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Q6RHW2

- HYAL3_PIG

UniProt

Q6RHW2 - HYAL3_PIG

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Protein
Hyaluronidase-3
Gene
HYAL3
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei129 – 1291Proton donor By similarity

GO - Molecular functioni

  1. hyalurononglucosaminidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. hyaluronan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.35. 6170.

Protein family/group databases

CAZyiGH56. Glycoside Hydrolase Family 56.

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronidase-3 (EC:3.2.1.35)
Short name:
Hyal-3
Alternative name(s):
Hyaluronoglucosaminidase-3
Gene namesi
Name:HYAL3
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

Secreted By similarity. Lysosome By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
  2. lysosome Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616 Reviewed prediction
Add
BLAST
Chaini17 – 419403Hyaluronidase-3
PRO_0000248202Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi42 ↔ 331 By similarity
Glycosylationi69 – 691N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi205 ↔ 220 By similarity
Glycosylationi215 – 2151N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi356 ↔ 367 By similarity
Disulfide bondi361 ↔ 395 By similarity
Disulfide bondi397 ↔ 406 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Highly expressed in bladder, spleen and liver. Expressed at low levels in the kidney.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000012156.

Structurei

3D structure databases

ProteinModelPortaliQ6RHW2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini352 – 40756EGF-like
Add
BLAST

Sequence similaritiesi

Contains 1 EGF-like domain.

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

eggNOGiNOG69101.
HOGENOMiHOG000015133.
HOVERGENiHBG052053.
KOiK01197.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000742. EG-like_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
IPR027260. Hyaluronidase-3.
[Graphical view]
PANTHERiPTHR11769. PTHR11769. 1 hit.
PfamiPF01630. Glyco_hydro_56. 1 hit.
[Graphical view]
PIRSFiPIRSF038193. Hyaluronidase. 1 hit.
PIRSF500776. Hyaluronidase_3. 1 hit.
PRINTSiPR00846. GLHYDRLASE56.
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6RHW2-1 [UniParc]FASTAAdd to Basket

« Hide

MTMQLGLALV LGVAMCLGCG QPLLRAPERP FCVLWNVPSA RCKARFGVHL    50
PLEALGITAN HGQRFHGQNI TIFYKSQLGL YPYFGPRGTA HNGGIPQAVS 100
LDHHLARAAY QIHRSLRPGF TGLAVLDWEE WCPLWAGNWG RRQAYQAASC 150
AWAQRVYPNL DPQEQLCKAR AGFEEAARAL MEDTLRLGRM LRPHGLWGFY 200
HYPACGNGWH GTASNYTGHC HAAALARNTQ LYWLWAASSA LFPSIYLPPG 250
LPPAYHQAFV RYRLEEAFRV ALVGHPHPLP VLAYARLTHR NSGRFLSQDE 300
LVQTIGVSAA LGASGVVLWG DLSFSSSEEE CWHLRGYLVG TLGPYVINVT 350
RAAMACSHQR CHGHGRCAWQ DPGQLKVFLH LHPGGSPGAW ESFSCRCYWG 400
WAGPTCQEPR PELGPEEAT 419
Length:419
Mass (Da):46,393
Last modified:July 5, 2004 - v1
Checksum:i8035CDE3D04324AC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY497545 mRNA. Translation: AAR91601.1.
AY472019 Genomic DNA. Translation: AAR33037.1.
RefSeqiNP_999604.1. NM_214439.1.
UniGeneiSsc.19656.

Genome annotation databases

GeneIDi404696.
KEGGissc:404696.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY497545 mRNA. Translation: AAR91601.1 .
AY472019 Genomic DNA. Translation: AAR33037.1 .
RefSeqi NP_999604.1. NM_214439.1.
UniGenei Ssc.19656.

3D structure databases

ProteinModelPortali Q6RHW2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9823.ENSSSCP00000012156.

Protein family/group databases

CAZyi GH56. Glycoside Hydrolase Family 56.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 404696.
KEGGi ssc:404696.

Organism-specific databases

CTDi 8372.

Phylogenomic databases

eggNOGi NOG69101.
HOGENOMi HOG000015133.
HOVERGENi HBG052053.
KOi K01197.

Enzyme and pathway databases

BRENDAi 3.2.1.35. 6170.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR000742. EG-like_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
IPR027260. Hyaluronidase-3.
[Graphical view ]
PANTHERi PTHR11769. PTHR11769. 1 hit.
Pfami PF01630. Glyco_hydro_56. 1 hit.
[Graphical view ]
PIRSFi PIRSF038193. Hyaluronidase. 1 hit.
PIRSF500776. Hyaluronidase_3. 1 hit.
PRINTSi PR00846. GLHYDRLASE56.
SMARTi SM00181. EGF. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular characterization of porcine hyaluronidase genes 1, 2, and 3 clustered on SSC13q21."
    Gatphayak K., Knorr C., Beck J., Brenig B.
    Cytogenet. Genome Res. 106:98-106(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Assignment of the porcine hyaluronidase-3 (HYAL3) gene to SSC13-->q21 by FISH and confirmation by hybrid panel analyses."
    Gatphayak K., Knorr C., Habermann F., Fries R., Brenig B.
    Cytogenet. Genome Res. 101:178-178(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 127-247.

Entry informationi

Entry nameiHYAL3_PIG
AccessioniPrimary (citable) accession number: Q6RHW2
Secondary accession number(s): Q6S3P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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