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Q6RI45

- BRWD3_HUMAN

UniProt

Q6RI45 - BRWD3_HUMAN

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Protein
Bromodomain and WD repeat-containing protein 3
Gene
BRWD3
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.1 Publication

GO - Biological processi

  1. cytoskeleton organization Source: UniProtKB
  2. regulation of cell shape Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ6RI45.

Names & Taxonomyi

Protein namesi
Recommended name:
Bromodomain and WD repeat-containing protein 3
Gene namesi
Name:BRWD3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome X

Organism-specific databases

HGNCiHGNC:17342. BRWD3.

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving BRWD3 can be found in patients with B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(X;11)(q21;q23) with ARHGAP20 does not result in fusion transcripts but disrupts both genes.
Mental retardation, X-linked 93 (MRX93) [MIM:300659]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. MRX93 is associated with macrocephaly.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1596 – 15961K → E in MRX93; may be a rare polymorphism. 1 Publication
VAR_036940

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

MIMi300659. phenotype.
Orphaneti323. FG syndrome.
PharmGKBiPA134900775.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 18021802Bromodomain and WD repeat-containing protein 3
PRO_0000283089Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei703 – 7031Phosphoserine1 Publication
Modified residuei1577 – 15771Phosphoserine1 Publication
Modified residuei1579 – 15791Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6RI45.
PaxDbiQ6RI45.
PRIDEiQ6RI45.

PTM databases

PhosphoSiteiQ6RI45.

Expressioni

Tissue specificityi

Found in most adult tissues. Down-regulated in a majority of the B-CLL cases examined.1 Publication

Developmental stagei

Expressed in fetal liver.

Gene expression databases

BgeeiQ6RI45.
CleanExiHS_BRWD3.
GenevestigatoriQ6RI45.

Organism-specific databases

HPAiHPA012802.

Interactioni

Protein-protein interaction databases

BioGridi129012. 2 interactions.
IntActiQ6RI45. 2 interactions.
STRINGi9606.ENSP00000362372.

Structurei

3D structure databases

ProteinModelPortaliQ6RI45.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati86 – 12742WD 1
Add
BLAST
Repeati178 – 21942WD 2
Add
BLAST
Repeati221 – 25939WD 3
Add
BLAST
Repeati262 – 30544WD 4
Add
BLAST
Repeati316 – 35540WD 5
Add
BLAST
Repeati360 – 40142WD 6
Add
BLAST
Repeati421 – 46040WD 7
Add
BLAST
Repeati463 – 50341WD 8
Add
BLAST
Repeati511 – 55040WD 9
Add
BLAST
Domaini1158 – 122871Bromo 1
Add
BLAST
Domaini1317 – 141296Bromo 2
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1659 – 171961Gly-rich
Add
BLAST

Sequence similaritiesi

Contains 2 bromo domains.
Contains 9 WD repeats.

Keywords - Domaini

Bromodomain, Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
HOVERGENiHBG108248.
InParanoidiQ6RI45.
KOiK11798.
OMAiIEWQSES.
OrthoDBiEOG7N37BR.
PhylomeDBiQ6RI45.
TreeFamiTF324197.

Family and domain databases

Gene3Di1.20.920.10. 2 hits.
2.130.10.10. 2 hits.
InterProiIPR001487. Bromodomain.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00439. Bromodomain. 2 hits.
PF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00503. BROMODOMAIN.
SMARTiSM00297. BROMO. 2 hits.
SM00320. WD40. 8 hits.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 2 hits.
SSF50978. SSF50978. 1 hit.
PROSITEiPS50014. BROMODOMAIN_2. 2 hits.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6RI45-1) [UniParc]FASTAAdd to Basket

