SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6RWA9

- AT1A_TAESO

UniProt

Q6RWA9 - AT1A_TAESO

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Sodium/potassium-transporting ATPase subunit alpha

Gene
N/A
Organism
Taenia solium (Pork tapeworm)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients By similarity.

Catalytic activityi

ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei368 – 36814-aspartylphosphate intermediate By similarity
Metal bindingi708 – 7081Magnesium By similarity
Metal bindingi712 – 7121Magnesium By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sodium:potassium-exchanging ATPase activity Source: UniProtKB-EC

GO - Biological processi

  1. ATP biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium/potassium-transporting ATPase subunit alpha (EC:3.6.3.9)
Short name:
Na(+)/K(+) ATPase alpha subunit
Alternative name(s):
Sodium pump subunit alpha
TNaK1-alpha
OrganismiTaenia solium (Pork tapeworm)
Taxonomic identifieri6204 [NCBI]
Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesCestodaEucestodaCyclophyllideaTaeniidaeTaenia

Subcellular locationi

Membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei124 – 14421Helical; Reviewed predictionAdd
BLAST
Transmembranei281 – 30020Helical; Reviewed predictionAdd
BLAST
Transmembranei313 – 33018Helical; Reviewed predictionAdd
BLAST
Transmembranei764 – 78320Helical; Reviewed predictionAdd
BLAST
Transmembranei794 – 81421Helical; Reviewed predictionAdd
BLAST
Transmembranei834 – 85623Helical; Reviewed predictionAdd
BLAST
Transmembranei909 – 92820Helical; Reviewed predictionAdd
BLAST
Transmembranei942 – 96019Helical; Reviewed predictionAdd
BLAST
Transmembranei976 – 99621Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10141014Sodium/potassium-transporting ATPase subunit alphaPRO_0000291569Add
BLAST

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ6RWA9.

Expressioni

Tissue specificityi

Preferentially localized in muscle cells and protonephridial ducts, and in small quantities in the tegument of cysticerci.1 Publication

Interactioni

Subunit structurei

Composed of three subunits: alpha (catalytic), beta and gamma By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ6RWA9.
SMRiQ6RWA9. Positions 20-1014.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

Gene3Di1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view]
PfamiPF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view]
PRINTSiPR00119. CATATPASE.
SMARTiSM00831. Cation_ATPase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6RWA9-1 [UniParc]FASTAAdd to Basket

« Hide

MGKSRGDKYR DATDGKKDAK KDLNELKQEL AMDEHQISLD ELYARLGTNP     50
DTGLTSEQAK TRLDRDGPNA LTPPKTTPEW VKFCKNMFGG FSLLLWIGAV 100
LCFIAHGIPC WCAGEPYLYD NLYLGIVLAA VVVITGCFSY YQESKSSKIM 150
ESFAKLVPQY AVVIRGGQRI DAPAEALVVG DIIDVKFGDR VPADIRVIKA 200
SSFKVDNSAL TGESEPQTRT AEYTNENPLE TKNLAFFSTN AVEGTCRGVV 250
VATGDRTVMG RIANLASGLE MGATPIAREI AHFIHIITGV AVFLGVTFFI 300
IAFILGYYWL DAVIFLIGII VANVPEGLLA TVTVCLTLTA KRMASKNCLV 350
KNLEAVETLG STSTICSDKT GTLTQNRMTV AHMWFDNKIF EADTSDDQST 400
ANYSRASSTW MALSRIAMLC NRAEFKPGEE TNPVLKRECN GDASESALLK 450
CVGLSIGGVT GYRTDKPKVA EIPFNSTNKY QVSVHQTDDG DERYLVVMKG 500
APERILDRCS TVLMEGQELH MDDQWRESFN NAYLELGGIG ERVLGFCDLR 550
LPADKFPRGF KFDIDEPNFP IEGMPFVGLM SMIDPPRAAV PDAVSKCRSA 600
GIKVVMVTGD HPITAKAIAK GVGIISDGNK TVEDIAAERG VPVSQVNPRE 650
ASACVVHGSD LRDMTPAQID EILENHSEIV FARTSPQQKL IIVEGIQRMG 700
AIVAVTGDGV NDSPALKKAD IGVAMGITGS DVSKQAADMI LLDDNFASIV 750
TGVEEGRIIF DNLKKSIAYT LTSNIPEITP FLIFILADVP LPLGTITILC 800
IDLGTDMVPA ISLAYEEAED IMKRMPRDPF RDKLVNERLI SMAYGQIGMI 850
QASGGFFVYF VIMAENGFWP SRLLGLRKQW DSPAINDVAD SYGQEWTYTQ 900
RKRLEYTCHT AFFASIVIVQ WTDLLICKTR KNSIYQQGMW NHHLTFGLFF 950
ETTLAIFLSY CPGLEHGLRM MPLRWTWWLP VLPFSVSIFI FDEVRKKFLR 1000
TLPPGNWVER ETNY 1014
Length:1,014
Mass (Da):111,990
Last modified:July 5, 2004 - v1
Checksum:i595741648A93D5D1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY487828 mRNA. Translation: AAS59168.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY487828 mRNA. Translation: AAS59168.1 .

3D structure databases

ProteinModelPortali Q6RWA9.
SMRi Q6RWA9. Positions 20-1014.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q6RWA9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.20.1110.10. 2 hits.
2.70.150.10. 2 hits.
3.40.1110.10. 1 hit.
InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
IPR004014. ATPase_P-typ_cation-transptr_N.
IPR023299. ATPase_P-typ_cyto_domN.
IPR005775. ATPase_P-typ_Na/K_IIC.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR001757. Cation_transp_P_typ_ATPase.
IPR023214. HAD-like_dom.
[Graphical view ]
Pfami PF00689. Cation_ATPase_C. 1 hit.
PF00690. Cation_ATPase_N. 1 hit.
PF00122. E1-E2_ATPase. 1 hit.
PF00702. Hydrolase. 1 hit.
[Graphical view ]
PRINTSi PR00119. CATATPASE.
SMARTi SM00831. Cation_ATPase_N. 1 hit.
[Graphical view ]
SUPFAMi SSF56784. SSF56784. 3 hits.
SSF81660. SSF81660. 1 hit.
TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cloning and expression of a Na(+), K(+)-ATPase alpha-subunit from Taenia solium (TNaK1alpha)."
    Willms K., Shoemaker C.B., Skelly P.J., Landa A.
    Mol. Biochem. Parasitol. 138:79-82(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiAT1A_TAESO
AccessioniPrimary (citable) accession number: Q6RWA9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi