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Q6RHW0

- K1C9_MOUSE

UniProt

Q6RHW0 - K1C9_MOUSE

Protein

Keratin, type I cytoskeletal 9

Gene

Krt9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 3 (13 Nov 2013)
      Previous versions | rss
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    Functioni

    May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly By similarity. Plays an essential role in the correct development of sperm.By similarity1 Publication

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    GO - Biological processi

    1. intermediate filament organization Source: UniProtKB
    2. skin development Source: UniProtKB
    3. spermatogenesis Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratin, type I cytoskeletal 9
    Alternative name(s):
    Cytokeratin-9
    Short name:
    CK-9
    Keratin-9
    Short name:
    K9
    Gene namesi
    Name:Krt9Imported
    Synonyms:K9Imported, Krt1-9Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:96696. Krt9.

    Subcellular locationi

    GO - Cellular componenti

    1. intermediate filament Source: UniProtKB-KW

    Keywords - Cellular componenti

    Intermediate filament, Keratin

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 743743Keratin, type I cytoskeletal 9PRO_0000308372Add
    BLAST

    Proteomic databases

    PRIDEiQ6RHW0.

    PTM databases

    PhosphoSiteiQ6RHW0.

    Expressioni

    Tissue specificityi

    Expressed in footpad epidermis and testis (at protein level).1 Publication

    Gene expression databases

    BgeeiQ6RHW0.
    CleanExiMM_KRT9.
    GenevestigatoriQ6RHW0.

    Interactioni

    Subunit structurei

    Heterotetramer of two type I and two type II keratins.Curated

    Protein-protein interaction databases

    BioGridi223461. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6RHW0.
    SMRiQ6RHW0. Positions 176-438.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 130130HeadSequence AnalysisAdd
    BLAST
    Regioni131 – 439309RodSequence AnalysisAdd
    BLAST
    Regioni131 – 16636Coil 1ASequence AnalysisAdd
    BLAST
    Regioni167 – 18519Linker 1Sequence AnalysisAdd
    BLAST
    Regioni186 – 27792Coil 1BSequence AnalysisAdd
    BLAST
    Regioni278 – 30023Linker 12Sequence AnalysisAdd
    BLAST
    Regioni301 – 439139Coil 2Sequence AnalysisAdd
    BLAST
    Regioni440 – 709270TailSequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi2 – 7372Ser-richSequence AnalysisAdd
    BLAST
    Compositional biasi18 – 125108Gly-richSequence AnalysisAdd
    BLAST
    Compositional biasi463 – 729267Ser-richSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the intermediate filament family.Sequence Analysis

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG148410.
    GeneTreeiENSGT00610000085921.
    HOVERGENiHBG013015.
    InParanoidiQ6RHW0.
    KOiK07604.
    OMAiEMQYETL.
    TreeFamiTF332742.

    Family and domain databases

    InterProiIPR001664. IF.
    IPR002957. Keratin_I.
    [Graphical view]
    PANTHERiPTHR23239. PTHR23239. 1 hit.
    PfamiPF00038. Filament. 1 hit.
    [Graphical view]
    PRINTSiPR01248. TYPE1KERATIN.

    Sequencei

    Sequence statusi: Complete.

