Shoemaker C.B., Skelly P.J., Landa A.
Mol. Biochem. Parasitol. 138:79-82(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY487828 mRNA. Translation: AAS59168.1.

3D structure databases

ProteinModelPortalQ6RWA9.
SMRQ6RWA9. Positions 20-1014.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEQ6RWA9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
SMARTSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAT1A_TAESO
AccessionPrimary (citable) accession number: Q6RWA9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families