Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Reticulon-3

Gene

Rtn3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, ER-Golgi transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-8849932. SALM protein interactions at the synapses.

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulon-3
Gene namesi
Name:Rtn3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi620988. Rtn3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 771CytoplasmicSequence analysisAdd BLAST770
Intramembranei772 – 795HelicalSequence analysisAdd BLAST24
Topological domaini796 – 852CytoplasmicSequence analysisAdd BLAST57
Intramembranei853 – 875HelicalSequence analysisAdd BLAST23
Topological domaini876 – 879CytoplasmicSequence analysis4
Intramembranei880 – 902HelicalSequence analysisAdd BLAST23
Topological domaini903 – 940CytoplasmicSequence analysisAdd BLAST38

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00002805412 – 940Reticulon-3Add BLAST939

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei31PhosphoserineCombined sources1
Modified residuei196PhosphoserineBy similarity1
Modified residuei204PhosphoserineBy similarity1
Modified residuei209PhosphoserineCombined sources1
Modified residuei212PhosphoserineCombined sources1
Modified residuei249PhosphoserineCombined sources1
Modified residuei282PhosphoserineBy similarity1
Modified residuei508PhosphoserineBy similarity1
Modified residuei572PhosphothreonineCombined sources1
Modified residuei575PhosphoserineCombined sources1
Modified residuei576PhosphoserineCombined sources1
Modified residuei652PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ6RJR6.
PRIDEiQ6RJR6.

PTM databases

iPTMnetiQ6RJR6.
PhosphoSitePlusiQ6RJR6.
SwissPalmiQ6RJR6.

Expressioni

Tissue specificityi

Present in olfactory bulb, olfactory epithelium and retina (at protein level).1 Publication

Developmental stagei

In the optic nerve, expressed more abundantly in the embryo than in the adult.1 Publication

Gene expression databases

BgeeiENSRNOG00000021202.
ExpressionAtlasiQ6RJR6. baseline and differential.
GenevisibleiQ6RJR6. RN.

Interactioni

Subunit structurei

Homodimer. Interacts with RTN4. Isoform 2 interacts with BACE1, BACE2, BCL2 and FADD. Interacts with ATL2. Interacts with TMEM33 (By similarity). Interacts with ATL1 (PubMed:19665976). Interacts with ZFYVE27 and with KIF5A in a ZFYVE27-dependent manner (By similarity).By similarity1 Publication

Protein-protein interaction databases

IntActiQ6RJR6. 1 interactor.
MINTiMINT-4577751.
STRINGi10116.ENSRNOP00000028785.

Structurei

3D structure databases

ProteinModelPortaliQ6RJR6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini752 – 940ReticulonPROSITE-ProRule annotationAdd BLAST189

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni895 – 940Interaction with FADDBy similarityAdd BLAST46
Regioni908 – 910Interaction with BACE1By similarity3

Sequence similaritiesi

Contains 1 reticulon domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1792. Eukaryota.
ENOG410XPKH. LUCA.
GeneTreeiENSGT00390000009934.
HOGENOMiHOG000154220.
HOVERGENiHBG093922.
InParanoidiQ6RJR6.
KOiK20723.
OMAiQFSHTTA.
OrthoDBiEOG091G0TIO.
PhylomeDBiQ6RJR6.

Family and domain databases

InterProiIPR003388. Reticulon.
[Graphical view]
PfamiPF02453. Reticulon. 1 hit.
[Graphical view]
PROSITEiPS50845. RETICULON. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6RJR6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAESSAATQS PSVSSSSSGA EPSTLGGGGG SPGACPALGA KSCGSSCAVG
60 70 80 90 100
LSSLCSDEPP SKIMTSSFLS SSEIYNPDPT TPLGSETLGS HLVAKDGKDP
110 120 130 140 150
LVLLDKKTLD SPQGTNKDRV DTPVSLAADI PCSHPSIPDS FPEQPTFLSK
160 170 180 190 200
ETDPTEEWVV KNQEPKNPSE VPSGEDRSAL DLGQRKAEHI CTHSLSPSEP
210 220 230 240 250
AVASVEKDSP ESPFEVIIDK ATFDREFKDL YKESTDDLGG WAAHGDRESP
260 270 280 290 300
ADLLEMNDKV FPLRNKEAGR YPSSALLGRQ FSHTTAALEE VSRCVNDMHN
310 320 330 340 350
FTNEILTWDL DPQAKQQADK SPCTTESTGL DRSEHRSEIP VINLKTSPQQ
360 370 380 390 400
KMPVCSFNGS TPITRSTGDW TETFTEGKPV KGYLSSTKEA GGKGVPDSSQ
410 420 430 440 450
PISGSGAATV EVTLPDLRGT WPNSVLGEVT EVDSSGESDD TVIEDTTENP
460 470 480 490 500
SVKNNKVLPE KSDSLPSAAV KTSERENKET TSHETVRSEM YENSEQQQAH
510 520 530 540 550
AETPTQRSLE GQMSPQVPNM LNEVIPENLA MTDTTRVCSA APPSVLSETG
560 570 580 590 600
FSLTVPASAK SESLLGKNVE DTDGSSPEDL MAALTGTEEK GTVDKEKGDV
610 620 630 640 650
LEAVLEKIAN VKNTLPVELL HENKLSSSET KNTKSKYSEH SRETNGGAPK
660 670 680 690 700
VSSDLEQEQL TIRAIKELGA KQVQAERMSP GGKLKRTFDP QSGPQNSSDI
710 720 730 740 750
LEHTDITTGS DLGIPKKPTI IKDTRIDSIS SLTKTETVNK HVLARLLSDF
760 770 780 790 800
PVHDLIFWRD VKKTGFVFGT TLIMLLSLAA FSVISVVSYL ILALLSVTIS
810 820 830 840 850
FRVYKSVIQA VQKSEEGHPF KAYLDVDITL SSEAFHSYMN AAMVHVNKAL
860 870 880 890 900
KLIIRLFLVE DLVDSLKLAV FMWLMTYVGA VFNGITLLIL AELLVFSVPI
910 920 930 940
VYEKYKTQID HYVGIARDQT KSIVEKIQAK LPGIAKKKAE
Length:940
Mass (Da):101,517
Last modified:July 5, 2004 - v1
Checksum:i701B0CF84473D36B
GO
Isoform 2 (identifier: Q6RJR6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     49-751: Missing.

Show »
Length:237
Mass (Da):25,431
Checksum:iE5E372302F8A4735
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26Missing in AAP47276 (PubMed:12832288).Curated1
Sequence conflicti26Missing in AAL35353 (PubMed:15946766).Curated1
Sequence conflicti26Missing in AAL35354 (PubMed:15946766).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_02377149 – 751Missing in isoform 2. 3 PublicationsAdd BLAST703

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY164698 mRNA. Translation: AAP47276.1.
AY496443 mRNA. Translation: AAR89918.1.
AF442357 mRNA. Translation: AAL35353.1.
AF442358 mRNA. Translation: AAL35354.1.
BC062068 mRNA. Translation: AAH62068.1.
BC107448 mRNA. Translation: AAI07449.1.
RefSeqiNP_001009953.2. NM_001009953.3. [Q6RJR6-2]
NP_543185.2. NM_080909.3. [Q6RJR6-1]
UniGeneiRn.11652.

Genome annotation databases

EnsembliENSRNOT00000028785; ENSRNOP00000028785; ENSRNOG00000021202. [Q6RJR6-1]
GeneIDi140945.
KEGGirno:140945.
UCSCiRGD:620988. rat. [Q6RJR6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY164698 mRNA. Translation: AAP47276.1.
AY496443 mRNA. Translation: AAR89918.1.
AF442357 mRNA. Translation: AAL35353.1.
AF442358 mRNA. Translation: AAL35354.1.
BC062068 mRNA. Translation: AAH62068.1.
BC107448 mRNA. Translation: AAI07449.1.
RefSeqiNP_001009953.2. NM_001009953.3. [Q6RJR6-2]
NP_543185.2. NM_080909.3. [Q6RJR6-1]
UniGeneiRn.11652.

3D structure databases

ProteinModelPortaliQ6RJR6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6RJR6. 1 interactor.
MINTiMINT-4577751.
STRINGi10116.ENSRNOP00000028785.

PTM databases

iPTMnetiQ6RJR6.
PhosphoSitePlusiQ6RJR6.
SwissPalmiQ6RJR6.

Proteomic databases

PaxDbiQ6RJR6.
PRIDEiQ6RJR6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028785; ENSRNOP00000028785; ENSRNOG00000021202. [Q6RJR6-1]
GeneIDi140945.
KEGGirno:140945.
UCSCiRGD:620988. rat. [Q6RJR6-1]

Organism-specific databases

CTDi10313.
RGDi620988. Rtn3.

Phylogenomic databases

eggNOGiKOG1792. Eukaryota.
ENOG410XPKH. LUCA.
GeneTreeiENSGT00390000009934.
HOGENOMiHOG000154220.
HOVERGENiHBG093922.
InParanoidiQ6RJR6.
KOiK20723.
OMAiQFSHTTA.
OrthoDBiEOG091G0TIO.
PhylomeDBiQ6RJR6.

Enzyme and pathway databases

ReactomeiR-RNO-8849932. SALM protein interactions at the synapses.

Miscellaneous databases

PROiQ6RJR6.

Gene expression databases

BgeeiENSRNOG00000021202.
ExpressionAtlasiQ6RJR6. baseline and differential.
GenevisibleiQ6RJR6. RN.

Family and domain databases

InterProiIPR003388. Reticulon.
[Graphical view]
PfamiPF02453. Reticulon. 1 hit.
[Graphical view]
PROSITEiPS50845. RETICULON. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRTN3_RAT
AccessioniPrimary (citable) accession number: Q6RJR6
Secondary accession number(s): Q6P6R3, Q8VBU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.