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Protein

Type-1 angiotensin II receptor-associated protein

Gene

AGTRAP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.1 Publication

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-6802952. Signaling by BRAF and RAF fusions.

Names & Taxonomyi

Protein namesi
Recommended name:
Type-1 angiotensin II receptor-associated protein
Alternative name(s):
AT1 receptor-associated protein
Gene namesi
Name:AGTRAP
Synonyms:ATRAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000177674.15.
HGNCiHGNC:13539. AGTRAP.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23ExtracellularIEP:Add BLAST23
Transmembranei24 – 44HelicalIEP:Add BLAST21
Topological domaini45 – 55CytoplasmicIEP:Add BLAST11
Transmembranei56 – 76HelicalIEP:Add BLAST21
Topological domaini77 – 86ExtracellularIEP:10
Transmembranei87 – 107HelicalIEP:Add BLAST21
Topological domaini108 – 159CytoplasmicIEP:Add BLAST52

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi57085.
OpenTargetsiENSG00000177674.
PharmGKBiPA38363.

Polymorphism and mutation databases

BioMutaiAGTRAP.
DMDMi71152303.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000647351 – 159Type-1 angiotensin II receptor-associated proteinAdd BLAST159

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei126PhosphoserineND:1
Modified residuei127PhosphoserineND:1
Modified residuei135PhosphothreonineND:1
Modified residuei138PhosphoserineND:1
Modified residuei153PhosphoserineND:1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6RW13.
MaxQBiQ6RW13.
PaxDbiQ6RW13.
PeptideAtlasiQ6RW13.
PRIDEiQ6RW13.
TopDownProteomicsiQ6RW13-1. [Q6RW13-1]
Q6RW13-2. [Q6RW13-2]

PTM databases

iPTMnetiQ6RW13.
PhosphoSitePlusiQ6RW13.
SwissPalmiQ6RW13.

Expressioni

Tissue specificityi

Ubiquitous but more abundant in kidney, heart, pancreas and thyroid.1 Publication

Gene expression databases

BgeeiENSG00000177674.
CleanExiHS_AGTRAP.
ExpressionAtlasiQ6RW13. baseline and differential.
GenevisibleiQ6RW13. HS.

Organism-specific databases

HPAiHPA044120.

Interactioni

Subunit structurei

Interacts with RACK1, and with the C-terminal region of AGTR1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ACSF2Q96CM83EBI-741181,EBI-2876502
ALDH18A1P548863EBI-741181,EBI-1210304
AP3M1Q9Y2T23EBI-741181,EBI-2371151
ARAFQ96II53EBI-741181,EBI-9383168
ARFIP2P533654EBI-741181,EBI-638194
BPIFA2Q96DR53EBI-741181,EBI-10284754
C12orf10Q86UA33EBI-741181,EBI-10258793
CAPNS1P046323EBI-741181,EBI-711828
CD160O959713EBI-741181,EBI-4314390
COQ8AQ8NI605EBI-11522760,EBI-745535
CRCT1Q9UGL93EBI-741181,EBI-713677
DDA1Q9BW613EBI-741181,EBI-2510241
DDX55Q8NHQ93EBI-741181,EBI-5459844
ECM29Q5VYK34EBI-11522760,EBI-521451
FAM114A1Q8IWE23EBI-741181,EBI-2686288
FAM160A2Q8N6123EBI-741181,EBI-742137
FARS2O953633EBI-741181,EBI-2513774
FASTKD3Q14CZ73EBI-741181,EBI-10234819
FATE1Q969F03EBI-741181,EBI-743099
GABARAPL2P605203EBI-741181,EBI-720116
GAD1Q8IVA83EBI-741181,EBI-10209663
GAD1Q992593EBI-741181,EBI-743184
GAD2Q053293EBI-741181,EBI-9304251
GDNFP399053EBI-741181,EBI-10207709
GTF3C1Q127893EBI-741181,EBI-357956
HARS2P495903EBI-741181,EBI-3909030
HIST1H4GQ995253EBI-741181,EBI-10294329
HMGB1P094293EBI-741181,EBI-389432
HSCBQ8IWL33EBI-741181,EBI-1805738
HSPA4P349323EBI-741181,EBI-356933
ISCUQ9H1K13EBI-741181,EBI-1047335
LMO2P257913EBI-741181,EBI-739696
LNX1Q8TBB13EBI-741181,EBI-739832
MCEEQ96PE75EBI-11522760,EBI-10292326
MIEF1Q9NQG63EBI-741181,EBI-740987
MIEF2Q96C033EBI-741181,EBI-750153
MRM1Q6IN843EBI-741181,EBI-5454865
MTERF3Q96E293EBI-741181,EBI-7825321
MUTYHQ9UIF7-33EBI-741181,EBI-10321956
NDRG4Q9ULP03EBI-741181,EBI-10323810
NFU1Q9UMS03EBI-741181,EBI-725252
NFYBP252083EBI-741181,EBI-389728
NKG7Q166173EBI-741181,EBI-3919611
PBX3Q5JS983EBI-741181,EBI-10244393
PBX3Q96AL53EBI-741181,EBI-741171
PCTPQ9UKL63EBI-741181,EBI-4402391
PDHXO003304EBI-741181,EBI-751566
PIMREGQ9BSJ63EBI-741181,EBI-2568609
PITPNC1Q9UKF76EBI-741181,EBI-749241
PNPOQ9NVS95EBI-11522760,EBI-11030787
PTPN9P433784EBI-741181,EBI-742898
PTPN9Q6IQ433EBI-741181,EBI-10250413
RMDN2Q96LZ73EBI-741181,EBI-2806908
SENP2Q9HC624EBI-11522760,EBI-714881
SNX1Q135963EBI-741181,EBI-2822329
SPG21Q9NZD84EBI-741181,EBI-742688
SSX3Q999093EBI-741181,EBI-10295431
SSX5O602253EBI-741181,EBI-10186198
STAG3L1Q7L1H23EBI-741181,EBI-10255998
SUCLA2E5KS603EBI-741181,EBI-10176959
SYT16Q17RD73EBI-741181,EBI-10238936
TBRG4Q969Z03EBI-741181,EBI-702328
TCEANC2Q96MN53EBI-741181,EBI-5462748
TFAMQ000593EBI-741181,EBI-1049924
TPD52L3Q96J773EBI-741181,EBI-932162
TUBA1BP683633EBI-741181,EBI-487083
TXN2Q997573EBI-741181,EBI-2932492
ZFYVE21Q9BQ243EBI-741181,EBI-2849569

Protein-protein interaction databases

BioGridi121356. 83 interactors.
IntActiQ6RW13. 105 interactors.
STRINGi9606.ENSP00000319713.

Structurei

3D structure databases

ProteinModelPortaliQ6RW13.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni110 – 122Interaction with AGTR1Add BLAST13

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IYP8. Eukaryota.
ENOG4111P37. LUCA.
GeneTreeiENSGT00390000017402.
HOGENOMiHOG000034218.
HOVERGENiHBG080881.
InParanoidiQ6RW13.
OMAiYHMYRER.
OrthoDBiEOG091G0TSZ.
PhylomeDBiQ6RW13.
TreeFamiTF324477.

Family and domain databases

InterProiView protein in InterPro
IPR009436. AGTRAP.
PANTHERiPTHR16521. PTHR16521. 1 hit.
PfamiView protein in Pfam
PF06396. AGTRAP. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD357679. PD357679. 1 hit.
SMARTiView protein in SMART
SM00805. AGTRAP. 1 hit.

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6RW13-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELPAVNLKV ILLGHWLLTT WGCIVFSGSY AWANFTILAL GVWAVAQRDS
60 70 80 90 100
IDAISMFLGG LLATIFLDIV HISIFYPRVS LTDTGRFGVG MAILSLLLKP
110 120 130 140 150
LSCCFVYHMY RERGGELLVH TGFLGSSQDR SAYQTIDSAE APADPFAVPE

GRSQDARGY
Length:159
Mass (Da):17,419
Last modified:July 5, 2004 - v1
Checksum:i7E1D5C7E79AE6BC5
GO
Isoform 2 (identifier: Q6RW13-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     115-121: Missing.

