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Q6R7H4

- RIR1_OSHVF

UniProt

Q6R7H4 - RIR1_OSHVF

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Protein

Ribonucleoside-diphosphate reductase large subunit

Gene
N/A
Organism
Ostreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.By similarity

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei222 – 2221SubstrateBy similarity
Sitei238 – 2381Important for hydrogen atom transferBy similarity
Binding sitei266 – 2661Substrate; via amide nitrogenBy similarity
Active sitei447 – 4471Proton acceptorBy similarity
Active sitei449 – 4491Cysteine radical intermediateBy similarity
Active sitei451 – 4511Proton acceptorBy similarity
Sitei464 – 4641Important for hydrogen atom transferBy similarity
Sitei797 – 7971Important for electron transferBy similarity
Sitei798 – 7981Important for electron transferBy similarity
Sitei830 – 8301Interacts with thioredoxin/glutaredoxinBy similarity
Sitei833 – 8331Interacts with thioredoxin/glutaredoxinBy similarity

GO - Molecular functioni

  1. ATP binding Source: InterPro
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase large subunit (EC:1.17.4.1)
OrganismiOstreid herpesvirus 1 (isolate France) (OsHV-1) (Pacific oyster herpesvirus)
Taxonomic identifieri654903 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesMalacoherpesviridaeOstreavirus
Virus hostiCrassostrea gigas (Pacific oyster) (Crassostrea angulata) [TaxID: 29159]
Pecten maximus (King scallop) (Pilgrim's clam) [TaxID: 6579]
ProteomesiUP000007021: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 835835Ribonucleoside-diphosphate reductase large subunitPRO_0000385023Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi238 ↔ 464Redox-activeBy similarity

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n By similarity.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ6R7H4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni237 – 2382Substrate bindingBy similarity
Regioni447 – 4515Substrate bindingBy similarity
Regioni660 – 6645Substrate bindingBy similarity

Sequence similaritiesi

Family and domain databases

InterProiIPR013346. NrdE_NrdA.
IPR000788. RNR_lg_C.
IPR013509. RNR_lsu_N.
IPR008926. RNR_R1-su_N.
[Graphical view]
PfamiPF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
[Graphical view]
PRINTSiPR01183. RIBORDTASEM1.
SUPFAMiSSF48168. SSF48168. 1 hit.
TIGRFAMsiTIGR02506. NrdE_NrdA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6R7H4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MACSMANAVR PGLSDLPEGV DLSNPKEVRS LLIKLTHARK STVYDTKIRR
60 70 80 90 100
LHGVIVNSIM ENYNSAEGEL DMAITPLIPS HPDYAFLAGR VSAYMTQINT
110 120 130 140 150
PKTFTDAVYG IQMAVGETNG FRSPMKPVKG GLSDEIVDFV NEHGARLDGM
160 170 180 190 200
IDDVRDYSHN YMGITGLLNG VAIKVNKKLY ERPQYVFMRV AMAMTDLSSE
210 220 230 240 250
TALEDIWQTY MLISGQCLSM ASPVLFNGGT SSSNTASCFL LDMGDNMVSI
260 270 280 290 300
TKKVAQTMTL IAKNGGIGIN FSKLRATGSK IGMAGKSSGI GGKLNLFDRV
310 320 330 340 350
AQSVDQGENK RPGAIAGYLT DWHADMYDWL YSRYSGSGNE VNKRHVLNMG
360 370 380 390 400
LVMSDLFMER VENDKEWSLF SPNDVVGLEE LYGEKFVRAY RAHEANPKIK
410 420 430 440 450
RTTVSARKLF SDIANMMWST GEPYILFKDA VNERSNHKHL GTIKNSNLCC
460 470 480 490 500
EIVQYCDTNE IAVCNLATIC VSNFVNVETG EIDFEGIADA AGVACKGINN
510 520 530 540 550
LIDKQNYDLG NEQLMRLADE RTEEVVEVNG IKFDAKYNLV SYSNLKHRPQ
560 570 580 590 600
GIGMQGLHDV FMKLKIPYDS EMAFRLAALI QEAIYYGAVR ESVKIAEEKG
610 620 630 640 650
PYPSYYWDNN THREGKLQFD FLEGFDRDRD LTHELFNWRE VLKKFEKFGI
660 670 680 690 700
NNSVVTAQPP SASSSQLNDN VESIEAITSN RFTKGIKDGK FIIINKHLQK
710 720 730 740 750
DLEDLGMWDA QMVGDIEAND GSIQNIERIP KNIREIYKTA REIDHKAVVK
760 770 780 790 800
ICAAIQPFID QTISKNMFVP KNVDNPVQLI MENVILGHKM KLKTGMYYTR
810 820 830
GIPAMKQQNF GKMNFQDKDI GKPVPELVDC EACSA
Length:835
Mass (Da):93,356
Last modified:July 5, 2004 - v1
Checksum:i4C5813635B9E5F47
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY509253 Genomic DNA. Translation: AAS00941.1.
RefSeqiYP_024594.1. NC_005881.2.

Genome annotation databases

GeneIDi2948194.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY509253 Genomic DNA. Translation: AAS00941.1 .
RefSeqi YP_024594.1. NC_005881.2.

3D structure databases

ProteinModelPortali Q6R7H4.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 2948194.

Enzyme and pathway databases

UniPathwayi UPA00326 .

Family and domain databases

InterProi IPR013346. NrdE_NrdA.
IPR000788. RNR_lg_C.
IPR013509. RNR_lsu_N.
IPR008926. RNR_R1-su_N.
[Graphical view ]
Pfami PF02867. Ribonuc_red_lgC. 1 hit.
PF00317. Ribonuc_red_lgN. 1 hit.
[Graphical view ]
PRINTSi PR01183. RIBORDTASEM1.
SUPFAMi SSF48168. SSF48168. 1 hit.
TIGRFAMsi TIGR02506. NrdE_NrdA. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Tinkering with a viral ribonucleotide reductase."
    Lembo D., Brune W.
    Trends Biochem. Sci. 34:25-32(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiRIR1_OSHVF
AccessioniPrimary (citable) accession number: Q6R7H4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3