    Q6RHW0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSCRQSSSSF WSSSSSCGGG GGRGGSGGSM RSSFSRSSRA GGGGGGRFNS    50
    SSGFSGGGFS ACGGGGGGSF GSSYGGGYGG GFSTGSYSGM FGGGSGGGFG 100
    GGSGGGFGGG SGGGFGGGSG GGEGGILNTN EKIVMQNLNS RLASYMEKVL 150
    ELEESNTAME KQIQDWYSKR GPKVFQKDNT HYYDTIEDLK DRIVDLTVRN 200
    NKTLVDIDNT RMTMDDFRVK LEMEQSLRQG VEGDINGLKK VLDDLVMAKS 250
    DLEILLDSLE DEKNALTKNH KEEMSQLTGQ NDGDVNVEIN VAPSTDLTRV 300
    LNDMREEYEQ LISKNRQDIE QHYESKMTQI EQQMTNSGQE MESNMKQVSQ 350
    LQHTIQELNV ELQTQLTTKS ALEKALEDTK NRYCGQLQQI QEQISELEAQ 400
    LAEIRAETEC QSQEYSILLS IKTRLEKEIE TYRELLEGGQ QDFESSGAGQ 450
    IGFGSGKGRQ RGSGGSYGGG SGGSYGGGSG GSYGGGSGGS YGGGSGGSYG 500
    GGSGGSHGGK SGGSHGGGSG GSYGGESGGS HGGGSGGSYG GGSGGSHGGK 550
    SGGGYGGGSS SGGGSGGSYG GGSGGSHGGG SGGSYGGGSG GSHGGKSGGG 600
    YGGGSSSGGG SGGSYGGGSG GSHGGKSGGS YGGGSGGSYG GGSGGSHGGK 650
    SGGGYGGGSS SGGGSGGSYG GGSGGSHGGK SGGSYGGGSS SGGGSGGSYG 700
    GGSGSGGGSG GSYGGGNRRP SQSQSSSKSA DCDDDSQEHK MRY 743
    Length:743
    Mass (Da):72,495
    Last modified:November 13, 2013 - v3
    Checksum:iC1A44B4FE65A4B5A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti226 – 2261S → T in AAR89518. (PubMed:16015579)Curated
    Sequence conflicti258 – 2581S → N in AAR89518. (PubMed:16015579)Curated
    Sequence conflicti267 – 2671T → P in AAR89518. (PubMed:16015579)Curated
    Sequence conflicti299 – 2991R → Q in AAR89518. (PubMed:16015579)Curated
    Sequence conflicti332 – 3321Q → H in AAR89518. (PubMed:16015579)Curated
    Sequence conflicti334 – 3341M → V in AAR89518. (PubMed:16015579)Curated
    Sequence conflicti605 – 6051S → T in AAR89518. (PubMed:16015579)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY497550 mRNA. Translation: AAR89518.1.
    GL456158 Genomic DNA. No translation available.
    CCDSiCCDS25412.1.
    RefSeqiNP_957707.2. NM_201255.2.
    UniGeneiMm.445335.

    Genome annotation databases

    EnsembliENSMUST00000059707; ENSMUSP00000055255; ENSMUSG00000051617.
    GeneIDi107656.
    KEGGimmu:107656.
    UCSCiuc007lkn.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY497550 mRNA. Translation: AAR89518.1 .
    GL456158 Genomic DNA. No translation available.
    CCDSi CCDS25412.1.
    RefSeqi NP_957707.2. NM_201255.2.
    UniGenei Mm.445335.

    3D structure databases

    ProteinModelPortali Q6RHW0.
    SMRi Q6RHW0. Positions 176-438.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 223461. 1 interaction.

    PTM databases

    PhosphoSitei Q6RHW0.

    Proteomic databases

    PRIDEi Q6RHW0.

    Protocols and materials databases

    DNASUi 107656.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000059707 ; ENSMUSP00000055255 ; ENSMUSG00000051617 .
    GeneIDi 107656.
    KEGGi mmu:107656.
    UCSCi uc007lkn.1. mouse.

    Organism-specific databases

    CTDi 3857.
    MGIi MGI:96696. Krt9.

    Phylogenomic databases

    eggNOGi NOG148410.
    GeneTreei ENSGT00610000085921.
    HOVERGENi HBG013015.
    InParanoidi Q6RHW0.
    KOi K07604.
    OMAi EMQYETL.
    TreeFami TF332742.

    Miscellaneous databases

    NextBioi 359198.
    PROi Q6RHW0.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6RHW0.
    CleanExi MM_KRT9.
    Genevestigatori Q6RHW0.

    Family and domain databases

    InterProi IPR001664. IF.
    IPR002957. Keratin_I.
    [Graphical view ]
    PANTHERi PTHR23239. PTHR23239. 1 hit.
    Pfami PF00038. Filament. 1 hit.
    [Graphical view ]
    PRINTSi PR01248. TYPE1KERATIN.
    ProtoNeti Search...

    Publicationsi

    1. "Sperm tail abnormalities in mutant mice with neo(r) gene insertion into an intron of the keratin 9 gene."
      Rivkin E., Eddy E.M., Willis W.D., Goulding E.H., Suganuma R., Yanagimachi R., Kierszenbaum A.L.
      Mol. Reprod. Dev. 72:259-271(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Strain: 129/SvJImported.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiK1C9_MOUSE
    AccessioniPrimary (citable) accession number: Q6RHW0
    Secondary accession number(s): A2A4G3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 23, 2007
    Last sequence update: November 13, 2013
    Last modified: October 1, 2014
    This is version 81 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3