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Q6RI45 (BRWD3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 92. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bromodomain and WD repeat-containing protein 3
Gene names
Name:BRWD3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1802 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape. Ref.6

Tissue specificity

Found in most adult tissues. Down-regulated in a majority of the B-CLL cases examined. Ref.1

Developmental stage

Expressed in fetal liver.

Involvement in disease

A chromosomal aberration involving BRWD3 can be found in patients with B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(X;11)(q21;q23) with ARHGAP20 does not result in fusion transcripts but disrupts both genes.

Mental retardation, X-linked 93 (MRX93) [MIM:300659]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. MRX93 is associated with macrocephaly.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.8

Sequence similarities

Contains 2 bromo domains.

Contains 9 WD repeats.

Caution

The translocation involving this gene was originally published as t(X;11)(q13;23) (Ref.1), but BRWD3 is localized to Xq21 and not to Xq13.

Sequence caution

The sequence BAC04641.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q6RI45-1)

Also known as: BRWD3-A;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q6RI45-2)

Also known as: BRWD3-B;

The sequence of this isoform differs from the canonical sequence as follows:
     1-171: Missing.
Isoform 3 (identifier: Q6RI45-3)

Also known as: BRWD3-C; BRWD3-D; BRWD3-E; BRWD3-F; BRWD3-G; BRWD3-L; BRWD3-M; BRWD3-N; BRWD3-O;

The sequence of this isoform differs from the canonical sequence as follows:
     1-404: Missing.
Isoform 4 (identifier: Q6RI45-4)

Also known as: BRWD3-H; BRWD3-I; BRWD3-K; BRWD3-P;

The sequence of this isoform differs from the canonical sequence as follows:
     1-330: Missing.
Isoform 5 (identifier: Q6RI45-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1385-1386: GS → DL
     1387-1802: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 18021802Bromodomain and WD repeat-containing protein 3
PRO_0000283089

Regions

Repeat86 – 12742WD 1
Repeat178 – 21942WD 2
Repeat221 – 25939WD 3
Repeat262 – 30544WD 4
Repeat316 – 35540WD 5
Repeat360 – 40142WD 6
Repeat421 – 46040WD 7
Repeat463 – 50341WD 8
Repeat511 – 55040WD 9
Domain1158 – 122871Bromo 1
Domain1317 – 141296Bromo 2
Compositional bias1659 – 171961Gly-rich

Amino acid modifications

Modified residue7031Phosphoserine Ref.5
Modified residue15771Phosphoserine Ref.5
Modified residue15791Phosphoserine Ref.7

Natural variations

Alternative sequence1 – 404404Missing in isoform 3.
VSP_024303
Alternative sequence1 – 330330Missing in isoform 4.
VSP_024304
Alternative sequence1 – 171171Missing in isoform 2.
VSP_024305
Alternative sequence1385 – 13862GS → DL in isoform 5.
VSP_024306
Alternative sequence1387 – 1802416Missing in isoform 5.
VSP_024307
Natural variant12881K → R. Ref.1 Ref.4
Corresponds to variant rs3122407 [ dbSNP | Ensembl ].
VAR_031491
Natural variant15961K → E in MRX93; may be a rare polymorphism. Ref.8
VAR_036940

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 (BRWD3-A) [UniParc].

Last modified November 30, 2010. Version 2.
Checksum: 8AA086ABFDCBA2C9

FASTA1,802203,598
        10         20         30         40         50         60 
MAAAPTQIEA ELYYLIARFL QSGPCNKSAQ VLVQELEEHQ LIPRRLDWEG KEHRRSFEDL 

        70         80         90        100        110        120 
VAANAHIPPD YLLKICERIG PLLDKEIPQS VPGVQTLLGV GRQSLLRDAK DCKSTLWNGS 

       130        140        150        160        170        180 
AFAALHRGRP PELPVNYVKP PNVVNITSAR QLTGCSRFGH IFPSSAYQHI KMHKRILGHL 

       190        200        210        220        230        240 
SSVYCVAFDR SGRRIFTGSD DCLVKIWATD DGRLLATLRG HSAEISDMAV NYENTLIAAG 

       250        260        270        280        290        300 
SCDKVVRVWC LRTCAPVAVL QGHSASITSI QFCPSTKGTN RYLTSTGADG TICFWQWHVK 

       310        320        330        340        350        360 
TMKFRDRPVK FTERSRPGVQ ISCSSFSSGG MFITTGSTDH VIRIYYLGSE VPEKIAELES 

       370        380        390        400        410        420 
HTDKVVAVQF CNNGDSLRFV SGSRDGTARI WQYQQQEWKS IVLDMATKMT GNNLPSGEDK 

       430        440        450        460        470        480 
ITKLKVTMVA WDRYDTTVIT AVNNFLLKVW NSITGQLLHT LSGHDDEVFV LEAHPFDQRI 

       490        500        510        520        530        540 
ILSAGHDGNI FIWDLDRGTK IRNYFNMIEG QGHGAVFDCK FSPDGNHFAC TDSHGHLLLF 

       550        560        570        580        590        600 
GFGCSKYYEK IPDQMFFHTD YRPLIRDANN YVLDEQTQQA PHLMPPPFLV DVDGNPHPTK 

       610        620        630        640        650        660 
FQRLVPGREN CKDEQLIPQL GYVANGDGEV VEQVIGQQTN DQDESILDGI IRELQREQDL 

       670        680        690        700        710        720 
RLINEGDVPH LPVNRAYSVN GALRSPNMDI SSSPNIRLRR HSSQIEGVRQ MHNNAPRSQM 

       730        740        750        760        770        780 
ATERDLMAWS RRVVVNELNN GVSRVQEECR TAKGDIEISL YTVEKKKKPS YTTQRNDYEP 

       790        800        810        820        830        840 
SCGRSLRRTQ RKRQHTYQTR SNIEHNSQAS CQNSGVQEDS DSSSEEDETV GTSDASVEDP 

       850        860        870        880        890        900 
VVEWQSESSS SDSSSEYSDW TADAGINLQP PKRQTRQTTR KICSSSDEEN LKSLEERQKK 

       910        920        930        940        950        960 
PKQTRKKKGG LVSIAGEPNE EWFAPQWILD TIPRRSPFVP QMGDELIYFR QGHEAYVRAV 

       970        980        990       1000       1010       1020 
RKSKIYSVNL QKQPWNKMDL REQEFVKIVG IKYEVGPPTL CCLKLAFLDP ISGKMTGESF 

      1030       1040       1050       1060       1070       1080 
SIKYHDMPDV IDFLVLHQFY NEAKERNWQI GDRFRSIIDD AWWFGTVESQ QPFQPEYPDS 

      1090       1100       1110       1120       1130       1140 
SFQCYSVHWD NNEREKMSPW DMEPIPEGTA FPDEVGAGVP VSQEELTALL YKPQEGEWGA 

      1150       1160       1170       1180       1190       1200 
HSRDEECERV IQGINHLLSL DFASPFAVPV DLSAYPLYCT VVAYPTDLNT IRRRLENRFY 

      1210       1220       1230       1240       1250       1260 
RRISALMWEV RYIEHNARTF NEPDSPIVKA AKIVTDVLLR FIGDQSCTDI LDTYNKIKAE 

      1270       1280       1290       1300       1310       1320 
ERNSTDAEED TEIVDLDSDG PGTSSGRKVK CRGRRQSLKC NPDAWKKQCK ELLSLIYERE 

      1330       1340       1350       1360       1370       1380 
DSEPFRQPAD LLSYPGHQEQ EGESSESVVP ERQQDSSLSE DYQDVIDTPV DFSTVKETLE 

      1390       1400       1410       1420       1430       1440 
AGNYGSPLEF YKDVRQIFNN SKAYTSNKKS RIYSMMLRLS ALFESHIKNI ISEYKSAIQS 

      1450       1460       1470       1480       1490       1500 
QKRRRPRYRK RLRSSSSSLS SSGAPSPKGK QKQMKLQPKN DQNTSVSHAR TSSPFSSPVS 

      1510       1520       1530       1540       1550       1560 
DAAEGLSLYL LDDEPDGPFS SSSFGGYSRS GNSHDPGKAK SFRNRVLPVK QDHSLDGPLT 

      1570       1580       1590       1600       1610       1620 
NGDGREPRTG IKRKLLSASE EDENMGGEDK EKKETKEKSH LSTSESGELG SSLSSESTCG 

      1630       1640       1650       1660       1670       1680 
SDSDSESTSR TDQDYVDGDH DYSKFIQTRP KRKLRKQHGN GKRNWKTRGT GGRGRWGRWG 

      1690       1700       1710       1720       1730       1740 
RWSRGGRGRG GRGRGSRGRG GGGTRGRGRG RGGRGASRGA TRAKRARIAD DEFDTMFSGR 

      1750       1760       1770       1780       1790       1800 
FSRLPRIKTR NQGRRTVLYN DDSDNDNFVS TEDPLNLGTS RSGRVRKMTE KARVSHLMGW 


NY 

« Hide

Isoform 2 (BRWD3-B) [UniParc].

Checksum: F7AC8B9608C0B2A9
Show »

FASTA1,631184,485
Isoform 3 (BRWD3-C) (BRWD3-D) (BRWD3-E) (BRWD3-F) (BRWD3-G) (BRWD3-L) (BRWD3-M) (BRWD3-N) (BRWD3-O) [UniParc].

Checksum: 2897D71915E102BD
Show »

FASTA1,398158,529
Isoform 4 (BRWD3-H) (BRWD3-I) (BRWD3-K) (BRWD3-P) [UniParc].

Checksum: FC57697514C87C5C
Show »

FASTA1,472166,977
Isoform 5 [UniParc].

Checksum: 936B9BFE5FB91B64
Show »

FASTA1,386157,335

References

« Hide 'large scale' references
[1]"Translocation t(X;11)(q13;q23) in B-cell chronic lymphocytic leukemia disrupts two novel genes."
Kalla C., Nentwich H., Schlotter M., Mertens D., Wildenberger K., Doehner H., Stilgenbauer S., Lichter P.
Genes Chromosomes Cancer 42:128-143(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), TISSUE SPECIFICITY, CHROMOSOMAL TRANSLOCATION WITH ARHGAP20, VARIANT ARG-1288.
[2]"The DNA sequence of the human X chromosome."
Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C. expand/collapse author list , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-768 (ISOFORM 1).
Tissue: Lymph.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 623-1802 (ISOFORM 5), VARIANT ARG-1288.
[5]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-703 AND SER-1577, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration."
Bai S.W., Herrera-Abreu M.T., Rohn J.L., Racine V., Tajadura V., Suryavanshi N., Bechtel S., Wiemann S., Baum B., Ridley A.J.
BMC Biol. 9:54-54(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[7]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1579, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"Mutations in the BRWD3 gene cause X-linked mental retardation associated with macrocephaly."
Field M., Tarpey P.S., Smith R., Edkins S., O'Meara S., Stevens C., Tofts C., Teague J., Butler A., Dicks E., Barthorpe S., Buck G., Cole J., Gray K., Halliday K., Hills K., Jenkinson A., Jones D. expand/collapse author list , Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Varian J., West S., Widaa S., Mallya U., Wooster R., Moon J., Luo Y., Hughes H., Shaw M., Friend K.L., Corbett M., Turner G., Partington M., Mulley J., Bobrow M., Schwartz C., Stevenson R., Gecz J., Stratton M.R., Futreal P.A., Raymond F.L.
Am. J. Hum. Genet. 81:367-374(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT MRX93 GLU-1596.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY497046 mRNA. Translation: AAS45471.1.
AY497047 mRNA. Translation: AAS45472.1.
AY497048 mRNA. Translation: AAS45473.1.
AY497049 mRNA. Translation: AAS45474.1.
AY497050 mRNA. Translation: AAS45475.1.
AY497051 mRNA. Translation: AAS45476.1.
AY497052 mRNA. Translation: AAS45477.1.
AY497053 mRNA. Translation: AAS45478.1.
AY497054 mRNA. Translation: AAS45479.1.
AY497055 mRNA. Translation: AAS45480.1.
AY497056 mRNA. Translation: AAS45481.1.
AY497057 mRNA. Translation: AAS45482.1.
AY497058 mRNA. Translation: AAS45483.1.
AY497059 mRNA. Translation: AAS45484.1.
AY497060 mRNA. Translation: AAS45485.1.
AL590031, AL512504, AL669934 Genomic DNA. Translation: CAI39936.2.
AL512504, AL590031, AL669934 Genomic DNA. Translation: CAI95143.1.
AL669934, AL512504, AL590031 Genomic DNA. Translation: CAI95405.1.
BC111490 mRNA. Translation: AAI11491.1.
AK095887 mRNA. Translation: BAC04641.1. Different initiation.
CCDSCCDS14447.1. [Q6RI45-1]
RefSeqNP_694984.4. NM_153252.4.
XP_005262172.1. XM_005262115.2. [Q6RI45-2]
XP_006724701.1. XM_006724638.1. [Q6RI45-3]
UniGeneHs.147027.
Hs.613180.

