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Protein

Protein UL141

Gene

UL141

Organism
Human cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Evasion of NK cell killing. Blocks surface expression of PVR which is a ligand for NK cell-activating receptors. Binds human PVR in the endoplasmic reticulum and prevents its maturation and transport to the cell surface. Targets also the natural killer cell activating ligand NECTIN2 for proteasome-mediated degradation. Additionally promotes intracellular retention of TNFRSF10A/TRAIL-R1 and TNFRSF10B/TRAIL-R2 and thus downregulates their cell surface expression.2 Publications

Caution

The UL/b' region coding for this gene is deleted in some HHV-5 laboratory strains, like strains AD169 or Towne.Curated

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Modulation of host NK-cell activity by virus, Viral immunoevasion

Names & Taxonomyi

Protein namesi
Recommended name:
Protein UL141
Gene namesi
Name:UL141
OrganismiHuman cytomegalovirus (strain Merlin) (HHV-5) (Human herpesvirus 5)
Taxonomic identifieri295027 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeBetaherpesvirinaeCytomegalovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000000938 Componenti: Genome
  • UP000169440 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini37 – 278ExtracellularSequence analysisAdd BLAST242
Transmembranei279 – 299HelicalSequence analysisAdd BLAST21
Topological domaini300 – 338CytoplasmicSequence analysisAdd BLAST39

GO - Cellular componenti

Keywords - Cellular componenti

Host endoplasmic reticulum, Host membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 36Add BLAST36
ChainiPRO_000025380237 – 338Protein UL141Add BLAST302

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi117N-linked (GlcNAc...) asparagine; by hostSequence analysis1 Publication1
Glycosylationi132N-linked (GlcNAc...) asparagine; by hostSequence analysis1 Publication1
Glycosylationi147N-linked (GlcNAc...) asparagine; by hostSequence analysis1 Publication1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ6RJQ3

PTM databases

iPTMnetiQ6RJQ3

Expressioni

Inductioni

Early-late protein.

Interactioni

Subunit structurei

Interacts with human PVR. Interacts with human TNFRSF10A and TNFRSF10B. Forms a homodimer that engages two TNFRSF10B monomers.3 Publications

Structurei

Secondary structure

1338
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi39 – 43Combined sources5
Helixi47 – 50Combined sources4
Beta strandi62 – 71Combined sources10
Beta strandi75 – 86Combined sources12
Beta strandi91 – 96Combined sources6
Turni97 – 99Combined sources3
Beta strandi102 – 105Combined sources4
Turni106 – 110Combined sources5
Beta strandi115 – 120Combined sources6
Beta strandi122 – 132Combined sources11
Turni135 – 137Combined sources3
Beta strandi139 – 146Combined sources8
Beta strandi148 – 165Combined sources18
Beta strandi183 – 186Combined sources4
Helixi192 – 194Combined sources3
Beta strandi195 – 199Combined sources5
Beta strandi209 – 213Combined sources5
Helixi235 – 238Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4I9XX-ray2.10A/B32-246[»]
4JM0X-ray3.25A/B30-279[»]
ProteinModelPortaliQ6RJQ3
SMRiQ6RJQ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK21049
OrthoDBiVOG090000EN

Family and domain databases

Gene3Di2.60.40.3790, 1 hit
InterProiView protein in InterPro
IPR036179 Ig-like_dom_sf
IPR031918 UL141
IPR038504 UL141-like_sf
PfamiView protein in Pfam
PF16758 UL141, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6RJQ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCRRESLRTL PWLFWVLLSC PRLLEYSSSS FPFATADIAE KMWAENYETT
60 70 80 90 100
SPAPVLVAEG EQVTIPCTVM THSWPMVSIR ARFCRSHDGS DELILDAVKG
110 120 130 140 150
HRLMNGLQYR LPYATWNFSQ LHLGQIFSLT FNVSTDTAGM YECVLRNYSH
160 170 180 190 200
GLIMQRFVIL TQLETLSRPD EPCCTPALGR YSLGDQIWSP TPWRLRNHDC
210 220 230 240 250
GMYRGFQRNY FYIGRADAED CWKPACPDEE PDRCWTVIQR YRLPGDCYRS
260 270 280 290 300
QPHPPKFLPV TPAPPADIDT GMSPWATRGI AAFLGFWSIF TVCFLCYLCY
310 320 330
LQCCGRWCPT PGRGRRGGEG YRRLPTYDSY PGVKKMKR
Length:338
Mass (Da):38,918
Last modified:July 5, 2004 - v1
Checksum:iD3E1152EB676F6CE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti8R → Q in strain: Isolate 1M. 1
Natural varianti16V → T in strain: Isolate 45J. 1
Natural varianti24L → F in strain: Isolate 1M, Isolate 10J, Isolate 2J, Isolate 29C, Isolate 27C, Isolate 18M, Isolate 33J, Isolate 14, Isolate 32C, Isolate 39J, Isolate 63J, Isolate 25J and Isolate 9J. 1
Natural varianti25E → K in strain: Isolate 10J, Isolate 2J, Isolate 29C, Isolate 27C, Isolate 18M, Isolate 33J, Isolate 14, Isolate 32C, Isolate 39J and Isolate 63J. 1
Natural varianti26Y → H in strain: Isolate 8J, Isolate 16m and Isolate 63J. 1
Natural varianti28S → F in strain: Isolate 84. 1
Natural varianti30S → L in strain: Isolate 8J and Isolate 16m. 1
Natural varianti35T → I in strain: Isolate 45J. 1
Natural varianti135T → M in strain: Isolate 2J, Isolate 10J, Isolate 29C, Isolate 27C, Isolate 18M, Isolate 33J, Isolate 45J and Isolate 14. 1
Natural varianti139G → S in strain: Isolate 10J. 1
Natural varianti202M → T in strain: Isolate 2J, Isolate 10J, Isolate 25J, Isolate 39J, Isolate 45J, Isolate 29C, Isolate 27C, Isolate 18M, Isolate 33 and Isolate 14. 1
Natural varianti218A → V in strain: Isolate 2J, Isolate 10J, Isolate 25J, Isolate 29C, Isolate 27C, Isolate 39J, Isolate 18M, Isolate 33J and Isolate 14. 1
Natural varianti306R → H. 1
Natural varianti323R → C in strain: Isolate 13J and Isolate 51C. 1
Natural varianti334K → R in strain: Isolate 2J, Isolate 10J, Isolate 45J, Isolate 29C, Isolate 27C, Isolate 18M, Isolate 33J and Isolate 14. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
JX512197 Genomic DNA Translation: AAR31489.1
AY446894 Genomic DNA Translation: AAR31679.1
AY600463 Genomic DNA Translation: AAT68302.1
AY496555 Genomic DNA Translation: AAR92108.1
AY496547 Genomic DNA Translation: AAR92100.1
AY600467 Genomic DNA Translation: AAT68306.1
AY496549 Genomic DNA Translation: AAR92102.1
AY496550 Genomic DNA Translation: AAR92103.1
AY941105 Genomic DNA Translation: AAX57274.1
AY496551 Genomic DNA Translation: AAR92104.1
AY600465 Genomic DNA Translation: AAT68304.1
AY600466 Genomic DNA Translation: AAT68305.1
AY600464 Genomic DNA Translation: AAT68303.1
AY600462 Genomic DNA Translation: AAT68301.1
AY496552 Genomic DNA Translation: AAR92105.1
AY496548 Genomic DNA Translation: AAR92101.1
AY600468 Genomic DNA Translation: AAT68307.1
AY600461 Genomic DNA Translation: AAT68300.1
AY600459 Genomic DNA Translation: AAT68298.1
AY941104 Genomic DNA Translation: AAX57273.1
AY496554 Genomic DNA Translation: AAR92107.1
AY600460 Genomic DNA Translation: AAT68299.1
AY496553 Genomic DNA Translation: AAR92106.1
RefSeqiYP_081575.1, NC_006273.2

Genome annotation databases

GeneIDi3077418
KEGGivg:3077418

Similar proteinsi

Entry informationi

Entry nameiUL141_HCMVM
AccessioniPrimary (citable) accession number: Q6RJQ3
Secondary accession number(s): Q56JA4
, Q6E2A5, Q6E2A6, Q6E2A7, Q6E2B3, Q6E2B4, Q6RJP5, Q6RJP6, Q6RJP7, Q6RJP9, Q6RJQ0, Q6RJQ1, Q6SWK7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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