Q6RFL5 (BSH_CHICK) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Brain-specific homeobox protein homolog

Gene names

Name:

BSX

Organism

Gallus gallus (Chicken) [Reference proteome]

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Sauropsida › Sauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	233 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	DNA binding protein that function as transcriptional activator By similarity. May play a role in the determination and function of cell types in the brain By similarity.
Subcellular location	Nucleus By similarity UniProtKB Q04787.
Sequence similarities	Belongs to the distal-less homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Activator
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	brain development Inferred from sequence or structural similarity. Source: UniProtKB eating behavior Inferred from electronic annotation. Source: Compara locomotory behavior Inferred from electronic annotation. Source: Compara mammary gland involution Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: Compara transcription factor complex Inferred from electronic annotation. Source: Compara
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: Compara sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 233	233	Brain-specific homeobox protein homolog		PRO_0000048843
Regions
	DNA binding	110 – 170	61	Homeobox
	Compositional bias	68 – 109	42	His-rich

Sequences

	Sequence		Length	Mass (Da)
	Q6RFL5 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 7CF5E9DA4953AB6C	FASTA	233	26,452
	10 20 30 40 50 60 MNLNFTSPVH PVPAPRPTSF FIEDILLHKP KPLREVPPEH FAGSLASRVP LLDYGYPLMP 70 80 90 100 110 120 APALLAPHPH PALHKPEHHH HHPYFLTTSG VPVPALFPHH AHAELPGKHC RRRKARTVFS 130 140 150 160 170 180 DSQLSGLEKR FEIQRYLSTP ERVELATALS LSETQVKTWF QNRRMKHKKQ LRKSQDDPIH 190 200 210 220 230 EENREQSSPE PELPEPAAAE PRKGPPGPFL LQDPEDEVDI LEEGDILAAP HRL

References

[1]	"Identification of vertebrate homologs of the Drosophila brain-specific homeobox gene." Assimacopoulos S., Ragsdale C.W. Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Forebrain.

Web resources

Protein Spotlight

Of fidgets and food - Issue 85 of August 2007

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY500594 mRNA. Translation: AAR89086.1.
IPI	IPI00581246.
RefSeq	NP_989843.1. NM_204512.1.
UniGene	Gga.9478.
3D structure databases
ProteinModelPortal	Q6RFL5.
SMR	Q6RFL5. Positions 106-169.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSGALT00000010527; ENSGALP00000010513; ENSGALG00000006515.
GeneID	395183.
KEGG	gga:395183.
Organism-specific databases
CTD	390259.
Phylogenomic databases
eggNOG	NOG242366.
GeneTree	ENSGT00700000104097.
HOGENOM	HOG000231924.
HOVERGEN	HBG050738.
InParanoid	Q6RFL5.
OMA	LHKPEHH.
OrthoDB	EOG4KKZ41.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	20815273.

Entry information

Entry name

BSH_CHICK

Accession

Primary (citable) accession number: Q6RFL5

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 31, 2004
Last sequence update:	July 5, 2004
Last modified:	April 3, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program