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Q6RI45

- BRWD3_HUMAN

UniProt

Q6RI45 - BRWD3_HUMAN

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Protein

Bromodomain and WD repeat-containing protein 3

Gene

BRWD3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.1 Publication

GO - Biological processi

  1. cytoskeleton organization Source: UniProtKB
  2. regulation of cell shape Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ6RI45.

Names & Taxonomyi

Protein namesi
Recommended name:
Bromodomain and WD repeat-containing protein 3
Gene namesi
Name:BRWD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:17342. BRWD3.

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving BRWD3 can be found in patients with B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(X;11)(q21;q23) with ARHGAP20 does not result in fusion transcripts but disrupts both genes.
Mental retardation, X-linked 93 (MRX93) [MIM:300659]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. MRX93 is associated with macrocephaly.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1596 – 15961K → E in MRX93; may be a rare polymorphism. 1 Publication
VAR_036940

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

MIMi300659. phenotype.
Orphaneti323. FG syndrome.
PharmGKBiPA134900775.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18021802Bromodomain and WD repeat-containing protein 3PRO_0000283089Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei703 – 7031Phosphoserine1 Publication
Modified residuei1577 – 15771Phosphoserine1 Publication
Modified residuei1579 – 15791Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6RI45.
PaxDbiQ6RI45.
PRIDEiQ6RI45.

PTM databases

PhosphoSiteiQ6RI45.

Expressioni

Tissue specificityi

Found in most adult tissues. Down-regulated in a majority of the B-CLL cases examined.1 Publication

Developmental stagei

Expressed in fetal liver.

Gene expression databases

BgeeiQ6RI45.
CleanExiHS_BRWD3.
GenevestigatoriQ6RI45.

Organism-specific databases

HPAiHPA012802.

Interactioni

Protein-protein interaction databases

BioGridi129012. 2 interactions.
IntActiQ6RI45. 2 interactions.
STRINGi9606.ENSP00000362372.

Structurei

3D structure databases

ProteinModelPortaliQ6RI45.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati86 – 12742WD 1Add
BLAST
Repeati178 – 21942WD 2Add
BLAST
Repeati221 – 25939WD 3Add
BLAST
Repeati262 – 30544WD 4Add
BLAST
Repeati316 – 35540WD 5Add
BLAST
Repeati360 – 40142WD 6Add
BLAST
Repeati421 – 46040WD 7Add
BLAST
Repeati463 – 50341WD 8Add
BLAST
Repeati511 – 55040WD 9Add
BLAST
Domaini1158 – 122871Bromo 1PROSITE-ProRule annotationAdd
BLAST
Domaini1317 – 141296Bromo 2PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1659 – 171961Gly-richAdd
BLAST

Sequence similaritiesi

Contains 2 bromo domains.PROSITE-ProRule annotation
Contains 9 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Bromodomain, Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
GeneTreeiENSGT00720000108687.
HOVERGENiHBG108248.
InParanoidiQ6RI45.
KOiK11798.
OMAiIEWQSES.
OrthoDBiEOG7N37BR.
PhylomeDBiQ6RI45.
TreeFamiTF324197.

Family and domain databases

Gene3Di1.20.920.10. 2 hits.
2.130.10.10. 2 hits.
InterProiIPR001487. Bromodomain.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00439. Bromodomain. 2 hits.
PF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 2 hits.
SM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 2 hits.
SSF50978. SSF50978. 1 hit.
PROSITEiPS50014. BROMODOMAIN_2. 2 hits.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6RI45-1) [UniParc]FASTAAdd to Basket

Also known as: BRWD3-A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAPTQIEA ELYYLIARFL QSGPCNKSAQ VLVQELEEHQ LIPRRLDWEG
60 70 80 90 100
KEHRRSFEDL VAANAHIPPD YLLKICERIG PLLDKEIPQS VPGVQTLLGV
110 120 130 140 150
GRQSLLRDAK DCKSTLWNGS AFAALHRGRP PELPVNYVKP PNVVNITSAR
160 170 180 190 200
QLTGCSRFGH IFPSSAYQHI KMHKRILGHL SSVYCVAFDR SGRRIFTGSD
210 220 230 240 250
DCLVKIWATD DGRLLATLRG HSAEISDMAV NYENTLIAAG SCDKVVRVWC
260 270 280 290 300
LRTCAPVAVL QGHSASITSI QFCPSTKGTN RYLTSTGADG TICFWQWHVK
310 320 330 340 350
TMKFRDRPVK FTERSRPGVQ ISCSSFSSGG MFITTGSTDH VIRIYYLGSE
360 370 380 390 400
VPEKIAELES HTDKVVAVQF CNNGDSLRFV SGSRDGTARI WQYQQQEWKS
410 420 430 440 450
IVLDMATKMT GNNLPSGEDK ITKLKVTMVA WDRYDTTVIT AVNNFLLKVW
460 470 480 490 500
NSITGQLLHT LSGHDDEVFV LEAHPFDQRI ILSAGHDGNI FIWDLDRGTK
510 520 530 540 550
IRNYFNMIEG QGHGAVFDCK FSPDGNHFAC TDSHGHLLLF GFGCSKYYEK
560 570 580 590 600
IPDQMFFHTD YRPLIRDANN YVLDEQTQQA PHLMPPPFLV DVDGNPHPTK
610 620 630 640 650
FQRLVPGREN CKDEQLIPQL GYVANGDGEV VEQVIGQQTN DQDESILDGI
660 670 680 690 700
IRELQREQDL RLINEGDVPH LPVNRAYSVN GALRSPNMDI SSSPNIRLRR
710 720 730 740 750
HSSQIEGVRQ MHNNAPRSQM ATERDLMAWS RRVVVNELNN GVSRVQEECR
760 770 780 790 800
TAKGDIEISL YTVEKKKKPS YTTQRNDYEP SCGRSLRRTQ RKRQHTYQTR
810 820 830 840 850
SNIEHNSQAS CQNSGVQEDS DSSSEEDETV GTSDASVEDP VVEWQSESSS
860 870 880 890 900
SDSSSEYSDW TADAGINLQP PKRQTRQTTR KICSSSDEEN LKSLEERQKK
910 920 930 940 950
PKQTRKKKGG LVSIAGEPNE EWFAPQWILD TIPRRSPFVP QMGDELIYFR
960 970 980 990 1000
QGHEAYVRAV RKSKIYSVNL QKQPWNKMDL REQEFVKIVG IKYEVGPPTL
1010 1020 1030 1040 1050
CCLKLAFLDP ISGKMTGESF SIKYHDMPDV IDFLVLHQFY NEAKERNWQI
1060 1070 1080 1090 1100
GDRFRSIIDD AWWFGTVESQ QPFQPEYPDS SFQCYSVHWD NNEREKMSPW
1110 1120 1130 1140 1150
DMEPIPEGTA FPDEVGAGVP VSQEELTALL YKPQEGEWGA HSRDEECERV
1160 1170 1180 1190 1200
IQGINHLLSL DFASPFAVPV DLSAYPLYCT VVAYPTDLNT IRRRLENRFY
1210 1220 1230 1240 1250
RRISALMWEV RYIEHNARTF NEPDSPIVKA AKIVTDVLLR FIGDQSCTDI
1260 1270 1280 1290 1300
LDTYNKIKAE ERNSTDAEED TEIVDLDSDG PGTSSGRKVK CRGRRQSLKC
1310 1320 1330 1340 1350
NPDAWKKQCK ELLSLIYERE DSEPFRQPAD LLSYPGHQEQ EGESSESVVP
1360 1370 1380 1390 1400
ERQQDSSLSE DYQDVIDTPV DFSTVKETLE AGNYGSPLEF YKDVRQIFNN
1410 1420 1430 1440 1450
SKAYTSNKKS RIYSMMLRLS ALFESHIKNI ISEYKSAIQS QKRRRPRYRK
1460 1470 1480 1490 1500
RLRSSSSSLS SSGAPSPKGK QKQMKLQPKN DQNTSVSHAR TSSPFSSPVS
1510 1520 1530 1540 1550
DAAEGLSLYL LDDEPDGPFS SSSFGGYSRS GNSHDPGKAK SFRNRVLPVK
1560 1570 1580 1590 1600
QDHSLDGPLT NGDGREPRTG IKRKLLSASE EDENMGGEDK EKKETKEKSH
1610 1620 1630 1640 1650
LSTSESGELG SSLSSESTCG SDSDSESTSR TDQDYVDGDH DYSKFIQTRP
1660 1670 1680 1690 1700
KRKLRKQHGN GKRNWKTRGT GGRGRWGRWG RWSRGGRGRG GRGRGSRGRG
1710 1720 1730 1740 1750
GGGTRGRGRG RGGRGASRGA TRAKRARIAD DEFDTMFSGR FSRLPRIKTR
1760 1770 1780 1790 1800
NQGRRTVLYN DDSDNDNFVS TEDPLNLGTS RSGRVRKMTE KARVSHLMGW

NY
Length:1,802
Mass (Da):203,598
Last modified:November 30, 2010 - v2
Checksum:i8AA086ABFDCBA2C9
GO
Isoform 2 (identifier: Q6RI45-2) [UniParc]FASTAAdd to Basket

Also known as: BRWD3-B

The sequence of this isoform differs from the canonical sequence as follows:
     1-171: Missing.

