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Q6RFH5

- WDR74_HUMAN

UniProt

Q6RFH5 - WDR74_HUMAN

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Protein
WD repeat-containing protein 74
Gene
WDR74, NSA1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. RNA metabolic process Source: Ensembl
  2. blastocyst formation Source: Ensembl
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ6RFH5.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat-containing protein 74
Alternative name(s):
NOP seven-associated protein 1
Gene namesi
Name:WDR74
Synonyms:NSA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:25529. WDR74.

Subcellular locationi

Nucleusnucleolus 1 Publication

GO - Cellular componenti

  1. nucleolus Source: UniProtKB
  2. nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670578.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 385385WD repeat-containing protein 74
PRO_0000051428Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei214 – 2141Phosphoserine1 Publication
Modified residuei361 – 3611Phosphoserine2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ6RFH5.
PaxDbiQ6RFH5.
PRIDEiQ6RFH5.

2D gel databases

SWISS-2DPAGEQ6RFH5.

PTM databases

PhosphoSiteiQ6RFH5.

Expressioni

Gene expression databases

ArrayExpressiQ6RFH5.
BgeeiQ6RFH5.
CleanExiHS_WDR74.
GenevestigatoriQ6RFH5.

Organism-specific databases

HPAiHPA037795.
HPA038419.

Interactioni

Protein-protein interaction databases

BioGridi120092. 13 interactions.
IntActiQ6RFH5. 3 interactions.
MINTiMINT-1433008.
STRINGi9606.ENSP00000278856.

Structurei

3D structure databases

ProteinModelPortaliQ6RFH5.
SMRiQ6RFH5. Positions 45-72, 99-300.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati40 – 8041WD 1
Add
BLAST
Repeati83 – 12240WD 2
Add
BLAST
Repeati128 – 16841WD 3
Add
BLAST
Repeati179 – 22042WD 4
Add
BLAST
Repeati224 – 26643WD 5
Add
BLAST
Repeati267 – 30640WD 6
Add
BLAST

Sequence similaritiesi

Contains 6 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG329513.
HOGENOMiHOG000006658.
HOVERGENiHBG052672.
InParanoidiQ6RFH5.
KOiK14841.
OMAiPQEPNKV.
PhylomeDBiQ6RFH5.
TreeFamiTF314666.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF00400. WD40. 1 hit.
[Graphical view]
SMARTiSM00320. WD40. 3 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6RFH5-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAAAAARWNH VWVGTETGIL KGVNLQRKQA ANFTAGGQPR REEAVSALCW    50
GTGGETQMLV GCADRTVKHF STEDGIFQGQ RHCPGGEGMF RGLAQADGTL 100
ITCVDSGILR VWHDKDKDTS SDPLLELRVG PGVCRMRQDP AHPHVVATGG 150
KENALKIWDL QGSEEPVFRA KNVRNDWLDL RVPIWDQDIQ FLPGSQKLVT 200
CTGYHQVRVY DPASPQRRPV LETTYGEYPL TAMTLTPGGN SVIVGNTHGQ 250
LAEIDLRQGR LLGCLKGLAG SVRGLQCHPS KPLLASCGLD RVLRIHRIQN 300
PRGLEHKVYL KSQLNCLLLS GRDNWEDEPQ EPQEPNKVPL EDTETDELWA 350
SLEAAAKRKL SGLEQPQGAL QTRRRKKKRP GSTSP 385
Length:385
Mass (Da):42,441
Last modified:July 5, 2004 - v1
Checksum:i8B4FA9730D8D5EC0
GO
Isoform 2 (identifier: Q6RFH5-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     308-326: Missing.

Note: No experimental confirmation available.

Show »
Length:366
Mass (Da):40,208
Checksum:iAB8D6910F3FF5C08
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei308 – 32619Missing in isoform 2.
VSP_011957Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 331F → L in BAA91610. 1 Publication
Sequence conflicti229 – 2291P → S in BAA91610. 1 Publication
Sequence conflicti297 – 2982RI → GT in BAA91610. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY500828 mRNA. Translation: AAS48499.1.
AK001301 mRNA. Translation: BAA91610.1.
AK025383 mRNA. Translation: BAB15122.1.
AK292330 mRNA. Translation: BAF85019.1.
BC006351 mRNA. Translation: AAH06351.1.
CCDSiCCDS44630.1. [Q6RFH5-1]
RefSeqiNP_060563.2. NM_018093.2. [Q6RFH5-1]
XP_005274112.1. XM_005274055.1. [Q6RFH5-1]
UniGeneiHs.654620.

Genome annotation databases

EnsembliENST00000278856; ENSP00000278856; ENSG00000133316. [Q6RFH5-1]
ENST00000311713; ENSP00000308931; ENSG00000133316. [Q6RFH5-2]
ENST00000525239; ENSP00000432119; ENSG00000133316. [Q6RFH5-1]
ENST00000529106; ENSP00000435726; ENSG00000133316. [Q6RFH5-1]
GeneIDi54663.
KEGGihsa:54663.
UCSCiuc001nvl.2. human. [Q6RFH5-2]
uc001nvm.2. human. [Q6RFH5-1]

Polymorphism databases

DMDMi55976441.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY500828 mRNA. Translation: AAS48499.1 .
AK001301 mRNA. Translation: BAA91610.1 .
AK025383 mRNA. Translation: BAB15122.1 .
AK292330 mRNA. Translation: BAF85019.1 .
BC006351 mRNA. Translation: AAH06351.1 .
CCDSi CCDS44630.1. [Q6RFH5-1 ]
RefSeqi NP_060563.2. NM_018093.2. [Q6RFH5-1 ]
XP_005274112.1. XM_005274055.1. [Q6RFH5-1 ]
UniGenei Hs.654620.

3D structure databases

ProteinModelPortali Q6RFH5.
SMRi Q6RFH5. Positions 45-72, 99-300.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 120092. 13 interactions.
IntActi Q6RFH5. 3 interactions.
MINTi MINT-1433008.
STRINGi 9606.ENSP00000278856.

PTM databases

PhosphoSitei Q6RFH5.

Polymorphism databases

DMDMi 55976441.

2D gel databases

SWISS-2DPAGE Q6RFH5.

Proteomic databases

MaxQBi Q6RFH5.
PaxDbi Q6RFH5.
PRIDEi Q6RFH5.

Protocols and materials databases

DNASUi 54663.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000278856 ; ENSP00000278856 ; ENSG00000133316 . [Q6RFH5-1 ]
ENST00000311713 ; ENSP00000308931 ; ENSG00000133316 . [Q6RFH5-2 ]
ENST00000525239 ; ENSP00000432119 ; ENSG00000133316 . [Q6RFH5-1 ]
ENST00000529106 ; ENSP00000435726 ; ENSG00000133316 . [Q6RFH5-1 ]
GeneIDi 54663.
KEGGi hsa:54663.
UCSCi uc001nvl.2. human. [Q6RFH5-2 ]
uc001nvm.2. human. [Q6RFH5-1 ]

Organism-specific databases

CTDi 54663.
GeneCardsi GC11M062600.
HGNCi HGNC:25529. WDR74.
HPAi HPA037795.
HPA038419.
neXtProti NX_Q6RFH5.
PharmGKBi PA142670578.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG329513.
HOGENOMi HOG000006658.
HOVERGENi HBG052672.
InParanoidi Q6RFH5.
KOi K14841.
OMAi PQEPNKV.
PhylomeDBi Q6RFH5.
TreeFami TF314666.

Enzyme and pathway databases

SignaLinki Q6RFH5.

Miscellaneous databases

ChiTaRSi WDR74. human.
GenomeRNAii 54663.
NextBioi 57206.
PROi Q6RFH5.

Gene expression databases

ArrayExpressi Q6RFH5.
Bgeei Q6RFH5.
CleanExi HS_WDR74.
Genevestigatori Q6RFH5.

Family and domain databases

Gene3Di 2.130.10.10. 2 hits.
InterProi IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF00400. WD40. 1 hit.
[Graphical view ]
SMARTi SM00320. WD40. 3 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Eilbracht J., Hofmann A., Schmidt-Zachmann M.S.
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Muscle.
  4. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-361, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-214 AND SER-361, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiWDR74_HUMAN
AccessioniPrimary (citable) accession number: Q6RFH5
Secondary accession number(s): A8K8G5
, Q9BRC9, Q9H6X8, Q9NVY2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 23, 2004
Last sequence update: July 5, 2004
Last modified: July 9, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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