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Q6R7K3

- RIR2_OSHVF

UniProt

Q6R7K3 - RIR2_OSHVF

Protein

Ribonucleoside-diphosphate reductase small chain

Gene

ORF20

Organism
Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 62 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.By similarity

    Catalytic activityi

    2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

    Cofactori

    Binds 2 iron ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi130 – 1301Iron 1By similarity
    Metal bindingi160 – 1601Iron 1By similarity
    Metal bindingi160 – 1601Iron 2By similarity
    Metal bindingi163 – 1631Iron 1By similarity
    Active sitei167 – 1671By similarity
    Metal bindingi225 – 2251Iron 2By similarity
    Metal bindingi258 – 2581Iron 2By similarity
    Metal bindingi261 – 2611Iron 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

    GO - Biological processi

    1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
    2. DNA replication Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00326.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1)
    Gene namesi
    ORF Names:ORF20
    OrganismiOstreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus)
    Taxonomic identifieri654903 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesMalacoherpesviridaeOstreavirus
    Virus hostiCrassostrea gigas (Pacific oyster) (Crassostrea angulata) [TaxID: 29159]
    Pecten maximus (King scallop) (Pilgrim's clam) [TaxID: 6579]
    ProteomesiUP000007021: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 579579Ribonucleoside-diphosphate reductase small chainPRO_0000385024Add
    BLAST

    Interactioni

    Subunit structurei

    Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ6R7K3.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini435 – 579145FidoPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 fido domain.PROSITE-ProRule annotation

    Family and domain databases

    Gene3Di1.10.3290.10. 1 hit.
    1.10.620.20. 1 hit.
    InterProiIPR009078. Ferritin-like_SF.
    IPR003812. Fido.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view]
    PANTHERiPTHR23409. PTHR23409. 1 hit.
    PfamiPF02661. Fic. 1 hit.
    PF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view]
    SUPFAMiSSF140931. SSF140931. 1 hit.
    SSF47240. SSF47240. 1 hit.
    PROSITEiPS51459. FIDO. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6R7K3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQSTIKFDL GELTTTQCAR LLSKFIRKAT LTPEQFEILN TSYDELTEFD    50
    DHPLYGGATD HHKDIVGKYD HALLKPAVYQ QLRDFATKME SSSWQQTEID 100
    AESDIPTWEQ ISENERDCVR KVLAFFAVGD TLVKDRIAIF ADEFPLPECK 150
    DFIDWQTVNE GVHQRVYNNY LDALVKDKIY LADLVNAYKD PEFAPIKKKV 200
    DWLGKIISVE NDSRGEMVVG QVCTEAIMFA ASFAILLKFR APYMRALVLG 250
    NEFIRRDETL HFRFYAELLR LMPDRPSDER IAELLTEATE IELEFAEYVV 300
    PEGVKYITKD RLIQHVKANT NQVCEMLDIN PIYFDQKGNV LLSPLLYMNT 350
    LESEQKINFF EGKATEYNTK QYKVDFNNLF PPVKKMIEFA DEEEFIAAIV 400
    EGEGLSKDRN KDIVKQQLCL AWDHLSSHDM EGLVDMTWTL KDVHRIAMNH 450
    VIFNNGEFSN GYKFTVIDSG KVMYPTYETV EILESAVQGL IDDYNRDFSA 500
    LDKGVEKFDK DKIRVAARFI LDLLYIHPFS DGNGRTARLI MAHLIGKMTT 550
    PINREEYLKS IYHYRQTGDV SVFVDQFYR 579
    Length:579
    Mass (Da):66,994
    Last modified:July 5, 2004 - v1
    Checksum:iE7B90F9E49DF0791
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY509253 Genomic DNA. Translation: AAS00912.1.
    RefSeqiYP_024565.1. NC_005881.2.

    Genome annotation databases

    GeneIDi2948202.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY509253 Genomic DNA. Translation: AAS00912.1 .
    RefSeqi YP_024565.1. NC_005881.2.

    3D structure databases

    ProteinModelPortali Q6R7K3.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 2948202.

    Enzyme and pathway databases

    UniPathwayi UPA00326 .

    Family and domain databases

    Gene3Di 1.10.3290.10. 1 hit.
    1.10.620.20. 1 hit.
    InterProi IPR009078. Ferritin-like_SF.
    IPR003812. Fido.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view ]
    PANTHERi PTHR23409. PTHR23409. 1 hit.
    Pfami PF02661. Fic. 1 hit.
    PF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view ]
    SUPFAMi SSF140931. SSF140931. 1 hit.
    SSF47240. SSF47240. 1 hit.
    PROSITEi PS51459. FIDO. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Tinkering with a viral ribonucleotide reductase."
      Lembo D., Brune W.
      Trends Biochem. Sci. 34:25-32(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiRIR2_OSHVF
    AccessioniPrimary (citable) accession number: Q6R7K3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 62 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3