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Protein

Constitutive coactivator of peroxisome proliferator-activated receptor gamma

Gene

Fam120b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions as a transactivator of PPARG and ESR1. Functions in adipogenesis through PPARG activation.1 Publication

GO - Biological processi

  • fat cell differentiation Source: MGI
  • peroxisome proliferator activated receptor signaling pathway Source: MGI
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Constitutive coactivator of peroxisome proliferator-activated receptor gamma
Short name:
Constitutive coactivator of PPAR-gamma
Short name:
Constitutive coactivator of PPARG
Alternative name(s):
Protein FAM120B
Gene namesi
Name:Fam120b
Synonyms:Ccpg, Kiaa1838
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1914794. Fam120b.

Subcellular locationi

  • Nucleus 1 Publication

GO - Cellular componenti

  • nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 786786Constitutive coactivator of peroxisome proliferator-activated receptor gammaPRO_0000332991Add
BLAST

Proteomic databases

MaxQBiQ6RI63.
PaxDbiQ6RI63.
PeptideAtlasiQ6RI63.
PRIDEiQ6RI63.

PTM databases

iPTMnetiQ6RI63.
PhosphoSiteiQ6RI63.

Expressioni

Tissue specificityi

Ubiquitously expressed (at protein level).1 Publication

Developmental stagei

Expressed throughout the embryonic developmental stages from E5 to E19 (at protein level).1 Publication

Inductioni

Up-regulated in differentiating adipocytes (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000014763.
GenevisibleiQ6RI63. MM.

Interactioni

Subunit structurei

Interacts with ESR1 and RXRA. Interacts with PPARG; in a ligand-independent manner.1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054420.

Structurei

3D structure databases

ProteinModelPortaliQ6RI63.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 561561Mediates transactivation of PPARGAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IGHB. Eukaryota.
ENOG410ZBE9. LUCA.
GeneTreeiENSGT00530000063168.
HOVERGENiHBG107861.
InParanoidiQ6RI63.
OMAiPRQEVPM.
OrthoDBiEOG091G0CII.
PhylomeDBiQ6RI63.
TreeFamiTF331093.

Family and domain databases

Gene3Di3.40.50.1010. 1 hit.
InterProiIPR026784. Coact_PPARg.
IPR029060. PIN_domain-like.
[Graphical view]
PANTHERiPTHR15976. PTHR15976. 1 hit.
SUPFAMiSSF88723. SSF88723. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6RI63-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGVRGLQGFV GSTCPHICTI VNIHELAERH RNKYPGCTPT IVVDAMCCLR
60 70 80 90 100
YWYTAESWVC GGQWREYYCA LRNFVAAFTS AGIKLIFFFD GMVEPGKRDE
110 120 130 140 150
WVKRRLKNNR EISKIFHYIK SKRDQPGRNM FFIPSGLAIF TRFALKTLGQ
160 170 180 190 200
ETFCSLQEAD YEVASYGLQH NCLGILGEDT DYLIYDTCPY FSIGDLCLES
210 220 230 240 250
LQTIMLCREK LCESLGLRVA DLPLLACLLG NDITPESMFE SFRYKCLSSY
260 270 280 290 300
ASVKENAGKK GNIILAVSDY ISKVLHLYQG EKKIEEMLPL GPNKALFYKG
310 320 330 340 350
VTSYLLPGQK SPWLVQKPKG MITDKQQMVS LNPESKQEVP MCIDPEFKQE
360 370 380 390 400
VPVCTNPESM QEVPMCMDPE PNQEASMCTD PESKQEVPMC TDSESKPEVS
410 420 430 440 450
QYTNPESKQK LPSGIDTEFN LEALMCTHPE FKQEDVMDME PEIKQVTMVS
460 470 480 490 500
ESEILKVARM HHVHSESYLV YNILSSGEIE CSNTLEDELD QALPSQAFIY
510 520 530 540 550
RPVRQRVYAL LLGDWKDGAS TGPVVKEWFV YPGNSLKHPD LVRPLQMTVQ
560 570 580 590 600
GGTPSLEVLW LSQEPAVQAQ RLDTLLACFN LSSSREELQA VESPLRALCC
610 620 630 640 650
LLIYLFVQVD TLSLEDLHAF IAQALCLQGK STSQLMHLQL DYINSRAVQL
660 670 680 690 700
GSLLVRGLTT LVLVNSACGF PWTTSEFMPW NVFDGKLFHQ KYLQSEKGYA
710 720 730 740 750
VEVLLEQNRS WLTKFHNLKA VVCKACSKEN RRIVGRTHWD SPYTGRQGRQ
760 770 780
GYSSYRTDST HGHSGQSWRN QGSGGRQHER NHWRRY
Length:786
Mass (Da):89,313
Last modified:July 5, 2004 - v1
Checksum:iA9B6EEFD99275D4C
GO
Isoform 2 (identifier: Q6RI63-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     457-493: VARMHHVHSESYLVYNILSSGEIECSNTLEDELDQAL → ASDCASPTSVHNVVIESVPTNGFDREKRTVGGCRRETS
     494-786: Missing.

