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Protein

Relaxin receptor 1

Gene

Rxfp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi45Calcium; via carbonyl oxygenBy similarity1
Metal bindingi48CalciumBy similarity1
Metal bindingi50Calcium; via carbonyl oxygenBy similarity1
Metal bindingi52CalciumBy similarity1
Metal bindingi58CalciumBy similarity1
Metal bindingi59CalciumBy similarity1

GO - Molecular functioni

  • G-protein coupled receptor activity Source: MGI
  • hormone binding Source: MGI
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: MGI
  • cell differentiation Source: MGI
  • extracellular matrix organization Source: MGI
  • lung connective tissue development Source: MGI
  • nipple morphogenesis Source: MGI
  • parturition Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.
R-MMU-444821. Relaxin receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Relaxin receptor 1
Alternative name(s):
Leucine-rich repeat-containing G-protein coupled receptor 7
Relaxin family peptide receptor 1
Gene namesi
Name:Rxfp1
Synonyms:Gm1018, Lgr7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2682211. Rxfp1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 409ExtracellularSequence analysisAdd BLAST409
Transmembranei410 – 430Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini431 – 443CytoplasmicSequence analysisAdd BLAST13
Transmembranei444 – 464Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini465 – 486ExtracellularSequence analysisAdd BLAST22
Transmembranei487 – 507Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini508 – 527CytoplasmicSequence analysisAdd BLAST20
Transmembranei528 – 548Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini549 – 577ExtracellularSequence analysisAdd BLAST29
Transmembranei578 – 598Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini599 – 629CytoplasmicSequence analysisAdd BLAST31
Transmembranei630 – 650Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini651ExtracellularSequence analysis1
Transmembranei652 – 672Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini673 – 758CytoplasmicSequence analysisAdd BLAST86

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003038871 – 758Relaxin receptor 1Add BLAST758

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 40By similarity
Disulfide bondi34 ↔ 53By similarity
Glycosylationi36N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi47 ↔ 62By similarity
Glycosylationi127N-linked (GlcNAc...)Sequence analysis1
Glycosylationi264N-linked (GlcNAc...)Sequence analysis1
Glycosylationi272N-linked (GlcNAc...)Sequence analysis1
Glycosylationi325N-linked (GlcNAc...)Sequence analysis1
Glycosylationi368N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi485 ↔ 563By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ6R6I7.
PaxDbiQ6R6I7.
PeptideAtlasiQ6R6I7.
PRIDEiQ6R6I7.

PTM databases

PhosphoSitePlusiQ6R6I7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034009.
CleanExiMM_RXFP1.
ExpressionAtlasiQ6R6I7. baseline and differential.
GenevisibleiQ6R6I7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077611.

Structurei

3D structure databases

ProteinModelPortaliQ6R6I7.
SMRiQ6R6I7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 63LDL-receptor class APROSITE-ProRule annotationAdd BLAST38
Repeati127 – 148LRR 1Add BLAST22
Repeati151 – 172LRR 2Add BLAST22
Repeati175 – 196LRR 3Add BLAST22
Repeati199 – 220LRR 4Add BLAST22
Repeati223 – 244LRR 5Add BLAST22
Repeati248 – 269LRR 6Add BLAST22
Repeati272 – 293LRR 7Add BLAST22
Repeati296 – 317LRR 8Add BLAST22
Repeati320 – 341LRR 9Add BLAST22
Repeati344 – 365LRR 10Add BLAST22

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Contains 1 LDL-receptor class A domain.PROSITE-ProRule annotation
Contains 10 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
KOG2087. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119088.
HOGENOMiHOG000049056.
HOVERGENiHBG026354.
InParanoidiQ6R6I7.
KOiK04306.
OMAiTRPFKEM.
OrthoDBiEOG091G01UA.
PhylomeDBiQ6R6I7.
TreeFamiTF326185.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
4.10.400.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR032675. L_dom-like.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR008112. Relaxin_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF00057. Ldl_recept_a. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01739. RELAXINR.
SMARTiSM00192. LDLa. 1 hit.
SM00369. LRR_TYP. 10 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF57424. SSF57424. 1 hit.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS51450. LRR. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6R6I7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSGPFFFCI FIIGKYFTLG SAQDVSCPLG SFPCGNMSRC LPQLLHCNGV
60 70 80 90 100
DDCGNRADED HCGDNNGWSL QLDKYFANYY KLASTNSFEA ETSECLVGSV
110 120 130 140 150
PMHCLCRDLE LDCDEANLRA VPSVSSNVTV MSLQRNFIRT LPPNGFRKYH
160 170 180 190 200
ELQKLCLQNN RIHSVSVSAF RGLRSLTKLY LSHNRITFLK PGVFEDLHRL
210 220 230 240 250
EWLIIEDNHL SRISPLTFYG LNSLILLVLM NNALTRLPDK PLCQHMPRLH
260 270 280 290 300
WLDFEGNRIH NLRNLTFISC NNLTVLVMRK NKINYLNEHA FTHLQKLDEL
310 320 330 340 350
DLGSNKIENL PPNIFKDLKE LSQLNISYNP IQKIEVNQFD CLAKLKSLSL
360 370 380 390 400
EGIEISNIQQ RMFRPLINLS HIYFKKFQYC GYAPHVRSCK PNTDGISSLE
410 420 430 440 450
NLLASIIQRV FVWVVSAITC FGNIFVICMR PYIRSENKLH AMSIISLCCA
460 470 480 490 500
DCLMGVYLFV IGAFDLKFRG EYNKHAQPWM ESVHCQFMGS LAILSTEVSV
510 520 530 540 550
LLLTFLTLEK YICIVYPFRC LRPRKCRTIT VLIFIWIIGF IVAFAPLGNK
560 570 580 590 600
EFFKNYYGTN GVCFPLHSED TGSTGAQIYS VVIFLGINLV AFIIIVFSYG
610 620 630 640 650
SMFYSVHQSS VTVTEIQKQV KKEVVLAKRF FFIVFTDALC WIPIFILKFL
660 670 680 690 700
SLLQVEIPDS ITSWVVIFIL PINSALNPII YTLTTRPFKE MIHQLWHNYR
710 720 730 740 750
QRRSVDRKET QKAYAPSFIW VEMWPLQEMS SGFMKPGAFT DPCDLSLVSQ

SSRLNSYS
Length:758
Mass (Da):86,957
Last modified:July 5, 2004 - v1
Checksum:i10D62BE70EC336E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY509975 mRNA. Translation: AAR97515.1.
AY255542 mRNA. Translation: AAO85054.1.
CCDSiCCDS17420.1.
RefSeqiNP_997617.1. NM_212452.1.
UniGeneiMm.331086.

Genome annotation databases

EnsembliENSMUST00000078527; ENSMUSP00000077611; ENSMUSG00000034009.
GeneIDi381489.
KEGGimmu:381489.
UCSCiuc008pnv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY509975 mRNA. Translation: AAR97515.1.
AY255542 mRNA. Translation: AAO85054.1.
CCDSiCCDS17420.1.
RefSeqiNP_997617.1. NM_212452.1.
UniGeneiMm.331086.

3D structure databases

ProteinModelPortaliQ6R6I7.
SMRiQ6R6I7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077611.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ6R6I7.

Proteomic databases

MaxQBiQ6R6I7.
PaxDbiQ6R6I7.
PeptideAtlasiQ6R6I7.
PRIDEiQ6R6I7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000078527; ENSMUSP00000077611; ENSMUSG00000034009.
GeneIDi381489.
KEGGimmu:381489.
UCSCiuc008pnv.1. mouse.

Organism-specific databases

CTDi59350.
MGIiMGI:2682211. Rxfp1.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
KOG2087. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119088.
HOGENOMiHOG000049056.
HOVERGENiHBG026354.
InParanoidiQ6R6I7.
KOiK04306.
OMAiTRPFKEM.
OrthoDBiEOG091G01UA.
PhylomeDBiQ6R6I7.
TreeFamiTF326185.

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.
R-MMU-444821. Relaxin receptors.

Miscellaneous databases

ChiTaRSiRxfp1. mouse.
PROiQ6R6I7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034009.
CleanExiMM_RXFP1.
ExpressionAtlasiQ6R6I7. baseline and differential.
GenevisibleiQ6R6I7. MM.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
4.10.400.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR032675. L_dom-like.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR008112. Relaxin_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF00057. Ldl_recept_a. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01739. RELAXINR.
SMARTiSM00192. LDLa. 1 hit.
SM00369. LRR_TYP. 10 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF57424. SSF57424. 1 hit.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS51450. LRR. 10 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRXFP1_MOUSE
AccessioniPrimary (citable) accession number: Q6R6I7
Secondary accession number(s): Q80UD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.