Q6RHW4 (HYAL1_PIG) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 47.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Hyaluronidase-1 Short name=Hyal-1 EC=3.2.1.35 Alternative name(s): Hyaluronoglucosaminidase-1 | ||
| Gene names |
| ||
| Organism | Sus scrofa (Pig) [Complete proteome] | ||
| Taxonomic identifier | 9823 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus |
Protein attributes
| Sequence length | 435 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth By similarity. |
| Catalytic activity | Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate. |
| Subcellular location | |
| Tissue specificity | Highly expressed in spleen, kidney, and lung. Ref.1 |
| Sequence similarities | Belongs to the glycosyl hydrolase 56 family. Contains 1 EGF-like domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Lysosome Secreted |
| Domain | EGF-like domain Signal |
| Molecular function | Glycosidase Hydrolase |
| PTM | Disulfide bond Glycoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro |
| Cellular component | extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell lysosomeInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | hyalurononglucosaminidase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 21 | 21 | Potential | ||||||||
| Chain | 22 – 435 | 414 | Hyaluronidase-1 | PRO_0000042625 | |||||||
Regions | |||||||||||
| Domain | 418 – 429 | 12 | EGF-like | ||||||||
Sites | |||||||||||
| Active site | 131 | 1 | Proton donor By similarity | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 70 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 99 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 107 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 121 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 216 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 256 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 350 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 43 ↔ 333 | By similarity | |||||||||
| Disulfide bond | 207 ↔ 221 | By similarity | |||||||||
| Disulfide bond | 358 ↔ 369 | By similarity | |||||||||
| Disulfide bond | 363 ↔ 418 | By similarity | |||||||||
| Disulfide bond | 420 ↔ 429 | By similarity | |||||||||
Sequences
| ||||||||||||||||||
References
| [1] | "Molecular characterization of porcine hyaluronidase genes 1, 2, and 3 clustered on SSC13q21." Gatphayak K., Knorr C., Beck J., Brenig B. Cytogenet. Genome Res. 106:98-106(2004) [PubMed: 15218248] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AY497543 mRNA. Translation: AAR91599.1. |
| RefSeq | NP_999606.1. NM_214441.1. |
| UniGene | Ssc.26119. |
3D structure databases | |
| ProteinModelPortal | Q6RHW4. |
| SMR | Q6RHW4. Positions 23-432. |
| ModBase | Search... |
Protein family/group databases | |
| CAZy | GH56. Glycoside Hydrolase Family 56. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 404698. |
| KEGG | ssc:404698. |
Organism-specific databases | |
| CTD | 3373. |
Phylogenomic databases | |
| GeneTree | ENSGT00550000074476. |
| HOVERGEN | HBG052053. |
| OrthoDB | EOG4VDPZD. |
Enzyme and pathway databases | |
| BRENDA | 3.2.1.35. 6170. |
Family and domain databases | |
| InterPro | IPR013785. Aldolase_TIM. IPR006210. EGF-like. IPR017853. Glycoside_hydrolase_SF. IPR018155. Hyaluronidase. [Graphical view] |
| Gene3D | G3DSA:3.20.20.70. Aldolase_TIM. 1 hit. |
| KO | K01197. |
| PANTHER | PTHR11769. Glyco_hydro_56. 1 hit. |
| Pfam | PF01630. Glyco_hydro_56. 1 hit. [Graphical view] |
| PIRSF | PIRSF038193. Hyaluronidase. 1 hit. |
| PRINTS | PR00846. GLHYDRLASE56. |
| SMART | SM00181. EGF. 1 hit. [Graphical view] |
| SUPFAM | SSF51445. Glyco_hydro_cat. 1 hit. |
| PROSITE | PS00022. EGF_1. 1 hit. PS01186. EGF_2. 1 hit. PS50026. EGF_3. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | HYAL1_PIG | ||||||||
| Accession | Primary (citable) accession number: Q6RHW4 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
Relevant documents
| Glycosyl hydrolases Classification of glycosyl hydrolase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with