SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6RHW0

- K1C9_MOUSE

UniProt

Q6RHW0 - K1C9_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Keratin, type I cytoskeletal 9
Gene
Krt9, K9, Krt1-9
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly By similarity. Plays an essential role in the correct development of sperm.By similarity1 Publication

GO - Molecular functioni

  1. structural molecule activity Source: InterPro

GO - Biological processi

  1. intermediate filament organization Source: UniProtKB
  2. skin development Source: UniProtKB
  3. spermatogenesis Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cytoskeletal 9
Alternative name(s):
Cytokeratin-9
Short name:
CK-9
Keratin-9
Short name:
K9
Gene namesi
Name:Krt9
Synonyms:K9, Krt1-9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:96696. Krt9.

Subcellular locationi

GO - Cellular componenti

  1. intermediate filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 743743Keratin, type I cytoskeletal 9
PRO_0000308372Add
BLAST

Proteomic databases

PRIDEiQ6RHW0.

PTM databases

PhosphoSiteiQ6RHW0.

Expressioni

Tissue specificityi

Expressed in footpad epidermis and testis (at protein level).1 Publication

Gene expression databases

BgeeiQ6RHW0.
CleanExiMM_KRT9.
GenevestigatoriQ6RHW0.

Interactioni

Subunit structurei

Heterotetramer of two type I and two type II keratins.

Protein-protein interaction databases

BioGridi223461. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ6RHW0.
SMRiQ6RHW0. Positions 176-438.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 130130Head
Add
BLAST
Regioni131 – 439309Rod
Add
BLAST
Regioni131 – 16636Coil 1A
Add
BLAST
Regioni167 – 18519Linker 1
Add
BLAST
Regioni186 – 27792Coil 1B
Add
BLAST
Regioni278 – 30023Linker 12
Add
BLAST
Regioni301 – 439139Coil 2
Add
BLAST
Regioni440 – 709270Tail
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2 – 7372Ser-rich
Add
BLAST
Compositional biasi18 – 125108Gly-rich
Add
BLAST
Compositional biasi463 – 729267Ser-rich
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG148410.
GeneTreeiENSGT00610000085921.
HOVERGENiHBG013015.
InParanoidiQ6RHW0.
KOiK07604.
OMAiEMQYETL.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.

Sequencei

Sequence statusi: Complete.

Q6RHW0-1 [UniParc]FASTAAdd to Basket

« Hide

MSCRQSSSSF WSSSSSCGGG GGRGGSGGSM RSSFSRSSRA GGGGGGRFNS    50
SSGFSGGGFS ACGGGGGGSF GSSYGGGYGG GFSTGSYSGM FGGGSGGGFG 100
GGSGGGFGGG SGGGFGGGSG GGEGGILNTN EKIVMQNLNS RLASYMEKVL 150
ELEESNTAME KQIQDWYSKR GPKVFQKDNT HYYDTIEDLK DRIVDLTVRN 200
NKTLVDIDNT RMTMDDFRVK LEMEQSLRQG VEGDINGLKK VLDDLVMAKS 250
DLEILLDSLE DEKNALTKNH KEEMSQLTGQ NDGDVNVEIN VAPSTDLTRV 300
LNDMREEYEQ LISKNRQDIE QHYESKMTQI EQQMTNSGQE MESNMKQVSQ 350
LQHTIQELNV ELQTQLTTKS ALEKALEDTK NRYCGQLQQI QEQISELEAQ 400
LAEIRAETEC QSQEYSILLS IKTRLEKEIE TYRELLEGGQ QDFESSGAGQ 450
IGFGSGKGRQ RGSGGSYGGG SGGSYGGGSG GSYGGGSGGS YGGGSGGSYG 500
GGSGGSHGGK SGGSHGGGSG GSYGGESGGS HGGGSGGSYG GGSGGSHGGK 550
SGGGYGGGSS SGGGSGGSYG GGSGGSHGGG SGGSYGGGSG GSHGGKSGGG 600
YGGGSSSGGG SGGSYGGGSG GSHGGKSGGS YGGGSGGSYG GGSGGSHGGK 650
SGGGYGGGSS SGGGSGGSYG GGSGGSHGGK SGGSYGGGSS SGGGSGGSYG 700
GGSGSGGGSG GSYGGGNRRP SQSQSSSKSA DCDDDSQEHK MRY 743
Length:743
Mass (Da):72,495
Last modified:November 13, 2013 - v3
Checksum:iC1A44B4FE65A4B5A
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti226 – 2261S → T in AAR89518. 1 Publication
Sequence conflicti258 – 2581S → N in AAR89518. 1 Publication
Sequence conflicti267 – 2671T → P in AAR89518. 1 Publication
Sequence conflicti299 – 2991R → Q in AAR89518. 1 Publication
Sequence conflicti332 – 3321Q → H in AAR89518. 1 Publication
Sequence conflicti334 – 3341M → V in AAR89518. 1 Publication
Sequence conflicti605 – 6051S → T in AAR89518. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY497550 mRNA. Translation: AAR89518.1.
GL456158 Genomic DNA. No translation available.
CCDSiCCDS25412.1.
RefSeqiNP_957707.2. NM_201255.2.
UniGeneiMm.445335.

