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Q6R7K3

- RIR2_OSHVF

UniProt

Q6R7K3 - RIR2_OSHVF

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Protein

Ribonucleoside-diphosphate reductase small chain

Gene

ORF20

Organism
Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).By similarity

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactori

Binds 2 iron ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi130 – 1301Iron 1By similarity
Metal bindingi160 – 1601Iron 1By similarity
Metal bindingi160 – 1601Iron 2By similarity
Metal bindingi163 – 1631Iron 1By similarity
Active sitei167 – 1671By similarity
Metal bindingi225 – 2251Iron 2By similarity
Metal bindingi258 – 2581Iron 2By similarity
Metal bindingi261 – 2611Iron 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
  2. DNA replication Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1)
Gene namesi
ORF Names:ORF20
OrganismiOstreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus)
Taxonomic identifieri654903 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesMalacoherpesviridaeOstreavirus
Virus hostiCrassostrea gigas (Pacific oyster) (Crassostrea angulata) [TaxID: 29159]
Pecten maximus (King scallop) (Pilgrim's clam) [TaxID: 6579]
ProteomesiUP000007021: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 579579Ribonucleoside-diphosphate reductase small chainPRO_0000385024Add
BLAST

Interactioni

Subunit structurei

Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6R7K3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini435 – 579145FidoPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 fido domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di1.10.3290.10. 1 hit.
1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR003812. Fido.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF02661. Fic. 1 hit.
PF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF140931. SSF140931. 1 hit.
SSF47240. SSF47240. 1 hit.
PROSITEiPS51459. FIDO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6R7K3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSQSTIKFDL GELTTTQCAR LLSKFIRKAT LTPEQFEILN TSYDELTEFD
60 70 80 90 100
DHPLYGGATD HHKDIVGKYD HALLKPAVYQ QLRDFATKME SSSWQQTEID
110 120 130 140 150
AESDIPTWEQ ISENERDCVR KVLAFFAVGD TLVKDRIAIF ADEFPLPECK
160 170 180 190 200
DFIDWQTVNE GVHQRVYNNY LDALVKDKIY LADLVNAYKD PEFAPIKKKV
210 220 230 240 250
DWLGKIISVE NDSRGEMVVG QVCTEAIMFA ASFAILLKFR APYMRALVLG
260 270 280 290 300
NEFIRRDETL HFRFYAELLR LMPDRPSDER IAELLTEATE IELEFAEYVV
310 320 330 340 350
PEGVKYITKD RLIQHVKANT NQVCEMLDIN PIYFDQKGNV LLSPLLYMNT
360 370 380 390 400
LESEQKINFF EGKATEYNTK QYKVDFNNLF PPVKKMIEFA DEEEFIAAIV
410 420 430 440 450
EGEGLSKDRN KDIVKQQLCL AWDHLSSHDM EGLVDMTWTL KDVHRIAMNH
460 470 480 490 500
VIFNNGEFSN GYKFTVIDSG KVMYPTYETV EILESAVQGL IDDYNRDFSA
510 520 530 540 550
LDKGVEKFDK DKIRVAARFI LDLLYIHPFS DGNGRTARLI MAHLIGKMTT
560 570
PINREEYLKS IYHYRQTGDV SVFVDQFYR
Length:579
Mass (Da):66,994
Last modified:July 5, 2004 - v1
Checksum:iE7B90F9E49DF0791
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY509253 Genomic DNA. Translation: AAS00912.1.
RefSeqiYP_024565.1. NC_005881.2.

Genome annotation databases

GeneIDi2948202.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY509253 Genomic DNA. Translation: AAS00912.1 .
RefSeqi YP_024565.1. NC_005881.2.

3D structure databases

ProteinModelPortali Q6R7K3.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2948202.

Enzyme and pathway databases

UniPathwayi UPA00326 .

Family and domain databases

Gene3Di 1.10.3290.10. 1 hit.
1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR003812. Fido.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF02661. Fic. 1 hit.
PF00268. Ribonuc_red_sm. 1 hit.
[Graphical view ]
SUPFAMi SSF140931. SSF140931. 1 hit.
SSF47240. SSF47240. 1 hit.
PROSITEi PS51459. FIDO. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Tinkering with a viral ribonucleotide reductase."
    Lembo D., Brune W.
    Trends Biochem. Sci. 34:25-32(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiRIR2_OSHVF
AccessioniPrimary (citable) accession number: Q6R7K3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 5, 2004
Last modified: October 1, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3