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Protein

Protein UL141

Gene

UL141

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Evasion of NK cell killing. Blocks surface expression of PVR which is a ligand for NK cell-activating receptors. Binds human PVR in the endoplasmic reticulum and prevents its maturation and transport to the cell surface. Targets also the natural killer cell activating ligand NECTIN2 for proteasome-mediated degradation. Additionally promotes intracellular retention of TNFRSF10A/TRAIL-R1 and TNFRSF10B/TRAIL-R2 and thus downregulates their cell surface expression.2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Modulation of host NK-cell activity by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Protein UL141
Gene namesi
Name:UL141
OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri295027 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000938 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini37 – 278242ExtracellularSequence analysisAdd
BLAST
Transmembranei279 – 29921HelicalSequence analysisAdd
BLAST
Topological domaini300 – 33839CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host endoplasmic reticulum, Host membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3636Add
BLAST
Chaini37 – 338302Protein UL141PRO_0000253802Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi117 – 1171N-linked (GlcNAc...); by hostSequence analysis1 Publication
Glycosylationi132 – 1321N-linked (GlcNAc...); by hostSequence analysis1 Publication
Glycosylationi147 – 1471N-linked (GlcNAc...); by hostSequence analysis1 Publication

Keywords - PTMi

Glycoprotein

Expressioni

Inductioni

Early-late protein.

Interactioni

Subunit structurei

Interacts with human PVR. Interacts with human TNFRSF10A and TNFRSF10B. Forms a homodimer that engages two TNFRSF10B monomers.3 Publications

Structurei

Secondary structure

1
338
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi39 – 435Combined sources
Helixi47 – 504Combined sources
Beta strandi62 – 7110Combined sources
Beta strandi75 – 8612Combined sources
Beta strandi91 – 966Combined sources
Turni97 – 993Combined sources
Beta strandi102 – 1054Combined sources
Turni106 – 1105Combined sources
Beta strandi115 – 1206Combined sources
Beta strandi122 – 13211Combined sources
Turni135 – 1373Combined sources
Beta strandi139 – 1468Combined sources
Beta strandi148 – 16518Combined sources
Beta strandi183 – 1864Combined sources
Helixi192 – 1943Combined sources
Beta strandi195 – 1995Combined sources
Beta strandi209 – 2135Combined sources
Helixi235 – 2384Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4I9XX-ray2.10A/B32-246[»]
4JM0X-ray3.25A/B30-279[»]
ProteinModelPortaliQ6RJQ3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR007110. Ig-like_dom.
IPR031918. UL141.
[Graphical view]
PfamiPF16758. UL141. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6RJQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCRRESLRTL PWLFWVLLSC PRLLEYSSSS FPFATADIAE KMWAENYETT
60 70 80 90 100
SPAPVLVAEG EQVTIPCTVM THSWPMVSIR ARFCRSHDGS DELILDAVKG
110 120 130 140 150
HRLMNGLQYR LPYATWNFSQ LHLGQIFSLT FNVSTDTAGM YECVLRNYSH
160 170 180 190 200
GLIMQRFVIL TQLETLSRPD EPCCTPALGR YSLGDQIWSP TPWRLRNHDC
210 220 230 240 250
GMYRGFQRNY FYIGRADAED CWKPACPDEE PDRCWTVIQR YRLPGDCYRS
260 270 280 290 300
QPHPPKFLPV TPAPPADIDT GMSPWATRGI AAFLGFWSIF TVCFLCYLCY
310 320 330
LQCCGRWCPT PGRGRRGGEG YRRLPTYDSY PGVKKMKR
Length:338
Mass (Da):38,918
Last modified:July 5, 2004 - v1
Checksum:iD3E1152EB676F6CE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti8 – 81R → Q in strain: Isolate 1M.
Natural varianti16 – 161V → T in strain: Isolate 45J.
Natural varianti24 – 241L → F in strain: Isolate 1M, Isolate 10J, Isolate 2J, Isolate 29C, Isolate 27C, Isolate 18M, Isolate 33J, Isolate 14, Isolate 32C, Isolate 39J, Isolate 63J, Isolate 25J and Isolate 9J.
Natural varianti25 – 251E → K in strain: Isolate 10J, Isolate 2J, Isolate 29C, Isolate 27C, Isolate 18M, Isolate 33J, Isolate 14, Isolate 32C, Isolate 39J and Isolate 63J.
Natural varianti26 – 261Y → H in strain: Isolate 8J, Isolate 16m and Isolate 63J.
Natural varianti28 – 281S → F in strain: Isolate 84.
Natural varianti30 – 301S → L in strain: Isolate 8J and Isolate 16m.
Natural varianti35 – 351T → I in strain: Isolate 45J.
Natural varianti135 – 1351T → M in strain: Isolate 2J, Isolate 10J, Isolate 29C, Isolate 27C, Isolate 18M, Isolate 33J, Isolate 45J and Isolate 14.
Natural varianti139 – 1391G → S in strain: Isolate 10J.
Natural varianti202 – 2021M → T in strain: Isolate 2J, Isolate 10J, Isolate 25J, Isolate 39J, Isolate 45J, Isolate 29C, Isolate 27C, Isolate 18M, Isolate 33 and Isolate 14.
Natural varianti218 – 2181A → V in strain: Isolate 2J, Isolate 10J, Isolate 25J, Isolate 29C, Isolate 27C, Isolate 39J, Isolate 18M, Isolate 33J and Isolate 14.
Natural varianti306 – 3061R → H.
Natural varianti323 – 3231R → C in strain: Isolate 13J and Isolate 51C.
Natural varianti334 – 3341K → R in strain: Isolate 2J, Isolate 10J, Isolate 45J, Isolate 29C, Isolate 27C, Isolate 18M, Isolate 33J and Isolate 14.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446870 Genomic DNA. Translation: AAR31489.1.
AY446894 Genomic DNA. Translation: AAR31679.1.
AY600463 Genomic DNA. Translation: AAT68302.1.
AY496555 Genomic DNA. Translation: AAR92108.1.
AY496547 Genomic DNA. Translation: AAR92100.1.
AY600467 Genomic DNA. Translation: AAT68306.1.
AY496549 Genomic DNA. Translation: AAR92102.1.
AY496550 Genomic DNA. Translation: AAR92103.1.
AY941105 Genomic DNA. Translation: AAX57274.1.
AY496551 Genomic DNA. Translation: AAR92104.1.
AY600465 Genomic DNA. Translation: AAT68304.1.
AY600466 Genomic DNA. Translation: AAT68305.1.
AY600464 Genomic DNA. Translation: AAT68303.1.
AY600462 Genomic DNA. Translation: AAT68301.1.
AY496552 Genomic DNA. Translation: AAR92105.1.
AY496548 Genomic DNA. Translation: AAR92101.1.
AY600468 Genomic DNA. Translation: AAT68307.1.
AY600461 Genomic DNA. Translation: AAT68300.1.
AY600459 Genomic DNA. Translation: AAT68298.1.
AY941104 Genomic DNA. Translation: AAX57273.1.
AY496554 Genomic DNA. Translation: AAR92107.1.
AY600460 Genomic DNA. Translation: AAT68299.1.
AY496553 Genomic DNA. Translation: AAR92106.1.
RefSeqiYP_081575.1. NC_006273.2.

