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Q6R739

- Q6R739_HUMAN

UniProt

Q6R739 - Q6R739_HUMAN

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Protein
Submitted name: MHC class I antigen
Gene
HLA-Cw, HLA-C
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Involved in the presentation of foreign antigens to the immune system By similarity.SAAS annotations

GO - Molecular functioni

  1. peptide antigen binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. antigen processing and presentation of peptide antigen via MHC class I Source: UniProtKB-KW
  2. immune response Source: InterPro
  3. positive regulation of T cell mediated cytotoxicity Source: InterPro
Complete GO annotation...

Keywords - Biological processi

Immunity

Names & Taxonomyi

Protein namesi
Submitted name:
MHC class I antigenImported
Gene namesi
Name:HLA-CwImported
Synonyms:HLA-CImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. MHC class I protein complex Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, MHC ISAAS annotations

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35057.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 PredictedImported
Add
BLAST
Chaini25 – 366342MHC class I antigenImported
PRO_5000092797Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the MHC class I family.UniRule annotation
Contains Ig-like C1-type (immunoglobulin-like) domain.SAAS annotations

Keywords - Domaini

SignalImported, Transmembrane, Transmembrane helixSAAS annotations

Phylogenomic databases

HOVERGENiHBG016709.
KOiK06751.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view]
PRINTSiPR01638. MHCCLASSI.
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF54452. SSF54452. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6R739-1 [UniParc]FASTAAdd to Basket

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MRVMAPRALL LLLSGGLALT ETWACSHSMR YFDTAVSRPG RGEPRFISVG    50
YVDDTQFVRF DSDAASPRGE PRAPWVEQEG PEYWDRETQK YKRQAQADRV 100
SLRNLRGYYN QSEDGSHTLQ RMSGCDLGPD GRLLRGYDQS AYDGKDYIAL 150
NEDLRSWTAA DTAAQITQRK LEAARAAEQL RAYLEGTCVE WLRRYLENGK 200
ETLQRAEPPK THVTHHPLSD HEATLRCWAL GFYPAEITLT WQRDGEDQTQ 250
DTELVETRPA GDGTFQKWAA VVVPSGQEQR YTCHMQHEGL QEPLTLSWEP 300
SSQPTIPIMG IVAGLAVLVV LAVLGAVVTA MMCRRKSSGG KGGSCSQAAC 350
SNSAQGSDES LITCKA 366
Length:366
Mass (Da):40,649
Last modified:July 5, 2004 - v1
Checksum:i59C23D95FD1D0BC8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY509618 Genomic DNA. Translation: AAR99594.1.
FJ515904 Genomic DNA. Translation: ACL37148.1.
FJ785731 Genomic DNA. Translation: ACN97197.1.
FJ811898 Genomic DNA. Translation: ACO37269.1.
GU376471 Genomic DNA. Translation: ADC79687.1.
HM543702 Genomic DNA. Translation: ADU18054.1.
AB679917 Genomic DNA. Translation: BAM66325.1.
AB679918 Genomic DNA. Translation: BAM66326.1.
AB774958 Genomic DNA. Translation: BAN59804.1.
HG794393 Genomic DNA. Translation: CDK41202.1.
LK021966 Genomic DNA. Translation: CDQ51647.1.
RefSeqiNP_002108.4. NM_002117.5.
UniGeneiHs.656020.
Hs.743218.
Hs.77961.

Genome annotation databases

GeneIDi3107.
KEGGihsa:3107.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY509618 Genomic DNA. Translation: AAR99594.1 .
FJ515904 Genomic DNA. Translation: ACL37148.1 .
FJ785731 Genomic DNA. Translation: ACN97197.1 .
FJ811898 Genomic DNA. Translation: ACO37269.1 .
GU376471 Genomic DNA. Translation: ADC79687.1 .
HM543702 Genomic DNA. Translation: ADU18054.1 .
AB679917 Genomic DNA. Translation: BAM66325.1 .
AB679918 Genomic DNA. Translation: BAM66326.1 .
AB774958 Genomic DNA. Translation: BAN59804.1 .
HG794393 Genomic DNA. Translation: CDK41202.1 .
LK021966 Genomic DNA. Translation: CDQ51647.1 .
RefSeqi NP_002108.4. NM_002117.5.
UniGenei Hs.656020.
Hs.743218.
Hs.77961.

3D structure databases

ModBasei Search...

Protocols and materials databases

DNASUi 3107.
Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 3107.
KEGGi hsa:3107.

Organism-specific databases

CTDi 3107.
PharmGKBi PA35057.

Phylogenomic databases

HOVERGENi HBG016709.
KOi K06751.

Miscellaneous databases

ChiTaRSi HLA-C. human.
GenomeRNAii 3107.
NextBioi 12327.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
3.30.500.10. 1 hit.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003597. Ig_C1-set.
IPR011161. MHC_I-like_Ag-recog.
IPR011162. MHC_I/II-like_Ag-recog.
IPR027648. MHC_I_a.
IPR001039. MHC_I_a_a1/a2.
IPR010579. MHC_I_a_C.
[Graphical view ]
Pfami PF07654. C1-set. 1 hit.
PF00129. MHC_I. 1 hit.
PF06623. MHC_I_C. 1 hit.
[Graphical view ]
PRINTSi PR01638. MHCCLASSI.
SMARTi SM00407. IGc1. 1 hit.
[Graphical view ]
SUPFAMi SSF54452. SSF54452. 1 hit.
PROSITEi PS50835. IG_LIKE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of novel HLA class I alleles."
    Robbins F.-M., Adams S., Barracchini K., Gress R., Stroncek D.
    Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: #30393SImported.
    Tissue: Peripheral bloodImported.
  2. "A novel HLA-Cw*04 allele, Cw*04010103, identified by genomic full length cloning and sequencing."
    Xu Y., Deng Z., Zeng J., Gao S., Wang D.
    Tissue Antigens 74:453-455(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  3. "Full-length sequence of a novel allele, HLA-Cw*070205."
    Zou H.Y., Jin S.Z., Li Z., Cheng L.H.
    Tissue Antigens 74:455-456(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  4. "HLA-Cw full length cloning and sequencing: Sequence analysis from 5' upstream region through 3' downstream region."
    Xu Y., Deng Z., Yang B.
    Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  5. "A new HLA-Cw*07 allele observed in Chinese Han."
    Zou H.-Y., Cheng L.-H., Li Z.
    Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  6. "HLA-C polymorphisms and PCR dropout in exons 2 and 3 of the Cw*0706 allele in sequence-based typing for unrelated Chinese marrow donors."
    Deng Z., Wang D., Xu Y., Gao S., Zhou H., Yu Q., Yang B.
    Hum. Immunol. 71:577-581(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  7. "Immunoscreening of cDNA expression library of Haemaphysalis longicornis unfed female tick."
    Zhang L.
    Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  8. "Analysis for complete genomic sequence of HLA-B and HLA-C alleles in the Chinese Han population."
    Zhu F., He Y., Zhang W., He J., He J., Xu X., Lv H., Yan L.
    Int. J. Immunogenet. 38:281-284(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  9. "Development of the Super high resolution Single molecule - Sequence Based Typing (SS-SBT) method for HLA class I genes."
    Suzuki S., Ozaki Y., Kikkawa E., Shigenari A., Oka A., Mitunaga S., Shiina T., Inoko H.
    Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
  10. "Phase-defined complete sequencing of the HLA genes by next-generation sequencing."
    Hosomichi K., Jinam T.A., Mitsunaga S., Nakaoka H., Inoue I.
    BMC Genomics 14:355-355(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  11. "Confirmatory sequencing of HLA-C*07:02:01:03."
    McWhinnie A.J., Robinson J.
    Submitted (NOV-2013) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: Saliva collectionImported.
  12. "Characterisation and Confirmation of new HLA-Alleles found by DKMS Life Science Lab."
    Albrecht V., Boehme I., Schmidt A.H.
    Submitted (APR-2014) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ6R739_HUMAN
AccessioniPrimary (citable) accession number: Q6R739
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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