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Q6RHW0 (K1C9_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Keratin, type I cytoskeletal 9
Alternative name(s):
Cytokeratin-9
Short name=CK-9
Keratin-9
Short name=K9
Gene names
Name:Krt9
Synonyms:K9, Krt1-9
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length743 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly By similarity. Plays an essential role in the correct development of sperm. Ref.1 UniProtKB P35527

Subunit structure

Heterotetramer of two type I and two type II keratins.

Tissue specificity

Expressed in footpad epidermis and testis (at protein level). Ref.1

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

Sequence similarities

Belongs to the intermediate filament family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 743743Keratin, type I cytoskeletal 9
PRO_0000308372

Regions

Region1 – 130130Head
Region131 – 439309Rod
Region131 – 16636Coil 1A
Region167 – 18519Linker 1
Region186 – 27792Coil 1B
Region278 – 30023Linker 12
Region301 – 439139Coil 2
Region440 – 709270Tail
Compositional bias2 – 7372Ser-rich
Compositional bias18 – 125108Gly-rich
Compositional bias463 – 729267Ser-rich

Experimental info

Sequence conflict2261T → S in CAM17775. Ref.2
Sequence conflict2581N → S in CAM17775. Ref.2
Sequence conflict2671P → T in CAM17775. Ref.2
Sequence conflict275 – 2762SQ → NH in AAR89518. Ref.1
Sequence conflict2801Q → L in AAR89518. Ref.1
Sequence conflict2991Q → R in CAM17775. Ref.2
Sequence conflict3321H → Q in CAM17775. Ref.2
Sequence conflict3341M → V in AAR89518. Ref.1
Sequence conflict6051T → S in CAM17775. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q6RHW0 [UniParc].

Last modified October 23, 2007. Version 2.
Checksum: 4C0E7BEEB27AB6A4

FASTA74372,527
        10         20         30         40         50         60 
MSCRQSSSSF WSSSSSCGGG GGRGGSGGSM RSSFSRSSRA GGGGGGRFNS SSGFSGGGFS 

        70         80         90        100        110        120 
ACGGGGGGSF GSSYGGGYGG GFSTGSYSGM FGGGSGGGFG GGSGGGFGGG SGGGFGGGSG 

       130        140        150        160        170        180 
GGEGGILNTN EKIVMQNLNS RLASYMEKVL ELEESNTAME KQIQDWYSKR GPKVFQKDNT 

       190        200        210        220        230        240 
HYYDTIEDLK DRIVDLTVRN NKTLVDIDNT RMTMDDFRVK LEMEQTLRQG VEGDINGLKK 

       250        260        270        280        290        300 
VLDDLVMAKS DLEILLDNLE DEKNALPKNH KEEMSQLTGQ NDGDVNVEIN VAPSTDLTQV 

       310        320        330        340        350        360 
LNDMREEYEQ LISKNRQDIE QHYESKMTQI EHQMTNSGQE MESNMKQVSQ LQHTIQELNV 

       370        380        390        400        410        420 
ELQTQLTTKS ALEKALEDTK NRYCGQLQQI QEQISELEAQ LAEIRAETEC QSQEYSILLS 

       430        440        450        460        470        480 
IKTRLEKEIE TYRELLEGGQ QDFESSGAGQ IGFGSGKGRQ RGSGGSYGGG SGGSYGGGSG 

       490        500        510        520        530        540 
GSYGGGSGGS YGGGSGGSYG GGSGGSHGGK SGGSHGGGSG GSYGGESGGS HGGGSGGSYG 

       550        560        570        580        590        600 
GGSGGSHGGK SGGGYGGGSS SGGGSGGSYG GGSGGSHGGG SGGSYGGGSG GSHGGKSGGG 

       610        620        630        640        650        660 
YGGGTSSGGG SGGSYGGGSG GSHGGKSGGS YGGGSGGSYG GGSGGSHGGK SGGGYGGGSS 

       670        680        690        700        710        720 
SGGGSGGSYG GGSGGSHGGK SGGSYGGGSS SGGGSGGSYG GGSGSGGGSG GSYGGGNRRP 

       730        740 
SQSQSSSKSA DCDDDSQEHK MRY

« Hide

References

« Hide 'large scale' references
[1]"Sperm tail abnormalities in mutant mice with neo(r) gene insertion into an intron of the keratin 9 gene."
Rivkin E., Eddy E.M., Willis W.D., Goulding E.H., Suganuma R., Yanagimachi R., Kierszenbaum A.L.
Mol. Reprod. Dev. 72:259-271(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
Strain: 129/SvJ.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY497550 mRNA. Translation: AAR89518.1.
AL590873 Genomic DNA. Translation: CAM17775.1.
IPIIPI00399610.
RefSeqNP_957707.2. NM_201255.2.
UniGeneMm.445335.

3D structure databases

ProteinModelPortalQ6RHW0.
SMRQ6RHW0. Positions 176-438.
ModBaseSearch...

PTM databases

PhosphoSiteQ6RHW0.

Proteomic databases

PRIDEQ6RHW0.

Protocols and materials databases

DNASU107656.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000059707; ENSMUSP00000055255; ENSMUSG00000051617.
GeneID107656.
KEGGmmu:107656.
UCSCuc007lkn.1. mouse.

Organism-specific databases

CTD3857.
MGIMGI:96696. Krt9.

Phylogenomic databases

eggNOGNOG148410.
GeneTreeENSGT00560000076905.
HOVERGENHBG013015.
InParanoidQ6RHW0.
KOK07604.
OrthoDBEOG4BCDNC.

Gene expression databases

BgeeQ6RHW0.
CleanExMM_KRT9.
GenevestigatorQ6RHW0.

Family and domain databases

InterProIPR016044. F.
IPR001664. IF.
IPR002957. Keratin_I.
[Graphical view]
PANTHERPTHR23239. PTHR23239. 1 hit.
PfamPF00038. Filament. 1 hit.
[Graphical view]
PRINTSPR01248. TYPE1KERATIN.
PROSITEPS00226. IF. False negative.
[Graphical view]
ProtoNetSearch...

Other

NextBio359198.
SOURCESearch...

Entry information

Entry nameK1C9_MOUSE
AccessionPrimary (citable) accession number: Q6RHW0
Secondary accession number(s): A2A4G3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: October 23, 2007
Last modified: May 1, 2013
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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