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Protein

Reticulon-3

Gene

Rtn3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. Induces the formation of endoplasmic reticulum tubules (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, ER-Golgi transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-8849932. SALM protein interactions at the synapse.

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulon-3
Gene namesi
Name:Rtn3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi620988. Rtn3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 771770CytoplasmicSequence analysisAdd
BLAST
Intramembranei772 – 79524HelicalSequence analysisAdd
BLAST
Topological domaini796 – 85257CytoplasmicSequence analysisAdd
BLAST
Intramembranei853 – 87523HelicalSequence analysisAdd
BLAST
Topological domaini876 – 8794CytoplasmicSequence analysis
Intramembranei880 – 90223HelicalSequence analysisAdd
BLAST
Topological domaini903 – 94038CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 940939Reticulon-3PRO_0000280541Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei31 – 311PhosphoserineCombined sources
Modified residuei196 – 1961PhosphoserineBy similarity
Modified residuei204 – 2041PhosphoserineBy similarity
Modified residuei209 – 2091PhosphoserineCombined sources
Modified residuei212 – 2121PhosphoserineCombined sources
Modified residuei249 – 2491PhosphoserineCombined sources
Modified residuei282 – 2821PhosphoserineBy similarity
Modified residuei508 – 5081PhosphoserineBy similarity
Modified residuei572 – 5721PhosphothreonineCombined sources
Modified residuei575 – 5751PhosphoserineCombined sources
Modified residuei576 – 5761PhosphoserineCombined sources
Modified residuei652 – 6521PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiQ6RJR6.
PRIDEiQ6RJR6.

PTM databases

iPTMnetiQ6RJR6.
PhosphoSiteiQ6RJR6.
SwissPalmiQ6RJR6.

Expressioni

Tissue specificityi

Present in olfactory bulb, olfactory epithelium and retina (at protein level).1 Publication

Developmental stagei

In the optic nerve, expressed more abundantly in the embryo than in the adult.1 Publication

Gene expression databases

BgeeiENSRNOG00000021202.
ExpressionAtlasiQ6RJR6. baseline and differential.
GenevisibleiQ6RJR6. RN.

Interactioni

Subunit structurei

Homodimer. Interacts with RTN4. Isoform 2 interacts with BACE1, BACE2, BCL2 and FADD. Interacts with ATL2. Interacts with TMEM33 (By similarity). Interacts with ATL1 (PubMed:19665976).By similarity1 Publication

Protein-protein interaction databases

IntActiQ6RJR6. 1 interaction.
MINTiMINT-4577751.
STRINGi10116.ENSRNOP00000028785.

Structurei

3D structure databases

ProteinModelPortaliQ6RJR6.
SMRiQ6RJR6. Positions 802-861.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini752 – 940189ReticulonPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni895 – 94046Interaction with FADDBy similarityAdd
BLAST
Regioni908 – 9103Interaction with BACE1By similarity

Sequence similaritiesi

Contains 1 reticulon domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1792. Eukaryota.
ENOG410XPKH. LUCA.
GeneTreeiENSGT00390000009934.
HOGENOMiHOG000154220.
HOVERGENiHBG093922.
InParanoidiQ6RJR6.
OMAiQFSHTTA.
OrthoDBiEOG091G0TIO.
PhylomeDBiQ6RJR6.

Family and domain databases

InterProiIPR003388. Reticulon.
[Graphical view]
PfamiPF02453. Reticulon. 1 hit.
[Graphical view]
PROSITEiPS50845. RETICULON. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6RJR6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAESSAATQS PSVSSSSSGA EPSTLGGGGG SPGACPALGA KSCGSSCAVG
60 70 80 90 100
LSSLCSDEPP SKIMTSSFLS SSEIYNPDPT TPLGSETLGS HLVAKDGKDP
110 120 130 140 150
LVLLDKKTLD SPQGTNKDRV DTPVSLAADI PCSHPSIPDS FPEQPTFLSK
160 170 180 190 200
ETDPTEEWVV KNQEPKNPSE VPSGEDRSAL DLGQRKAEHI CTHSLSPSEP
210 220 230 240 250
AVASVEKDSP ESPFEVIIDK ATFDREFKDL YKESTDDLGG WAAHGDRESP
260 270 280 290 300
ADLLEMNDKV FPLRNKEAGR YPSSALLGRQ FSHTTAALEE VSRCVNDMHN
310 320 330 340 350
FTNEILTWDL DPQAKQQADK SPCTTESTGL DRSEHRSEIP VINLKTSPQQ
360 370 380 390 400
KMPVCSFNGS TPITRSTGDW TETFTEGKPV KGYLSSTKEA GGKGVPDSSQ
410 420 430 440 450
PISGSGAATV EVTLPDLRGT WPNSVLGEVT EVDSSGESDD TVIEDTTENP
460 470 480 490 500
SVKNNKVLPE KSDSLPSAAV KTSERENKET TSHETVRSEM YENSEQQQAH
510 520 530 540 550
AETPTQRSLE GQMSPQVPNM LNEVIPENLA MTDTTRVCSA APPSVLSETG
560 570 580 590 600
FSLTVPASAK SESLLGKNVE DTDGSSPEDL MAALTGTEEK GTVDKEKGDV
610 620 630 640 650
LEAVLEKIAN VKNTLPVELL HENKLSSSET KNTKSKYSEH SRETNGGAPK
660 670 680 690 700
VSSDLEQEQL TIRAIKELGA KQVQAERMSP GGKLKRTFDP QSGPQNSSDI
710 720 730 740 750
LEHTDITTGS DLGIPKKPTI IKDTRIDSIS SLTKTETVNK HVLARLLSDF
760 770 780 790 800
PVHDLIFWRD VKKTGFVFGT TLIMLLSLAA FSVISVVSYL ILALLSVTIS
810 820 830 840 850
FRVYKSVIQA VQKSEEGHPF KAYLDVDITL SSEAFHSYMN AAMVHVNKAL
860 870 880 890 900
KLIIRLFLVE DLVDSLKLAV FMWLMTYVGA VFNGITLLIL AELLVFSVPI
910 920 930 940
VYEKYKTQID HYVGIARDQT KSIVEKIQAK LPGIAKKKAE
Length:940
Mass (Da):101,517
Last modified:July 5, 2004 - v1
Checksum:i701B0CF84473D36B
GO
Isoform 2 (identifier: Q6RJR6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     49-751: Missing.

