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Q6R739

- Q6R739_HUMAN

UniProt

Q6R739 - Q6R739_HUMAN

Protein
Submitted name:

MHC class I antigen

Gene

HLA-Cw

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Involved in the presentation of foreign antigens to the immune system.SAAS annotation

    GO - Molecular functioni

    1. peptide antigen binding Source: InterPro

    GO - Biological processi

    1. antigen processing and presentation of peptide antigen via MHC class I Source: UniProtKB-KW
    2. immune response Source: InterPro
    3. positive regulation of T cell mediated cytotoxicity Source: InterPro

    Keywords - Biological processi

    Immunity

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    MHC class I antigenImported
    Gene namesi
    Name:HLA-CwImported
    Synonyms:HLA-CImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. MHC class I protein complex Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, MHC ISAAS annotation

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35057.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424 PotentialImportedAdd
    BLAST
    Chaini25 – 366342MHC class I antigenImportedPRO_5000092797Add
    BLAST

    Structurei

    3D structure databases

    SMRiQ6R739. Positions 26-298.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the MHC class I family.UniRule annotation
    Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotation

    Keywords - Domaini

    SignalImported, Transmembrane, Transmembrane helixSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG016709.
    KOiK06751.
    PhylomeDBiQ6R739.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    IPR010579. MHC_I_a_C.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    PF06623. MHC_I_C. 1 hit.
    [Graphical view]
    PRINTSiPR01638. MHCCLASSI.
    SMARTiSM00407. IGc1. 1 hit.
    [Graphical view]
    SUPFAMiSSF54452. SSF54452. 1 hit.
    PROSITEiPS50835. IG_LIKE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q6R739-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRVMAPRALL LLLSGGLALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG    50
    YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQADRV 100
    SLRNLRGYYN QSEDGSHTLQ RMSGCDLGPD GRLLRGYDQS AYDGKDYIAL 150
    NEDLRSWTAA DTAAQITQRK LEAARAAEQL RAYLEGTCVE WLRRYLENGK 200
    ETLQRAEPPK THVTHHPLSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ 250
    DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHMQHEGL QEPLTLSWEP 300
    SSQPTIPIMG IVAGLAVLVV LAVLGAVVTA MMCRRKSSGG KGGSCSQAAC 350
    SNSAQGSDES LITCKA 366
    Length:366
    Mass (Da):40,649
    Last modified:July 5, 2004 - v1
    Checksum:i59C23D95FD1D0BC8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY509618 Genomic DNA. Translation: AAR99594.1.
    FJ515904 Genomic DNA. Translation: ACL37148.1.
    FJ785731 Genomic DNA. Translation: ACN97197.1.
    FJ811898 Genomic DNA. Translation: ACO37269.1.
    GU376471 Genomic DNA. Translation: ADC79687.1.
    HM543702 Genomic DNA. Translation: ADU18054.1.
    AB679917 Genomic DNA. Translation: BAM66325.1.
    AB679918 Genomic DNA. Translation: BAM66326.1.
    AB774958 Genomic DNA. Translation: BAN59804.1.
    HG794393 Genomic DNA. Translation: CDK41202.1.
    LK021966 Genomic DNA. Translation: CDQ51647.1.
    RefSeqiNP_002108.4. NM_002117.5.
    UniGeneiHs.656020.
    Hs.743218.
    Hs.77961.

    Genome annotation databases

    GeneIDi3107.
    KEGGihsa:3107.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY509618 Genomic DNA. Translation: AAR99594.1 .
    FJ515904 Genomic DNA. Translation: ACL37148.1 .
    FJ785731 Genomic DNA. Translation: ACN97197.1 .
    FJ811898 Genomic DNA. Translation: ACO37269.1 .
    GU376471 Genomic DNA. Translation: ADC79687.1 .
    HM543702 Genomic DNA. Translation: ADU18054.1 .
    AB679917 Genomic DNA. Translation: BAM66325.1 .
    AB679918 Genomic DNA. Translation: BAM66326.1 .
    AB774958 Genomic DNA. Translation: BAN59804.1 .
    HG794393 Genomic DNA. Translation: CDK41202.1 .
    LK021966 Genomic DNA. Translation: CDQ51647.1 .
    RefSeqi NP_002108.4. NM_002117.5.
    UniGenei Hs.656020.
    Hs.743218.
    Hs.77961.

    3D structure databases

    SMRi Q6R739. Positions 26-298.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    DNASUi 3107.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3107.
    KEGGi hsa:3107.

    Organism-specific databases

    CTDi 3107.
    PharmGKBi PA35057.

    Phylogenomic databases

    HOVERGENi HBG016709.
    KOi K06751.
    PhylomeDBi Q6R739.

    Miscellaneous databases

    ChiTaRSi HLA-C. human.
    GenomeRNAii 3107.
    NextBioi 12327.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    3.30.500.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003597. Ig_C1-set.
    IPR011161. MHC_I-like_Ag-recog.
    IPR011162. MHC_I/II-like_Ag-recog.
    IPR027648. MHC_I_a.
    IPR001039. MHC_I_a_a1/a2.
    IPR010579. MHC_I_a_C.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    PF00129. MHC_I. 1 hit.
    PF06623. MHC_I_C. 1 hit.
    [Graphical view ]
    PRINTSi PR01638. MHCCLASSI.
    SMARTi SM00407. IGc1. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54452. SSF54452. 1 hit.
    PROSITEi PS50835. IG_LIKE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of novel HLA class I alleles."
      Robbins F.-M., Adams S., Barracchini K., Gress R., Stroncek D.
      Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: #30393SImported.
      Tissue: Peripheral bloodImported.
    2. "A novel HLA-Cw*04 allele, Cw*04010103, identified by genomic full length cloning and sequencing."
      Xu Y., Deng Z., Zeng J., Gao S., Wang D.
      Tissue Antigens 74:453-455(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    3. "Full-length sequence of a novel allele, HLA-Cw*070205."
      Zou H.Y., Jin S.Z., Li Z., Cheng L.H.
      Tissue Antigens 74:455-456(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    4. "HLA-Cw full length cloning and sequencing: Sequence analysis from 5' upstream region through 3' downstream region."
      Xu Y., Deng Z., Yang B.
      Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    5. "A new HLA-Cw*07 allele observed in Chinese Han."
      Zou H.-Y., Cheng L.-H., Li Z.
      Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    6. "HLA-C polymorphisms and PCR dropout in exons 2 and 3 of the Cw*0706 allele in sequence-based typing for unrelated Chinese marrow donors."
      Deng Z., Wang D., Xu Y., Gao S., Zhou H., Yu Q., Yang B.
      Hum. Immunol. 71:577-581(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    7. "Immunoscreening of cDNA expression library of Haemaphysalis longicornis unfed female tick."
      Zhang L.
      Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    8. "Analysis for complete genomic sequence of HLA-B and HLA-C alleles in the Chinese Han population."
      Zhu F., He Y., Zhang W., He J., He J., Xu X., Lv H., Yan L.
      Int. J. Immunogenet. 38:281-284(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    9. "Development of the Super high resolution Single molecule - Sequence Based Typing (SS-SBT) method for HLA class I genes."
      Suzuki S., Ozaki Y., Kikkawa E., Shigenari A., Oka A., Mitunaga S., Shiina T., Inoko H.
      Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
    10. "Phase-defined complete sequencing of the HLA genes by next-generation sequencing."
      Hosomichi K., Jinam T.A., Mitsunaga S., Nakaoka H., Inoue I.
      BMC Genomics 14:355-355(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    11. "Confirmatory sequencing of HLA-C*07:02:01:03."
      McWhinnie A.J., Robinson J.
      Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: Saliva collectionImported.
    12. "Characterisation and Confirmation of new HLA-Alleles found by DKMS Life Science Lab."
      Albrecht V., Boehme I., Schmidt A.H.
      Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ6R739_HUMAN
    AccessioniPrimary (citable) accession number: Q6R739
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 102 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.