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Q6RFL5

- BSH_CHICK

UniProt

Q6RFL5 - BSH_CHICK

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Protein

Brain-specific homeobox protein homolog

Gene

BSX

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

DNA binding protein that function as transcriptional activator. May play a role in the determination and function of cell types in the brain.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi110 – 17061HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: Ensembl
  2. sequence-specific DNA binding transcription factor activity Source: Ensembl

GO - Biological processi

  1. brain development Source: UniProtKB
  2. eating behavior Source: Ensembl
  3. locomotory behavior Source: Ensembl
  4. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  5. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Brain-specific homeobox protein homolog
Gene namesi
Name:BSXImported
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
ProteomesiUP000000539: Chromosome 24

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: UniProtKB-KW
  3. transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 233233Brain-specific homeobox protein homologPRO_0000048843Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000010513.

Structurei

3D structure databases

ProteinModelPortaliQ6RFL5.
SMRiQ6RFL5. Positions 106-169.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi68 – 10942His-richAdd
BLAST

Sequence similaritiesi

Belongs to the distal-less homeobox family.Sequence Analysis
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG242366.
GeneTreeiENSGT00760000118844.
HOGENOMiHOG000231924.
HOVERGENiHBG050738.
InParanoidiQ6RFL5.
OMAiLHKPEHH.
OrthoDBiEOG7QVM51.
PhylomeDBiQ6RFL5.
TreeFamiTF350735.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6RFL5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNLNFTSPVH PVPAPRPTSF FIEDILLHKP KPLREVPPEH FAGSLASRVP
60 70 80 90 100
LLDYGYPLMP APALLAPHPH PALHKPEHHH HHPYFLTTSG VPVPALFPHH
110 120 130 140 150
AHAELPGKHC RRRKARTVFS DSQLSGLEKR FEIQRYLSTP ERVELATALS
160 170 180 190 200
LSETQVKTWF QNRRMKHKKQ LRKSQDDPIH EENREQSSPE PELPEPAAAE
210 220 230
PRKGPPGPFL LQDPEDEVDI LEEGDILAAP HRL
Length:233
Mass (Da):26,452
Last modified:July 5, 2004 - v1
Checksum:i7CF5E9DA4953AB6C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY500594 mRNA. Translation: AAR89086.1.
RefSeqiNP_989843.1. NM_204512.1.
UniGeneiGga.9478.

Genome annotation databases

EnsembliENSGALT00000010527; ENSGALP00000010513; ENSGALG00000006515.
GeneIDi395183.
KEGGigga:395183.

Cross-referencesi

Web resourcesi

Protein Spotlight

Of fidgets and food - Issue 85 of August 2007

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY500594 mRNA. Translation: AAR89086.1 .
RefSeqi NP_989843.1. NM_204512.1.
UniGenei Gga.9478.

3D structure databases

ProteinModelPortali Q6RFL5.
SMRi Q6RFL5. Positions 106-169.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9031.ENSGALP00000010513.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSGALT00000010527 ; ENSGALP00000010513 ; ENSGALG00000006515 .
GeneIDi 395183.
KEGGi gga:395183.

Organism-specific databases

CTDi 390259.

Phylogenomic databases

eggNOGi NOG242366.
GeneTreei ENSGT00760000118844.
HOGENOMi HOG000231924.
HOVERGENi HBG050738.
InParanoidi Q6RFL5.
OMAi LHKPEHH.
OrthoDBi EOG7QVM51.
PhylomeDBi Q6RFL5.
TreeFami TF350735.

Miscellaneous databases

NextBioi 20815273.
PROi Q6RFL5.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of vertebrate homologs of the Drosophila brain-specific homeobox gene."
    Assimacopoulos S., Ragsdale C.W.
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: ForebrainImported.

Entry informationi

Entry nameiBSH_CHICK
AccessioniPrimary (citable) accession number: Q6RFL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 31, 2004
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3