Also known as: BRWD3-A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAAAPTQIEA ELYYLIARFL QSGPCNKSAQ VLVQELEEHQ LIPRRLDWEG     50
KEHRRSFEDL VAANAHIPPD YLLKICERIG PLLDKEIPQS VPGVQTLLGV 100
GRQSLLRDAK DCKSTLWNGS AFAALHRGRP PELPVNYVKP PNVVNITSAR 150
QLTGCSRFGH IFPSSAYQHI KMHKRILGHL SSVYCVAFDR SGRRIFTGSD 200
DCLVKIWATD DGRLLATLRG HSAEISDMAV NYENTLIAAG SCDKVVRVWC 250
LRTCAPVAVL QGHSASITSI QFCPSTKGTN RYLTSTGADG TICFWQWHVK 300
TMKFRDRPVK FTERSRPGVQ ISCSSFSSGG MFITTGSTDH VIRIYYLGSE 350
VPEKIAELES HTDKVVAVQF CNNGDSLRFV SGSRDGTARI WQYQQQEWKS 400
IVLDMATKMT GNNLPSGEDK ITKLKVTMVA WDRYDTTVIT AVNNFLLKVW 450
NSITGQLLHT LSGHDDEVFV LEAHPFDQRI ILSAGHDGNI FIWDLDRGTK 500
IRNYFNMIEG QGHGAVFDCK FSPDGNHFAC TDSHGHLLLF GFGCSKYYEK 550
IPDQMFFHTD YRPLIRDANN YVLDEQTQQA PHLMPPPFLV DVDGNPHPTK 600
FQRLVPGREN CKDEQLIPQL GYVANGDGEV VEQVIGQQTN DQDESILDGI 650
IRELQREQDL RLINEGDVPH LPVNRAYSVN GALRSPNMDI SSSPNIRLRR 700
HSSQIEGVRQ MHNNAPRSQM ATERDLMAWS RRVVVNELNN GVSRVQEECR 750
TAKGDIEISL YTVEKKKKPS YTTQRNDYEP SCGRSLRRTQ RKRQHTYQTR 800
SNIEHNSQAS CQNSGVQEDS DSSSEEDETV GTSDASVEDP VVEWQSESSS 850
SDSSSEYSDW TADAGINLQP PKRQTRQTTR KICSSSDEEN LKSLEERQKK 900
PKQTRKKKGG LVSIAGEPNE EWFAPQWILD TIPRRSPFVP QMGDELIYFR 950
QGHEAYVRAV RKSKIYSVNL QKQPWNKMDL REQEFVKIVG IKYEVGPPTL 1000
CCLKLAFLDP ISGKMTGESF SIKYHDMPDV IDFLVLHQFY NEAKERNWQI 1050
GDRFRSIIDD AWWFGTVESQ QPFQPEYPDS SFQCYSVHWD NNEREKMSPW 1100
DMEPIPEGTA FPDEVGAGVP VSQEELTALL YKPQEGEWGA HSRDEECERV 1150
IQGINHLLSL DFASPFAVPV DLSAYPLYCT VVAYPTDLNT IRRRLENRFY 1200
RRISALMWEV RYIEHNARTF NEPDSPIVKA AKIVTDVLLR FIGDQSCTDI 1250
LDTYNKIKAE ERNSTDAEED TEIVDLDSDG PGTSSGRKVK CRGRRQSLKC 1300
NPDAWKKQCK ELLSLIYERE DSEPFRQPAD LLSYPGHQEQ EGESSESVVP 1350
ERQQDSSLSE DYQDVIDTPV DFSTVKETLE AGNYGSPLEF YKDVRQIFNN 1400
SKAYTSNKKS RIYSMMLRLS ALFESHIKNI ISEYKSAIQS QKRRRPRYRK 1450
RLRSSSSSLS SSGAPSPKGK QKQMKLQPKN DQNTSVSHAR TSSPFSSPVS 1500
DAAEGLSLYL LDDEPDGPFS SSSFGGYSRS GNSHDPGKAK SFRNRVLPVK 1550
QDHSLDGPLT NGDGREPRTG IKRKLLSASE EDENMGGEDK EKKETKEKSH 1600
LSTSESGELG SSLSSESTCG SDSDSESTSR TDQDYVDGDH DYSKFIQTRP 1650
KRKLRKQHGN GKRNWKTRGT GGRGRWGRWG RWSRGGRGRG GRGRGSRGRG 1700
GGGTRGRGRG RGGRGASRGA TRAKRARIAD DEFDTMFSGR FSRLPRIKTR 1750
NQGRRTVLYN DDSDNDNFVS TEDPLNLGTS RSGRVRKMTE KARVSHLMGW 1800
NY 1802
Length:1,802
Mass (Da):203,598
Last modified:November 30, 2010 - v2
Checksum:i8AA086ABFDCBA2C9
GO
Isoform 2 (identifier: Q6RI45-2) [UniParc]FASTAAdd to Basket

Also known as: BRWD3-B

The sequence of this isoform differs from the canonical sequence as follows:
     1-171: Missing.

