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Q6REU8

- TYSY_XENNA

UniProt

Q6REU8 - TYSY_XENNA

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Protein

Thymidylate synthase

Gene
thyA, XNC1_4048
Organism
Xenorhabdus nematophila (strain ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Provides the sole de novo source of dTMP for DNA biosynthesis By similarity.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei146 – 1461 By similarity

GO - Molecular functioni

  1. thymidylate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dTMP biosynthetic process Source: UniProtKB-HAMAP
  2. dTTP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Enzyme and pathway databases

BioCyciXNEM406817:GHY4-4028-MONOMER.
UniPathwayiUPA00575.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate synthase (EC:2.1.1.45)
Short name:
TS
Short name:
TSase
Gene namesi
Name:thyA
Ordered Locus Names:XNC1_4048
OrganismiXenorhabdus nematophila (strain ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6)
Taxonomic identifieri406817 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeXenorhabdus
ProteomesiUP000008075: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264Thymidylate synthaseUniRule annotationPRO_0000141048Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ6REU8.
SMRiQ6REU8. Positions 1-264.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000257899.
KOiK00560.

Family and domain databases

Gene3Di3.30.572.10. 1 hit.
HAMAPiMF_00008. Thymidy_synth_bact.
InterProiIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
PfamiPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSiPR00108. THYMDSNTHASE.
SUPFAMiSSF55831. SSF55831. 1 hit.
TIGRFAMsiTIGR03284. thym_sym. 2 hits.
PROSITEiPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6REU8-1 [UniParc]FASTAAdd to Basket

« Hide

MKQYLDLMKK VLEEGTAKDD RTGTGTRSIF GHQMRFNLQE GFPLVTTKRC    50
HLRSIIHELL WFLNGDTNIK YLHDNGVSIW DEWADENGDL GPVYGKQWRA 100
WGSADGRHID QLTQVLEQLK GDPDSRRIIV SAWNVGELDK MALAPCHAFF 150
QFYVADGKLS CQLYQRSCDV FLGLPFNIAS YALLVHMMAQ QCNLDVGDFV 200
WTGGDTHLYN NHLEQTHLQL SREPRALPKL VIKRKPDSLF DYRFEDFEIV 250
DYDPYPGIKA PVAI 264
Length:264
Mass (Da):30,352
Last modified:July 5, 2004 - v1
Checksum:i2A7C5C0336794B07
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY502024 Genomic DNA. Translation: AAS80323.1.
FN667742 Genomic DNA. Translation: CBJ92073.1.
RefSeqiWP_013185453.1. NC_014228.1.
YP_003714161.1. NC_014228.1.

Genome annotation databases

EnsemblBacteriaiCBJ92073; CBJ92073; XNC1_4048.
GeneIDi9431860.
KEGGixne:XNC1_4048.
PATRICi42467566. VBIXenNem38452_3714.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY502024 Genomic DNA. Translation: AAS80323.1 .
FN667742 Genomic DNA. Translation: CBJ92073.1 .
RefSeqi WP_013185453.1. NC_014228.1.
YP_003714161.1. NC_014228.1.

3D structure databases

ProteinModelPortali Q6REU8.
SMRi Q6REU8. Positions 1-264.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CBJ92073 ; CBJ92073 ; XNC1_4048 .
GeneIDi 9431860.
KEGGi xne:XNC1_4048.
PATRICi 42467566. VBIXenNem38452_3714.

Phylogenomic databases

HOGENOMi HOG000257899.
KOi K00560.

Enzyme and pathway databases

UniPathwayi UPA00575 .
BioCyci XNEM406817:GHY4-4028-MONOMER.

Family and domain databases

Gene3Di 3.30.572.10. 1 hit.
HAMAPi MF_00008. Thymidy_synth_bact.
InterProi IPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view ]
Pfami PF00303. Thymidylat_synt. 1 hit.
[Graphical view ]
PRINTSi PR00108. THYMDSNTHASE.
SUPFAMi SSF55831. SSF55831. 1 hit.
TIGRFAMsi TIGR03284. thym_sym. 2 hits.
PROSITEi PS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of dTMP synthesis in Xenorhabdus nematophila and evaluation of dT availability in the insect and nematode hosts."
    Orchard S.S., Goodrich-Blair H.
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6.
  2. "Complete genome sequence of Xenorhabdus nematophila (strain ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6)."
    Goodrich-Blair H., Barbazuk B., Bode H.B., Darby C., Du Z., Forst S., Gaudriault S., Goldman B.S., Goodner B., Henkhaus J., Latreille P., Medigue C., Miller N., Norton S., Ogier J.C., Rouy Z., Slater S., Suen G.
    Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 19061 / DSM 3370 / LMG 1036 / NCIB 9965 / AN6.

Entry informationi

Entry nameiTYSY_XENNA
AccessioniPrimary (citable) accession number: Q6REU8
Secondary accession number(s): D3VCN8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2005
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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