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Protein

Von Hippel-Lindau-like protein

Gene

VHLL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a dominant-negative VHL to serve as a protector of HIFalpha.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Von Hippel-Lindau-like protein
Short name:
VHL-like protein
Short name:
VLP
Gene namesi
Name:VHLL
Synonyms:VLP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:30666. VHLL.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi93 – 96NFRS → SYRG: Preferentially binds to a hydroxylated ODD peptide. 1 Publication4

Organism-specific databases

DisGeNETi391104.
OpenTargetsiENSG00000189030.
PharmGKBiPA134987272.

Polymorphism and mutation databases

BioMutaiVHLL.
DMDMi74749322.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002650871 – 139Von Hippel-Lindau-like proteinAdd BLAST139

Proteomic databases

PaxDbiQ6RSH7.
PRIDEiQ6RSH7.

PTM databases

iPTMnetiQ6RSH7.
PhosphoSitePlusiQ6RSH7.

Expressioni

Tissue specificityi

Abundantly expressed in the placenta.1 Publication

Gene expression databases

BgeeiENSG00000189030.
CleanExiHS_VHLL.

Interactioni

Subunit structurei

Interacts via the beta domain with the ODD domain of HIF1A. This interaction is independent of prolyl hydroxylation of HIF1A.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
DAZAP2Q150383EBI-10254232,EBI-724310
RBPMSQ930623EBI-10254232,EBI-740322

Protein-protein interaction databases

BioGridi133800. 3 interactors.
IntActiQ6RSH7. 2 interactors.
STRINGi9606.ENSP00000464258.

Structurei

3D structure databases

ProteinModelPortaliQ6RSH7.
SMRiQ6RSH7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni54 – 135Beta-domainAdd BLAST82

Sequence similaritiesi

Belongs to the VHL family.Curated

Phylogenomic databases

eggNOGiKOG4710. Eukaryota.
ENOG4111PRU. LUCA.
GeneTreeiENSGT00390000014353.
InParanoidiQ6RSH7.
OMAiAGPEEYC.
OrthoDBiEOG091G0NHA.
PhylomeDBiQ6RSH7.
TreeFamiTF318985.

Family and domain databases

CDDicd05468. pVHL. 1 hit.
Gene3Di2.60.40.780. 1 hit.
InterProiIPR002714. VHL.
IPR024053. VHL_beta_dom.
IPR022772. VHL_tumour_suppress_b/a_dom.
[Graphical view]
PANTHERiPTHR15160:SF5. PTHR15160:SF5. 1 hit.
PfamiPF01847. VHL. 1 hit.
[Graphical view]
SUPFAMiSSF49468. SSF49468. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6RSH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPWRAGNGVG LEAQAGTQEA GPEEYCQEEL GAEEEMAARA AWPVLRSVNS
60 70 80 90 100
RELSRIIICN HSPRIVLPVW LNYYGKLLPY LTLLPGRDFR IHNFRSHPWL
110 120 130
FRDARTHDKL LVNQTELFVP SSNVNGQPVF ANITLQCIP
Length:139
Mass (Da):15,781
Last modified:July 5, 2004 - v1
Checksum:i80246038C7F94311
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY494836 mRNA. Translation: AAS48916.1.
BC130596 mRNA. Translation: AAI30597.1.
BC130598 mRNA. Translation: AAI30599.1.
RefSeqiNP_001004319.1. NM_001004319.2.
UniGeneiHs.532378.

Genome annotation databases

EnsembliENST00000339922; ENSP00000464258; ENSG00000189030.
GeneIDi391104.
KEGGihsa:391104.
UCSCiuc001fok.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY494836 mRNA. Translation: AAS48916.1.
BC130596 mRNA. Translation: AAI30597.1.
BC130598 mRNA. Translation: AAI30599.1.
RefSeqiNP_001004319.1. NM_001004319.2.
UniGeneiHs.532378.

3D structure databases

ProteinModelPortaliQ6RSH7.
SMRiQ6RSH7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi133800. 3 interactors.
IntActiQ6RSH7. 2 interactors.
STRINGi9606.ENSP00000464258.

PTM databases

iPTMnetiQ6RSH7.
PhosphoSitePlusiQ6RSH7.

Polymorphism and mutation databases

BioMutaiVHLL.
DMDMi74749322.

Proteomic databases

PaxDbiQ6RSH7.
PRIDEiQ6RSH7.

Protocols and materials databases

DNASUi391104.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339922; ENSP00000464258; ENSG00000189030.
GeneIDi391104.
KEGGihsa:391104.
UCSCiuc001fok.4. human.

Organism-specific databases

CTDi391104.
DisGeNETi391104.
GeneCardsiVHLL.
HGNCiHGNC:30666. VHLL.
neXtProtiNX_Q6RSH7.
OpenTargetsiENSG00000189030.
PharmGKBiPA134987272.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4710. Eukaryota.
ENOG4111PRU. LUCA.
GeneTreeiENSGT00390000014353.
InParanoidiQ6RSH7.
OMAiAGPEEYC.
OrthoDBiEOG091G0NHA.
PhylomeDBiQ6RSH7.
TreeFamiTF318985.

Miscellaneous databases

GenomeRNAii391104.
PROiQ6RSH7.

Gene expression databases

BgeeiENSG00000189030.
CleanExiHS_VHLL.

Family and domain databases

CDDicd05468. pVHL. 1 hit.
Gene3Di2.60.40.780. 1 hit.
InterProiIPR002714. VHL.
IPR024053. VHL_beta_dom.
IPR022772. VHL_tumour_suppress_b/a_dom.
[Graphical view]
PANTHERiPTHR15160:SF5. PTHR15160:SF5. 1 hit.
PfamiPF01847. VHL. 1 hit.
[Graphical view]
SUPFAMiSSF49468. SSF49468. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiVHLL_HUMAN
AccessioniPrimary (citable) accession number: Q6RSH7
Secondary accession number(s): A1L4M4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Has little or no E3 ubiquitin ligase activity as it lacks the alpha domain required for nucleating the multiprotein E3 ubiquitin ligase complex.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.