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Q6RHW2

- HYAL3_PIG

UniProt

Q6RHW2 - HYAL3_PIG

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Protein

Hyaluronidase-3

Gene

HYAL3

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei129 – 1291Proton donorBy similarity

GO - Molecular functioni

  1. hyalurononglucosaminidase activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
  2. hyaluronan catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

BRENDAi3.2.1.35. 6170.

Protein family/group databases

CAZyiGH56. Glycoside Hydrolase Family 56.

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronidase-3 (EC:3.2.1.35)
Short name:
Hyal-3
Alternative name(s):
Hyaluronoglucosaminidase-3
Gene namesi
Name:HYAL3
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

Secreted By similarity. Lysosome By similarity

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
  2. lysosome Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Lysosome, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence AnalysisAdd
BLAST
Chaini17 – 419403Hyaluronidase-3PRO_0000248202Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi42 ↔ 331By similarity
Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi205 ↔ 220By similarity
Glycosylationi215 – 2151N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi356 ↔ 367By similarity
Disulfide bondi361 ↔ 395By similarity
Disulfide bondi397 ↔ 406By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Highly expressed in bladder, spleen and liver. Expressed at low levels in the kidney.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000012156.

Structurei

3D structure databases

ProteinModelPortaliQ6RHW2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini352 – 40756EGF-likeAdd
BLAST

Sequence similaritiesi

Belongs to the glycosyl hydrolase 56 family.Curated
Contains 1 EGF-like domain.Curated

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

eggNOGiNOG69101.
HOGENOMiHOG000015133.
HOVERGENiHBG052053.
InParanoidiQ6RHW2.
KOiK01197.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000742. EG-like_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
IPR027260. Hyaluronidase-3.
[Graphical view]
PANTHERiPTHR11769. PTHR11769. 1 hit.
PfamiPF01630. Glyco_hydro_56. 1 hit.
[Graphical view]
PIRSFiPIRSF038193. Hyaluronidase. 1 hit.
PIRSF500776. Hyaluronidase_3. 1 hit.
PRINTSiPR00846. GLHYDRLASE56.
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
SUPFAMiSSF51445. SSF51445. 1 hit.
PROSITEiPS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6RHW2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTMQLGLALV LGVAMCLGCG QPLLRAPERP FCVLWNVPSA RCKARFGVHL
60 70 80 90 100
PLEALGITAN HGQRFHGQNI TIFYKSQLGL YPYFGPRGTA HNGGIPQAVS
110 120 130 140 150
LDHHLARAAY QIHRSLRPGF TGLAVLDWEE WCPLWAGNWG RRQAYQAASC
160 170 180 190 200
AWAQRVYPNL DPQEQLCKAR AGFEEAARAL MEDTLRLGRM LRPHGLWGFY
210 220 230 240 250
HYPACGNGWH GTASNYTGHC HAAALARNTQ LYWLWAASSA LFPSIYLPPG
260 270 280 290 300
LPPAYHQAFV RYRLEEAFRV ALVGHPHPLP VLAYARLTHR NSGRFLSQDE
310 320 330 340 350
LVQTIGVSAA LGASGVVLWG DLSFSSSEEE CWHLRGYLVG TLGPYVINVT
360 370 380 390 400
RAAMACSHQR CHGHGRCAWQ DPGQLKVFLH LHPGGSPGAW ESFSCRCYWG
410
WAGPTCQEPR PELGPEEAT
Length:419
Mass (Da):46,393
Last modified:July 5, 2004 - v1
Checksum:i8035CDE3D04324AC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY497545 mRNA. Translation: AAR91601.1.
AY472019 Genomic DNA. Translation: AAR33037.1.
RefSeqiNP_999604.1. NM_214439.1.
UniGeneiSsc.19656.

Genome annotation databases

GeneIDi404696.
KEGGissc:404696.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY497545 mRNA. Translation: AAR91601.1 .
AY472019 Genomic DNA. Translation: AAR33037.1 .
RefSeqi NP_999604.1. NM_214439.1.
UniGenei Ssc.19656.

3D structure databases

ProteinModelPortali Q6RHW2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9823.ENSSSCP00000012156.

Protein family/group databases

CAZyi GH56. Glycoside Hydrolase Family 56.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 404696.
KEGGi ssc:404696.

Organism-specific databases

CTDi 8372.

Phylogenomic databases

eggNOGi NOG69101.
HOGENOMi HOG000015133.
HOVERGENi HBG052053.
InParanoidi Q6RHW2.
KOi K01197.

Enzyme and pathway databases

BRENDAi 3.2.1.35. 6170.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR000742. EG-like_dom.
IPR017853. Glycoside_hydrolase_SF.
IPR018155. Hyaluronidase.
IPR027260. Hyaluronidase-3.
[Graphical view ]
PANTHERi PTHR11769. PTHR11769. 1 hit.
Pfami PF01630. Glyco_hydro_56. 1 hit.
[Graphical view ]
PIRSFi PIRSF038193. Hyaluronidase. 1 hit.
PIRSF500776. Hyaluronidase_3. 1 hit.
PRINTSi PR00846. GLHYDRLASE56.
SMARTi SM00181. EGF. 1 hit.
[Graphical view ]
SUPFAMi SSF51445. SSF51445. 1 hit.
PROSITEi PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular characterization of porcine hyaluronidase genes 1, 2, and 3 clustered on SSC13q21."
    Gatphayak K., Knorr C., Beck J., Brenig B.
    Cytogenet. Genome Res. 106:98-106(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Assignment of the porcine hyaluronidase-3 (HYAL3) gene to SSC13-->q21 by FISH and confirmation by hybrid panel analyses."
    Gatphayak K., Knorr C., Habermann F., Fries R., Brenig B.
    Cytogenet. Genome Res. 101:178-178(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 127-247.

Entry informationi

Entry nameiHYAL3_PIG
AccessioniPrimary (citable) accession number: Q6RHW2
Secondary accession number(s): Q6S3P5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3