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Q6R7H4

- RIR1_OSHVF

UniProt

Q6R7H4 - RIR1_OSHVF

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Protein
Ribonucleoside-diphosphate reductase large subunit
Gene
N/A
Organism
Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei222 – 2221Substrate By similarity
Sitei238 – 2381Important for hydrogen atom transfer By similarity
Binding sitei266 – 2661Substrate; via amide nitrogen By similarity
Active sitei447 – 4471Proton acceptor By similarity
Active sitei449 – 4491Cysteine radical intermediate By similarity
Active sitei451 – 4511Proton acceptor By similarity
Sitei464 – 4641Important for hydrogen atom transfer By similarity
Sitei797 – 7971Important for electron transfer By similarity
Sitei798 – 7981Important for electron transfer By similarity
Sitei830 – 8301Interacts with thioredoxin/glutaredoxin By similarity
Sitei833 – 8331Interacts with thioredoxin/glutaredoxin By similarity

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase large subunit (EC:1.17.4.1)
OrganismiOstreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus)
Taxonomic identifieri654903 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesMalacoherpesviridaeOstreavirus
Virus hostiCrassostrea gigas (Pacific oyster) (Crassostrea angulata) [TaxID: 29159]
Pecten maximus (King scallop) (Pilgrim's clam) [TaxID: 6579]
ProteomesiUP000007021: Genome

Subcellular locationi

GO - Cellular componenti

  1. ribonucleoside-diphosphate reductase complex Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 835835Ribonucleoside-diphosphate reductase large subunit
PRO_0000385023Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi238 ↔ 464Redox-active By similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ6R7H4.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni237 – 2382Substrate binding By similarity
Regioni447 – 4515Substrate binding By similarity
Regioni660 – 6645Substrate binding By similarity

Sequence similaritiesi

Family and domain databases

InterProiIPR013346. NrdE_NrdA.
IPR000788. RNR_lg_C.
IPR013509. RNR_lsu_N.
IPR008926. RNR_R1-su_N.
[Graphical view]
PfamiPF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
[Graphical view]
PRINTSiPR01183. RIBORDTASEM1.
SUPFAMiSSF48168. SSF48168. 1 hit.
TIGRFAMsiTIGR02506. NrdE_NrdA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6R7H4-1 [UniParc]FASTAAdd to Basket

« Hide

MACSMANAVR PGLSDLPEGV DLSNPKEVRS LLIKLTHARK STVYDTKIRR    50
LHGVIVNSIM ENYNSAEGEL DMAITPLIPS HPDYAFLAGR VSAYMTQINT 100
PKTFTDAVYG IQMAVGETNG FRSPMKPVKG GLSDEIVDFV NEHGARLDGM 150
IDDVRDYSHN YMGITGLLNG VAIKVNKKLY ERPQYVFMRV AMAMTDLSSE 200
TALEDIWQTY MLISGQCLSM ASPVLFNGGT SSSNTASCFL LDMGDNMVSI 250
TKKVAQTMTL IAKNGGIGIN FSKLRATGSK IGMAGKSSGI GGKLNLFDRV 300
AQSVDQGENK RPGAIAGYLT DWHADMYDWL YSRYSGSGNE VNKRHVLNMG 350
LVMSDLFMER VENDKEWSLF SPNDVVGLEE LYGEKFVRAY RAHEANPKIK 400
RTTVSARKLF SDIANMMWST GEPYILFKDA VNERSNHKHL GTIKNSNLCC 450
EIVQYCDTNE IAVCNLATIC VSNFVNVETG EIDFEGIADA AGVACKGINN 500
LIDKQNYDLG NEQLMRLADE RTEEVVEVNG IKFDAKYNLV SYSNLKHRPQ 550
GIGMQGLHDV FMKLKIPYDS EMAFRLAALI QEAIYYGAVR ESVKIAEEKG 600
PYPSYYWDNN THREGKLQFD FLEGFDRDRD LTHELFNWRE VLKKFEKFGI 650
NNSVVTAQPP SASSSQLNDN VESIEAITSN RFTKGIKDGK FIIINKHLQK 700
DLEDLGMWDA QMVGDIEAND GSIQNIERIP KNIREIYKTA REIDHKAVVK 750
ICAAIQPFID QTISKNMFVP KNVDNPVQLI MENVILGHKM KLKTGMYYTR 800
GIPAMKQQNF GKMNFQDKDI GKPVPELVDC EACSA 835
Length:835
Mass (Da):93,356
Last modified:July 5, 2004 - v1
Checksum:i4C5813635B9E5F47
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY509253 Genomic DNA. Translation: AAS00941.1.
RefSeqiYP_024594.1. NC_005881.2.

Genome annotation databases

GeneIDi2948194.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY509253 Genomic DNA. Translation: AAS00941.1 .
RefSeqi YP_024594.1. NC_005881.2.

3D structure databases

ProteinModelPortali Q6R7H4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2948194.

Enzyme and pathway databases

UniPathwayi UPA00326 .

Family and domain databases

InterProi IPR013346. NrdE_NrdA.
IPR000788. RNR_lg_C.
IPR013509. RNR_lsu_N.
IPR008926. RNR_R1-su_N.
[Graphical view ]
Pfami PF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
[Graphical view ]
PRINTSi PR01183. RIBORDTASEM1.
SUPFAMi SSF48168. SSF48168. 1 hit.
TIGRFAMsi TIGR02506. NrdE_NrdA. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Tinkering with a viral ribonucleotide reductase."
    Lembo D., Brune W.
    Trends Biochem. Sci. 34:25-32(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiRIR1_OSHVF
AccessioniPrimary (citable) accession number: Q6R7H4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 5, 2004
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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