Show »
Length:1,631
Mass (Da):184,485
Checksum:iF7AC8B9608C0B2A9
GO
Isoform 3 (identifier: Q6RI45-3) [UniParc]FASTAAdd to Basket

Also known as: BRWD3-C, BRWD3-D, BRWD3-E, BRWD3-F, BRWD3-G, BRWD3-L, BRWD3-M, BRWD3-N, BRWD3-O

The sequence of this isoform differs from the canonical sequence as follows:
     1-404: Missing.

Show »
Length:1,398
Mass (Da):158,529
Checksum:i2897D71915E102BD
GO
Isoform 4 (identifier: Q6RI45-4) [UniParc]FASTAAdd to Basket

Also known as: BRWD3-H, BRWD3-I, BRWD3-K, BRWD3-P

The sequence of this isoform differs from the canonical sequence as follows:
     1-330: Missing.

Show »
Length:1,472
Mass (Da):166,977
Checksum:iFC57697514C87C5C
GO
Isoform 5 (identifier: Q6RI45-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1385-1386: GS → DL
     1387-1802: Missing.

Note: No experimental confirmation available.

Show »
Length:1,386
Mass (Da):157,335
Checksum:i936B9BFE5FB91B64
GO

Sequence cautioni

The sequence BAC04641.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1288 – 12881K → R.2 Publications
Corresponds to variant rs3122407 [ dbSNP | Ensembl ].
VAR_031491
Natural varianti1596 – 15961K → E in MRX93; may be a rare polymorphism. 1 Publication
VAR_036940

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 404404Missing in isoform 3. 1 PublicationVSP_024303Add
BLAST
Alternative sequencei1 – 330330Missing in isoform 4. 1 PublicationVSP_024304Add
BLAST
Alternative sequencei1 – 171171Missing in isoform 2. 1 PublicationVSP_024305Add
BLAST
Alternative sequencei1385 – 13862GS → DL in isoform 5. 1 PublicationVSP_024306
Alternative sequencei1387 – 1802416Missing in isoform 5. 1 PublicationVSP_024307Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY497046 mRNA. Translation: AAS45471.1.
AY497047 mRNA. Translation: AAS45472.1.
AY497048 mRNA. Translation: AAS45473.1.
AY497049 mRNA. Translation: AAS45474.1.
AY497050 mRNA. Translation: AAS45475.1.
AY497051 mRNA. Translation: AAS45476.1.
AY497052 mRNA. Translation: AAS45477.1.
AY497053 mRNA. Translation: AAS45478.1.
AY497054 mRNA. Translation: AAS45479.1.
AY497055 mRNA. Translation: AAS45480.1.
AY497056 mRNA. Translation: AAS45481.1.
AY497057 mRNA. Translation: AAS45482.1.
AY497058 mRNA. Translation: AAS45483.1.
AY497059 mRNA. Translation: AAS45484.1.
AY497060 mRNA. Translation: AAS45485.1.
AL590031, AL512504, AL669934 Genomic DNA. Translation: CAI39936.2.
AL512504, AL590031, AL669934 Genomic DNA. Translation: CAI95143.1.
AL669934, AL512504, AL590031 Genomic DNA. Translation: CAI95405.1.
BC111490 mRNA. Translation: AAI11491.1.
AK095887 mRNA. Translation: BAC04641.1. Different initiation.
CCDSiCCDS14447.1. [Q6RI45-1]
RefSeqiNP_694984.4. NM_153252.4.
XP_005262172.1. XM_005262115.2. [Q6RI45-2]
XP_006724701.1. XM_006724638.1. [Q6RI45-3]
UniGeneiHs.147027.
Hs.613180.

Genome annotation databases

EnsembliENST00000373275; ENSP00000362372; ENSG00000165288. [Q6RI45-1]
GeneIDi254065.
KEGGihsa:254065.
UCSCiuc004edo.3. human. [Q6RI45-1]

