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Protein

Hyaluronidase-3

Gene

HYAL3

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei129Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.35. 6170.

Protein family/group databases

CAZyiGH56. Glycoside Hydrolase Family 56.

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronidase-3 (EC:3.2.1.35)
Short name:
Hyal-3
Alternative name(s):
Hyaluronoglucosaminidase-3
Gene namesi
Name:HYAL3
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Lysosome, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000024820217 – 419Hyaluronidase-3Add BLAST403

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi42 ↔ 331By similarity
Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi205 ↔ 220By similarity
Glycosylationi215N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi356 ↔ 367By similarity
Disulfide bondi361 ↔ 395By similarity
Disulfide bondi397 ↔ 406By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6RHW2.
PRIDEiQ6RHW2.

Expressioni

Tissue specificityi

Highly expressed in bladder, spleen and liver. Expressed at low levels in the kidney.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000012156.

Structurei

3D structure databases

ProteinModelPortaliQ6RHW2.
SMRiQ6RHW2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini352 – 407EGF-likeAdd BLAST56

Sequence similaritiesi

Belongs to the glycosyl hydrolase 56 family.Curated

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

eggNOGiENOG410IH0U. Eukaryota.
ENOG410XPZT. LUCA.
HOGENOMiHOG000015133.
HOVERGENiHBG052053.
InParanoidiQ6RHW2.
KOiK01197.

Family and domain databases

Gene3Di3.20.20.70. 2 hits.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
IPR027260. Hyaluronidase-3.
PANTHERiPTHR11769. PTHR11769. 1 hit.
PTHR11769:SF34. PTHR11769:SF34. 1 hit.
PfamiView protein in Pfam
PF01630. Glyco_hydro_56. 1 hit.
PIRSFiPIRSF038193. Hyaluronidase. 1 hit.
PIRSF500776. Hyaluronidase_3. 1 hit.
PRINTSiPR00846. GLHYDRLASE56.
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiView protein in PROSITE
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6RHW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTMQLGLALV LGVAMCLGCG QPLLRAPERP FCVLWNVPSA RCKARFGVHL
60 70 80 90 100
PLEALGITAN HGQRFHGQNI TIFYKSQLGL YPYFGPRGTA HNGGIPQAVS
110 120 130 140 150
LDHHLARAAY QIHRSLRPGF TGLAVLDWEE WCPLWAGNWG RRQAYQAASC
160 170 180 190 200
AWAQRVYPNL DPQEQLCKAR AGFEEAARAL MEDTLRLGRM LRPHGLWGFY
210 220 230 240 250
HYPACGNGWH GTASNYTGHC HAAALARNTQ LYWLWAASSA LFPSIYLPPG
260 270 280 290 300
LPPAYHQAFV RYRLEEAFRV ALVGHPHPLP VLAYARLTHR NSGRFLSQDE
310 320 330 340 350
LVQTIGVSAA LGASGVVLWG DLSFSSSEEE CWHLRGYLVG TLGPYVINVT
360 370 380 390 400
RAAMACSHQR CHGHGRCAWQ DPGQLKVFLH LHPGGSPGAW ESFSCRCYWG
410
WAGPTCQEPR PELGPEEAT
Length:419
Mass (Da):46,393
Last modified:July 5, 2004 - v1
Checksum:i8035CDE3D04324AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY497545 mRNA. Translation: AAR91601.1.
AY472019 Genomic DNA. Translation: AAR33037.1.
RefSeqiNP_999604.1. NM_214439.1.
UniGeneiSsc.19656.
Ssc.94538.

Genome annotation databases

GeneIDi404696.
KEGGissc:404696.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiHYAL3_PIG
AccessioniPrimary (citable) accession number: Q6RHW2
Secondary accession number(s): Q6S3P5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: July 5, 2004
Last modified: May 10, 2017
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families