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Protein

von Hippel-Lindau-like protein

Gene

VHLL

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Functions as a dominant-negative VHL to serve as a protector of HIFalpha.1 Publication

Miscellaneous

Has little or no E3 ubiquitin ligase activity as it lacks the alpha domain required for nucleating the multiprotein E3 ubiquitin ligase complex.

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
von Hippel-Lindau-like protein
Short name:
VHL-like protein
Short name:
VLP
Gene namesi
Name:VHLL
Synonyms:VLP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000189030.9
HGNCiHGNC:30666 VHLL
neXtProtiNX_Q6RSH7

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi93 – 96NFRS → SYRG: Preferentially binds to a hydroxylated ODD peptide. 1 Publication4

Organism-specific databases

DisGeNETi391104
PharmGKBiPA134987272

Polymorphism and mutation databases

BioMutaiVHLL
DMDMi74749322

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002650871 – 139von Hippel-Lindau-like proteinAdd BLAST139

Proteomic databases

PaxDbiQ6RSH7
PeptideAtlasiQ6RSH7
PRIDEiQ6RSH7

PTM databases

iPTMnetiQ6RSH7
PhosphoSitePlusiQ6RSH7

Expressioni

Tissue specificityi

Abundantly expressed in the placenta.1 Publication

Gene expression databases

BgeeiENSG00000189030
CleanExiHS_VHLL

Interactioni

Subunit structurei

Interacts via the beta domain with the ODD domain of HIF1A. This interaction is independent of prolyl hydroxylation of HIF1A.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi133800, 3 interactors
IntActiQ6RSH7, 4 interactors
STRINGi9606.ENSP00000464258

Structurei

3D structure databases

ProteinModelPortaliQ6RSH7
SMRiQ6RSH7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni54 – 135Beta-domainAdd BLAST82

Sequence similaritiesi

Belongs to the VHL family.Curated

Phylogenomic databases

eggNOGiKOG4710 Eukaryota
ENOG4111PRU LUCA
GeneTreeiENSGT00390000014353
InParanoidiQ6RSH7
OMAiAGPEEYC
OrthoDBiEOG091G0NHA
PhylomeDBiQ6RSH7
TreeFamiTF318985

Family and domain databases

CDDicd05468 pVHL, 1 hit
Gene3Di2.60.40.780, 1 hit
InterProiView protein in InterPro
IPR002714 VHL
IPR024053 VHL_beta_dom
IPR037140 VHL_beta_dom_sf
IPR036208 VHL_sf
IPR022772 VHL_tumour_suppress_b/a_dom
PANTHERiPTHR15160:SF1 PTHR15160:SF1, 1 hit
PfamiView protein in Pfam
PF01847 VHL, 1 hit
SUPFAMiSSF49468 SSF49468, 1 hit

Sequencei

Sequence statusi: Complete.

Q6RSH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPWRAGNGVG LEAQAGTQEA GPEEYCQEEL GAEEEMAARA AWPVLRSVNS
60 70 80 90 100
RELSRIIICN HSPRIVLPVW LNYYGKLLPY LTLLPGRDFR IHNFRSHPWL
110 120 130
FRDARTHDKL LVNQTELFVP SSNVNGQPVF ANITLQCIP
Length:139
Mass (Da):15,781
Last modified:July 5, 2004 - v1
Checksum:i80246038C7F94311
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY494836 mRNA Translation: AAS48916.1
BC130596 mRNA Translation: AAI30597.1
BC130598 mRNA Translation: AAI30599.1
RefSeqiNP_001004319.1, NM_001004319.2
UniGeneiHs.532378

Genome annotation databases

EnsembliENST00000339922; ENSP00000464258; ENSG00000189030
GeneIDi391104
KEGGihsa:391104
UCSCiuc001fok.4 human

Similar proteinsi

Entry informationi

Entry nameiVHLL_HUMAN
AccessioniPrimary (citable) accession number: Q6RSH7
Secondary accession number(s): A1L4M4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: July 5, 2004
Last modified: February 28, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

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