Show »
Length:1,631
Mass (Da):184,485
Checksum:iF7AC8B9608C0B2A9
GO
Isoform 3 (identifier: Q6RI45-3) [UniParc]FASTAAdd to Basket

Also known as: BRWD3-C, BRWD3-D, BRWD3-E, BRWD3-F, BRWD3-G, BRWD3-L, BRWD3-M, BRWD3-N, BRWD3-O

The sequence of this isoform differs from the canonical sequence as follows:
     1-404: Missing.

Show »
Length:1,398
Mass (Da):158,529
Checksum:i2897D71915E102BD
GO
Isoform 4 (identifier: Q6RI45-4) [UniParc]FASTAAdd to Basket

Also known as: BRWD3-H, BRWD3-I, BRWD3-K, BRWD3-P

The sequence of this isoform differs from the canonical sequence as follows:
     1-330: Missing.

Show »
Length:1,472
Mass (Da):166,977
Checksum:iFC57697514C87C5C
GO
Isoform 5 (identifier: Q6RI45-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1385-1386: GS → DL
     1387-1802: Missing.

Note: No experimental confirmation available.

Show »
Length:1,386
Mass (Da):157,335
Checksum:i936B9BFE5FB91B64
GO

Sequence cautioni

The sequence BAC04641.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti1288 – 12881K → R.2 Publications
Corresponds to variant rs3122407 [ dbSNP | Ensembl ].
VAR_031491
Natural varianti1596 – 15961K → E in MRX93; may be a rare polymorphism. 1 Publication
VAR_036940

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 404404Missing in isoform 3.
VSP_024303Add
BLAST
Alternative sequencei1 – 330330Missing in isoform 4.
VSP_024304Add
BLAST
Alternative sequencei1 – 171171Missing in isoform 2.
VSP_024305Add
BLAST
Alternative sequencei1385 – 13862GS → DL in isoform 5.
VSP_024306
Alternative sequencei1387 – 1802416Missing in isoform 5.
VSP_024307Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY497046 mRNA. Translation: AAS45471.1.
AY497047 mRNA. Translation: AAS45472.1.
AY497048 mRNA. Translation: AAS45473.1.
AY497049 mRNA. Translation: AAS45474.1.
AY497050 mRNA. Translation: AAS45475.1.
AY497051 mRNA. Translation: AAS45476.1.
AY497052 mRNA. Translation: AAS45477.1.
AY497053 mRNA. Translation: AAS45478.1.
AY497054 mRNA. Translation: AAS45479.1.
AY497055 mRNA. Translation: AAS45480.1.
AY497056 mRNA. Translation: AAS45481.1.
AY497057 mRNA. Translation: AAS45482.1.
AY497058 mRNA. Translation: AAS45483.1.
AY497059 mRNA. Translation: AAS45484.1.
AY497060 mRNA. Translation: AAS45485.1.
AL590031, AL512504, AL669934 Genomic DNA. Translation: CAI39936.2.
AL512504, AL590031, AL669934 Genomic DNA. Translation: CAI95143.1.
AL669934, AL512504, AL590031 Genomic DNA. Translation: CAI95405.1.
BC111490 mRNA. Translation: AAI11491.1.
AK095887 mRNA. Translation: BAC04641.1. Different initiation.
CCDSiCCDS14447.1. [Q6RI45-1]
RefSeqiNP_694984.4. NM_153252.4.
XP_005262172.1. XM_005262115.2. [Q6RI45-2]
XP_006724701.1. XM_006724638.1. [Q6RI45-3]
UniGeneiHs.147027.
Hs.613180.

Genome annotation databases

EnsembliENST00000373275; ENSP00000362372; ENSG00000165288. [Q6RI45-1]
GeneIDi254065.
KEGGihsa:254065.
UCSCiuc004edo.3. human. [Q6RI45-1]

Polymorphism databases

DMDMi313104082.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY497046 mRNA. Translation: AAS45471.1 .
AY497047 mRNA. Translation: AAS45472.1 .
AY497048 mRNA. Translation: AAS45473.1 .
AY497049 mRNA. Translation: AAS45474.1 .
AY497050 mRNA. Translation: AAS45475.1 .
AY497051 mRNA. Translation: AAS45476.1 .
AY497052 mRNA. Translation: AAS45477.1 .
AY497053 mRNA. Translation: AAS45478.1 .
AY497054 mRNA. Translation: AAS45479.1 .
AY497055 mRNA. Translation: AAS45480.1 .
AY497056 mRNA. Translation: AAS45481.1 .
AY497057 mRNA. Translation: AAS45482.1 .
AY497058 mRNA. Translation: AAS45483.1 .
AY497059 mRNA. Translation: AAS45484.1 .
AY497060 mRNA. Translation: AAS45485.1 .
AL590031 , AL512504 , AL669934 Genomic DNA. Translation: CAI39936.2 .
AL512504 , AL590031 , AL669934 Genomic DNA. Translation: CAI95143.1 .
AL669934 , AL512504 , AL590031 Genomic DNA. Translation: CAI95405.1 .
BC111490 mRNA. Translation: AAI11491.1 .
AK095887 mRNA. Translation: BAC04641.1 . Different initiation.
CCDSi CCDS14447.1. [Q6RI45-1 ]
RefSeqi NP_694984.4. NM_153252.4.
XP_005262172.1. XM_005262115.2. [Q6RI45-2 ]
XP_006724701.1. XM_006724638.1. [Q6RI45-3 ]
UniGenei Hs.147027.
Hs.613180.

