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Q6RHW0

- K1C9_MOUSE

UniProt

Q6RHW0 - K1C9_MOUSE

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Protein

Keratin, type I cytoskeletal 9

Gene

Krt9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly (By similarity). Plays an essential role in the correct development of sperm.By similarity1 Publication

GO - Molecular functioni

  1. structural molecule activity Source: InterPro

GO - Biological processi

  1. intermediate filament organization Source: UniProtKB
  2. skin development Source: UniProtKB
  3. spermatogenesis Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 9
Alternative name(s):
Cytokeratin-9
Short name:
CK-9
Keratin-9
Short name:
K9
Gene namesi
Name:Krt9Imported
Synonyms:K9Imported, Krt1-9Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:96696. Krt9.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. extracellular vesicular exosome Source: Ensembl
  3. intermediate filament Source: UniProtKB-KW
  4. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 743743Keratin, type I cytoskeletal 9PRO_0000308372Add
BLAST

Proteomic databases

PRIDEiQ6RHW0.

PTM databases

PhosphoSiteiQ6RHW0.

Expressioni

Tissue specificityi

Expressed in footpad epidermis and testis (at protein level).1 Publication

Gene expression databases

BgeeiQ6RHW0.
CleanExiMM_KRT9.
GenevestigatoriQ6RHW0.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.Curated

Protein-protein interaction databases

BioGridi223461. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ6RHW0.
SMRiQ6RHW0. Positions 176-438.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 130130HeadSequence AnalysisAdd
BLAST
Regioni131 – 439309RodSequence AnalysisAdd
BLAST
Regioni131 – 16636Coil 1ASequence AnalysisAdd
BLAST
Regioni167 – 18519Linker 1Sequence AnalysisAdd
BLAST
Regioni186 – 27792Coil 1BSequence AnalysisAdd
BLAST
Regioni278 – 30023Linker 12Sequence AnalysisAdd
BLAST
Regioni301 – 439139Coil 2Sequence AnalysisAdd
BLAST
Regioni440 – 709270TailSequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2 – 7372Ser-richSequence AnalysisAdd
BLAST
Compositional biasi18 – 125108Gly-richSequence AnalysisAdd
BLAST
Compositional biasi463 – 729267Ser-richSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Sequence Analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG148410.
GeneTreeiENSGT00760000119046.
HOVERGENiHBG013015.
InParanoidiQ6RHW0.
KOiK07604.
OMAiEMQYETL.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.

Sequencei

Sequence statusi: Complete.

Q6RHW0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSCRQSSSSF WSSSSSCGGG GGRGGSGGSM RSSFSRSSRA GGGGGGRFNS
60 70 80 90 100
SSGFSGGGFS ACGGGGGGSF GSSYGGGYGG GFSTGSYSGM FGGGSGGGFG
110 120 130 140 150
GGSGGGFGGG SGGGFGGGSG GGEGGILNTN EKIVMQNLNS RLASYMEKVL
160 170 180 190 200
ELEESNTAME KQIQDWYSKR GPKVFQKDNT HYYDTIEDLK DRIVDLTVRN
210 220 230 240 250
NKTLVDIDNT RMTMDDFRVK LEMEQSLRQG VEGDINGLKK VLDDLVMAKS
260 270 280 290 300
DLEILLDSLE DEKNALTKNH KEEMSQLTGQ NDGDVNVEIN VAPSTDLTRV
310 320 330 340 350
LNDMREEYEQ LISKNRQDIE QHYESKMTQI EQQMTNSGQE MESNMKQVSQ
360 370 380 390 400
LQHTIQELNV ELQTQLTTKS ALEKALEDTK NRYCGQLQQI QEQISELEAQ
410 420 430 440 450
LAEIRAETEC QSQEYSILLS IKTRLEKEIE TYRELLEGGQ QDFESSGAGQ
460 470 480 490 500
IGFGSGKGRQ RGSGGSYGGG SGGSYGGGSG GSYGGGSGGS YGGGSGGSYG
510 520 530 540 550
GGSGGSHGGK SGGSHGGGSG GSYGGESGGS HGGGSGGSYG GGSGGSHGGK
560 570 580 590 600
SGGGYGGGSS SGGGSGGSYG GGSGGSHGGG SGGSYGGGSG GSHGGKSGGG
610 620 630 640 650
YGGGSSSGGG SGGSYGGGSG GSHGGKSGGS YGGGSGGSYG GGSGGSHGGK
660 670 680 690 700
SGGGYGGGSS SGGGSGGSYG GGSGGSHGGK SGGSYGGGSS SGGGSGGSYG
710 720 730 740
GGSGSGGGSG GSYGGGNRRP SQSQSSSKSA DCDDDSQEHK MRY
Length:743
Mass (Da):72,495
Last modified:November 13, 2013 - v3
Checksum:iC1A44B4FE65A4B5A
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti226 – 2261S → T in AAR89518. (PubMed:16015579)Curated
Sequence conflicti258 – 2581S → N in AAR89518. (PubMed:16015579)Curated
Sequence conflicti267 – 2671T → P in AAR89518. (PubMed:16015579)Curated
Sequence conflicti299 – 2991R → Q in AAR89518. (PubMed:16015579)Curated
Sequence conflicti332 – 3321Q → H in AAR89518. (PubMed:16015579)Curated
Sequence conflicti334 – 3341M → V in AAR89518. (PubMed:16015579)Curated
Sequence conflicti605 – 6051S → T in AAR89518. (PubMed:16015579)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY497550 mRNA. Translation: AAR89518.1.
GL456158 Genomic DNA. No translation available.
CCDSiCCDS25412.1.
RefSeqiNP_957707.2. NM_201255.2.
UniGeneiMm.445335.

Genome annotation databases

EnsembliENSMUST00000059707; ENSMUSP00000055255; ENSMUSG00000051617.
GeneIDi107656.
KEGGimmu:107656.
UCSCiuc007lkn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY497550 mRNA. Translation: AAR89518.1 .
GL456158 Genomic DNA. No translation available.
CCDSi CCDS25412.1.
RefSeqi NP_957707.2. NM_201255.2.
UniGenei Mm.445335.

3D structure databases

ProteinModelPortali Q6RHW0.
SMRi Q6RHW0. Positions 176-438.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 223461. 1 interaction.

PTM databases

PhosphoSitei Q6RHW0.

Proteomic databases

PRIDEi Q6RHW0.

Protocols and materials databases

DNASUi 107656.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000059707 ; ENSMUSP00000055255 ; ENSMUSG00000051617 .
GeneIDi 107656.
KEGGi mmu:107656.
UCSCi uc007lkn.1. mouse.

Organism-specific databases

CTDi 3857.
MGIi MGI:96696. Krt9.

Phylogenomic databases

eggNOGi NOG148410.
GeneTreei ENSGT00760000119046.
HOVERGENi HBG013015.
InParanoidi Q6RHW0.
KOi K07604.
OMAi EMQYETL.
TreeFami TF332742.

Miscellaneous databases

NextBioi 359198.
PROi Q6RHW0.
SOURCEi Search...

Gene expression databases

Bgeei Q6RHW0.
CleanExi MM_KRT9.
Genevestigatori Q6RHW0.

Family and domain databases

InterProi IPR001664. IF.
IPR002957. Keratin_I.
[Graphical view ]
PANTHERi PTHR23239. PTHR23239. 1 hit.
Pfami PF00038. Filament. 1 hit.
[Graphical view ]
PRINTSi PR01248. TYPE1KERATIN.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sperm tail abnormalities in mutant mice with neo(r) gene insertion into an intron of the keratin 9 gene."
    Rivkin E., Eddy E.M., Willis W.D., Goulding E.H., Suganuma R., Yanagimachi R., Kierszenbaum A.L.
    Mol. Reprod. Dev. 72:259-271(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: 129/SvJImported.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiK1C9_MOUSE
AccessioniPrimary (citable) accession number: Q6RHW0
Secondary accession number(s): A2A4G3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: November 13, 2013
Last modified: October 29, 2014
This is version 82 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3