Show »
Length:494
Mass (Da):55,823
Checksum:i8EE54DA87BD3FAC7
GO

Sequence cautioni

The sequence AAH03200 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAB24339 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAD90470 differs from that shown. Reason: Erroneous translation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti41 – 411I → N in BAC36239 (PubMed:16141072).Curated
Sequence conflicti178 – 1781E → K in BAC34186 (PubMed:16141072).Curated
Sequence conflicti549 – 5491V → I in AAH03200 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei457 – 49337VARMH…LDQAL → ASDCASPTSVHNVVIESVPT NGFDREKRTVGGCRRETS in isoform 2. 3 PublicationsVSP_033417Add
BLAST
Alternative sequencei494 – 786293Missing in isoform 2. 3 PublicationsVSP_033418Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ873694 mRNA. Translation: ABH09085.1.
AK005957 mRNA. Translation: BAB24339.1. Different initiation.
AK028911 mRNA. Translation: BAC26191.1.
AK050319 mRNA. Translation: BAC34186.1.
AK076185 mRNA. Translation: BAC36239.1.
AK078215 mRNA. Translation: BAC37177.1.
AK132211 mRNA. Translation: BAE21035.1.
AK220425 Transcribed RNA. Translation: BAD90470.1. Sequence problems.
AY497019 Genomic DNA. Translation: AAR30868.1.
BC003200 mRNA. Translation: AAH03200.1. Different initiation.
BC085163 mRNA. Translation: AAH85163.1.
CCDSiCCDS37453.1. [Q6RI63-1]
RefSeqiNP_077165.2. NM_024203.3. [Q6RI63-1]
XP_006524890.1. XM_006524827.2. [Q6RI63-1]
UniGeneiMm.35039.

Genome annotation databases

EnsembliENSMUST00000055352; ENSMUSP00000054420; ENSMUSG00000014763. [Q6RI63-1]
GeneIDi67544.
KEGGimmu:67544.
UCSCiuc008aoj.2. mouse. [Q6RI63-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ873694 mRNA. Translation: ABH09085.1.
AK005957 mRNA. Translation: BAB24339.1. Different initiation.
AK028911 mRNA. Translation: BAC26191.1.
AK050319 mRNA. Translation: BAC34186.1.
AK076185 mRNA. Translation: BAC36239.1.
AK078215 mRNA. Translation: BAC37177.1.
AK132211 mRNA. Translation: BAE21035.1.
AK220425 Transcribed RNA. Translation: BAD90470.1. Sequence problems.
AY497019 Genomic DNA. Translation: AAR30868.1.
BC003200 mRNA. Translation: AAH03200.1. Different initiation.
BC085163 mRNA. Translation: AAH85163.1.
CCDSiCCDS37453.1. [Q6RI63-1]
RefSeqiNP_077165.2. NM_024203.3. [Q6RI63-1]
XP_006524890.1. XM_006524827.2. [Q6RI63-1]
UniGeneiMm.35039.

3D structure databases

ProteinModelPortaliQ6RI63.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000054420.

PTM databases

iPTMnetiQ6RI63.
PhosphoSiteiQ6RI63.

Proteomic databases

MaxQBiQ6RI63.
PaxDbiQ6RI63.
PeptideAtlasiQ6RI63.
PRIDEiQ6RI63.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055352; ENSMUSP00000054420; ENSMUSG00000014763. [Q6RI63-1]
GeneIDi67544.
KEGGimmu:67544.
UCSCiuc008aoj.2. mouse. [Q6RI63-1]

Organism-specific databases

CTDi84498.
MGIiMGI:1914794. Fam120b.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410IGHB. Eukaryota.
ENOG410ZBE9. LUCA.
GeneTreeiENSGT00530000063168.
HOVERGENiHBG107861.
InParanoidiQ6RI63.
OMAiPRQEVPM.
OrthoDBiEOG091G0CII.
PhylomeDBiQ6RI63.
TreeFamiTF331093.

Miscellaneous databases

PROiQ6RI63.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000014763.
GenevisibleiQ6RI63. MM.

Family and domain databases

Gene3Di3.40.50.1010. 1 hit.
InterProiIPR026784. Coact_PPARg.
IPR029060. PIN_domain-like.
[Graphical view]
PANTHERiPTHR15976. PTHR15976. 1 hit.
SUPFAMiSSF88723. SSF88723. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiF120B_MOUSE
AccessioniPrimary (citable) accession number: Q6RI63
Secondary accession number(s): Q5DTU5
, Q8BK59, Q8BVH5, Q8BWQ3, Q8C158, Q99LL4, Q9DAC3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.