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Q6RW13

- ATRAP_HUMAN

UniProt

Q6RW13 - ATRAP_HUMAN

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Protein

Type-1 angiotensin II receptor-associated protein

Gene

AGTRAP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.1 Publication

GO - Molecular functioni

  1. angiotensin type II receptor activity Source: Ensembl

GO - Biological processi

  1. regulation of blood pressure Source: Ensembl
  2. response to hypoxia Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Type-1 angiotensin II receptor-associated protein
Alternative name(s):
AT1 receptor-associated protein
Gene namesi
Name:AGTRAP
Synonyms:ATRAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:13539. AGTRAP.

Subcellular locationi

Endoplasmic reticulum membrane 1 Publication; Multi-pass membrane protein 1 Publication. Golgi apparatus membrane 1 Publication; Multi-pass membrane protein 1 Publication. Cytoplasmic vesicle membrane 1 Publication; Multi-pass membrane protein 1 Publication
Note: Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323ExtracellularSequence AnalysisAdd
BLAST
Transmembranei24 – 4421HelicalSequence AnalysisAdd
BLAST
Topological domaini45 – 5511CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei56 – 7621HelicalSequence AnalysisAdd
BLAST
Topological domaini77 – 8610ExtracellularSequence Analysis
Transmembranei87 – 10721HelicalSequence AnalysisAdd
BLAST
Topological domaini108 – 15952CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell cortex Source: Ensembl
  2. cytoplasmic vesicle Source: UniProtKB-KW
  3. endoplasmic reticulum Source: UniProtKB-KW
  4. Golgi apparatus Source: UniProtKB-KW
  5. integral component of membrane Source: UniProtKB-KW
  6. plasma membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38363.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 159159Type-1 angiotensin II receptor-associated proteinPRO_0000064735Add
BLAST

Proteomic databases

MaxQBiQ6RW13.
PaxDbiQ6RW13.
PeptideAtlasiQ6RW13.
PRIDEiQ6RW13.

PTM databases

PhosphoSiteiQ6RW13.

Expressioni

Tissue specificityi

Ubiquitous but more abundant in kidney, heart, pancreas and thyroid.1 Publication

Gene expression databases

BgeeiQ6RW13.
CleanExiHS_AGTRAP.
ExpressionAtlasiQ6RW13. baseline and differential.
GenevestigatoriQ6RW13.

Organism-specific databases

HPAiHPA044120.

Interactioni

Subunit structurei

Interacts with GNB2L1/RACK1, and with the C-terminal region of AGTR1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
PBX3Q96AL53EBI-741181,EBI-741171
PITPNC1Q9UKF73EBI-741181,EBI-749241

Protein-protein interaction databases

BioGridi121356. 9 interactions.
IntActiQ6RW13. 10 interactions.
STRINGi9606.ENSP00000319713.

Structurei

3D structure databases

ProteinModelPortaliQ6RW13.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni110 – 12213Interaction with AGTR1Add
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG45277.
GeneTreeiENSGT00390000017402.
HOGENOMiHOG000034218.
HOVERGENiHBG080881.
InParanoidiQ6RW13.
OMAiVHISIFY.
OrthoDBiEOG7SFHZD.
PhylomeDBiQ6RW13.
TreeFamiTF324477.

Family and domain databases

InterProiIPR009436. Angiotensin_II_typ1_rcpt-assoc.
[Graphical view]
PfamiPF06396. AGTRAP. 1 hit.
[Graphical view]
ProDomiPD357679. PD357679. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM00805. AGTRAP. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6RW13-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MELPAVNLKV ILLGHWLLTT WGCIVFSGSY AWANFTILAL GVWAVAQRDS
60 70 80 90 100
IDAISMFLGG LLATIFLDIV HISIFYPRVS LTDTGRFGVG MAILSLLLKP
110 120 130 140 150
LSCCFVYHMY RERGGELLVH TGFLGSSQDR SAYQTIDSAE APADPFAVPE

GRSQDARGY
Length:159
Mass (Da):17,419
Last modified:July 5, 2004 - v1
Checksum:i7E1D5C7E79AE6BC5
GO
Isoform 2 (identifier: Q6RW13-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     115-121: Missing.

Show »
Length:152
Mass (Da):16,669
Checksum:i637C01214175C3C9
GO
Isoform 3 (identifier: Q6RW13-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     21-159: WGCIVFSGSY...EGRSQDARGY → CFWRHFSAKP...RLPHVPGARG

Note: No experimental confirmation available.

Show »
Length:147
Mass (Da):16,048
Checksum:i27B4716DE9C64CEC
GO
Isoform 5 (identifier: Q6RW13-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     21-159: WGCIVFSGSY...EGRSQDARGY → CFWRHFSAKP...RGFPWVFSGP

Show »
Length:155
Mass (Da):16,966
Checksum:iC78BE559AC52A0A0
GO
Isoform 4 (identifier: Q6RW13-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     10-159: VILLGHWLLT...EGRSQDARGY → GLHCILRLLC...RGFPWVFSGP

Note: No experimental confirmation available.

Show »
Length:111
Mass (Da):11,948
Checksum:i5ECC78C7CD1D332B
GO

Sequence cautioni

The sequence CAI15876.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti158 – 1581G → R in AAF89547. 1 PublicationCurated
Sequence conflicti159 – 1591Y → S in AAL26806. (PubMed:11733189)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti143 – 1431A → V.1 Publication
Corresponds to variant rs17875960 [ dbSNP | Ensembl ].
VAR_023075

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei10 – 159150VILLG…DARGY → GLHCILRLLCLGQLHHPGLG RVGCGSAGLHRRHKHVSGWL AGHHLPGHRAHQHLLPAGQP HGHGPLWRGHGHPQLAAQAA LLLLRLPHVPGARGFPWVFS GP in isoform 4. 1 PublicationVSP_039291Add
BLAST
Alternative sequencei21 – 159139WGCIV…DARGY → CFWRHFSAKPRLETIELTCA LCKLRSAAHRATAGLHCILR LLCLGQLHHPGLGRVGCGSA GLHRRHKHVSGWLAGHHLPG HRAHQHLLPAGQPHGHGPLW RGHGHPQLAAQAALLLLRLP HVPGARG in isoform 3. CuratedVSP_039290Add
BLAST
Alternative sequencei21 – 159139WGCIV…DARGY → CFWRHFSAKPRLETIELTCA LCKLRSAAHRATAGLHCILR LLCLGQLHHPGLGRVGCGSA GLHRRHKHVSGWLAGHHLPG HRAHQHLLPAGQPHGHGPLW RGHGHPQLAAQAALLLLRLP HVPGARGFPWVFSGP in isoform 5. 1 PublicationVSP_040406Add
BLAST
Alternative sequencei115 – 1217Missing in isoform 2. 1 PublicationVSP_014839

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312374 mRNA. Translation: AAL26806.1.
AF165187 mRNA. Translation: AAF89547.1.
CA866314 mRNA. No translation available.
AY488088 Genomic DNA. Translation: AAR25556.1.
AL953897 Genomic DNA. Translation: CAI15876.1. Sequence problems.
AL953897 Genomic DNA. Translation: CAI15877.1.
AL953897 Genomic DNA. Translation: CAI15878.1.
AL953897 Genomic DNA. Translation: CAI15879.1.
CH471130 Genomic DNA. Translation: EAW71702.1.
BC017328 mRNA. Translation: AAH17328.1.
BE782705 mRNA. No translation available.
CCDSiCCDS136.1. [Q6RW13-1]
CCDS30585.1. [Q6RW13-2]
CCDS30586.1. [Q6RW13-4]
CCDS41248.1. [Q6RW13-3]
CCDS44056.1. [Q6RW13-5]
RefSeqiNP_001035284.1. NM_001040194.1. [Q6RW13-2]
NP_001035285.1. NM_001040195.1. [Q6RW13-4]
NP_001035286.1. NM_001040196.1. [Q6RW13-5]
NP_001035287.1. NM_001040197.1. [Q6RW13-3]
NP_065083.3. NM_020350.4. [Q6RW13-1]
UniGeneiHs.464438.

Genome annotation databases

EnsembliENST00000314340; ENSP00000319713; ENSG00000177674. [Q6RW13-1]
ENST00000376629; ENSP00000365816; ENSG00000177674. [Q6RW13-2]
ENST00000376637; ENSP00000365824; ENSG00000177674. [Q6RW13-4]
ENST00000400895; ENSP00000383688; ENSG00000177674. [Q6RW13-3]
ENST00000452018; ENSP00000408505; ENSG00000177674. [Q6RW13-5]
GeneIDi57085.
KEGGihsa:57085.
UCSCiuc001ast.3. human. [Q6RW13-3]
uc001asu.3. human. [Q6RW13-5]
uc001asv.3. human. [Q6RW13-1]
uc001asw.3. human. [Q6RW13-2]
uc001asx.3. human. [Q6RW13-4]

Polymorphism databases

DMDMi71152303.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF312374 mRNA. Translation: AAL26806.1 .
AF165187 mRNA. Translation: AAF89547.1 .
CA866314 mRNA. No translation available.
AY488088 Genomic DNA. Translation: AAR25556.1 .
AL953897 Genomic DNA. Translation: CAI15876.1 . Sequence problems.
AL953897 Genomic DNA. Translation: CAI15877.1 .
AL953897 Genomic DNA. Translation: CAI15878.1 .
AL953897 Genomic DNA. Translation: CAI15879.1 .
CH471130 Genomic DNA. Translation: EAW71702.1 .
BC017328 mRNA. Translation: AAH17328.1 .
BE782705 mRNA. No translation available.
CCDSi CCDS136.1. [Q6RW13-1 ]
CCDS30585.1. [Q6RW13-2 ]
CCDS30586.1. [Q6RW13-4 ]
CCDS41248.1. [Q6RW13-3 ]
CCDS44056.1. [Q6RW13-5 ]
RefSeqi NP_001035284.1. NM_001040194.1. [Q6RW13-2 ]
NP_001035285.1. NM_001040195.1. [Q6RW13-4 ]
NP_001035286.1. NM_001040196.1. [Q6RW13-5 ]
NP_001035287.1. NM_001040197.1. [Q6RW13-3 ]
NP_065083.3. NM_020350.4. [Q6RW13-1 ]
UniGenei Hs.464438.

3D structure databases

ProteinModelPortali Q6RW13.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 121356. 9 interactions.
IntActi Q6RW13. 10 interactions.
STRINGi 9606.ENSP00000319713.

PTM databases

PhosphoSitei Q6RW13.

Polymorphism databases

DMDMi 71152303.

Proteomic databases

MaxQBi Q6RW13.
PaxDbi Q6RW13.
PeptideAtlasi Q6RW13.
PRIDEi Q6RW13.

Protocols and materials databases

DNASUi 57085.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000314340 ; ENSP00000319713 ; ENSG00000177674 . [Q6RW13-1 ]
ENST00000376629 ; ENSP00000365816 ; ENSG00000177674 . [Q6RW13-2 ]
ENST00000376637 ; ENSP00000365824 ; ENSG00000177674 . [Q6RW13-4 ]
ENST00000400895 ; ENSP00000383688 ; ENSG00000177674 . [Q6RW13-3 ]
ENST00000452018 ; ENSP00000408505 ; ENSG00000177674 . [Q6RW13-5 ]
GeneIDi 57085.
KEGGi hsa:57085.
UCSCi uc001ast.3. human. [Q6RW13-3 ]
uc001asu.3. human. [Q6RW13-5 ]
uc001asv.3. human. [Q6RW13-1 ]
uc001asw.3. human. [Q6RW13-2 ]
uc001asx.3. human. [Q6RW13-4 ]

Organism-specific databases

CTDi 57085.
GeneCardsi GC01P011796.
HGNCi HGNC:13539. AGTRAP.
HPAi HPA044120.
MIMi 608729. gene.
neXtProti NX_Q6RW13.
PharmGKBi PA38363.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG45277.
GeneTreei ENSGT00390000017402.
HOGENOMi HOG000034218.
HOVERGENi HBG080881.
InParanoidi Q6RW13.
OMAi VHISIFY.
OrthoDBi EOG7SFHZD.
PhylomeDBi Q6RW13.
TreeFami TF324477.

Miscellaneous databases

ChiTaRSi AGTRAP. human.
GeneWikii AGTRAP.
GenomeRNAii 57085.
NextBioi 62875.
PROi Q6RW13.
SOURCEi Search...

Gene expression databases

Bgeei Q6RW13.
CleanExi HS_AGTRAP.
ExpressionAtlasi Q6RW13. baseline and differential.
Genevestigatori Q6RW13.

Family and domain databases

InterProi IPR009436. Angiotensin_II_typ1_rcpt-assoc.
[Graphical view ]
Pfami PF06396. AGTRAP. 1 hit.
[Graphical view ]
ProDomi PD357679. PD357679. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SMARTi SM00805. AGTRAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of AGTRAP, a human homolog of murine angiotensin II receptor-associated protein (Agtrap)."
    Wang W., Huang Y., Zhou Z., Tang R., Zhao W., Zeng L., Xu M., Cheng C., Gu S., Ying K., Xie Y., Mao Y.
    Int. J. Biochem. Cell Biol. 34:93-102(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INTERACTION WITH GNB2L1 AND AGTR1.
    Tissue: Fetal brain.
  2. Ye R.D., He R.
    Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Kidney.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Pancreas islet cell.
  4. SeattleSNPs variation discovery resource
    Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-143.
  5. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5).
    Tissue: Colon and Eye.
  8. "The angiotensin II type I receptor-associated protein, ATRAP, is a transmembrane protein and a modulator of angiotensin II signaling."
    Lopez-Ilasaca M., Liu X., Tamura K., Dzau V.J.
    Mol. Biol. Cell 14:5038-5050(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH AGTR1.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiATRAP_HUMAN
AccessioniPrimary (citable) accession number: Q6RW13
Secondary accession number(s): A8MVQ5
, Q5SNV4, Q5SNV5, Q96AC0, Q96PL4, Q9NRW9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3