Show »
Length:152
Mass (Da):16,669
Checksum:i637C01214175C3C9
GO
Isoform 3 (identifier: Q6RW13-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     21-159: WGCIVFSGSY...EGRSQDARGY → CFWRHFSAKP...RLPHVPGARG

Note: No experimental confirmation available.
Show »
Length:147
Mass (Da):16,048
Checksum:i27B4716DE9C64CEC
GO
Isoform 5 (identifier: Q6RW13-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     21-159: WGCIVFSGSY...EGRSQDARGY → CFWRHFSAKP...RGFPWVFSGP

Show »
Length:155
Mass (Da):16,966
Checksum:iC78BE559AC52A0A0
GO
Isoform 4 (identifier: Q6RW13-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     10-159: VILLGHWLLT...EGRSQDARGY → GLHCILRLLC...RGFPWVFSGP

Note: No experimental confirmation available.
Show »
Length:111
Mass (Da):11,948
Checksum:i5ECC78C7CD1D332B
GO

Sequence cautioni

The sequence CAI15876 differs from that shown. Reason: Erroneous gene model prediction.IKR:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti158G → R in AAF89547 (Ref. 2) IKR:1
Sequence conflicti159Y → S in AAL26806 (PubMed:11733189).IKR:1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_023075143A → V1 PublicationCorresponds to variant dbSNP:rs17875960Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_03929110 – 159VILLG…DARGY → GLHCILRLLCLGQLHHPGLG RVGCGSAGLHRRHKHVSGWL AGHHLPGHRAHQHLLPAGQP HGHGPLWRGHGHPQLAAQAA LLLLRLPHVPGARGFPWVFS GP in isoform 4. IBD:Add BLAST150
Alternative sequenceiVSP_03929021 – 159WGCIV…DARGY → CFWRHFSAKPRLETIELTCA LCKLRSAAHRATAGLHCILR LLCLGQLHHPGLGRVGCGSA GLHRRHKHVSGWLAGHHLPG HRAHQHLLPAGQPHGHGPLW RGHGHPQLAAQAALLLLRLP HVPGARG in isoform 3. IKR:Add BLAST139
Alternative sequenceiVSP_04040621 – 159WGCIV…DARGY → CFWRHFSAKPRLETIELTCA LCKLRSAAHRATAGLHCILR LLCLGQLHHPGLGRVGCGSA GLHRRHKHVSGWLAGHHLPG HRAHQHLLPAGQPHGHGPLW RGHGHPQLAAQAALLLLRLP HVPGARGFPWVFSGP in isoform 5. IBD:Add BLAST139
Alternative sequenceiVSP_014839115 – 121Missing in isoform 2. IBD:7

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312374 mRNA. Translation: AAL26806.1.
AF165187 mRNA. Translation: AAF89547.1.
CA866314 mRNA. No translation available.
AY488088 Genomic DNA. Translation: AAR25556.1.
AL953897 Genomic DNA. Translation: CAI15876.1. Sequence problems.
AL953897 Genomic DNA. Translation: CAI15877.1.
AL953897 Genomic DNA. Translation: CAI15878.1.
AL953897 Genomic DNA. Translation: CAI15879.1.
CH471130 Genomic DNA. Translation: EAW71702.1.
BC017328 mRNA. Translation: AAH17328.1.
BE782705 mRNA. No translation available.
CCDSiCCDS136.1. [Q6RW13-1]
CCDS30585.1. [Q6RW13-2]
CCDS30586.1. [Q6RW13-4]
CCDS41248.1. [Q6RW13-3]
CCDS44056.1. [Q6RW13-5]
RefSeqiNP_001035284.1. NM_001040194.1. [Q6RW13-2]
NP_001035285.1. NM_001040195.1. [Q6RW13-4]
NP_001035286.1. NM_001040196.1. [Q6RW13-5]
NP_001035287.1. NM_001040197.1. [Q6RW13-3]
NP_065083.3. NM_020350.4. [Q6RW13-1]
UniGeneiHs.464438.

Genome annotation databases

EnsembliENST00000314340; ENSP00000319713; ENSG00000177674. [Q6RW13-1]
ENST00000376629; ENSP00000365816; ENSG00000177674. [Q6RW13-2]
ENST00000376637; ENSP00000365824; ENSG00000177674. [Q6RW13-4]
ENST00000400895; ENSP00000383688; ENSG00000177674. [Q6RW13-3]
ENST00000452018; ENSP00000408505; ENSG00000177674. [Q6RW13-5]
GeneIDi57085.
KEGGihsa:57085.
UCSCiuc001ast.4. human. [Q6RW13-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiATRAP_HUMAN
AccessioniPrimary (citable) accession number: Q6RW13
Secondary accession number(s): A8MVQ5
, Q5SNV4, Q5SNV5, Q96AC0, Q96PL4, Q9NRW9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 5, 2004
Last modified: November 22, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot