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Q6RHW2 (HYAL3_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Hyaluronidase-3

Short name=Hyal-3
EC=3.2.1.35
Alternative name(s):
Hyaluronoglucosaminidase-3
Gene names
Name:HYAL3
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length419 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

Subcellular location

Secreted By similarity. Lysosome By similarity.

Tissue specificity

Highly expressed in bladder, spleen and liver. Expressed at low levels in the kidney. Ref.1

Sequence similarities

Belongs to the glycosyl hydrolase 56 family.

Contains 1 EGF-like domain.

Ontologies

Keywords
   Cellular componentLysosome
Secreted
   DomainEGF-like domain
Signal
   Molecular functionGlycosidase
Hydrolase
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcarbohydrate metabolic process

Inferred from electronic annotation. Source: InterPro

hyaluronan catabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

lysosome

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionhyalurononglucosaminidase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1616 Potential
Chain17 – 419403Hyaluronidase-3
PRO_0000248202

Regions

Domain352 – 40756EGF-like

Sites

Active site1291Proton donor By similarity

Amino acid modifications

Glycosylation691N-linked (GlcNAc...) Potential
Glycosylation2151N-linked (GlcNAc...) Potential
Disulfide bond42 ↔ 331 By similarity
Disulfide bond205 ↔ 220 By similarity
Disulfide bond356 ↔ 367 By similarity
Disulfide bond361 ↔ 395 By similarity
Disulfide bond397 ↔ 406 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6RHW2 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 8035CDE3D04324AC

FASTA41946,393
        10         20         30         40         50         60 
MTMQLGLALV LGVAMCLGCG QPLLRAPERP FCVLWNVPSA RCKARFGVHL PLEALGITAN 

        70         80         90        100        110        120 
HGQRFHGQNI TIFYKSQLGL YPYFGPRGTA HNGGIPQAVS LDHHLARAAY QIHRSLRPGF 

       130        140        150        160        170        180 
TGLAVLDWEE WCPLWAGNWG RRQAYQAASC AWAQRVYPNL DPQEQLCKAR AGFEEAARAL 

       190        200        210        220        230        240 
MEDTLRLGRM LRPHGLWGFY HYPACGNGWH GTASNYTGHC HAAALARNTQ LYWLWAASSA 

       250        260        270        280        290        300 
LFPSIYLPPG LPPAYHQAFV RYRLEEAFRV ALVGHPHPLP VLAYARLTHR NSGRFLSQDE 

       310        320        330        340        350        360 
LVQTIGVSAA LGASGVVLWG DLSFSSSEEE CWHLRGYLVG TLGPYVINVT RAAMACSHQR 

       370        380        390        400        410 
CHGHGRCAWQ DPGQLKVFLH LHPGGSPGAW ESFSCRCYWG WAGPTCQEPR PELGPEEAT 

« Hide

References

[1]"Molecular characterization of porcine hyaluronidase genes 1, 2, and 3 clustered on SSC13q21."
Gatphayak K., Knorr C., Beck J., Brenig B.
Cytogenet. Genome Res. 106:98-106(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"Assignment of the porcine hyaluronidase-3 (HYAL3) gene to SSC13-->q21 by FISH and confirmation by hybrid panel analyses."
Gatphayak K., Knorr C., Habermann F., Fries R., Brenig B.
Cytogenet. Genome Res. 101:178-178(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 127-247.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY497545 mRNA. Translation: AAR91601.1.
AY472019 Genomic DNA. Translation: AAR33037.1.
RefSeqNP_999604.1. NM_214439.1.
UniGeneSsc.19656.

3D structure databases

ProteinModelPortalQ6RHW2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9823.ENSSSCP00000012156.

Protein family/group databases

CAZyGH56. Glycoside Hydrolase Family 56.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID404696.
KEGGssc:404696.

Organism-specific databases

CTD8372.

Phylogenomic databases

eggNOGNOG69101.
HOGENOMHOG000015133.
HOVERGENHBG052053.
KOK01197.

Enzyme and pathway databases

BRENDA3.2.1.35. 6170.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR000742. EG-like_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
IPR027260. Hyaluronidase-3.
[Graphical view]
PANTHERPTHR11769. PTHR11769. 1 hit.
PfamPF01630. Glyco_hydro_56. 1 hit.
[Graphical view]
PIRSFPIRSF038193. Hyaluronidase. 1 hit.
PIRSF500776. Hyaluronidase_3. 1 hit.
PRINTSPR00846. GLHYDRLASE56.
SMARTSM00181. EGF. 1 hit.
[Graphical view]
SUPFAMSSF51445. SSF51445. 1 hit.
PROSITEPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameHYAL3_PIG
AccessionPrimary (citable) accession number: Q6RHW2
Secondary accession number(s): Q6S3P5
Entry history
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries