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Protein

Ribonucleoside-diphosphate reductase small chain

Gene

ORF20

Organism
Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).By similarity

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactori

Fe cationBy similarityNote: Binds 2 iron ions per subunit.By similarity

Pathwayi: DNA replication

This protein is involved in the pathway DNA replication, which is part of Genetic information processing.
View all proteins of this organism that are known to be involved in the pathway DNA replication and in Genetic information processing.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi130Iron 1By similarity1
Metal bindingi160Iron 1By similarity1
Metal bindingi160Iron 2By similarity1
Metal bindingi163Iron 1By similarity1
Active sitei167By similarity1
Metal bindingi225Iron 2By similarity1
Metal bindingi258Iron 2By similarity1
Metal bindingi261Iron 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processDNA replication
LigandIron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1)
Gene namesi
ORF Names:ORF20
OrganismiOstreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus)
Taxonomic identifieri654903 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesMalacoherpesviridaeOstreavirus
Virus hostiCrassostrea gigas (Pacific oyster) (Crassostrea angulata) [TaxID: 29159]
Pecten maximus (King scallop) (Pilgrim's clam) [TaxID: 6579]
Proteomesi
  • UP000007021 Componenti: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003850241 – 579Ribonucleoside-diphosphate reductase small chainAdd BLAST579

Proteomic databases

PRIDEiQ6R7K3

Interactioni

Subunit structurei

Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6R7K3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini435 – 579FidoPROSITE-ProRule annotationAdd BLAST145

Sequence similaritiesi

Phylogenomic databases

OrthoDBiVOG090000AL

Family and domain databases

CDDicd01049 RNRR2, 1 hit
Gene3Di1.10.3290.10, 1 hit
1.10.620.20, 1 hit
InterProiView protein in InterPro
IPR009078 Ferritin-like_SF
IPR003812 Fido
IPR036597 Fido-like_dom_sf
IPR012348 RNR-like
IPR033909 RNR_small
IPR000358 RNR_small_fam
PANTHERiPTHR23409 PTHR23409, 1 hit
PfamiView protein in Pfam
PF02661 Fic, 1 hit
PF00268 Ribonuc_red_sm, 1 hit
SUPFAMiSSF140931 SSF140931, 1 hit
SSF47240 SSF47240, 1 hit
PROSITEiView protein in PROSITE
PS51459 FIDO, 1 hit

Sequencei

Sequence statusi: Complete.

Q6R7K3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQSTIKFDL GELTTTQCAR LLSKFIRKAT LTPEQFEILN TSYDELTEFD
60 70 80 90 100
DHPLYGGATD HHKDIVGKYD HALLKPAVYQ QLRDFATKME SSSWQQTEID
110 120 130 140 150
AESDIPTWEQ ISENERDCVR KVLAFFAVGD TLVKDRIAIF ADEFPLPECK
160 170 180 190 200
DFIDWQTVNE GVHQRVYNNY LDALVKDKIY LADLVNAYKD PEFAPIKKKV
210 220 230 240 250
DWLGKIISVE NDSRGEMVVG QVCTEAIMFA ASFAILLKFR APYMRALVLG
260 270 280 290 300
NEFIRRDETL HFRFYAELLR LMPDRPSDER IAELLTEATE IELEFAEYVV
310 320 330 340 350
PEGVKYITKD RLIQHVKANT NQVCEMLDIN PIYFDQKGNV LLSPLLYMNT
360 370 380 390 400
LESEQKINFF EGKATEYNTK QYKVDFNNLF PPVKKMIEFA DEEEFIAAIV
410 420 430 440 450
EGEGLSKDRN KDIVKQQLCL AWDHLSSHDM EGLVDMTWTL KDVHRIAMNH
460 470 480 490 500
VIFNNGEFSN GYKFTVIDSG KVMYPTYETV EILESAVQGL IDDYNRDFSA
510 520 530 540 550
LDKGVEKFDK DKIRVAARFI LDLLYIHPFS DGNGRTARLI MAHLIGKMTT
560 570
PINREEYLKS IYHYRQTGDV SVFVDQFYR
Length:579
Mass (Da):66,994
Last modified:July 5, 2004 - v1
Checksum:iE7B90F9E49DF0791
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY509253 Genomic DNA Translation: AAS00912.1
RefSeqiYP_024565.1, NC_005881.2

Genome annotation databases

GeneIDi2948202
KEGGivg:2948202

Similar proteinsi

Entry informationi

Entry nameiRIR2_OSHVF
AccessioniPrimary (citable) accession number: Q6R7K3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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