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Protein

Keratin, type I cytoskeletal 9

Gene

Krt9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly (By similarity). Plays an essential role in the correct development of sperm.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

  • intermediate filament organization Source: UniProtKB
  • skin development Source: UniProtKB
  • spermatogenesis Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 9
Alternative name(s):
Cytokeratin-9
Short name:
CK-9
Keratin-9
Short name:
K9
Gene namesi
Name:Krt9Imported
Synonyms:K9Imported, Krt1-9Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96696. Krt9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003083721 – 743Keratin, type I cytoskeletal 9Add BLAST743

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei14PhosphoserineBy similarity1
Modified residuei16PhosphoserineBy similarity1
Modified residuei55PhosphoserineBy similarity1
Modified residuei155PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6RHW0.
PaxDbiQ6RHW0.
PRIDEiQ6RHW0.

PTM databases

iPTMnetiQ6RHW0.
PhosphoSitePlusiQ6RHW0.

Expressioni

Tissue specificityi

Expressed in footpad epidermis and testis (at protein level).1 Publication

Gene expression databases

CleanExiMM_KRT9.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.Curated

Protein-protein interaction databases

BioGridi223461. 1 interactor.
IntActiQ6RHW0. 1 interactor.
STRINGi10090.ENSMUSP00000055255.

Structurei

3D structure databases

ProteinModelPortaliQ6RHW0.
SMRiQ6RHW0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 130HeadSequence analysisAdd BLAST130
Regioni131 – 439RodSequence analysisAdd BLAST309
Regioni131 – 166Coil 1ASequence analysisAdd BLAST36
Regioni167 – 185Linker 1Sequence analysisAdd BLAST19
Regioni186 – 277Coil 1BSequence analysisAdd BLAST92
Regioni278 – 300Linker 12Sequence analysisAdd BLAST23
Regioni301 – 439Coil 2Sequence analysisAdd BLAST139
Regioni440 – 709TailSequence analysisAdd BLAST270

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 73Ser-richSequence analysisAdd BLAST72
Compositional biasi18 – 125Gly-richSequence analysisAdd BLAST108
Compositional biasi463 – 729Ser-richSequence analysisAdd BLAST267

