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Q6RHW4

- HYAL1_PIG

UniProt

Q6RHW4 - HYAL1_PIG

Protein

Hyaluronidase-1

Gene

HYAL1

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 63 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth By similarity.By similarity

    Catalytic activityi

    Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei131 – 1311Proton donorBy similarity

    GO - Molecular functioni

    1. hyaluronan synthase activity Source: UniProtKB
    2. hyalurononglucosaminidase activity Source: UniProtKB
    3. transcription factor binding Source: UniProtKB

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. cartilage development Source: UniProtKB
    3. cellular response to interleukin-1 Source: UniProtKB
    4. cellular response to pH Source: UniProtKB
    5. cellular response to platelet-derived growth factor stimulus Source: UniProtKB
    6. cellular response to UV-B Source: UniProtKB
    7. hyaluronan biosynthetic process Source: UniProtKB
    8. hyaluronan catabolic process Source: UniProtKB
    9. hyaluronan metabolic process Source: UniProtKB
    10. inflammatory response Source: UniProtKB
    11. negative regulation of cell growth Source: UniProtKB
    12. positive regulation of angiogenesis Source: UniProtKB
    13. positive regulation of cell adhesion Source: UniProtKB
    14. positive regulation of cell growth Source: UniProtKB
    15. positive regulation of epithelial cell migration Source: UniProtKB
    16. positive regulation of epithelial cell proliferation Source: UniProtKB
    17. positive regulation of growth Source: UniProtKB
    18. positive regulation of hyaluranon cable assembly Source: UniProtKB
    19. response to antibiotic Source: UniProtKB
    20. response to reactive oxygen species Source: UniProtKB
    21. response to virus Source: UniProtKB

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Enzyme and pathway databases

    BRENDAi3.2.1.35. 6170.

    Protein family/group databases

    CAZyiGH56. Glycoside Hydrolase Family 56.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hyaluronidase-1 (EC:3.2.1.35)
    Short name:
    Hyal-1
    Alternative name(s):
    Hyaluronoglucosaminidase-1
    Gene namesi
    Name:HYAL1
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Unplaced

    Subcellular locationi

    Secreted By similarity. Lysosome By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytoplasmic vesicle Source: UniProtKB
    3. extracellular space Source: UniProtKB
    4. hyaluranon cable Source: UniProtKB
    5. lysosome Source: UniProtKB

    Keywords - Cellular componenti

    Lysosome, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 435414Hyaluronidase-1PRO_0000042625Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi43 ↔ 333By similarity
    Glycosylationi70 – 701N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi107 – 1071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi207 ↔ 221By similarity
    Glycosylationi216 – 2161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi256 – 2561N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi350 – 3501N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi358 ↔ 369By similarity
    Disulfide bondi363 ↔ 418By similarity
    Disulfide bondi420 ↔ 429By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Expressioni

    Tissue specificityi

    Highly expressed in spleen, kidney, and lung.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ6RHW4.
    SMRiQ6RHW4. Positions 23-432.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini418 – 42912EGF-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 56 family.Curated
    Contains 1 EGF-like domain.Curated

    Keywords - Domaini

    EGF-like domain, Signal

    Phylogenomic databases

    eggNOGiNOG77606.
    HOGENOMiHOG000015133.
    HOVERGENiHBG052053.
    KOiK01197.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR000742. EG-like_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR018155. Hyaluronidase.
    [Graphical view]
    PANTHERiPTHR11769. PTHR11769. 1 hit.
    PfamiPF01630. Glyco_hydro_56. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038193. Hyaluronidase. 1 hit.
    PRINTSiPR00846. GLHYDRLASE56.
    SMARTiSM00181. EGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.
    PROSITEiPS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6RHW4-1 [UniParc]FASTAAdd to Basket

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    MAAHLLPICT LFLNLLSVAQ GSRDPVVLNR PFTTIWNANT QWCLKRHGVD    50
    VDVSVFEVVV NPGQTFRGPN MTIFYSSQLG TYPYYTSAGE PVFGGLPQNA 100
    SLDVHLNRTF KDILAAMPES NFSGLAVIDW EAWRPRWAFN WDAKDIYRQR 150
    SRALVQKQHP DWPAPWVEAA AQDQFQEAAQ TWMAGTLKLG QTLRPHGLWG 200
    FYGFPDCYNY DFQSSNYTGQ CPPGVSAQND QLGWLWGQSR ALYPSIYLPS 250
    ALEGTNKTQL YVQHRVNEAF RVAAAAGDPN LPVLPYAQIF HDMTNRLLSR 300
    EELEHSLGES AAQGAAGVVL WVSWENTRTK ESCQSIKEYV DTTLGPFILN 350
    VTSGALLCSQ AVCSGHGRCV RRPSHTEALP ILNPSSFSIK PTPGGGPLTL 400
    QGALSLKDRV QMAEEFQCRC YPGWRGTWCE QQGTR 435
    Length:435
    Mass (Da):48,507
    Last modified:July 5, 2004 - v1
    Checksum:i5C5B7FB408B70B28
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY497543 mRNA. Translation: AAR91599.1.
    RefSeqiNP_999606.1. NM_214441.1.
    UniGeneiSsc.26119.

    Genome annotation databases

    GeneIDi404698.
    KEGGissc:404698.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY497543 mRNA. Translation: AAR91599.1 .
    RefSeqi NP_999606.1. NM_214441.1.
    UniGenei Ssc.26119.

    3D structure databases

    ProteinModelPortali Q6RHW4.
    SMRi Q6RHW4. Positions 23-432.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    CAZyi GH56. Glycoside Hydrolase Family 56.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 404698.
    KEGGi ssc:404698.

    Organism-specific databases

    CTDi 3373.

    Phylogenomic databases

    eggNOGi NOG77606.
    HOGENOMi HOG000015133.
    HOVERGENi HBG052053.
    KOi K01197.

    Enzyme and pathway databases

    BRENDAi 3.2.1.35. 6170.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR000742. EG-like_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR018155. Hyaluronidase.
    [Graphical view ]
    PANTHERi PTHR11769. PTHR11769. 1 hit.
    Pfami PF01630. Glyco_hydro_56. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038193. Hyaluronidase. 1 hit.
    PRINTSi PR00846. GLHYDRLASE56.
    SMARTi SM00181. EGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    PROSITEi PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of porcine hyaluronidase genes 1, 2, and 3 clustered on SSC13q21."
      Gatphayak K., Knorr C., Beck J., Brenig B.
      Cytogenet. Genome Res. 106:98-106(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiHYAL1_PIG
    AccessioniPrimary (citable) accession number: Q6RHW4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 63 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3