Show »
Length:237
Mass (Da):25,431
Checksum:iE5E372302F8A4735
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti26 – 261Missing in AAP47276 (PubMed:12832288).Curated
Sequence conflicti26 – 261Missing in AAL35353 (PubMed:15946766).Curated
Sequence conflicti26 – 261Missing in AAL35354 (PubMed:15946766).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei49 – 751703Missing in isoform 2. 3 PublicationsVSP_023771Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY164698 mRNA. Translation: AAP47276.1.
AY496443 mRNA. Translation: AAR89918.1.
AF442357 mRNA. Translation: AAL35353.1.
AF442358 mRNA. Translation: AAL35354.1.
BC062068 mRNA. Translation: AAH62068.1.
BC107448 mRNA. Translation: AAI07449.1.
RefSeqiNP_001009953.2. NM_001009953.3. [Q6RJR6-2]
NP_543185.2. NM_080909.3. [Q6RJR6-1]
UniGeneiRn.11652.

Genome annotation databases

EnsembliENSRNOT00000028785; ENSRNOP00000028785; ENSRNOG00000021202. [Q6RJR6-1]
GeneIDi140945.
KEGGirno:140945.
UCSCiRGD:620988. rat. [Q6RJR6-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY164698 mRNA. Translation: AAP47276.1.
AY496443 mRNA. Translation: AAR89918.1.
AF442357 mRNA. Translation: AAL35353.1.
AF442358 mRNA. Translation: AAL35354.1.
BC062068 mRNA. Translation: AAH62068.1.
BC107448 mRNA. Translation: AAI07449.1.
RefSeqiNP_001009953.2. NM_001009953.3. [Q6RJR6-2]
NP_543185.2. NM_080909.3. [Q6RJR6-1]
UniGeneiRn.11652.

3D structure databases

ProteinModelPortaliQ6RJR6.
SMRiQ6RJR6. Positions 802-861.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6RJR6. 1 interaction.
MINTiMINT-4577751.
STRINGi10116.ENSRNOP00000028785.

PTM databases

iPTMnetiQ6RJR6.
PhosphoSiteiQ6RJR6.
SwissPalmiQ6RJR6.

Proteomic databases

PaxDbiQ6RJR6.
PRIDEiQ6RJR6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000028785; ENSRNOP00000028785; ENSRNOG00000021202. [Q6RJR6-1]
GeneIDi140945.
KEGGirno:140945.
UCSCiRGD:620988. rat. [Q6RJR6-1]

Organism-specific databases

CTDi10313.
RGDi620988. Rtn3.

Phylogenomic databases

eggNOGiKOG1792. Eukaryota.
ENOG410XPKH. LUCA.
GeneTreeiENSGT00390000009934.
HOGENOMiHOG000154220.
HOVERGENiHBG093922.
InParanoidiQ6RJR6.
OMAiQFSHTTA.
OrthoDBiEOG091G0TIO.
PhylomeDBiQ6RJR6.

Enzyme and pathway databases

ReactomeiR-RNO-8849932. SALM protein interactions at the synapse.

Miscellaneous databases

PROiQ6RJR6.

Gene expression databases

BgeeiENSRNOG00000021202.
ExpressionAtlasiQ6RJR6. baseline and differential.
GenevisibleiQ6RJR6. RN.

Family and domain databases

InterProiIPR003388. Reticulon.
[Graphical view]
PfamiPF02453. Reticulon. 1 hit.
[Graphical view]
PROSITEiPS50845. RETICULON. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRTN3_RAT
AccessioniPrimary (citable) accession number: Q6RJR6
Secondary accession number(s): Q6P6R3, Q8VBU0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.