Genome annotation databases

GeneIDi3077418.
KEGGivg:3077418.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY446870 Genomic DNA. Translation: AAR31489.1.
AY446894 Genomic DNA. Translation: AAR31679.1.
AY600463 Genomic DNA. Translation: AAT68302.1.
AY496555 Genomic DNA. Translation: AAR92108.1.
AY496547 Genomic DNA. Translation: AAR92100.1.
AY600467 Genomic DNA. Translation: AAT68306.1.
AY496549 Genomic DNA. Translation: AAR92102.1.
AY496550 Genomic DNA. Translation: AAR92103.1.
AY941105 Genomic DNA. Translation: AAX57274.1.
AY496551 Genomic DNA. Translation: AAR92104.1.
AY600465 Genomic DNA. Translation: AAT68304.1.
AY600466 Genomic DNA. Translation: AAT68305.1.
AY600464 Genomic DNA. Translation: AAT68303.1.
AY600462 Genomic DNA. Translation: AAT68301.1.
AY496552 Genomic DNA. Translation: AAR92105.1.
AY496548 Genomic DNA. Translation: AAR92101.1.
AY600468 Genomic DNA. Translation: AAT68307.1.
AY600461 Genomic DNA. Translation: AAT68300.1.
AY600459 Genomic DNA. Translation: AAT68298.1.
AY941104 Genomic DNA. Translation: AAX57273.1.
AY496554 Genomic DNA. Translation: AAR92107.1.
AY600460 Genomic DNA. Translation: AAT68299.1.
AY496553 Genomic DNA. Translation: AAR92106.1.
RefSeqiYP_081575.1. NC_006273.2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4I9XX-ray2.10A/B32-246[»]
4JM0X-ray3.25A/B30-279[»]
ProteinModelPortaliQ6RJQ3.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3077418.
KEGGivg:3077418.

Family and domain databases

InterProiIPR007110. Ig-like_dom.
IPR031918. UL141.
[Graphical view]
PfamiPF16758. UL141. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Sequence variability of the human cytomegalovirus UL141 open reading frame in clinical strains."
    Ma Y.P., Ruan Q., He R., Qi Y., Sun Z.R., Ji Y.H., Huang Y.J., Liu Q., Chen S.R., Wang J.D.
    Arch. Virol. 151:827-835(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Isolate 10J, Isolate 12M, Isolate 13J, Isolate 14J, Isolate 16m, Isolate 18M, Isolate 1M, Isolate 20M, Isolate 27C, Isolate 29C, Isolate 2J, Isolate 32C, Isolate 33J, Isolate 39J, Isolate 51C, Isolate 63J, Isolate 84, Isolate 8J and Isolate 9J.
  3. Cited for: INTERACTION WITH HUMAN PVR.
  4. "Human cytomegalovirus UL141 promotes efficient downregulation of the natural killer cell activating ligand CD112."
    Prod'homme V., Sugrue D.M., Stanton R.J., Nomoto A., Davies J., Rickards C.R., Cochrane D., Moore M., Wilkinson G.W., Tomasec P.
    J. Gen. Virol. 91:2034-2039(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. Cited for: FUNCTION, INTERACTION WITH HUMAN TNFRSF10A AND TNFRSF10B.
  6. "Structure of human cytomegalovirus UL141 binding to TRAIL-R2 reveals novel, non-canonical death receptor interactions."
    Nemcovicova I., Benedict C.A., Zajonc D.M.
    PLoS Pathog. 9:E1003224-E1003224(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 32-246, INTERACTION WITH HOST TNFRSF10B, GLYCOSYLATION AT ASN-117; ASN-132 AND ASN-147.

Entry informationi

Entry nameiUL141_HCMVM
AccessioniPrimary (citable) accession number: Q6RJQ3
Secondary accession number(s): Q56JA4
, Q6E2A5, Q6E2A6, Q6E2A7, Q6E2B3, Q6E2B4, Q6RJP5, Q6RJP6, Q6RJP7, Q6RJP9, Q6RJQ0, Q6RJQ1, Q6SWK7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Caution

The UL/b' region coding for this gene is deleted in some HHV-5 laboratory strains, like strains AD169 or Towne.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.