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Q6RHW4

- HYAL1_PIG

UniProt

Q6RHW4 - HYAL1_PIG

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Protein

Hyaluronidase-1

Gene

HYAL1

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth (By similarity).By similarity

Catalytic activityi

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei131 – 1311Proton donorBy similarity

GO - Molecular functioni

  1. hyaluronan synthase activity Source: UniProtKB
  2. hyalurononglucosaminidase activity Source: UniProtKB
  3. transcription factor binding Source: UniProtKB

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. cartilage development Source: UniProtKB
  3. cellular response to interleukin-1 Source: UniProtKB
  4. cellular response to pH Source: UniProtKB
  5. cellular response to platelet-derived growth factor stimulus Source: UniProtKB
  6. cellular response to UV-B Source: UniProtKB
  7. hyaluronan biosynthetic process Source: UniProtKB
  8. hyaluronan catabolic process Source: UniProtKB
  9. hyaluronan metabolic process Source: UniProtKB
  10. inflammatory response Source: UniProtKB
  11. negative regulation of cell growth Source: UniProtKB
  12. positive regulation of angiogenesis Source: UniProtKB
  13. positive regulation of cell adhesion Source: UniProtKB
  14. positive regulation of cell growth Source: UniProtKB
  15. positive regulation of epithelial cell migration Source: UniProtKB
  16. positive regulation of epithelial cell proliferation Source: UniProtKB
  17. positive regulation of growth Source: UniProtKB
  18. positive regulation of hyaluranon cable assembly Source: UniProtKB
  19. response to antibiotic Source: UniProtKB
  20. response to reactive oxygen species Source: UniProtKB
  21. response to virus Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.35. 6170.

Protein family/group databases

CAZyiGH56. Glycoside Hydrolase Family 56.

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronidase-1 (EC:3.2.1.35)
Short name:
Hyal-1
Alternative name(s):
Hyaluronoglucosaminidase-1
Gene namesi
Name:HYAL1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

Secreted By similarity. Lysosome By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytoplasmic vesicle Source: UniProtKB
  3. extracellular space Source: UniProtKB
  4. hyaluranon cable Source: UniProtKB
  5. lysosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 435414Hyaluronidase-1PRO_0000042625Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi43 ↔ 333By similarity
Glycosylationi70 – 701N-linked (GlcNAc...)Sequence Analysis
Glycosylationi99 – 991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi107 – 1071N-linked (GlcNAc...)Sequence Analysis
Glycosylationi121 – 1211N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi207 ↔ 221By similarity
Glycosylationi216 – 2161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi256 – 2561N-linked (GlcNAc...)Sequence Analysis
Glycosylationi350 – 3501N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi358 ↔ 369By similarity
Disulfide bondi363 ↔ 418By similarity
Disulfide bondi420 ↔ 429By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Highly expressed in spleen, kidney, and lung.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ6RHW4.
SMRiQ6RHW4. Positions 23-432.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini418 – 42912EGF-likeAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 56 family.Curated
Contains 1 EGF-like domain.Curated

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

eggNOGiNOG77606.
HOGENOMiHOG000015133.
HOVERGENiHBG052053.
InParanoidiQ6RHW4.
KOiK01197.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000742. EG-like_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
[Graphical view]
PANTHERiPTHR11769. PTHR11769. 1 hit.
PfamiPF01630. Glyco_hydro_56. 1 hit.
[Graphical view]
PIRSFiPIRSF038193. Hyaluronidase. 1 hit.
PRINTSiPR00846. GLHYDRLASE56.
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6RHW4-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MAAHLLPICT LFLNLLSVAQ GSRDPVVLNR PFTTIWNANT QWCLKRHGVD
60 70 80 90 100
VDVSVFEVVV NPGQTFRGPN MTIFYSSQLG TYPYYTSAGE PVFGGLPQNA
110 120 130 140 150
SLDVHLNRTF KDILAAMPES NFSGLAVIDW EAWRPRWAFN WDAKDIYRQR
160 170 180 190 200
SRALVQKQHP DWPAPWVEAA AQDQFQEAAQ TWMAGTLKLG QTLRPHGLWG
210 220 230 240 250
FYGFPDCYNY DFQSSNYTGQ CPPGVSAQND QLGWLWGQSR ALYPSIYLPS
260 270 280 290 300
ALEGTNKTQL YVQHRVNEAF RVAAAAGDPN LPVLPYAQIF HDMTNRLLSR
310 320 330 340 350
EELEHSLGES AAQGAAGVVL WVSWENTRTK ESCQSIKEYV DTTLGPFILN
360 370 380 390 400
VTSGALLCSQ AVCSGHGRCV RRPSHTEALP ILNPSSFSIK PTPGGGPLTL
410 420 430
QGALSLKDRV QMAEEFQCRC YPGWRGTWCE QQGTR
Length:435
Mass (Da):48,507
Last modified:July 5, 2004 - v1
Checksum:i5C5B7FB408B70B28
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY497543 mRNA. Translation: AAR91599.1.
RefSeqiNP_999606.1. NM_214441.1.
UniGeneiSsc.26119.

Genome annotation databases

GeneIDi404698.
KEGGissc:404698.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY497543 mRNA. Translation: AAR91599.1 .
RefSeqi NP_999606.1. NM_214441.1.
UniGenei Ssc.26119.

3D structure databases

ProteinModelPortali Q6RHW4.
SMRi Q6RHW4. Positions 23-432.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH56. Glycoside Hydrolase Family 56.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 404698.
KEGGi ssc:404698.

Organism-specific databases

CTDi 3373.

Phylogenomic databases

eggNOGi NOG77606.
HOGENOMi HOG000015133.
HOVERGENi HBG052053.
InParanoidi Q6RHW4.
KOi K01197.

Enzyme and pathway databases

BRENDAi 3.2.1.35. 6170.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR000742. EG-like_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
[Graphical view ]
PANTHERi PTHR11769. PTHR11769. 1 hit.
Pfami PF01630. Glyco_hydro_56. 1 hit.
[Graphical view ]
PIRSFi PIRSF038193. Hyaluronidase. 1 hit.
PRINTSi PR00846. GLHYDRLASE56.
SMARTi SM00181. EGF. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular characterization of porcine hyaluronidase genes 1, 2, and 3 clustered on SSC13q21."
    Gatphayak K., Knorr C., Beck J., Brenig B.
    Cytogenet. Genome Res. 106:98-106(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.

Entry informationi

Entry nameiHYAL1_PIG
AccessioniPrimary (citable) accession number: Q6RHW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3