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Protein

Vitellogenin

Gene
N/A
Organism
Fenneropenaeus merguiensis (Banana prawn) (Penaeus merguiensis)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Precursor of the egg-yolk proteins that are sources of nutrients during embryonic development.Curated

GO - Molecular functioni

  • lipid binding Source: UniProtKB-KW
  • lipid transporter activity Source: UniProtKB
  • nutrient reservoir activity Source: UniProtKB-KW

GO - Biological processi

  • oogenesis Source: UniProtKB

Keywordsi

Molecular functionStorage protein
Biological processLipid transport, Transport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Vitellogenin
Cleaved into the following chain:
OrganismiFenneropenaeus merguiensis (Banana prawn) (Penaeus merguiensis)
Taxonomic identifieri71412 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaCrustaceaMalacostracaEumalacostracaEucaridaDecapodaDendrobranchiataPenaeoideaPenaeidaeFenneropenaeus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 181 PublicationAdd BLAST18
ChainiPRO_000025941319 – 2586Vitellogenin1 PublicationAdd BLAST2568
ChainiPRO_000025941419 – ?Vitellin1 Publication

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi170 ↔ 194PROSITE-ProRule annotation

Post-translational modificationi

Glycosylated.1 Publication
May be modified covalently by lipidation.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein

Proteomic databases

PRIDEiQ6RG02.

Expressioni

Tissue specificityi

Expressed in the ovary and hepatopancrease of vitellogenic females. Not expressed in the muscle, heart and intestine of female or in the hepatopancrease of the male. Detected in the ovary and hemolymph of female (at protein level). Not detected in the female hepatopancreas or in the male hemolymph and testis (at protein level).2 Publications

Developmental stagei

Vitellogenin is detected in stage 1 of the ovarian cycle and protein levels increase to reach a maximum in stage 3. Thereafter vitellogen levels in the ovary decrease gradually. Vitellin is detected at low levels in stage 1 of the ovarian cycle and protein levels increase steadily in stages 2 through to 4.1 Publication

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini42 – 653VitellogeninPROSITE-ProRule annotationAdd BLAST612
Domaini2354 – 2546VWFDPROSITE-ProRule annotationAdd BLAST193