3D structure databases

ProteinModelPortali Q6RI45.
ModBasei Search...

Protein-protein interaction databases

BioGridi 129012. 2 interactions.
IntActi Q6RI45. 2 interactions.
STRINGi 9606.ENSP00000362372.

PTM databases

PhosphoSitei Q6RI45.

Polymorphism databases

DMDMi 313104082.

Proteomic databases

MaxQBi Q6RI45.
PaxDbi Q6RI45.
PRIDEi Q6RI45.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000373275 ; ENSP00000362372 ; ENSG00000165288 . [Q6RI45-1 ]
GeneIDi 254065.
KEGGi hsa:254065.
UCSCi uc004edo.3. human. [Q6RI45-1 ]

Organism-specific databases

CTDi 254065.
GeneCardsi GC0XM079926.
HGNCi HGNC:17342. BRWD3.
HPAi HPA012802.
MIMi 300553. gene.
300659. phenotype.
neXtProti NX_Q6RI45.
Orphaneti 323. FG syndrome.
PharmGKBi PA134900775.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2319.
HOVERGENi HBG108248.
InParanoidi Q6RI45.
KOi K11798.
OMAi IEWQSES.
OrthoDBi EOG7N37BR.
PhylomeDBi Q6RI45.
TreeFami TF324197.

Enzyme and pathway databases

SignaLinki Q6RI45.

Miscellaneous databases

GeneWikii BRWD3.
GenomeRNAii 254065.
NextBioi 92253.
PROi Q6RI45.
SOURCEi Search...

Gene expression databases

Bgeei Q6RI45.
CleanExi HS_BRWD3.
Genevestigatori Q6RI45.

Family and domain databases

Gene3Di 1.20.920.10. 2 hits.
2.130.10.10. 2 hits.
InterProi IPR001487. Bromodomain.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00439. Bromodomain. 2 hits.
PF00400. WD40. 5 hits.
[Graphical view ]
PRINTSi PR00503. BROMODOMAIN.
SMARTi SM00297. BROMO. 2 hits.
SM00320. WD40. 8 hits.
[Graphical view ]
SUPFAMi SSF47370. SSF47370. 2 hits.
SSF50978. SSF50978. 1 hit.
PROSITEi PS50014. BROMODOMAIN_2. 2 hits.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 5 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Translocation t(X;11)(q13;q23) in B-cell chronic lymphocytic leukemia disrupts two novel genes."
    Kalla C., Nentwich H., Schlotter M., Mertens D., Wildenberger K., Doehner H., Stilgenbauer S., Lichter P.
    Genes Chromosomes Cancer 42:128-143(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), TISSUE SPECIFICITY, CHROMOSOMAL TRANSLOCATION WITH ARHGAP20, VARIANT ARG-1288.
  2. "The DNA sequence of the human X chromosome."
    Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
    , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
    Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-768 (ISOFORM 1).
    Tissue: Lymph.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 623-1802 (ISOFORM 5), VARIANT ARG-1288.
  5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-703 AND SER-1577, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration."
    Bai S.W., Herrera-Abreu M.T., Rohn J.L., Racine V., Tajadura V., Suryavanshi N., Bechtel S., Wiemann S., Baum B., Ridley A.J.
    BMC Biol. 9:54-54(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1579, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: VARIANT MRX93 GLU-1596.

Entry informationi

Entry nameiBRWD3_HUMAN
AccessioniPrimary (citable) accession number: Q6RI45
Secondary accession number(s): C9IZ39
, C9J3F3, Q2T9J6, Q5JRN1, Q6RI37, Q6RI42, Q6RI44, Q8N916
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: November 30, 2010
Last modified: July 9, 2014
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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