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Q6RW13 (ATRAP_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 90. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Type-1 angiotensin II receptor-associated protein
Alternative name(s):
AT1 receptor-associated protein
Gene names
Name:AGTRAP
Synonyms:ATRAP
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length159 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalisation as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity. Ref.8

Subunit structure

Interacts with GNB2L1/RACK1, and with the C-terminal region of AGTR1. Ref.1 Ref.8

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Note: Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles. Ref.8

Tissue specificity

Ubiquitous but more abundant in kidney, heart, pancreas and thyroid. Ref.1

Sequence caution

The sequence CAI15876.1 differs from that shown. Reason: Erroneous gene model prediction.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PBX3Q96AL53EBI-741181,EBI-741171
PITPNC1Q9UKF73EBI-741181,EBI-749241

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6RW13-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6RW13-2)

The sequence of this isoform differs from the canonical sequence as follows:
     115-121: Missing.
Isoform 3 (identifier: Q6RW13-3)

The sequence of this isoform differs from the canonical sequence as follows:
     21-159: WGCIVFSGSY...EGRSQDARGY → CFWRHFSAKP...RLPHVPGARG
Note: No experimental confirmation available.
Isoform 5 (identifier: Q6RW13-5)

The sequence of this isoform differs from the canonical sequence as follows:
     21-159: WGCIVFSGSY...EGRSQDARGY → CFWRHFSAKP...RGFPWVFSGP
Isoform 4 (identifier: Q6RW13-4)

The sequence of this isoform differs from the canonical sequence as follows:
     10-159: VILLGHWLLT...EGRSQDARGY → GLHCILRLLC...RGFPWVFSGP
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 159159Type-1 angiotensin II receptor-associated protein
PRO_0000064735

Regions

Topological domain1 – 2323Extracellular Potential
Transmembrane24 – 4421Helical; Potential
Topological domain45 – 5511Cytoplasmic Potential
Transmembrane56 – 7621Helical; Potential
Topological domain77 – 8610Extracellular Potential
Transmembrane87 – 10721Helical; Potential
Topological domain108 – 15952Cytoplasmic Potential
Region110 – 12213Interaction with AGTR1

Natural variations

Alternative sequence10 – 159150VILLG…DARGY → GLHCILRLLCLGQLHHPGLG RVGCGSAGLHRRHKHVSGWL AGHHLPGHRAHQHLLPAGQP HGHGPLWRGHGHPQLAAQAA LLLLRLPHVPGARGFPWVFS GP in isoform 4.
VSP_039291
Alternative sequence21 – 159139WGCIV…DARGY → CFWRHFSAKPRLETIELTCA LCKLRSAAHRATAGLHCILR LLCLGQLHHPGLGRVGCGSA GLHRRHKHVSGWLAGHHLPG HRAHQHLLPAGQPHGHGPLW RGHGHPQLAAQAALLLLRLP HVPGARG in isoform 3.
VSP_039290
Alternative sequence21 – 159139WGCIV…DARGY → CFWRHFSAKPRLETIELTCA LCKLRSAAHRATAGLHCILR LLCLGQLHHPGLGRVGCGSA GLHRRHKHVSGWLAGHHLPG HRAHQHLLPAGQPHGHGPLW RGHGHPQLAAQAALLLLRLP HVPGARGFPWVFSGP in isoform 5.
VSP_040406
Alternative sequence115 – 1217Missing in isoform 2.
VSP_014839
Natural variant1431A → V. Ref.4
Corresponds to variant rs17875960 [ dbSNP | Ensembl ].
VAR_023075

Experimental info

Sequence conflict1581G → R in AAF89547. Ref.2
Sequence conflict1591Y → S in AAL26806. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 7E1D5C7E79AE6BC5

FASTA15917,419
        10         20         30         40         50         60 
MELPAVNLKV ILLGHWLLTT WGCIVFSGSY AWANFTILAL GVWAVAQRDS IDAISMFLGG 

        70         80         90        100        110        120 
LLATIFLDIV HISIFYPRVS LTDTGRFGVG MAILSLLLKP LSCCFVYHMY RERGGELLVH 

       130        140        150 
TGFLGSSQDR SAYQTIDSAE APADPFAVPE GRSQDARGY 

« Hide

Isoform 2 [UniParc].

Checksum: 637C01214175C3C9
Show »

FASTA15216,669
Isoform 3 [UniParc].

Checksum: 27B4716DE9C64CEC
Show »

FASTA14716,048
Isoform 5 [UniParc].

Checksum: C78BE559AC52A0A0
Show »

FASTA15516,966
Isoform 4 [UniParc].

Checksum: 5ECC78C7CD1D332B
Show »

FASTA11111,948

References

« Hide 'large scale' references
[1]"Identification and characterization of AGTRAP, a human homolog of murine angiotensin II receptor-associated protein (Agtrap)."
Wang W., Huang Y., Zhou Z., Tang R., Zhao W., Zeng L., Xu M., Cheng C., Gu S., Ying K., Xie Y., Mao Y.
Int. J. Biochem. Cell Biol. 34:93-102(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INTERACTION WITH GNB2L1 AND AGTR1.
Tissue: Fetal brain.
[2]Ye R.D., He R.
Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Kidney.
[3]Melton D., Brown J., Kenty G., Permutt A., Lee C., Kaestner K., Lemishka I., Scearce M., Brestelli J., Gradwohl G., Clifton S., Hillier L., Marra M., Pape D., Wylie T., Martin J., Blistain A., Schmitt A. expand/collapse author list , Theising B., Ritter E., Ronko I., Bennett J., Cardenas M., Gibbons M., McCann R., Cole R., Tsagareishvili R., Williams T., Jackson Y., Bowers Y.
Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
Tissue: Pancreas islet cell.
[4]SeattleSNPs variation discovery resource
Submitted (NOV-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-143.
[5]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 5).
Tissue: Colon and Eye.
[8]"The angiotensin II type I receptor-associated protein, ATRAP, is a transmembrane protein and a modulator of angiotensin II signaling."
Lopez-Ilasaca M., Liu X., Tamura K., Dzau V.J.
Mol. Biol. Cell 14:5038-5050(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH AGTR1.
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF312374 mRNA. Translation: AAL26806.1.
AF165187 mRNA. Translation: AAF89547.1.
CA866314 mRNA. No translation available.
AY488088 Genomic DNA. Translation: AAR25556.1.
AL953897 Genomic DNA. Translation: CAI15876.1. Sequence problems.
AL953897 Genomic DNA. Translation: CAI15877.1.
AL953897 Genomic DNA. Translation: CAI15878.1.
AL953897 Genomic DNA. Translation: CAI15879.1.
CH471130 Genomic DNA. Translation: EAW71702.1.
BC017328 mRNA. Translation: AAH17328.1.
BE782705 mRNA. No translation available.
RefSeqNP_001035284.1. NM_001040194.1.
NP_001035285.1. NM_001040195.1.
NP_001035286.1. NM_001040196.1.
NP_001035287.1. NM_001040197.1.
NP_065083.3. NM_020350.4.
UniGeneHs.464438.

3D structure databases

ProteinModelPortalQ6RW13.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid121356. 8 interactions.
IntActQ6RW13. 10 interactions.
STRING9606.ENSP00000319713.

PTM databases

PhosphoSiteQ6RW13.

Polymorphism databases

DMDM71152303.

Proteomic databases

PaxDbQ6RW13.
PeptideAtlasQ6RW13.
PRIDEQ6RW13.

Protocols and materials databases

DNASU57085.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000314340; ENSP00000319713; ENSG00000177674. [Q6RW13-1]
ENST00000376629; ENSP00000365816; ENSG00000177674. [Q6RW13-2]
ENST00000376637; ENSP00000365824; ENSG00000177674. [Q6RW13-4]
ENST00000400895; ENSP00000383688; ENSG00000177674. [Q6RW13-3]
ENST00000452018; ENSP00000408505; ENSG00000177674. [Q6RW13-5]
GeneID57085.
KEGGhsa:57085.
UCSCuc001ast.3. human. [Q6RW13-3]
uc001asu.3. human. [Q6RW13-5]
uc001asv.3. human. [Q6RW13-1]
uc001asw.3. human. [Q6RW13-2]
uc001asx.3. human. [Q6RW13-4]

Organism-specific databases

CTD57085.
GeneCardsGC01P011796.
HGNCHGNC:13539. AGTRAP.
HPAHPA044120.
MIM608729. gene.
neXtProtNX_Q6RW13.
PharmGKBPA38363.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG45277.
HOGENOMHOG000034218.
HOVERGENHBG080881.
InParanoidQ6RW13.
OMADAISMFL.
OrthoDBEOG7SFHZD.
PhylomeDBQ6RW13.
TreeFamTF324477.

Gene expression databases

ArrayExpressQ6RW13.
BgeeQ6RW13.
CleanExHS_AGTRAP.
GenevestigatorQ6RW13.

Family and domain databases

InterProIPR009436. Angiotensin_II_typ1_rcpt-assoc.
[Graphical view]
PfamPF06396. AGTRAP. 1 hit.
[Graphical view]
ProDomPD357679. PD357679. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00805. AGTRAP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSAGTRAP. human.
GeneWikiAGTRAP.
GenomeRNAi57085.
NextBio62875.
PROQ6RW13.
SOURCESearch...

Entry information

Entry nameATRAP_HUMAN
AccessionPrimary (citable) accession number: Q6RW13
Secondary accession number(s): A8MVQ5 expand/collapse secondary AC list , Q5SNV4, Q5SNV5, Q96AC0, Q96PL4, Q9NRW9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2005
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM