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Q6RW13

- ATRAP_HUMAN

UniProt

Q6RW13 - ATRAP_HUMAN

Protein

Type-1 angiotensin II receptor-associated protein

Gene

AGTRAP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.1 Publication

    GO - Molecular functioni

    1. angiotensin type II receptor activity Source: Ensembl
    2. protein binding Source: IntAct

    GO - Biological processi

    1. regulation of blood pressure Source: Ensembl
    2. response to hypoxia Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Type-1 angiotensin II receptor-associated protein
    Alternative name(s):
    AT1 receptor-associated protein
    Gene namesi
    Name:AGTRAP
    Synonyms:ATRAP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:13539. AGTRAP.

    Subcellular locationi

    Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication. Golgi apparatus membrane 1 Publication; Multi-pass membrane protein 1 Publication. Cytoplasmic vesicle membrane 1 Publication; Multi-pass membrane protein 1 Publication
    Note: Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles.

    GO - Cellular componenti

    1. cell cortex Source: Ensembl
    2. cytoplasmic vesicle membrane Source: UniProtKB-SubCell
    3. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    4. Golgi membrane Source: UniProtKB-SubCell
    5. integral component of membrane Source: UniProtKB-KW
    6. plasma membrane Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA38363.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 159159Type-1 angiotensin II receptor-associated proteinPRO_0000064735Add
    BLAST

    Proteomic databases

    MaxQBiQ6RW13.
    PaxDbiQ6RW13.
    PeptideAtlasiQ6RW13.
    PRIDEiQ6RW13.

    PTM databases

    PhosphoSiteiQ6RW13.

    Expressioni

    Tissue specificityi

    Ubiquitous but more abundant in kidney, heart, pancreas and thyroid.1 Publication

    Gene expression databases

    ArrayExpressiQ6RW13.
    BgeeiQ6RW13.
    CleanExiHS_AGTRAP.
    GenevestigatoriQ6RW13.

    Organism-specific databases

    HPAiHPA044120.

    Interactioni

    Subunit structurei

    Interacts with GNB2L1/RACK1, and with the C-terminal region of AGTR1.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PBX3Q96AL53EBI-741181,EBI-741171
    PITPNC1Q9UKF73EBI-741181,EBI-749241

    Protein-protein interaction databases

    BioGridi121356. 7 interactions.
    IntActiQ6RW13. 10 interactions.
    STRINGi9606.ENSP00000319713.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6RW13.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini45 – 5511CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini77 – 8610ExtracellularSequence Analysis
    Topological domaini108 – 15952CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei56 – 7621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei87 – 10721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni110 – 12213Interaction with AGTR1Add
    BLAST

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG45277.
    HOGENOMiHOG000034218.
    HOVERGENiHBG080881.
    InParanoidiQ6RW13.
    OMAiVHISIFY.
    OrthoDBiEOG7SFHZD.
    PhylomeDBiQ6RW13.
    TreeFamiTF324477.

    Family and domain databases

    InterProiIPR009436. Angiotensin_II_typ1_rcpt-assoc.
    [Graphical view]
    PfamiPF06396. AGTRAP. 1 hit.
    [Graphical view]
    ProDomiPD357679. PD357679. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SMARTiSM00805. AGTRAP. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6RW13-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MELPAVNLKV ILLGHWLLTT WGCIVFSGSY AWANFTILAL GVWAVAQRDS    50
    IDAISMFLGG LLATIFLDIV HISIFYPRVS LTDTGRFGVG MAILSLLLKP 100
    LSCCFVYHMY RERGGELLVH TGFLGSSQDR SAYQTIDSAE APADPFAVPE 150
    GRSQDARGY 159
    Length:159
    Mass (Da):17,419
    Last modified:July 5, 2004 - v1
    Checksum:i7E1D5C7E79AE6BC5
    GO
    Isoform 2 (identifier: Q6RW13-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         115-121: Missing.

    Show »
    Length:152
    Mass (Da):16,669
    Checksum:i637C01214175C3C9
    GO
    Isoform 3 (identifier: Q6RW13-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         21-159: WGCIVFSGSY...EGRSQDARGY → CFWRHFSAKP...RLPHVPGARG

    Note: No experimental confirmation available.

    Show »
    Length:147
    Mass (Da):16,048
    Checksum:i27B4716DE9C64CEC
    GO
    Isoform 5 (identifier: Q6RW13-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         21-159: WGCIVFSGSY...EGRSQDARGY → CFWRHFSAKP...RGFPWVFSGP

    Show »
    Length:155
    Mass (Da):16,966
    Checksum:iC78BE559AC52A0A0
    GO
    Isoform 4 (identifier: Q6RW13-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         10-159: VILLGHWLLT...EGRSQDARGY → GLHCILRLLC...RGFPWVFSGP

    Note: No experimental confirmation available.

    Show »
    Length:111
    Mass (Da):11,948
    Checksum:i5ECC78C7CD1D332B
    GO

    Sequence cautioni

    The sequence CAI15876.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti158 – 1581G → R in AAF89547. 1 PublicationCurated
    Sequence conflicti159 – 1591Y → S in AAL26806. (PubMed:11733189)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti143 – 1431A → V.1 Publication
    Corresponds to variant rs17875960 [ dbSNP | Ensembl ].
    VAR_023075

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei10 – 159150VILLG…DARGY → GLHCILRLLCLGQLHHPGLG RVGCGSAGLHRRHKHVSGWL AGHHLPGHRAHQHLLPAGQP HGHGPLWRGHGHPQLAAQAA LLLLRLPHVPGARGFPWVFS GP in isoform 4. 1 PublicationVSP_039291Add
    BLAST
    Alternative sequencei21 – 159139WGCIV…DARGY → CFWRHFSAKPRLETIELTCA LCKLRSAAHRATAGLHCILR LLCLGQLHHPGLGRVGCGSA GLHRRHKHVSGWLAGHHLPG HRAHQHLLPAGQPHGHGPLW RGHGHPQLAAQAALLLLRLP HVPGARG in isoform 3. CuratedVSP_039290Add
    BLAST
    Alternative sequencei21 – 159139WGCIV…DARGY → CFWRHFSAKPRLETIELTCA LCKLRSAAHRATAGLHCILR LLCLGQLHHPGLGRVGCGSA GLHRRHKHVSGWLAGHHLPG HRAHQHLLPAGQPHGHGPLW RGHGHPQLAAQAALLLLRLP HVPGARGFPWVFSGP in isoform 5. 1 PublicationVSP_040406Add
    BLAST
    Alternative sequencei115 – 1217Missing in isoform 2. 1 PublicationVSP_014839

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF312374 mRNA. Translation: AAL26806.1.
    AF165187 mRNA. Translation: AAF89547.1.
    CA866314 mRNA. No translation available.
    AY488088 Genomic DNA. Translation: AAR25556.1.
    AL953897 Genomic DNA. Translation: CAI15876.1. Sequence problems.
    AL953897 Genomic DNA. Translation: CAI15877.1.
    AL953897 Genomic DNA. Translation: CAI15878.1.
    AL953897 Genomic DNA. Translation: CAI15879.1.
    CH471130 Genomic DNA. Translation: EAW71702.1.
    BC017328 mRNA. Translation: AAH17328.1.
    BE782705 mRNA. No translation available.
    CCDSiCCDS136.1. [Q6RW13-1]
    CCDS30585.1. [Q6RW13-2]
    CCDS30586.1. [Q6RW13-4]
    CCDS41248.1. [Q6RW13-3]
    CCDS44056.1. [Q6RW13-5]
    RefSeqiNP_001035284.1. NM_001040194.1. [Q6RW13-2]
    NP_001035285.1. NM_001040195.1. [Q6RW13-4]
    NP_001035286.1. NM_001040196.1. [Q6RW13-5]
    NP_001035287.1. NM_001040197.1. [Q6RW13-3]
    NP_065083.3. NM_020350.4. [Q6RW13-1]
    UniGeneiHs.464438.

    Genome annotation databases

    EnsembliENST00000314340; ENSP00000319713; ENSG00000177674. [Q6RW13-1]
    ENST00000376629; ENSP00000365816; ENSG00000177674. [Q6RW13-2]
    ENST00000376637; ENSP00000365824; ENSG00000177674. [Q6RW13-4]
    ENST00000400895; ENSP00000383688; ENSG00000177674. [Q6RW13-3]
    ENST00000452018; ENSP00000408505; ENSG00000177674. [Q6RW13-5]
    GeneIDi57085.
    KEGGihsa:57085.
    UCSCiuc001ast.3. human. [Q6RW13-3]
    uc001asu.3. human. [Q6RW13-5]
    uc001asv.3. human. [Q6RW13-1]
    uc001asw.3. human. [Q6RW13-2]
    uc001asx.3. human. [Q6RW13-4]

    Polymorphism databases

    DMDMi71152303.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    SeattleSNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF312374 mRNA. Translation: AAL26806.1 .
    AF165187 mRNA. Translation: AAF89547.1 .
    CA866314 mRNA. No translation available.
    AY488088 Genomic DNA. Translation: AAR25556.1 .
    AL953897 Genomic DNA. Translation: CAI15876.1 . Sequence problems.
    AL953897 Genomic DNA. Translation: CAI15877.1 .
    AL953897 Genomic DNA. Translation: CAI15878.1 .
    AL953897 Genomic DNA. Translation: CAI15879.1 .
    CH471130 Genomic DNA. Translation: EAW71702.1 .
    BC017328 mRNA. Translation: AAH17328.1 .
    BE782705 mRNA. No translation available.
    CCDSi CCDS136.1. [Q6RW13-1 ]
    CCDS30585.1. [Q6RW13-2 ]
    CCDS30586.1. [Q6RW13-4 ]
    CCDS41248.1. [Q6RW13-3 ]
    CCDS44056.1. [Q6RW13-5 ]
    RefSeqi NP_001035284.1. NM_001040194.1. [Q6RW13-2 ]
    NP_001035285.1. NM_001040195.1. [Q6RW13-4 ]
    NP_001035286.1. NM_001040196.1. [Q6RW13-5 ]
    NP_001035287.1. NM_001040197.1. [Q6RW13-3 ]
    NP_065083.3. NM_020350.4. [Q6RW13-1 ]
    UniGenei Hs.464438.

    3D structure databases

    ProteinModelPortali Q6RW13.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 121356. 7 interactions.
    IntActi Q6RW13. 10 interactions.
    STRINGi 9606.ENSP00000319713.

    PTM databases

    PhosphoSitei Q6RW13.

    Polymorphism databases

    DMDMi 71152303.

    Proteomic databases

    MaxQBi Q6RW13.
    PaxDbi Q6RW13.
    PeptideAtlasi Q6RW13.
    PRIDEi Q6RW13.

    Protocols and materials databases

    DNASUi 57085.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000314340 ; ENSP00000319713 ; ENSG00000177674 . [Q6RW13-1 ]
    ENST00000376629 ; ENSP00000365816 ; ENSG00000177674 . [Q6RW13-2 ]
    ENST00000376637 ; ENSP00000365824 ; ENSG00000177674 . [Q6RW13-4 ]
    ENST00000400895 ; ENSP00000383688 ; ENSG00000177674 . [Q6RW13-3 ]
    ENST00000452018 ; ENSP00000408505 ; ENSG00000177674 . [Q6RW13-5 ]
    GeneIDi 57085.
    KEGGi hsa:57085.
    UCSCi uc001ast.3. human. [Q6RW13-3 ]
    uc001asu.3. human. [Q6RW13-5 ]
    uc001asv.3. human. [Q6RW13-1 ]
    uc001asw.3. human. [Q6RW13-2 ]
    uc001asx.3. human. [Q6RW13-4 ]

    Organism-specific databases

    CTDi 57085.
    GeneCardsi GC01P011796.
    HGNCi HGNC:13539. AGTRAP.
    HPAi HPA044120.
    MIMi 608729. gene.
    neXtProti NX_Q6RW13.
    PharmGKBi PA38363.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG45277.
    HOGENOMi HOG000034218.
    HOVERGENi HBG080881.
    InParanoidi Q6RW13.
    OMAi VHISIFY.
    OrthoDBi EOG7SFHZD.
    PhylomeDBi Q6RW13.
    TreeFami TF324477.

    Miscellaneous databases

    ChiTaRSi AGTRAP. human.
    GeneWikii AGTRAP.
    GenomeRNAii 57085.
    NextBioi 62875.
    PROi Q6RW13.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6RW13.
    Bgeei Q6RW13.
    CleanExi HS_AGTRAP.
    Genevestigatori Q6RW13.

    Family and domain databases

    InterProi IPR009436. Angiotensin_II_typ1_rcpt-assoc.
    [Graphical view ]
    Pfami PF06396. AGTRAP. 1 hit.
    [Graphical view ]
    ProDomi PD357679. PD357679. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SMARTi SM00805. AGTRAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of AGTRAP, a human homolog of murine angiotensin II receptor-associated protein (Agtrap)."
      Wang W., Huang Y., Zhou Z., Tang R., Zhao W., Zeng L., Xu M., Cheng C., Gu S., Ying K., Xie Y., Mao Y.
      Int. J. Biochem. Cell Biol. 34:93-102(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INTERACTION WITH GNB2L1 AND AGTR1.
      Tissue: Fetal brain.
    2. Ye R.D., He R.
      Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Kidney.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Pancreas islet cell.
    4. SeattleSNPs variation discovery resource
      Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-143.
    5. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5).
      Tissue: Colon and Eye.
    8. "The angiotensin II type I receptor-associated protein, ATRAP, is a transmembrane protein and a modulator of angiotensin II signaling."
      Lopez-Ilasaca M., Liu X., Tamura K., Dzau V.J.
      Mol. Biol. Cell 14:5038-5050(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH AGTR1.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiATRAP_HUMAN
    AccessioniPrimary (citable) accession number: Q6RW13
    Secondary accession number(s): A8MVQ5
    , Q5SNV4, Q5SNV5, Q96AC0, Q96PL4, Q9NRW9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3