Polymorphism databases

DMDMi313104082.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY497046 mRNA. Translation: AAS45471.1 .
AY497047 mRNA. Translation: AAS45472.1 .
AY497048 mRNA. Translation: AAS45473.1 .
AY497049 mRNA. Translation: AAS45474.1 .
AY497050 mRNA. Translation: AAS45475.1 .
AY497051 mRNA. Translation: AAS45476.1 .
AY497052 mRNA. Translation: AAS45477.1 .
AY497053 mRNA. Translation: AAS45478.1 .
AY497054 mRNA. Translation: AAS45479.1 .
AY497055 mRNA. Translation: AAS45480.1 .
AY497056 mRNA. Translation: AAS45481.1 .
AY497057 mRNA. Translation: AAS45482.1 .
AY497058 mRNA. Translation: AAS45483.1 .
AY497059 mRNA. Translation: AAS45484.1 .
AY497060 mRNA. Translation: AAS45485.1 .
AL590031 , AL512504 , AL669934 Genomic DNA. Translation: CAI39936.2 .
AL512504 , AL590031 , AL669934 Genomic DNA. Translation: CAI95143.1 .
AL669934 , AL512504 , AL590031 Genomic DNA. Translation: CAI95405.1 .
BC111490 mRNA. Translation: AAI11491.1 .
AK095887 mRNA. Translation: BAC04641.1 . Different initiation.
CCDSi CCDS14447.1. [Q6RI45-1 ]
RefSeqi NP_694984.4. NM_153252.4.
XP_005262172.1. XM_005262115.2. [Q6RI45-2 ]
XP_006724701.1. XM_006724638.1. [Q6RI45-3 ]
UniGenei Hs.147027.
Hs.613180.

3D structure databases

ProteinModelPortali Q6RI45.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 129012. 2 interactions.
IntActi Q6RI45. 2 interactions.
STRINGi 9606.ENSP00000362372.

PTM databases

PhosphoSitei Q6RI45.

Polymorphism databases

DMDMi 313104082.

Proteomic databases

MaxQBi Q6RI45.
PaxDbi Q6RI45.
PRIDEi Q6RI45.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000373275 ; ENSP00000362372 ; ENSG00000165288 . [Q6RI45-1 ]
GeneIDi 254065.
KEGGi hsa:254065.
UCSCi uc004edo.3. human. [Q6RI45-1 ]

Organism-specific databases

CTDi 254065.
GeneCardsi GC0XM079926.
HGNCi HGNC:17342. BRWD3.
HPAi HPA012802.
MIMi 300553. gene.
300659. phenotype.
neXtProti NX_Q6RI45.
Orphaneti 323. FG syndrome.
PharmGKBi PA134900775.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2319.
GeneTreei ENSGT00720000108687.
HOVERGENi HBG108248.
InParanoidi Q6RI45.
KOi K11798.
OMAi IEWQSES.
OrthoDBi EOG7N37BR.
PhylomeDBi Q6RI45.
TreeFami TF324197.

Enzyme and pathway databases

SignaLinki Q6RI45.

Miscellaneous databases

GeneWikii BRWD3.
GenomeRNAii 254065.
NextBioi 92253.
PROi Q6RI45.
SOURCEi Search...

Gene expression databases

Bgeei Q6RI45.
CleanExi HS_BRWD3.
Genevestigatori Q6RI45.

Family and domain databases

Gene3Di 1.20.920.10. 2 hits.
2.130.10.10. 2 hits.
InterProi IPR001487. Bromodomain.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00439. Bromodomain. 2 hits.
PF00400. WD40. 5 hits.
[Graphical view ]
PRINTSi PR00503. BROMODOMAIN.
SMARTi SM00297. BROMO. 2 hits.
SM00320. WD40. 8 hits.
[Graphical view ]
SUPFAMi SSF47370. SSF47370. 2 hits.
SSF50978. SSF50978. 1 hit.
PROSITEi PS50014. BROMODOMAIN_2. 2 hits.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Translocation t(X;11)(q13;q23) in B-cell chronic lymphocytic leukemia disrupts two novel genes."
    Kalla C., Nentwich H., Schlotter M., Mertens D., Wildenberger K., Doehner H., Stilgenbauer S., Lichter P.
    Genes Chromosomes Cancer 42:128-143(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), TISSUE SPECIFICITY, CHROMOSOMAL TRANSLOCATION WITH ARHGAP20, VARIANT ARG-1288.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-768 (ISOFORM 1).
    Tissue: Lymph.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 623-1802 (ISOFORM 5), VARIANT ARG-1288.
  5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-703 AND SER-1577, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration."
    Bai S.W., Herrera-Abreu M.T., Rohn J.L., Racine V., Tajadura V., Suryavanshi N., Bechtel S., Wiemann S., Baum B., Ridley A.J.
    BMC Biol. 9:54-54(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1579, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: VARIANT MRX93 GLU-1596.

Entry informationi

Entry nameiBRWD3_HUMAN
AccessioniPrimary (citable) accession number: Q6RI45
Secondary accession number(s): C9IZ39
, C9J3F3, Q2T9J6, Q5JRN1, Q6RI37, Q6RI42, Q6RI44, Q8N916
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: November 30, 2010
Last modified: October 29, 2014
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3