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Q6R739 (Q6R739_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified February 19, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:HLA-Cw EMBL AAR99594.1
Synonyms:HLA-C EMBL ADU18054.1
OrganismHomo sapiens (Human) EMBL AAR99594.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length366 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the presentation of foreign antigens to the immune system By similarity. SAAS SAAS027648

Sequence similarities

Belongs to the MHC class I family. RuleBase RU004439

Contains Ig-like C1-type (immunoglobulin-like) domain. SAAS SAAS010579

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential EMBL AAR99594.1
Chain25 – 366342MHC class I antigen EMBL AAR99594.1
PRO_5000092797

Sequences

Sequence LengthMass (Da)Tools
Q6R739 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 59C23D95FD1D0BC8

FASTA36640,649
        10         20         30         40         50         60 
MRVMAPRALL LLLSGGLALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG YVDDTQFVRF 

        70         80         90        100        110        120 
DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQADRV SLRNLRGYYN QSEDGSHTLQ 

       130        140        150        160        170        180 
RMSGCDLGPD GRLLRGYDQS AYDGKDYIAL NEDLRSWTAA DTAAQITQRK LEAARAAEQL 

       190        200        210        220        230        240 
RAYLEGTCVE WLRRYLENGK ETLQRAEPPK THVTHHPLSD HEATLRCWAL GFYPAEITLT 

       250        260        270        280        290        300 
WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHMQHEGL QEPLTLSWEP 

       310        320        330        340        350        360 
SSQPTIPIMG IVAGLAVLVV LAVLGAVVTA MMCRRKSSGG KGGSCSQAAC SNSAQGSDES 


LITCKA 

« Hide

References

[1]"Identification of novel HLA class I alleles."
Robbins F.-M., Adams S., Barracchini K., Gress R., Stroncek D.
Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: #30393S EMBL AAR99594.1.
Tissue: Peripheral blood EMBL AAR99594.1.
[2]"A novel HLA-Cw*04 allele, Cw*04010103, identified by genomic full length cloning and sequencing."
Xu Y., Deng Z., Zeng J., Gao S., Wang D.
Tissue Antigens 74:453-455(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[3]"Full-length sequence of a novel allele, HLA-Cw*070205."
Zou H.Y., Jin S.Z., Li Z., Cheng L.H.
Tissue Antigens 74:455-456(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[4]"HLA-Cw full length cloning and sequencing: Sequence analysis from 5' upstream region through 3' downstream region."
Xu Y., Deng Z., Yang B.
Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[5]"A new HLA-Cw*07 allele observed in Chinese Han."
Zou H.-Y., Cheng L.-H., Li Z.
Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[6]"HLA-C polymorphisms and PCR dropout in exons 2 and 3 of the Cw*0706 allele in sequence-based typing for unrelated Chinese marrow donors."
Deng Z., Wang D., Xu Y., Gao S., Zhou H., Yu Q., Yang B.
Hum. Immunol. 71:577-581(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[7]"Immunoscreening of cDNA expression library of Haemaphysalis longicornis unfed female tick."
Zhang L.
Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[8]"Analysis for complete genomic sequence of HLA-B and HLA-C alleles in the Chinese Han population."
Zhu F., He Y., Zhang W., He J., He J., Xu X., Lv H., Yan L.
Int. J. Immunogenet. 38:281-284(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[9]"Development of the Super high resolution Single molecule - Sequence Based Typing (SS-SBT) method for HLA class I genes."
Suzuki S., Ozaki Y., Kikkawa E., Shigenari A., Oka A., Mitunaga S., Shiina T., Inoko H.
Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
[10]"Phase-defined complete sequencing of the HLA genes by next-generation sequencing."
Hosomichi K., Jinam T.A., Mitsunaga S., Nakaoka H., Inoue I.
BMC Genomics 14:355-355(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[11]"Confirmatory sequencing of HLA-C*07:02:01:03."
McWhinnie A.J., Robinson J.
Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Tissue: Saliva collection EMBL CDK41202.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY509618 Genomic DNA. Translation: AAR99594.1.
FJ515904 Genomic DNA. Translation: ACL37148.1.
FJ785731 Genomic DNA. Translation: ACN97197.1.
FJ811898 Genomic DNA. Translation: ACO37269.1.
GU376471 Genomic DNA. Translation: ADC79687.1.
HM543702 Genomic DNA. Translation: ADU18054.1.
AB679917 Genomic DNA. Translation: BAM66325.1.
AB679918 Genomic DNA. Translation: BAM66326.1.
AB774958 Genomic DNA. Translation: BAN59804.1.
HG794393 Genomic DNA. Translation: CDK41202.1.
RefSeqNP_002108.4. NM_002117.5.
UniGeneHs.656020.
Hs.743218.
Hs.77961.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

DNASU3107.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID3107.
KEGGhsa:3107.

Organism-specific databases

CTD3107.
PharmGKBPA35057.

Phylogenomic databases

HOVERGENHBG016709.
KOK06751.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSPR01638. MHCCLASSI.
SMARTSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMSSF54452. SSF54452. 1 hit.
PROSITEPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHLA-C. human.
GenomeRNAi3107.
NextBio12327.

Entry information

Entry nameQ6R739_HUMAN
AccessionPrimary (citable) accession number: Q6R739
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.