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.20.50.20. 1 hit.
2.30.230.10. 1 hit.
InterProiView protein in InterPro
IPR015819. Lipid_transp_b-sht_shell.
IPR001747. Lipid_transpt_N.
IPR009454. Lipid_transpt_open_b-sht.
IPR015816. Vitellinogen_b-sht_N.
IPR015255. Vitellinogen_open_b-sht.
IPR015817. Vitellinogen_open_b-sht_sub1.
IPR011030. Vitellinogen_superhlx.
IPR001846. VWF_type-D.
PfamiView protein in Pfam
PF06448. DUF1081. 1 hit.
PF09172. DUF1943. 1 hit.
PF01347. Vitellogenin_N. 1 hit.
PF00094. VWD. 1 hit.
SMARTiView protein in SMART
SM01169. DUF1943. 1 hit.
SM00638. LPD_N. 1 hit.
SUPFAMiSSF48431. SSF48431. 1 hit.
SSF56968. SSF56968. 2 hits.
PROSITEiView protein in PROSITE
PS51211. VITELLOGENIN. 1 hit.
PS51233. VWFD. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6RG02-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTSTLLFVL AFVAGGLAAP WGADVPRCST ECPVTGSPKL AYQPDKTYAY
60 70 80 90 100
AYSGKSTVQL KGVDNGDTET EWTAGVDLTW ISPCDMAISF RNTKMDGARG
110 120 130 140 150
PTAARTLERY PLVVAVVDGR VQHVCAHPED EAWAINLKKG VASAFQNSIP
160 170 180 190 200
SLSAVSSGIT VTETDVVGKC PTKYEIETEG EKVIVVKEKN HRHCQERYPT
210 220 230 240 250
PAALPAPWLK APLPIEESKS QCRQEIANGI YTAITCQDKN IVRPAIGIYK
260 270 280 290 300
YVEASQYSTL RFISESSDTS AISGIPSGEL NIESLLYNHE TMKDPQLAPE
310 320 330 340 350
LDELMKEICD KTKDTVEAEA GALVAKALHV LRRIPDTVVV ETAQKVRQGH
360 370 380 390 400
YCSDSARLES IFLDAVAFIH ESGAVKVMVN EIENGRATGG RLALYTAALY
410 420 430 440 450
LIPRPNIEAV KALTPLFESP RPMPSLLLAA ATMVNHYCRH TPACYEKAPV
460 470 480 490 500
ARIAEILANR VQTHCSPSAG VEDNEVALAI FKTIGNMGVA TPAVTRAAVH
510 520 530 540 550
CIEVEGLETS VRVAAAEAFR QANCFRPAVE KLVDIAVRPA FETEVRIASY
560 570 580 590 600
LAAVRCAEQE HLETIIEKIS KEENTQVRGF VLGHLINIQE STCPAKENLR
610 620 630 640 650
YLLANVIPTD FERDFRKFSR NIDVAYHAPA FGMGAGLESN IIYAPGSFVP
660 670 680 690 700
RAVNLKMKAD VDETHMDIAE IGARFVGIES IIEEPLGPQG YLRTATFGKI
710 720 730 740 750
MEDITGFAGE KGYKVMEQLK HTLRTRRSID SSVIADFFGK LYGKSRSHTH
760 770 780 790 800
AELFARFMGH EITYADVAGS LKGVTADTLI ETFFSFFENS LEHMKDLNLN
810 820 830 840 850
TARTAQLSMD YSLPTIQGTP LRLRLAGTAV AGLKMEGNVN IAQILSDLGN
860 870 880 890 900
SQTGVKFFPG LSVHATGFVG FDWLLARVGI EMQNTISSAT GAAIKIRTTE
910 920 930 940 950
NKKIEMELEV PEKMELLNIK AETYLVKAVG KKMTEISPSS MRDVRIQRNS
960 970 980 990 1000
CIGALEPVFG LKVCYDMNIP DVFRANALPL GEPAIAKLYV EKADPSMRGY
1010 1020 1030 1040 1050
LVTAAIKNKR GNKVIKMNVE AAGASTPRRA EMTLSYTKEE GSHIVSAKLD
1060 1070 1080 1090 1100
SSSIAAGVWT TLTNEQGHKA METYVNFNYG QIAISRGIKL EAIAREASVG
1110 1120 1130 1140 1150
EEFQVNVFSS GTRSFPSESH IVEARFIKKT SGPEFNVDVI CRTKNALAEL
1160 1170 1180 1190 1200
FDLNIEVGAD FMKFSPKNLY PARYIPKTRI VLPVNLRKME INAATAAWKL
1210 1220 1230 1240 1250
