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Protein
Submitted name:

HLA class I antigen

Gene

HLA-Cw

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in the presentation of foreign antigens to the immune system.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Submitted name:
HLA class I antigenImported
Submitted name:
HLA-C proteinImported
Submitted name:
MHC class I antigenImported
Gene namesi
Name:HLA-CwImported
Synonyms:HLA-CImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC ISAAS annotation

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35057.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 PotentialImportedAdd
BLAST
Chaini25 – 366342MHC class I antigenImportedPRO_5000092797Add
BLAST

Expressioni

Gene expression databases

ExpressionAtlasiQ6R739. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ6R739.
SMRiQ6R739. Positions 26-298.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotation
Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotation

Keywords - Domaini

SignalImported, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00760000118960.
HOVERGENiHBG016709.
KOiK06751.
PhylomeDBiQ6R739.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6R739-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVMAPRALL LLLSGGLALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG
60 70 80 90 100
YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQADRV
110 120 130 140 150
SLRNLRGYYN QSEDGSHTLQ RMSGCDLGPD GRLLRGYDQS AYDGKDYIAL
160 170 180 190 200
NEDLRSWTAA DTAAQITQRK LEAARAAEQL RAYLEGTCVE WLRRYLENGK
210 220 230 240 250
ETLQRAEPPK THVTHHPLSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ
260 270 280 290 300
DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHMQHEGL QEPLTLSWEP
310 320 330 340 350
SSQPTIPIMG IVAGLAVLVV LAVLGAVVTA MMCRRKSSGG KGGSCSQAAC
360
SNSAQGSDES LITCKA
Length:366
Mass (Da):40,649
Last modified:July 5, 2004 - v1
Checksum:i59C23D95FD1D0BC8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY509618 Genomic DNA. Translation: AAR99594.1.
FJ515904 Genomic DNA. Translation: ACL37148.1.
FJ785731 Genomic DNA. Translation: ACN97197.1.
FJ811898 Genomic DNA. Translation: ACO37269.1.
GU376471 Genomic DNA. Translation: ADC79687.1.
HM543702 Genomic DNA. Translation: ADU18054.1.
AB679917 Genomic DNA. Translation: BAM66325.1.
AB679918 Genomic DNA. Translation: BAM66326.1.
AB774958 Genomic DNA. Translation: BAN59804.1.
HG794393 Genomic DNA. Translation: CDK41202.1.
LK021966 Genomic DNA. Translation: CDQ51647.1.
LN600106 Genomic DNA. Translation: CEF48096.1.
LN811474 Genomic DNA. Translation: CEP25301.1.
LN811513 Genomic DNA. Translation: CEP25340.1.
RefSeqiNP_002108.4. NM_002117.5.
UniGeneiHs.656020.
Hs.743218.
Hs.77961.

Genome annotation databases

GeneIDi3107.
KEGGihsa:3107.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY509618 Genomic DNA. Translation: AAR99594.1.
FJ515904 Genomic DNA. Translation: ACL37148.1.
FJ785731 Genomic DNA. Translation: ACN97197.1.
FJ811898 Genomic DNA. Translation: ACO37269.1.
GU376471 Genomic DNA. Translation: ADC79687.1.
HM543702 Genomic DNA. Translation: ADU18054.1.
AB679917 Genomic DNA. Translation: BAM66325.1.
AB679918 Genomic DNA. Translation: BAM66326.1.
AB774958 Genomic DNA. Translation: BAN59804.1.
HG794393 Genomic DNA. Translation: CDK41202.1.
LK021966 Genomic DNA. Translation: CDQ51647.1.
LN600106 Genomic DNA. Translation: CEF48096.1.
LN811474 Genomic DNA. Translation: CEP25301.1.
LN811513 Genomic DNA. Translation: CEP25340.1.
RefSeqiNP_002108.4. NM_002117.5.
UniGeneiHs.656020.
Hs.743218.
Hs.77961.

3D structure databases

ProteinModelPortaliQ6R739.
SMRiQ6R739. Positions 26-298.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

DNASUi3107.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3107.
KEGGihsa:3107.

Organism-specific databases

CTDi3107.
PharmGKBiPA35057.

Phylogenomic databases

GeneTreeiENSGT00760000118960.
HOVERGENiHBG016709.
KOiK06751.
PhylomeDBiQ6R739.

Miscellaneous databases

ChiTaRSiHLA-C. human.
GenomeRNAii3107.
NextBioi12327.

Gene expression databases

ExpressionAtlasiQ6R739. baseline and differential.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of novel HLA class I alleles."
    Robbins F.-M., Adams S., Barracchini K., Gress R., Stroncek D.
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: #30393SImported.
    Tissue: Peripheral bloodImported.
  2. "A novel HLA-Cw*04 allele, Cw*04010103, identified by genomic full length cloning and sequencing."
    Xu Y., Deng Z., Zeng J., Gao S., Wang D.
    Tissue Antigens 74:453-455(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Full-length sequence of a novel allele, HLA-Cw*070205."
    Zou H.Y., Jin S.Z., Li Z., Cheng L.H.
    Tissue Antigens 74:455-456(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  4. "HLA-Cw full length cloning and sequencing: Sequence analysis from 5' upstream region through 3' downstream region."
    Xu Y., Deng Z., Yang B.
    Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  5. "A new HLA-Cw*07 allele observed in Chinese Han."
    Zou H.-Y., Cheng L.-H., Li Z.
    Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  6. "HLA-C polymorphisms and PCR dropout in exons 2 and 3 of the Cw*0706 allele in sequence-based typing for unrelated Chinese marrow donors."
    Deng Z., Wang D., Xu Y., Gao S., Zhou H., Yu Q., Yang B.
    Hum. Immunol. 71:577-581(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  7. "Immunoscreening of cDNA expression library of Haemaphysalis longicornis unfed female tick."
    Zhang L.
    Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  8. "Analysis for complete genomic sequence of HLA-B and HLA-C alleles in the Chinese Han population."
    Zhu F., He Y., Zhang W., He J., He J., Xu X., Lv H., Yan L.
    Int. J. Immunogenet. 38:281-284(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  9. "Development of the Super high resolution Single molecule - Sequence Based Typing (SS-SBT) method for HLA class I genes."
    Suzuki S., Ozaki Y., Kikkawa E., Shigenari A., Oka A., Mitunaga S., Shiina T., Inoko H.
    Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  10. "Phase-defined complete sequencing of the HLA genes by next-generation sequencing."
    Hosomichi K., Jinam T.A., Mitsunaga S., Nakaoka H., Inoue I.
    BMC Genomics 14:355-355(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  11. "Confirmatory sequencing of HLA-C*07:02:01:03."
    McWhinnie A.J., Robinson J.
    Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Saliva collectionImported.
  12. "Characterisation and Confirmation of new HLA-Alleles found by DKMS Life Science Lab."
    Albrecht V., Boehme I., Schmidt A.H.
    Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  13. "Characterisation and Confirmation of new HLA-Alleles found by DKMS Life Science Lab."
    Albrecht V., Boehme I., Schmidt A.H.
    Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  14. "Characterisation and Confirmation of new HLA-Alleles found by DKMS Life Science Lab."
    Albrecht V., Boehme I., Schmidt A.H.
    Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ6R739_HUMAN
AccessioniPrimary (citable) accession number: Q6R739
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 27, 2015
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.