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Q6RWA9

- AT1A_TAESO

UniProt

Q6RWA9 - AT1A_TAESO

Protein

Sodium/potassium-transporting ATPase subunit alpha

Gene
N/A
Organism
Taenia solium (Pork tapeworm)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients By similarity.By similarity

    Catalytic activityi

    ATP + H2O + Na+(In) + K+(Out) = ADP + phosphate + Na+(Out) + K+(In).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei368 – 36814-aspartylphosphate intermediateBy similarity
    Metal bindingi708 – 7081MagnesiumBy similarity
    Metal bindingi712 – 7121MagnesiumBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sodium:potassium-exchanging ATPase activity Source: UniProtKB-EC

    GO - Biological processi

    1. ATP biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Ion transport, Potassium transport, Sodium transport, Sodium/potassium transport, Transport

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium/potassium-transporting ATPase subunit alpha (EC:3.6.3.9)
    Short name:
    Na(+)/K(+) ATPase alpha subunit
    Alternative name(s):
    Sodium pump subunit alpha
    TNaK1-alpha
    OrganismiTaenia solium (Pork tapeworm)
    Taxonomic identifieri6204 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaPlatyhelminthesCestodaEucestodaCyclophyllideaTaeniidaeTaenia

    Subcellular locationi

    Membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10141014Sodium/potassium-transporting ATPase subunit alphaPRO_0000291569Add
    BLAST

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ6RWA9.

    Expressioni

    Tissue specificityi

    Preferentially localized in muscle cells and protonephridial ducts, and in small quantities in the tegument of cysticerci.1 Publication

    Interactioni

    Subunit structurei

    Composed of three subunits: alpha (catalytic), beta and gamma.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6RWA9.
    SMRiQ6RWA9. Positions 20-1014.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei124 – 14421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei281 – 30020HelicalSequence AnalysisAdd
    BLAST
    Transmembranei313 – 33018HelicalSequence AnalysisAdd
    BLAST
    Transmembranei764 – 78320HelicalSequence AnalysisAdd
    BLAST
    Transmembranei794 – 81421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei834 – 85623HelicalSequence AnalysisAdd
    BLAST
    Transmembranei909 – 92820HelicalSequence AnalysisAdd
    BLAST
    Transmembranei942 – 96019HelicalSequence AnalysisAdd
    BLAST
    Transmembranei976 – 99621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Family and domain databases

    Gene3Di1.20.1110.10. 2 hits.
    2.70.150.10. 2 hits.
    3.40.1110.10. 1 hit.
    InterProiIPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR005775. ATPase_P-typ_Na/K_IIC.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view]
    PfamiPF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view]
    PRINTSiPR00119. CATATPASE.
    SMARTiSM00831. Cation_ATPase_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF56784. SSF56784. 3 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsiTIGR01106. ATPase-IIC_X-K. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6RWA9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKSRGDKYR DATDGKKDAK KDLNELKQEL AMDEHQISLD ELYARLGTNP     50
    DTGLTSEQAK TRLDRDGPNA LTPPKTTPEW VKFCKNMFGG FSLLLWIGAV 100
    LCFIAHGIPC WCAGEPYLYD NLYLGIVLAA VVVITGCFSY YQESKSSKIM 150
    ESFAKLVPQY AVVIRGGQRI DAPAEALVVG DIIDVKFGDR VPADIRVIKA 200
    SSFKVDNSAL TGESEPQTRT AEYTNENPLE TKNLAFFSTN AVEGTCRGVV 250
    VATGDRTVMG RIANLASGLE MGATPIAREI AHFIHIITGV AVFLGVTFFI 300
    IAFILGYYWL DAVIFLIGII VANVPEGLLA TVTVCLTLTA KRMASKNCLV 350
    KNLEAVETLG STSTICSDKT GTLTQNRMTV AHMWFDNKIF EADTSDDQST 400
    ANYSRASSTW MALSRIAMLC NRAEFKPGEE TNPVLKRECN GDASESALLK 450
    CVGLSIGGVT GYRTDKPKVA EIPFNSTNKY QVSVHQTDDG DERYLVVMKG 500
    APERILDRCS TVLMEGQELH MDDQWRESFN NAYLELGGIG ERVLGFCDLR 550
    LPADKFPRGF KFDIDEPNFP IEGMPFVGLM SMIDPPRAAV PDAVSKCRSA 600
    GIKVVMVTGD HPITAKAIAK GVGIISDGNK TVEDIAAERG VPVSQVNPRE 650
    ASACVVHGSD LRDMTPAQID EILENHSEIV FARTSPQQKL IIVEGIQRMG 700
    AIVAVTGDGV NDSPALKKAD IGVAMGITGS DVSKQAADMI LLDDNFASIV 750
    TGVEEGRIIF DNLKKSIAYT LTSNIPEITP FLIFILADVP LPLGTITILC 800
    IDLGTDMVPA ISLAYEEAED IMKRMPRDPF RDKLVNERLI SMAYGQIGMI 850
    QASGGFFVYF VIMAENGFWP SRLLGLRKQW DSPAINDVAD SYGQEWTYTQ 900
    RKRLEYTCHT AFFASIVIVQ WTDLLICKTR KNSIYQQGMW NHHLTFGLFF 950
    ETTLAIFLSY CPGLEHGLRM MPLRWTWWLP VLPFSVSIFI FDEVRKKFLR 1000
    TLPPGNWVER ETNY 1014
    Length:1,014
    Mass (Da):111,990
    Last modified:July 5, 2004 - v1
    Checksum:i595741648A93D5D1
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY487828 mRNA. Translation: AAS59168.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY487828 mRNA. Translation: AAS59168.1 .

    3D structure databases

    ProteinModelPortali Q6RWA9.
    SMRi Q6RWA9. Positions 20-1014.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q6RWA9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.20.1110.10. 2 hits.
    2.70.150.10. 2 hits.
    3.40.1110.10. 1 hit.
    InterProi IPR006068. ATPase_P-typ_cation-transptr_C.
    IPR004014. ATPase_P-typ_cation-transptr_N.
    IPR023299. ATPase_P-typ_cyto_domN.
    IPR005775. ATPase_P-typ_Na/K_IIC.
    IPR018303. ATPase_P-typ_P_site.
    IPR023298. ATPase_P-typ_TM_dom.
    IPR008250. ATPase_P-typ_transduc_dom_A.
    IPR001757. Cation_transp_P_typ_ATPase.
    IPR023214. HAD-like_dom.
    [Graphical view ]
    Pfami PF00689. Cation_ATPase_C. 1 hit.
    PF00690. Cation_ATPase_N. 1 hit.
    PF00122. E1-E2_ATPase. 1 hit.
    PF00702. Hydrolase. 1 hit.
    [Graphical view ]
    PRINTSi PR00119. CATATPASE.
    SMARTi SM00831. Cation_ATPase_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56784. SSF56784. 3 hits.
    SSF81660. SSF81660. 1 hit.
    TIGRFAMsi TIGR01106. ATPase-IIC_X-K. 1 hit.
    TIGR01494. ATPase_P-type. 2 hits.
    PROSITEi PS00154. ATPASE_E1_E2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of a Na(+), K(+)-ATPase alpha-subunit from Taenia solium (TNaK1alpha)."
      Willms K., Shoemaker C.B., Skelly P.J., Landa A.
      Mol. Biochem. Parasitol. 138:79-82(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiAT1A_TAESO
    AccessioniPrimary (citable) accession number: Q6RWA9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 26, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 56 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3