ISYIRAGSQS GGSREFISAL KLAKGRKDFI SVQATHTIEG TFPQNIIIKN
1260 1270 1280 1290 1300
VATAEVGRSS YKAMYDLFYH SEKMGASLEV LQAAGNEKVA HLEAIYELSG
1310 1320 1330 1340 1350
SKYCTKFLAE IPGYIQPVKV EAGIEQGAEG RYTLESAITY GQRTVLEASG
1360 1370 1380 1390 1400
PIMARFSSKI AKLQANIKVR AMASEPYIIG ANVAFGSKKQ MIAMEIKGRS
1410 1420 1430 1440 1450
EAVIGLEWKM VRESSEKTTV GIVFVLPALI ENKIDAEITD GLIHVSFNNL
1460 1470 1480 1490 1500
VLPKTSSRRR VKGFADVHIA EKKANVEFSW DADNAPEKKL VLDASLISSS
1510 1520 1530 1540 1550
ANPGHAEIHG NIVIAGEPFH AKLVLTAANL VEHMEGENGF KLILTTPSQK
1560 1570 1580 1590 1600
TIVLGASCDV QVAGATTKVI STVEYKNMKD RKYKYASVIA YEKLGGPFDY
1610 1620 1630 1640 1650
AVEAKVTYKQ PGTAEIKLGT AVKHHWTPEE HVVAVRVEAD APILKTPATI
1660 1670 1680 1690 1700
EFSIHNAPNA FVGFCKIERN APATVFEWNV QITPEGGIEA VEAGVDMKAI
1710 1720 1730 1740 1750
IEVLKIVHAA ATLQEESYET YGPHTSQYQY RFTRPSPTSY TMQMRTPTRT
1760 1770 1780 1790 1800
MEGRAKLSPR ESGIKFYPNK GKTESKYEIG YKANHEGRWG GHASKLEVRM
1810 1820 1830 1840 1850
NHPVLPKPIM AAVQYTVAEE TTKGTIELDI FPEEANKITG SLETQRISEN
1860 1870 1880 1890 1900
AIRAEAFLTS RMLKVNPKAI ITAAYAPETV AFDVVFHKTP SAAPIFAIAA
1910 1920 1930 1940 1950
KYDKTAAHNA AATFTVKMEE RPVFEITAVT EPEEAATCNG IRMRAVAYAA
1960 1970 1980 1990 2000
TFGKYNVISK MCRPAFIEVT AMRPGGAKEY IAKLGLRYPD AAEAGVYVAS
2010 2020 2030 2040 2050
GRAGETHGVA VAAVKLASPT MLKVEMAYEP QEAEAIINEM TEEFEKIAAS
2060 2070 2080 2090 2100
FTSVEMEVVE FLKQEAAAKG IQFPSSQLVN LLGVAKEEIA EIYRDIVSEA
2110 2120 2130 2140 2150
IIFDTEILGD ILGSPVVSFI SRVYFGVWSE IIHLQHHLSV SLIQTIERFQ
2160 2170 2180 2190 2200
QELGSISEIL MEVVMTAARM AETGEVPGVV FDALEEIKAT KVFRIVRREV
2210 2220 2230 2240 2250
DAILEEYPEE YEAVKHIVHN VVAILKRDVG IVRERLMEIP AVLKIIDYTM
2260 2270 2280 2290 2300
YHFHSERAFA AEAEKLVSLM LNELLFVSME REGNGVAVRI PLHRPLYSLT
2310 2320 2330 2340 2350
QVAQEAVPNP VTMLENLIFA YVDYIPIPVS DAIWAFYNLV PRYITDVLPP
2360 2370 2380 2390 2400
YPRTATVVGG SEILTFSGLV VRAPRSPCKV VLAAHGSHRL MMSHPQASAP
2410 2420 2430 2440 2450
AQFELKTPAA TVMIKPDFEV VVNGQPLAGS QQTIGNVRIV NTAEHIEVGC
2460 2470 2480 2490 2500
PLMKVVVAKA GEAVAVEASG WVFGRVAGLL GPNNGEIAHD RLMPSGAAAS
2510 2520 2530 2540 2550
NPRDLVAAWQ EDRQCSTPEV PRAETTVARL IQCEALLGIR SRCNPVVHPQ
2560 2570 2580
PFIKMCHAAH KACDAAQAYR TVCSLRGVGE VFPLGC
Length:2,586
Mass (Da):283,029
Last modified:May 10, 2005 - v2
Checksum:iE68C3991C9783F06
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY499620 mRNA. Translation: AAR88442.2.

Similar proteinsi

Entry informationi

Entry nameiVIT_FENME
AccessioniPrimary (citable) accession number: Q6RG02
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 10, 2005
Last modified: May 10, 2017
This is version 42 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing