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Q6RI85

- PGK2_PIG

UniProt

Q6RI85 - PGK2_PIG

Protein

Phosphoglycerate kinase 2

Gene

PGK2

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 56 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.Curated

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei39 – 391SubstrateBy similarity
    Binding sitei123 – 1231SubstrateBy similarity
    Binding sitei171 – 1711SubstrateBy similarity
    Binding sitei220 – 2201ATPBy similarity
    Binding sitei344 – 3441ATPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi373 – 3764ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB
    2. phosphoglycerate kinase activity Source: UniProtKB

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway
    2. phosphorylation Source: UniProtKB

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinase 2 (EC:2.7.2.3)
    Alternative name(s):
    Phosphoglycerate kinase, testis specific
    Gene namesi
    Name:PGK2Imported
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Unplaced

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 417417Phosphoglycerate kinase 2PRO_0000145838Add
    BLAST

    Proteomic databases

    PRIDEiQ6RI85.

    Expressioni

    Tissue specificityi

    Testis specific.1 Publication

    Developmental stagei

    Expression is highest in the adult, lower in a 10 month old and very weak in an 8 week old.1 Publication

    Interactioni

    Subunit structurei

    Monomer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6RI85.
    SMRiQ6RI85. Positions 2-417.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni24 – 263Substrate bindingBy similarity
    Regioni63 – 664Substrate bindingBy similarity

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.Sequence Analysis

    Phylogenomic databases

    HOVERGENiHBG008177.
    KOiK00927.

    Family and domain databases

    Gene3Di3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 1 hit.
    PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6RI85-1 [UniParc]FASTAAdd to Basket

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    MSLSKKLTLD KLDVKGKRVI MRVDFNVPMK RNQVTNNQRI KASLPSIRYC    50
    LDNGARSVVL MSHLGRPDGV AMPDKYSLEP VAAELKSLLG KDVLFLKDCV 100
    GSEAEQACAN PPAGSVILLE NLRFHVEEEG KGQDPSGNKL KAEPDKVEAF 150
    RASLSKLGDV YVNDAFGTAH RAHSSMVGVN LPQKASGFLM KKELDYFAKA 200
    LENPERPFLA ILGGAKVADK IQLIKNMLDK VNEMIIGGGM AFTFLKVLNN 250
    MEIGASLFDK EGATIVKEIM AKAEKNRVNI TFPVDFVIAD KFEENAKVGQ 300
    ATVASGIPAG WVALDCGPET NKKYAQVVAR AKLIVWNGPL GVFEWDAFAN 350
    GTKALMDEIV KATSKGCITI IGGGDTATCC AKWNTEDKVS HVSTGGGASL 400
    ELLEGKVLPG VEALSNL 417
    Length:417
    Mass (Da):44,895
    Last modified:January 23, 2007 - v3
    Checksum:i1DB0048021528BA0
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti324 – 3241Y → N in AAR89550. (PubMed:15599558)Curated

    Polymorphismi

    Contains at least 10 polymorphisms. Those that lead to amino acid substitutions may alter protein secondary structures and may influence male fertility.1 Publication

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti102 – 1021S → P in SNP-A; possible loss of CK2 phosphorylation site. 1 Publication
    Natural varianti264 – 2641T → K in SNP-B; increased semen volume in ejaculate. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY496962 mRNA. Translation: AAR88362.1.
    AY500132 Genomic DNA. Translation: AAR89550.1.
    RefSeqiNP_998947.1. NM_213782.1.
    UniGeneiSsc.58731.

    Genome annotation databases

    GeneIDi396673.
    KEGGissc:396673.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY496962 mRNA. Translation: AAR88362.1 .
    AY500132 Genomic DNA. Translation: AAR89550.1 .
    RefSeqi NP_998947.1. NM_213782.1.
    UniGenei Ssc.58731.

    3D structure databases

    ProteinModelPortali Q6RI85.
    SMRi Q6RI85. Positions 2-417.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q6RI85.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396673.
    KEGGi ssc:396673.

    Organism-specific databases

    CTDi 5232.

    Phylogenomic databases

    HOVERGENi HBG008177.
    KOi K00927.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .

    Family and domain databases

    Gene3Di 3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 1 hit.
    PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of the porcine testis-specific phosphoglycerate kinase 2 (PGK2) gene and its association with male fertility."
      Chen K., Knorr C., Moser G., Gatphayak K., Brenig B.
      Mamm. Genome 15:996-1006(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, VARIANTS PRO-102 AND LYS-264.

    Entry informationi

    Entry nameiPGK2_PIG
    AccessioniPrimary (citable) accession number: Q6RI85
    Secondary accession number(s): Q6RFZ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 12, 2005
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 56 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3