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Q6RHW2

- HYAL3_PIG

UniProt

Q6RHW2 - HYAL3_PIG

Protein

Hyaluronidase-3

Gene

HYAL3

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei129 – 1291Proton donorBy similarity

    GO - Molecular functioni

    1. hyalurononglucosaminidase activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. hyaluronan catabolic process Source: InterPro

    Keywords - Molecular functioni

    Glycosidase, Hydrolase

    Enzyme and pathway databases

    BRENDAi3.2.1.35. 6170.

    Protein family/group databases

    CAZyiGH56. Glycoside Hydrolase Family 56.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hyaluronidase-3 (EC:3.2.1.35)
    Short name:
    Hyal-3
    Alternative name(s):
    Hyaluronoglucosaminidase-3
    Gene namesi
    Name:HYAL3
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Unplaced

    Subcellular locationi

    Secreted By similarity. Lysosome By similarity

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell
    2. lysosome Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Lysosome, Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1616Sequence AnalysisAdd
    BLAST
    Chaini17 – 419403Hyaluronidase-3PRO_0000248202Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi42 ↔ 331By similarity
    Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi205 ↔ 220By similarity
    Glycosylationi215 – 2151N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi356 ↔ 367By similarity
    Disulfide bondi361 ↔ 395By similarity
    Disulfide bondi397 ↔ 406By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Expressioni

    Tissue specificityi

    Highly expressed in bladder, spleen and liver. Expressed at low levels in the kidney.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi9823.ENSSSCP00000012156.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6RHW2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini352 – 40756EGF-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 56 family.Curated
    Contains 1 EGF-like domain.Curated

    Keywords - Domaini

    EGF-like domain, Signal

    Phylogenomic databases

    eggNOGiNOG69101.
    HOGENOMiHOG000015133.
    HOVERGENiHBG052053.
    KOiK01197.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR000742. EG-like_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR018155. Hyaluronidase.
    IPR027260. Hyaluronidase-3.
    [Graphical view]
    PANTHERiPTHR11769. PTHR11769. 1 hit.
    PfamiPF01630. Glyco_hydro_56. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038193. Hyaluronidase. 1 hit.
    PIRSF500776. Hyaluronidase_3. 1 hit.
    PRINTSiPR00846. GLHYDRLASE56.
    SMARTiSM00181. EGF. 1 hit.
    [Graphical view]
    SUPFAMiSSF51445. SSF51445. 1 hit.
    PROSITEiPS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6RHW2-1 [UniParc]FASTAAdd to Basket

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    MTMQLGLALV LGVAMCLGCG QPLLRAPERP FCVLWNVPSA RCKARFGVHL    50
    PLEALGITAN HGQRFHGQNI TIFYKSQLGL YPYFGPRGTA HNGGIPQAVS 100
    LDHHLARAAY QIHRSLRPGF TGLAVLDWEE WCPLWAGNWG RRQAYQAASC 150
    AWAQRVYPNL DPQEQLCKAR AGFEEAARAL MEDTLRLGRM LRPHGLWGFY 200
    HYPACGNGWH GTASNYTGHC HAAALARNTQ LYWLWAASSA LFPSIYLPPG 250
    LPPAYHQAFV RYRLEEAFRV ALVGHPHPLP VLAYARLTHR NSGRFLSQDE 300
    LVQTIGVSAA LGASGVVLWG DLSFSSSEEE CWHLRGYLVG TLGPYVINVT 350
    RAAMACSHQR CHGHGRCAWQ DPGQLKVFLH LHPGGSPGAW ESFSCRCYWG 400
    WAGPTCQEPR PELGPEEAT 419
    Length:419
    Mass (Da):46,393
    Last modified:July 5, 2004 - v1
    Checksum:i8035CDE3D04324AC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY497545 mRNA. Translation: AAR91601.1.
    AY472019 Genomic DNA. Translation: AAR33037.1.
    RefSeqiNP_999604.1. NM_214439.1.
    UniGeneiSsc.19656.

    Genome annotation databases

    GeneIDi404696.
    KEGGissc:404696.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY497545 mRNA. Translation: AAR91601.1 .
    AY472019 Genomic DNA. Translation: AAR33037.1 .
    RefSeqi NP_999604.1. NM_214439.1.
    UniGenei Ssc.19656.

    3D structure databases

    ProteinModelPortali Q6RHW2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9823.ENSSSCP00000012156.

    Protein family/group databases

    CAZyi GH56. Glycoside Hydrolase Family 56.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 404696.
    KEGGi ssc:404696.

    Organism-specific databases

    CTDi 8372.

    Phylogenomic databases

    eggNOGi NOG69101.
    HOGENOMi HOG000015133.
    HOVERGENi HBG052053.
    KOi K01197.

    Enzyme and pathway databases

    BRENDAi 3.2.1.35. 6170.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR000742. EG-like_dom.
    IPR017853. Glycoside_hydrolase_SF.
    IPR018155. Hyaluronidase.
    IPR027260. Hyaluronidase-3.
    [Graphical view ]
    PANTHERi PTHR11769. PTHR11769. 1 hit.
    Pfami PF01630. Glyco_hydro_56. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038193. Hyaluronidase. 1 hit.
    PIRSF500776. Hyaluronidase_3. 1 hit.
    PRINTSi PR00846. GLHYDRLASE56.
    SMARTi SM00181. EGF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51445. SSF51445. 1 hit.
    PROSITEi PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular characterization of porcine hyaluronidase genes 1, 2, and 3 clustered on SSC13q21."
      Gatphayak K., Knorr C., Beck J., Brenig B.
      Cytogenet. Genome Res. 106:98-106(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "Assignment of the porcine hyaluronidase-3 (HYAL3) gene to SSC13-->q21 by FISH and confirmation by hybrid panel analyses."
      Gatphayak K., Knorr C., Habermann F., Fries R., Brenig B.
      Cytogenet. Genome Res. 101:178-178(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 127-247.

    Entry informationi

    Entry nameiHYAL3_PIG
    AccessioniPrimary (citable) accession number: Q6RHW2
    Secondary accession number(s): Q6S3P5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 66 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3