ID PGK2_PIG Reviewed; 417 AA. AC Q6RI85; Q6RFZ5; DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot. DT 23-JAN-2007, sequence version 3. DT 27-MAR-2024, entry version 99. DE RecName: Full=Phosphoglycerate kinase 2; DE EC=2.7.2.3; DE AltName: Full=Phosphoglycerate kinase, testis specific; GN Name=PGK2 {ECO:0000312|EMBL:AAR89550.1}; OS Sus scrofa (Pig). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus. OX NCBI_TaxID=9823; RN [1] {ECO:0000305, ECO:0000312|EMBL:AAR89550.1} RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL RP STAGE, AND VARIANTS PRO-102 AND LYS-264. RX PubMed=15599558; DOI=10.1007/s00335-004-2405-1; RA Chen K., Knorr C., Moser G., Gatphayak K., Brenig B.; RT "Molecular characterization of the porcine testis-specific phosphoglycerate RT kinase 2 (PGK2) gene and its association with male fertility."; RL Mamm. Genome 15:996-1006(2004). CC -!- FUNCTION: Essential for sperm motility and male fertility but is not CC required for the completion of spermatogenesis. CC {ECO:0000250|UniProtKB:P09041}. CC -!- CATALYTIC ACTIVITY: CC Reaction=(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl CC phosphate + ADP; Xref=Rhea:RHEA:14801, ChEBI:CHEBI:30616, CC ChEBI:CHEBI:57604, ChEBI:CHEBI:58272, ChEBI:CHEBI:456216; EC=2.7.2.3; CC Evidence={ECO:0000305}; CC -!- PATHWAY: Carbohydrate degradation; glycolysis; pyruvate from D- CC glyceraldehyde 3-phosphate: step 2/5. CC -!- SUBUNIT: Monomer. {ECO:0000250|UniProtKB:P09041}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. CC -!- TISSUE SPECIFICITY: Testis specific. {ECO:0000269|PubMed:15599558}. CC -!- DEVELOPMENTAL STAGE: Expression is highest in the adult, lower in a 10 CC month old and very weak in an 8 week old. CC {ECO:0000269|PubMed:15599558}. CC -!- POLYMORPHISM: Contains at least 10 polymorphisms. Those that lead to CC amino acid substitutions may alter protein secondary structures and may CC influence male fertility. {ECO:0000269|PubMed:15599558}. CC -!- SIMILARITY: Belongs to the phosphoglycerate kinase family. CC {ECO:0000255}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AY496962; AAR88362.1; -; mRNA. DR EMBL; AY500132; AAR89550.1; -; Genomic_DNA. DR RefSeq; NP_998947.1; NM_213782.1. DR AlphaFoldDB; Q6RI85; -. DR SMR; Q6RI85; -. DR IntAct; Q6RI85; 1. DR STRING; 9823.ENSSSCP00000045543; -. DR PeptideAtlas; Q6RI85; -. DR Ensembl; ENSSSCT00000001943.4; ENSSSCP00000045543.1; ENSSSCG00000001738.4. DR Ensembl; ENSSSCT00005008811.1; ENSSSCP00005005203.1; ENSSSCG00005005823.1. DR Ensembl; ENSSSCT00030039845.1; ENSSSCP00030018351.1; ENSSSCG00030028466.1. DR Ensembl; ENSSSCT00040037149.1; ENSSSCP00040015448.1; ENSSSCG00040027666.1. DR Ensembl; ENSSSCT00050004221.1; ENSSSCP00050001635.1; ENSSSCG00050003199.1. DR Ensembl; ENSSSCT00055011631.1; ENSSSCP00055009207.1; ENSSSCG00055005986.1. DR Ensembl; ENSSSCT00060065813.1; ENSSSCP00060028173.1; ENSSSCG00060048462.1. DR Ensembl; ENSSSCT00065007143.1; ENSSSCP00065003084.1; ENSSSCG00065005263.1. DR Ensembl; ENSSSCT00070040987.1; ENSSSCP00070034394.1; ENSSSCG00070020628.1. DR GeneID; 396673; -. DR KEGG; ssc:396673; -. DR CTD; 5232; -. DR VGNC; VGNC:91351; PGK2. DR GeneTree; ENSGT00390000008820; -. DR InParanoid; Q6RI85; -. DR OMA; DMIFDIG; -. DR OrthoDB; 5477183at2759; -. DR BRENDA; 2.7.2.3; 6170. DR Reactome; R-SSC-70171; Glycolysis. DR Reactome; R-SSC-70263; Gluconeogenesis. DR UniPathway; UPA00109; UER00185. DR Proteomes; UP000008227; Chromosome 7. DR Proteomes; UP000314985; Chromosome 7. DR Proteomes; UP000694570; Unplaced. DR Proteomes; UP000694571; Unplaced. DR Proteomes; UP000694720; Unplaced. DR Proteomes; UP000694722; Unplaced. DR Proteomes; UP000694723; Unplaced. DR Proteomes; UP000694724; Unplaced. DR Proteomes; UP000694725; Unplaced. DR Proteomes; UP000694726; Unplaced. DR Proteomes; UP000694727; Unplaced. DR Proteomes; UP000694728; Unplaced. DR Bgee; ENSSSCG00000001738; Expressed in testis and 4 other cell types or tissues. DR ExpressionAtlas; Q6RI85; differential. DR GO; GO:0005829; C:cytosol; IBA:GO_Central. DR GO; GO:0035686; C:sperm fibrous sheath; IBA:GO_Central. DR GO; GO:0043531; F:ADP binding; IBA:GO_Central. DR GO; GO:0005524; F:ATP binding; ISS:UniProtKB. DR GO; GO:0004618; F:phosphoglycerate kinase activity; ISS:UniProtKB. DR GO; GO:0006094; P:gluconeogenesis; IBA:GO_Central. DR GO; GO:0006096; P:glycolytic process; IBA:GO_Central. DR GO; GO:0016310; P:phosphorylation; ISS:UniProtKB. DR CDD; cd00318; Phosphoglycerate_kinase; 1. DR Gene3D; 3.40.50.1260; Phosphoglycerate kinase, N-terminal domain; 3. DR HAMAP; MF_00145; Phosphoglyc_kinase; 1. DR InterPro; IPR001576; Phosphoglycerate_kinase. DR InterPro; IPR015911; Phosphoglycerate_kinase_CS. DR InterPro; IPR015824; Phosphoglycerate_kinase_N. DR InterPro; IPR036043; Phosphoglycerate_kinase_sf. DR PANTHER; PTHR11406; PHOSPHOGLYCERATE KINASE; 1. DR PANTHER; PTHR11406:SF10; PHOSPHOGLYCERATE KINASE 2; 1. DR Pfam; PF00162; PGK; 1. DR PIRSF; PIRSF000724; Pgk; 1. DR PRINTS; PR00477; PHGLYCKINASE. DR SUPFAM; SSF53748; Phosphoglycerate kinase; 1. DR PROSITE; PS00111; PGLYCERATE_KINASE; 1. PE 2: Evidence at transcript level; KW Acetylation; ATP-binding; Cytoplasm; Glycolysis; Kinase; KW Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase. FT INIT_MET 1 FT /note="Removed" FT /evidence="ECO:0000250|UniProtKB:P00558" FT CHAIN 2..417 FT /note="Phosphoglycerate kinase 2" FT /id="PRO_0000145838" FT BINDING 24..26 FT /ligand="substrate" FT /evidence="ECO:0000250" FT BINDING 39 FT /ligand="substrate" FT /evidence="ECO:0000250" FT BINDING 63..66 FT /ligand="substrate" FT /evidence="ECO:0000250" FT BINDING 123 FT /ligand="substrate" FT /evidence="ECO:0000250" FT BINDING 171 FT /ligand="substrate" FT /evidence="ECO:0000250" FT BINDING 220 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000250" FT BINDING 344 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000250" FT BINDING 373..376 FT /ligand="ATP" FT /ligand_id="ChEBI:CHEBI:30616" FT /evidence="ECO:0000250" FT MOD_RES 2 FT /note="N-acetylserine" FT /evidence="ECO:0000250|UniProtKB:P00558" FT MOD_RES 2 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:P00558" FT MOD_RES 4 FT /note="Phosphoserine" FT /evidence="ECO:0000250|UniProtKB:P00558" FT MOD_RES 11 FT /note="N6-acetyllysine" FT /evidence="ECO:0000250|UniProtKB:P00558" FT MOD_RES 75 FT /note="N6-acetyllysine" FT /evidence="ECO:0000250|UniProtKB:P00558" FT MOD_RES 86 FT /note="N6-acetyllysine" FT /evidence="ECO:0000250|UniProtKB:P00558" FT MOD_RES 97 FT /note="N6-acetyllysine" FT /evidence="ECO:0000250|UniProtKB:P00558" FT MOD_RES 131 FT /note="N6-acetyllysine" FT /evidence="ECO:0000250|UniProtKB:P00558" FT MOD_RES 146 FT /note="N6-acetyllysine" FT /evidence="ECO:0000250|UniProtKB:P00558" FT MOD_RES 196 FT /note="Phosphotyrosine" FT /evidence="ECO:0000250|UniProtKB:P00558" FT MOD_RES 199 FT /note="N6-acetyllysine" FT /evidence="ECO:0000250|UniProtKB:P00558" FT MOD_RES 267 FT /note="N6-acetyllysine" FT /evidence="ECO:0000250|UniProtKB:P00558" FT MOD_RES 291 FT /note="N6-acetyllysine" FT /evidence="ECO:0000250|UniProtKB:P00558" FT VARIANT 102 FT /note="S -> P (in SNP-A; possible loss of CK2 FT phosphorylation site)" FT /evidence="ECO:0000269|PubMed:15599558" FT VARIANT 264 FT /note="T -> K (in SNP-B; increased semen volume in FT ejaculate)" FT /evidence="ECO:0000269|PubMed:15599558" FT CONFLICT 324 FT /note="Y -> N (in Ref. 1; AAR89550)" FT /evidence="ECO:0000305" SQ SEQUENCE 417 AA; 44895 MW; 1DB0048021528BA0 CRC64; MSLSKKLTLD KLDVKGKRVI MRVDFNVPMK RNQVTNNQRI KASLPSIRYC LDNGARSVVL MSHLGRPDGV AMPDKYSLEP VAAELKSLLG KDVLFLKDCV GSEAEQACAN PPAGSVILLE NLRFHVEEEG KGQDPSGNKL KAEPDKVEAF RASLSKLGDV YVNDAFGTAH RAHSSMVGVN LPQKASGFLM KKELDYFAKA LENPERPFLA ILGGAKVADK IQLIKNMLDK VNEMIIGGGM AFTFLKVLNN MEIGASLFDK EGATIVKEIM AKAEKNRVNI TFPVDFVIAD KFEENAKVGQ ATVASGIPAG WVALDCGPET NKKYAQVVAR AKLIVWNGPL GVFEWDAFAN GTKALMDEIV KATSKGCITI IGGGDTATCC AKWNTEDKVS HVSTGGGASL ELLEGKVLPG VEALSNL //