Genome annotation databases

EnsembliENSMUST00000059707; ENSMUSP00000055255; ENSMUSG00000051617.
GeneIDi107656.
KEGGimmu:107656.
UCSCiuc007lkn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY497550 mRNA. Translation: AAR89518.1 .
GL456158 Genomic DNA. No translation available.
CCDSi CCDS25412.1.
RefSeqi NP_957707.2. NM_201255.2.
UniGenei Mm.445335.

3D structure databases

ProteinModelPortali Q6RHW0.
SMRi Q6RHW0. Positions 176-438.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 223461. 1 interaction.

PTM databases

PhosphoSitei Q6RHW0.

Proteomic databases

PRIDEi Q6RHW0.

Protocols and materials databases

DNASUi 107656.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000059707 ; ENSMUSP00000055255 ; ENSMUSG00000051617 .
GeneIDi 107656.
KEGGi mmu:107656.
UCSCi uc007lkn.1. mouse.

Organism-specific databases

CTDi 3857.
MGIi MGI:96696. Krt9.

Phylogenomic databases

eggNOGi NOG148410.
GeneTreei ENSGT00610000085921.
HOVERGENi HBG013015.
InParanoidi Q6RHW0.
KOi K07604.
OMAi EMQYETL.
TreeFami TF332742.

Miscellaneous databases

NextBioi 359198.
PROi Q6RHW0.
SOURCEi Search...

Gene expression databases

Bgeei Q6RHW0.
CleanExi MM_KRT9.
Genevestigatori Q6RHW0.

Family and domain databases

InterProi IPR001664. IF.
IPR002957. Keratin_I.
[Graphical view ]
PANTHERi PTHR23239. PTHR23239. 1 hit.
Pfami PF00038. Filament. 1 hit.
[Graphical view ]
PRINTSi PR01248. TYPE1KERATIN.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sperm tail abnormalities in mutant mice with neo(r) gene insertion into an intron of the keratin 9 gene."
    Rivkin E., Eddy E.M., Willis W.D., Goulding E.H., Suganuma R., Yanagimachi R., Kierszenbaum A.L.
    Mol. Reprod. Dev. 72:259-271(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: 129/SvJ.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiK1C9_MOUSE
AccessioniPrimary (citable) accession number: Q6RHW0
Secondary accession number(s): A2A4G3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: November 13, 2013
Last modified: July 9, 2014
This is version 80 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

There are two types of cytoskeletal and microfibrillar keratin, I (acidic) and II (neutral to basic) (40-55 and 56-70 kDa, respectively).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi