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Q6RI45

- BRWD3_HUMAN

UniProt

Q6RI45 - BRWD3_HUMAN

Protein

Bromodomain and WD repeat-containing protein 3

Gene

BRWD3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 93 (01 Oct 2014)
      Sequence version 2 (30 Nov 2010)
      Previous versions | rss
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    Functioni

    Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape.1 Publication

    GO - Biological processi

    1. cytoskeleton organization Source: UniProtKB
    2. regulation of cell shape Source: UniProtKB

    Enzyme and pathway databases

    SignaLinkiQ6RI45.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bromodomain and WD repeat-containing protein 3
    Gene namesi
    Name:BRWD3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome X

    Organism-specific databases

    HGNCiHGNC:17342. BRWD3.

    Pathology & Biotechi

    Involvement in diseasei

    A chromosomal aberration involving BRWD3 can be found in patients with B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(X;11)(q21;q23) with ARHGAP20 does not result in fusion transcripts but disrupts both genes.
    Mental retardation, X-linked 93 (MRX93) [MIM:300659]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Intellectual deficiency is the only primary symptom of non-syndromic X-linked mental retardation, while syndromic mental retardation presents with associated physical, neurological and/or psychiatric manifestations. MRX93 is associated with macrocephaly.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti1596 – 15961K → E in MRX93; may be a rare polymorphism. 1 Publication
    VAR_036940

    Keywords - Diseasei

    Disease mutation, Mental retardation

    Organism-specific databases

    MIMi300659. phenotype.
    Orphaneti323. FG syndrome.
    PharmGKBiPA134900775.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 18021802Bromodomain and WD repeat-containing protein 3PRO_0000283089Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei703 – 7031Phosphoserine1 Publication
    Modified residuei1577 – 15771Phosphoserine1 Publication
    Modified residuei1579 – 15791Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ6RI45.
    PaxDbiQ6RI45.
    PRIDEiQ6RI45.

    PTM databases

    PhosphoSiteiQ6RI45.

    Expressioni

    Tissue specificityi

    Found in most adult tissues. Down-regulated in a majority of the B-CLL cases examined.1 Publication

    Developmental stagei

    Expressed in fetal liver.

    Gene expression databases

    BgeeiQ6RI45.
    CleanExiHS_BRWD3.
    GenevestigatoriQ6RI45.

    Organism-specific databases

    HPAiHPA012802.

    Interactioni

    Protein-protein interaction databases

    BioGridi129012. 2 interactions.
    IntActiQ6RI45. 2 interactions.
    STRINGi9606.ENSP00000362372.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6RI45.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati86 – 12742WD 1Add
    BLAST
    Repeati178 – 21942WD 2Add
    BLAST
    Repeati221 – 25939WD 3Add
    BLAST
    Repeati262 – 30544WD 4Add
    BLAST
    Repeati316 – 35540WD 5Add
    BLAST
    Repeati360 – 40142WD 6Add
    BLAST
    Repeati421 – 46040WD 7Add
    BLAST
    Repeati463 – 50341WD 8Add
    BLAST
    Repeati511 – 55040WD 9Add
    BLAST
    Domaini1158 – 122871Bromo 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1317 – 141296Bromo 2PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1659 – 171961Gly-richAdd
    BLAST

    Sequence similaritiesi

    Contains 2 bromo domains.PROSITE-ProRule annotation
    Contains 9 WD repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Bromodomain, Repeat, WD repeat

    Phylogenomic databases

    eggNOGiCOG2319.
    HOVERGENiHBG108248.
    InParanoidiQ6RI45.
    KOiK11798.
    OMAiIEWQSES.
    OrthoDBiEOG7N37BR.
    PhylomeDBiQ6RI45.
    TreeFamiTF324197.

    Family and domain databases

    Gene3Di1.20.920.10. 2 hits.
    2.130.10.10. 2 hits.
    InterProiIPR001487. Bromodomain.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view]
    PfamiPF00439. Bromodomain. 2 hits.
    PF00400. WD40. 5 hits.
    [Graphical view]
    PRINTSiPR00503. BROMODOMAIN.
    SMARTiSM00297. BROMO. 2 hits.
    SM00320. WD40. 8 hits.
    [Graphical view]
    SUPFAMiSSF47370. SSF47370. 2 hits.
    SSF50978. SSF50978. 1 hit.
    PROSITEiPS50014. BROMODOMAIN_2. 2 hits.
    PS00678. WD_REPEATS_1. 2 hits.
    PS50082. WD_REPEATS_2. 5 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6RI45-1) [UniParc]FASTAAdd to Basket

    Also known as: BRWD3-A

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAAPTQIEA ELYYLIARFL QSGPCNKSAQ VLVQELEEHQ LIPRRLDWEG     50
    KEHRRSFEDL VAANAHIPPD YLLKICERIG PLLDKEIPQS VPGVQTLLGV 100
    GRQSLLRDAK DCKSTLWNGS AFAALHRGRP PELPVNYVKP PNVVNITSAR 150
    QLTGCSRFGH IFPSSAYQHI KMHKRILGHL SSVYCVAFDR SGRRIFTGSD 200
    DCLVKIWATD DGRLLATLRG HSAEISDMAV NYENTLIAAG SCDKVVRVWC 250
    LRTCAPVAVL QGHSASITSI QFCPSTKGTN RYLTSTGADG TICFWQWHVK 300
    TMKFRDRPVK FTERSRPGVQ ISCSSFSSGG MFITTGSTDH VIRIYYLGSE 350
    VPEKIAELES HTDKVVAVQF CNNGDSLRFV SGSRDGTARI WQYQQQEWKS 400
    IVLDMATKMT GNNLPSGEDK ITKLKVTMVA WDRYDTTVIT AVNNFLLKVW 450
    NSITGQLLHT LSGHDDEVFV LEAHPFDQRI ILSAGHDGNI FIWDLDRGTK 500
    IRNYFNMIEG QGHGAVFDCK FSPDGNHFAC TDSHGHLLLF GFGCSKYYEK 550
    IPDQMFFHTD YRPLIRDANN YVLDEQTQQA PHLMPPPFLV DVDGNPHPTK 600
    FQRLVPGREN CKDEQLIPQL GYVANGDGEV VEQVIGQQTN DQDESILDGI 650
    IRELQREQDL RLINEGDVPH LPVNRAYSVN GALRSPNMDI SSSPNIRLRR 700
    HSSQIEGVRQ MHNNAPRSQM ATERDLMAWS RRVVVNELNN GVSRVQEECR 750
    TAKGDIEISL YTVEKKKKPS YTTQRNDYEP SCGRSLRRTQ RKRQHTYQTR 800
    SNIEHNSQAS CQNSGVQEDS DSSSEEDETV GTSDASVEDP VVEWQSESSS 850
    SDSSSEYSDW TADAGINLQP PKRQTRQTTR KICSSSDEEN LKSLEERQKK 900
    PKQTRKKKGG LVSIAGEPNE EWFAPQWILD TIPRRSPFVP QMGDELIYFR 950
    QGHEAYVRAV RKSKIYSVNL QKQPWNKMDL REQEFVKIVG IKYEVGPPTL 1000
    CCLKLAFLDP ISGKMTGESF SIKYHDMPDV IDFLVLHQFY NEAKERNWQI 1050
    GDRFRSIIDD AWWFGTVESQ QPFQPEYPDS SFQCYSVHWD NNEREKMSPW 1100
    DMEPIPEGTA FPDEVGAGVP VSQEELTALL YKPQEGEWGA HSRDEECERV 1150
    IQGINHLLSL DFASPFAVPV DLSAYPLYCT VVAYPTDLNT IRRRLENRFY 1200
    RRISALMWEV RYIEHNARTF NEPDSPIVKA AKIVTDVLLR FIGDQSCTDI 1250
    LDTYNKIKAE ERNSTDAEED TEIVDLDSDG PGTSSGRKVK CRGRRQSLKC 1300
    NPDAWKKQCK ELLSLIYERE DSEPFRQPAD LLSYPGHQEQ EGESSESVVP 1350
    ERQQDSSLSE DYQDVIDTPV DFSTVKETLE AGNYGSPLEF YKDVRQIFNN 1400
    SKAYTSNKKS RIYSMMLRLS ALFESHIKNI ISEYKSAIQS QKRRRPRYRK 1450
    RLRSSSSSLS SSGAPSPKGK QKQMKLQPKN DQNTSVSHAR TSSPFSSPVS 1500
    DAAEGLSLYL LDDEPDGPFS SSSFGGYSRS GNSHDPGKAK SFRNRVLPVK 1550
    QDHSLDGPLT NGDGREPRTG IKRKLLSASE EDENMGGEDK EKKETKEKSH 1600
    LSTSESGELG SSLSSESTCG SDSDSESTSR TDQDYVDGDH DYSKFIQTRP 1650
    KRKLRKQHGN GKRNWKTRGT GGRGRWGRWG RWSRGGRGRG GRGRGSRGRG 1700
    GGGTRGRGRG RGGRGASRGA TRAKRARIAD DEFDTMFSGR FSRLPRIKTR 1750
    NQGRRTVLYN DDSDNDNFVS TEDPLNLGTS RSGRVRKMTE KARVSHLMGW 1800
    NY 1802
    Length:1,802
    Mass (Da):203,598
    Last modified:November 30, 2010 - v2
    Checksum:i8AA086ABFDCBA2C9
    GO
    Isoform 2 (identifier: Q6RI45-2) [UniParc]FASTAAdd to Basket

