Q6R739 (Q6R739_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
MHC class I antigen EMBL AAR99594.1

Gene names

Name:	HLA-Cw EMBL AAR99594.1
Synonyms:	HLA-C EMBL ADU18054.1

Organism

Homo sapiens (Human) EMBL AAR99594.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in the presentation of foreign antigens to the immune system By similarity. SAAS SAAS010579
Sequence similarities	Belongs to the MHC class I family. RuleBase RU004439 Contains 1 Ig-like C1-type (immunoglobulin-like) domain. SAAS SAAS010579

Ontologies

Keywords
Biological process	Immunity
Cellular component	MHC I SAAS SAAS010579 Membrane
Domain	Signal EMBL AAR99594.1 Transmembrane Transmembrane helix SAAS SAAS010579
Gene Ontology (GO)
Biological_process	antigen processing and presentation of peptide antigen via MHC class I Inferred from electronic annotation. Source: UniProtKB-KW immune response Inferred from electronic annotation. Source: InterPro
Cellular_component	MHC class I protein complex Inferred from electronic annotation. Source: UniProtKB-KW integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 24	24	Potential EMBL AAR99594.1
	Chain	25 – 366	342	MHC class I antigen EMBL AAR99594.1		PRO_5000092797

Sequences

	Sequence		Length	Mass (Da)
	Q6R739 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 59C23D95FD1D0BC8	FASTA	366	40,649
	10 20 30 40 50 60 MRVMAPRALL LLLSGGLALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG YVDDTQFVRF 70 80 90 100 110 120 DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQADRV SLRNLRGYYN QSEDGSHTLQ 130 140 150 160 170 180 RMSGCDLGPD GRLLRGYDQS AYDGKDYIAL NEDLRSWTAA DTAAQITQRK LEAARAAEQL 190 200 210 220 230 240 RAYLEGTCVE WLRRYLENGK ETLQRAEPPK THVTHHPLSD HEATLRCWAL GFYPAEITLT 250 260 270 280 290 300 WQRDGEDQTQ DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHMQHEGL QEPLTLSWEP 310 320 330 340 350 360 SSQPTIPIMG IVAGLAVLVV LAVLGAVVTA MMCRRKSSGG KGGSCSQAAC SNSAQGSDES LITCKA

References

[1]	"Identification of novel HLA class I alleles." Robbins F.-M., Adams S., Barracchini K., Gress R., Stroncek D. Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: #30393S EMBL AAR99594.1. Tissue: Peripheral blood EMBL AAR99594.1.
[2]	"A novel HLA-Cw*04 allele, Cw*04010103, identified by genomic full length cloning and sequencing." Xu Y., Deng Z., Zeng J., Gao S., Wang D. Tissue Antigens 74:453-455(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[3]	"Full-length sequence of a novel allele, HLA-Cw*070205." Zou H.Y., Jin S.Z., Li Z., Cheng L.H. Tissue Antigens 74:455-456(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[4]	"HLA-Cw full length cloning and sequencing: Sequence analysis from 5' upstream region through 3' downstream region." Xu Y., Deng Z., Yang B. Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[5]	"A new HLA-Cw*07 allele observed in Chinese Han." Zou H.-Y., Cheng L.-H., Li Z. Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[6]	"HLA-C polymorphisms and PCR dropout in exons 2 and 3 of the Cw*0706 allele in sequence-based typing for unrelated Chinese marrow donors." Deng Z., Wang D., Xu Y., Gao S., Zhou H., Yu Q., Yang B. Hum. Immunol. 71:577-581(2010) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[7]	"Immunoscreening of cDNA expression library of Haemaphysalis longicornis unfed female tick." Zhang L. Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
[8]	"Analysis for complete genomic sequence of HLA-B and HLA-C alleles in the Chinese Han population." Zhu F., He Y., Zhang W., He J., He J., Xu X., Lv H., Yan L. Int. J. Immunogenet. 38:281-284(2011) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[9]	"Development of the Super high resolution Single molecule - Sequence Based Typing (SS-SBT) method for HLA class I genes." Suzuki S., Ozaki Y., Kikkawa E., Shigenari A., Oka A., Mitunaga S., Shiina T., Inoko H. Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY509618 Genomic DNA. Translation: AAR99594.1. FJ515904 Genomic DNA. Translation: ACL37148.1. FJ785731 Genomic DNA. Translation: ACN97197.1. FJ811898 Genomic DNA. Translation: ACO37269.1. GU376471 Genomic DNA. Translation: ADC79687.1. HM543702 Genomic DNA. Translation: ADU18054.1. AB679917 Genomic DNA. Translation: BAM66325.1. AB679918 Genomic DNA. Translation: BAM66326.1.
IPI	IPI00642409.
RefSeq	NP_002108.4. NM_002117.5.
UniGene	Hs.654404. Hs.656020.
3D structure databases
HSSP	HSSP built from PDB template 1B0R based on UniProtKB Q9TQH5.
ProteinModelPortal	Q6R739.
ModBase	Search...
Protein-protein interaction databases
STRING	Q6R739.
Proteomic databases
PRIDE	Q6R739.
Protocols and materials databases
DNASU	3107.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3107.
KEGG	hsa:3107.
Organism-specific databases
CTD	3107.
PharmGKB	PA35057.
Phylogenomic databases
HOVERGEN	HBG016709.
KO	K06751.
PhylomeDB	Q6R739.
Gene expression databases
ArrayExpress	Q6R739.
Family and domain databases
Gene3D	2.60.40.10. 1 hit. 3.30.500.10. 1 hit.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003597. Ig_C1-set. IPR011161. MHC_I-like_Ag-recog. IPR011162. MHC_I/II-like_Ag-recog. IPR001039. MHC_I_a_a1/a2. IPR010579. MHC_I_a_C. [Graphical view]
Pfam	PF07654. C1-set. 1 hit. PF00129. MHC_I. 1 hit. PF06623. MHC_I_C. 1 hit. [Graphical view]
PRINTS	PR01638. MHCCLASSI.
SMART	SM00407. IGc1. 1 hit. [Graphical view]
SUPFAM	SSF54452. MHC_I/II-like_Ag-recog. 1 hit.
PROSITE	PS50835. IG_LIKE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	HLA-C. human.
GenomeRNAi	3107.
NextBio	12327.

Entry information

Entry name

Q6R739_HUMAN

Accession

Primary (citable) accession number: Q6R739

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.