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IEYG. Eukaryota.
ENOG4111C5Z. LUCA.
GeneTreeiENSGT00760000118808.
HOVERGENiHBG013015.
InParanoidiQ6RHW0.
KOiK07604.
OMAiEMQYETL.
OrthoDBiEOG091G087I.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6RHW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCRQSSSSF WSSSSSCGGG GGRGGSGGSM RSSFSRSSRA GGGGGGRFNS
60 70 80 90 100
SSGFSGGGFS ACGGGGGGSF GSSYGGGYGG GFSTGSYSGM FGGGSGGGFG
110 120 130 140 150
GGSGGGFGGG SGGGFGGGSG GGEGGILNTN EKIVMQNLNS RLASYMEKVL
160 170 180 190 200
ELEESNTAME KQIQDWYSKR GPKVFQKDNT HYYDTIEDLK DRIVDLTVRN
210 220 230 240 250
NKTLVDIDNT RMTMDDFRVK LEMEQSLRQG VEGDINGLKK VLDDLVMAKS
260 270 280 290 300
DLEILLDSLE DEKNALTKNH KEEMSQLTGQ NDGDVNVEIN VAPSTDLTRV
310 320 330 340 350
LNDMREEYEQ LISKNRQDIE QHYESKMTQI EQQMTNSGQE MESNMKQVSQ
360 370 380 390 400
LQHTIQELNV ELQTQLTTKS ALEKALEDTK NRYCGQLQQI QEQISELEAQ
410 420 430 440 450
LAEIRAETEC QSQEYSILLS IKTRLEKEIE TYRELLEGGQ QDFESSGAGQ
460 470 480 490 500
IGFGSGKGRQ RGSGGSYGGG SGGSYGGGSG GSYGGGSGGS YGGGSGGSYG
510 520 530 540 550
GGSGGSHGGK SGGSHGGGSG GSYGGESGGS HGGGSGGSYG GGSGGSHGGK
560 570 580 590 600
SGGGYGGGSS SGGGSGGSYG GGSGGSHGGG SGGSYGGGSG GSHGGKSGGG
610 620 630 640 650
YGGGSSSGGG SGGSYGGGSG GSHGGKSGGS YGGGSGGSYG GGSGGSHGGK
660 670 680 690 700
SGGGYGGGSS SGGGSGGSYG GGSGGSHGGK SGGSYGGGSS SGGGSGGSYG
710 720 730 740
GGSGSGGGSG GSYGGGNRRP SQSQSSSKSA DCDDDSQEHK MRY
Length:743
Mass (Da):72,495
Last modified:November 13, 2013 - v3
Checksum:iC1A44B4FE65A4B5A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti226S → T in AAR89518 (PubMed:16015579).Curated1
Sequence conflicti258S → N in AAR89518 (PubMed:16015579).Curated1
Sequence conflicti267T → P in AAR89518 (PubMed:16015579).Curated1
Sequence conflicti299R → Q in AAR89518 (PubMed:16015579).Curated1
Sequence conflicti332Q → H in AAR89518 (PubMed:16015579).Curated1
Sequence conflicti334M → V in AAR89518 (PubMed:16015579).Curated1
Sequence conflicti605S → T in AAR89518 (PubMed:16015579).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY497550 mRNA. Translation: AAR89518.1.
GL456158 Genomic DNA. No translation available.
CCDSiCCDS25412.1.
RefSeqiNP_957707.2. NM_201255.2.
UniGeneiMm.445335.

Genome annotation databases

EnsembliENSMUST00000059707; ENSMUSP00000055255; ENSMUSG00000051617.
GeneIDi107656.
KEGGimmu:107656.
UCSCiuc007lkn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY497550 mRNA. Translation: AAR89518.1.
GL456158 Genomic DNA. No translation available.
CCDSiCCDS25412.1.
RefSeqiNP_957707.2. NM_201255.2.
UniGeneiMm.445335.

3D structure databases

ProteinModelPortaliQ6RHW0.
SMRiQ6RHW0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi223461. 1 interactor.
IntActiQ6RHW0. 1 interactor.
STRINGi10090.ENSMUSP00000055255.

PTM databases

iPTMnetiQ6RHW0.
PhosphoSitePlusiQ6RHW0.

Proteomic databases

EPDiQ6RHW0.
PaxDbiQ6RHW0.
PRIDEiQ6RHW0.

Protocols and materials databases

DNASUi107656.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059707; ENSMUSP00000055255; ENSMUSG00000051617.
GeneIDi107656.
KEGGimmu:107656.
UCSCiuc007lkn.1. mouse.

Organism-specific databases

CTDi3857.
MGIiMGI:96696. Krt9.

Phylogenomic databases

eggNOGiENOG410IEYG. Eukaryota.
ENOG4111C5Z. LUCA.
GeneTreeiENSGT00760000118808.
HOVERGENiHBG013015.
InParanoidiQ6RHW0.
KOiK07604.
OMAiEMQYETL.
OrthoDBiEOG091G087I.
TreeFamiTF332742.

Enzyme and pathway databases

ReactomeiR-MMU-6805567. Keratinization.
R-MMU-6809371. Formation of the cornified envelope.

Miscellaneous databases

PROiQ6RHW0.
SOURCEiSearch...

Gene expression databases

CleanExiMM_KRT9.

Family and domain databases

InterProiIPR001664. IF.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK1C9_MOUSE
AccessioniPrimary (citable) accession number: Q6RHW0
Secondary accession number(s): A2A4G3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: November 13, 2013
Last modified: November 30, 2016
This is version 96 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.