3D structure databases

ProteinModelPortalQ6RI45.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid129012. 2 interactions.
IntActQ6RI45. 2 interactions.
STRING9606.ENSP00000362372.

PTM databases

PhosphoSiteQ6RI45.

Polymorphism databases

DMDM313104082.

Proteomic databases

MaxQBQ6RI45.
PaxDbQ6RI45.
PRIDEQ6RI45.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000373275; ENSP00000362372; ENSG00000165288. [Q6RI45-1]
GeneID254065.
KEGGhsa:254065.
UCSCuc004edo.3. human. [Q6RI45-1]

Organism-specific databases

CTD254065.
GeneCardsGC0XM079926.
HGNCHGNC:17342. BRWD3.
HPAHPA012802.
MIM300553. gene.
300659. phenotype.
neXtProtNX_Q6RI45.
Orphanet323. FG syndrome.
PharmGKBPA134900775.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG2319.
HOVERGENHBG108248.
InParanoidQ6RI45.
KOK11798.
OMAIEWQSES.
OrthoDBEOG7N37BR.
PhylomeDBQ6RI45.
TreeFamTF324197.

Enzyme and pathway databases

SignaLinkQ6RI45.

Gene expression databases

BgeeQ6RI45.
CleanExHS_BRWD3.
GenevestigatorQ6RI45.

Family and domain databases

Gene3D1.20.920.10. 2 hits.
2.130.10.10. 2 hits.
InterProIPR001487. Bromodomain.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamPF00439. Bromodomain. 2 hits.
PF00400. WD40. 5 hits.
[Graphical view]
PRINTSPR00503. BROMODOMAIN.
SMARTSM00297. BROMO. 2 hits.
SM00320. WD40. 8 hits.
[Graphical view]
SUPFAMSSF47370. SSF47370. 2 hits.
SSF50978. SSF50978. 1 hit.
PROSITEPS50014. BROMODOMAIN_2. 2 hits.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiBRWD3.
GenomeRNAi254065.
NextBio92253.
PROQ6RI45.
SOURCESearch...

Entry information

Entry nameBRWD3_HUMAN
AccessionPrimary (citable) accession number: Q6RI45
Secondary accession number(s): C9IZ39 expand/collapse secondary AC list , C9J3F3, Q2T9J6, Q5JRN1, Q6RI37, Q6RI42, Q6RI44, Q8N916
Entry history
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: November 30, 2010
Last modified: July 9, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome X

Human chromosome X: entries, gene names and cross-references to MIM