    Also known as: BRWD3-B

    The sequence of this isoform differs from the canonical sequence as follows:
         1-171: Missing.

    Show »
    Length:1,631
    Mass (Da):184,485
    Checksum:iF7AC8B9608C0B2A9
    GO
    Isoform 3 (identifier: Q6RI45-3) [UniParc]FASTAAdd to Basket

    Also known as: BRWD3-C, BRWD3-D, BRWD3-E, BRWD3-F, BRWD3-G, BRWD3-L, BRWD3-M, BRWD3-N, BRWD3-O

    The sequence of this isoform differs from the canonical sequence as follows:
         1-404: Missing.

    Show »
    Length:1,398
    Mass (Da):158,529
    Checksum:i2897D71915E102BD
    GO
    Isoform 4 (identifier: Q6RI45-4) [UniParc]FASTAAdd to Basket

    Also known as: BRWD3-H, BRWD3-I, BRWD3-K, BRWD3-P

    The sequence of this isoform differs from the canonical sequence as follows:
         1-330: Missing.

    Show »
    Length:1,472
    Mass (Da):166,977
    Checksum:iFC57697514C87C5C
    GO
    Isoform 5 (identifier: Q6RI45-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1385-1386: GS → DL
         1387-1802: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,386
    Mass (Da):157,335
    Checksum:i936B9BFE5FB91B64
    GO

    Sequence cautioni

    The sequence BAC04641.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti1288 – 12881K → R.2 Publications
    Corresponds to variant rs3122407 [ dbSNP | Ensembl ].
    VAR_031491
    Natural varianti1596 – 15961K → E in MRX93; may be a rare polymorphism. 1 Publication
    VAR_036940

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 404404Missing in isoform 3. 1 PublicationVSP_024303Add
    BLAST
    Alternative sequencei1 – 330330Missing in isoform 4. 1 PublicationVSP_024304Add
    BLAST
    Alternative sequencei1 – 171171Missing in isoform 2. 1 PublicationVSP_024305Add
    BLAST
    Alternative sequencei1385 – 13862GS → DL in isoform 5. 1 PublicationVSP_024306
    Alternative sequencei1387 – 1802416Missing in isoform 5. 1 PublicationVSP_024307Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY497046 mRNA. Translation: AAS45471.1.
    AY497047 mRNA. Translation: AAS45472.1.
    AY497048 mRNA. Translation: AAS45473.1.
    AY497049 mRNA. Translation: AAS45474.1.
    AY497050 mRNA. Translation: AAS45475.1.
    AY497051 mRNA. Translation: AAS45476.1.
    AY497052 mRNA. Translation: AAS45477.1.
    AY497053 mRNA. Translation: AAS45478.1.
    AY497054 mRNA. Translation: AAS45479.1.
    AY497055 mRNA. Translation: AAS45480.1.
    AY497056 mRNA. Translation: AAS45481.1.
    AY497057 mRNA. Translation: AAS45482.1.
    AY497058 mRNA. Translation: AAS45483.1.
    AY497059 mRNA. Translation: AAS45484.1.
    AY497060 mRNA. Translation: AAS45485.1.
    AL590031, AL512504, AL669934 Genomic DNA. Translation: CAI39936.2.
    AL512504, AL590031, AL669934 Genomic DNA. Translation: CAI95143.1.
    AL669934, AL512504, AL590031 Genomic DNA. Translation: CAI95405.1.
    BC111490 mRNA. Translation: AAI11491.1.
    AK095887 mRNA. Translation: BAC04641.1. Different initiation.
    CCDSiCCDS14447.1. [Q6RI45-1]
    RefSeqiNP_694984.4. NM_153252.4.
    XP_005262172.1. XM_005262115.2. [Q6RI45-2]
    XP_006724701.1. XM_006724638.1. [Q6RI45-3]
    UniGeneiHs.147027.
    Hs.613180.

    Genome annotation databases

    EnsembliENST00000373275; ENSP00000362372; ENSG00000165288. [Q6RI45-1]
    GeneIDi254065.
    KEGGihsa:254065.
    UCSCiuc004edo.3. human. [Q6RI45-1]

    Polymorphism databases

    DMDMi313104082.

    Keywords - Coding sequence diversityi

    Alternative splicing, Chromosomal rearrangement, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY497046 mRNA. Translation: AAS45471.1 .
    AY497047 mRNA. Translation: AAS45472.1 .
    AY497048 mRNA. Translation: AAS45473.1 .
    AY497049 mRNA. Translation: AAS45474.1 .
    AY497050 mRNA. Translation: AAS45475.1 .
    AY497051 mRNA. Translation: AAS45476.1 .
    AY497052 mRNA. Translation: AAS45477.1 .
    AY497053 mRNA. Translation: AAS45478.1 .
    AY497054 mRNA. Translation: AAS45479.1 .
    AY497055 mRNA. Translation: AAS45480.1 .
    AY497056 mRNA. Translation: AAS45481.1 .
    AY497057 mRNA. Translation: AAS45482.1 .
    AY497058 mRNA. Translation: AAS45483.1 .
    AY497059 mRNA. Translation: AAS45484.1 .
    AY497060 mRNA. Translation: AAS45485.1 .
    AL590031 , AL512504 , AL669934 Genomic DNA. Translation: CAI39936.2 .
    AL512504 , AL590031 , AL669934 Genomic DNA. Translation: CAI95143.1 .
    AL669934 , AL512504 , AL590031 Genomic DNA. Translation: CAI95405.1 .
    BC111490 mRNA. Translation: AAI11491.1 .
    AK095887 mRNA. Translation: BAC04641.1 . Different initiation.
    CCDSi CCDS14447.1. [Q6RI45-1 ]
    RefSeqi NP_694984.4. NM_153252.4.
    XP_005262172.1. XM_005262115.2. [Q6RI45-2 ]
    XP_006724701.1. XM_006724638.1. [Q6RI45-3 ]
    UniGenei Hs.147027.
    Hs.613180.

    3D structure databases

    ProteinModelPortali Q6RI45.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 129012. 2 interactions.
    IntActi Q6RI45. 2 interactions.
    STRINGi 9606.ENSP00000362372.

    PTM databases

    PhosphoSitei Q6RI45.

    Polymorphism databases

    DMDMi 313104082.

    Proteomic databases

    MaxQBi Q6RI45.
    PaxDbi Q6RI45.
    PRIDEi Q6RI45.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000373275 ; ENSP00000362372 ; ENSG00000165288 . [Q6RI45-1 ]
    GeneIDi 254065.
    KEGGi hsa:254065.
    UCSCi uc004edo.3. human. [Q6RI45-1 ]

    Organism-specific databases

    CTDi 254065.
    GeneCardsi GC0XM079926.
    HGNCi HGNC:17342. BRWD3.
    HPAi HPA012802.
    MIMi 300553. gene.
    300659. phenotype.
    neXtProti NX_Q6RI45.
    Orphaneti 323. FG syndrome.
    PharmGKBi PA134900775.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2319.
    HOVERGENi HBG108248.
    InParanoidi Q6RI45.
    KOi K11798.
    OMAi IEWQSES.
    OrthoDBi EOG7N37BR.
    PhylomeDBi Q6RI45.
    TreeFami TF324197.

    Enzyme and pathway databases

    SignaLinki Q6RI45.

    Miscellaneous databases

    GeneWikii BRWD3.
    GenomeRNAii 254065.
    NextBioi 92253.
    PROi Q6RI45.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6RI45.
    CleanExi HS_BRWD3.
    Genevestigatori Q6RI45.

    Family and domain databases

    Gene3Di 1.20.920.10. 2 hits.
    2.130.10.10. 2 hits.
    InterProi IPR001487. Bromodomain.
    IPR015943. WD40/YVTN_repeat-like_dom.
    IPR001680. WD40_repeat.
    IPR019775. WD40_repeat_CS.
    IPR017986. WD40_repeat_dom.
    [Graphical view ]
    Pfami PF00439. Bromodomain. 2 hits.
    PF00400. WD40. 5 hits.
    [Graphical view ]
    PRINTSi PR00503. BROMODOMAIN.
    SMARTi SM00297. BROMO. 2 hits.
    SM00320. WD40. 8 hits.
    [Graphical view ]
    SUPFAMi SSF47370. SSF47370. 2 hits.
    SSF50978. SSF50978. 1 hit.
    PROSITEi PS50014. BROMODOMAIN_2. 2 hits.
    PS00678. WD_REPEATS_1. 2 hits.
    PS50082. WD_REPEATS_2. 5 hits.
    PS50294. WD_REPEATS_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Translocation t(X;11)(q13;q23) in B-cell chronic lymphocytic leukemia disrupts two novel genes."
      Kalla C., Nentwich H., Schlotter M., Mertens D., Wildenberger K., Doehner H., Stilgenbauer S., Lichter P.
      Genes Chromosomes Cancer 42:128-143(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3 AND 4), TISSUE SPECIFICITY, CHROMOSOMAL TRANSLOCATION WITH ARHGAP20, VARIANT ARG-1288.
    2. "The DNA sequence of the human X chromosome."
      Ross M.T., Grafham D.V., Coffey A.J., Scherer S., McLay K., Muzny D., Platzer M., Howell G.R., Burrows C., Bird C.P., Frankish A., Lovell F.L., Howe K.L., Ashurst J.L., Fulton R.S., Sudbrak R., Wen G., Jones M.C.
      , Hurles M.E., Andrews T.D., Scott C.E., Searle S., Ramser J., Whittaker A., Deadman R., Carter N.P., Hunt S.E., Chen R., Cree A., Gunaratne P., Havlak P., Hodgson A., Metzker M.L., Richards S., Scott G., Steffen D., Sodergren E., Wheeler D.A., Worley K.C., Ainscough R., Ambrose K.D., Ansari-Lari M.A., Aradhya S., Ashwell R.I., Babbage A.K., Bagguley C.L., Ballabio A., Banerjee R., Barker G.E., Barlow K.F., Barrett I.P., Bates K.N., Beare D.M., Beasley H., Beasley O., Beck A., Bethel G., Blechschmidt K., Brady N., Bray-Allen S., Bridgeman A.M., Brown A.J., Brown M.J., Bonnin D., Bruford E.A., Buhay C., Burch P., Burford D., Burgess J., Burrill W., Burton J., Bye J.M., Carder C., Carrel L., Chako J., Chapman J.C., Chavez D., Chen E., Chen G., Chen Y., Chen Z., Chinault C., Ciccodicola A., Clark S.Y., Clarke G., Clee C.M., Clegg S., Clerc-Blankenburg K., Clifford K., Cobley V., Cole C.G., Conquer J.S., Corby N., Connor R.E., David R., Davies J., Davis C., Davis J., Delgado O., Deshazo D., Dhami P., Ding Y., Dinh H., Dodsworth S., Draper H., Dugan-Rocha S., Dunham A., Dunn M., Durbin K.J., Dutta I., Eades T., Ellwood M., Emery-Cohen A., Errington H., Evans K.L., Faulkner L., Francis F., Frankland J., Fraser A.E., Galgoczy P., Gilbert J., Gill R., Gloeckner G., Gregory S.G., Gribble S., Griffiths C., Grocock R., Gu Y., Gwilliam R., Hamilton C., Hart E.A., Hawes A., Heath P.D., Heitmann K., Hennig S., Hernandez J., Hinzmann B., Ho S., Hoffs M., Howden P.J., Huckle E.J., Hume J., Hunt P.J., Hunt A.R., Isherwood J., Jacob L., Johnson D., Jones S., de Jong P.J., Joseph S.S., Keenan S., Kelly S., Kershaw J.K., Khan Z., Kioschis P., Klages S., Knights A.J., Kosiura A., Kovar-Smith C., Laird G.K., Langford C., Lawlor S., Leversha M., Lewis L., Liu W., Lloyd C., Lloyd D.M., Loulseged H., Loveland J.E., Lovell J.D., Lozado R., Lu J., Lyne R., Ma J., Maheshwari M., Matthews L.H., McDowall J., McLaren S., McMurray A., Meidl P., Meitinger T., Milne S., Miner G., Mistry S.L., Morgan M., Morris S., Mueller I., Mullikin J.C., Nguyen N., Nordsiek G., Nyakatura G., O'dell C.N., Okwuonu G., Palmer S., Pandian R., Parker D., Parrish J., Pasternak S., Patel D., Pearce A.V., Pearson D.M., Pelan S.E., Perez L., Porter K.M., Ramsey Y., Reichwald K., Rhodes S., Ridler K.A., Schlessinger D., Schueler M.G., Sehra H.K., Shaw-Smith C., Shen H., Sheridan E.M., Shownkeen R., Skuce C.D., Smith M.L., Sotheran E.C., Steingruber H.E., Steward C.A., Storey R., Swann R.M., Swarbreck D., Tabor P.E., Taudien S., Taylor T., Teague B., Thomas K., Thorpe A., Timms K., Tracey A., Trevanion S., Tromans A.C., d'Urso M., Verduzco D., Villasana D., Waldron L., Wall M., Wang Q., Warren J., Warry G.L., Wei X., West A., Whitehead S.L., Whiteley M.N., Wilkinson J.E., Willey D.L., Williams G., Williams L., Williamson A., Williamson H., Wilming L., Woodmansey R.L., Wray P.W., Yen J., Zhang J., Zhou J., Zoghbi H., Zorilla S., Buck D., Reinhardt R., Poustka A., Rosenthal A., Lehrach H., Meindl A., Minx P.J., Hillier L.W., Willard H.F., Wilson R.K., Waterston R.H., Rice C.M., Vaudin M., Coulson A., Nelson D.L., Weinstock G., Sulston J.E., Durbin R.M., Hubbard T., Gibbs R.A., Beck S., Rogers J., Bentley D.R.
      Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-768 (ISOFORM 1).
      Tissue: Lymph.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 623-1802 (ISOFORM 5), VARIANT ARG-1288.
    5. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-703 AND SER-1577, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration."
      Bai S.W., Herrera-Abreu M.T., Rohn J.L., Racine V., Tajadura V., Suryavanshi N., Bechtel S., Wiemann S., Baum B., Ridley A.J.
      BMC Biol. 9:54-54(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1579, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: VARIANT MRX93 GLU-1596.

    Entry informationi

    Entry nameiBRWD3_HUMAN
    AccessioniPrimary (citable) accession number: Q6RI45
    Secondary accession number(s): C9IZ39
    , C9J3F3, Q2T9J6, Q5JRN1, Q6RI37, Q6RI42, Q6RI44, Q8N916
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 3, 2007
    Last sequence update: November 30, 2010
    Last modified: October 1, 2014
    This is version 93 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome X
      Human chromosome X: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3