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Q6R6I7

- RXFP1_MOUSE

UniProt

Q6R6I7 - RXFP1_MOUSE

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Protein

Relaxin receptor 1

Gene
Rxfp1, Gm1018, Lgr7
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi45 – 451Calcium; via carbonyl oxygen By similarity
Metal bindingi48 – 481Calcium By similarity
Metal bindingi50 – 501Calcium; via carbonyl oxygen By similarity
Metal bindingi52 – 521Calcium By similarity
Metal bindingi58 – 581Calcium By similarity
Metal bindingi59 – 591Calcium By similarity

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: MGI
  2. hormone binding Source: MGI
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: MGI
  2. cell differentiation Source: MGI
  3. extracellular matrix organization Source: MGI
  4. lung connective tissue development Source: MGI
  5. nipple morphogenesis Source: MGI
  6. parturition Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_198713. Relaxin receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Relaxin receptor 1
Alternative name(s):
Leucine-rich repeat-containing G-protein coupled receptor 7
Relaxin family peptide receptor 1
Gene namesi
Name:Rxfp1
Synonyms:Gm1018, Lgr7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:2682211. Rxfp1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 409409Extracellular Reviewed predictionAdd
BLAST
Transmembranei410 – 43021Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini431 – 44313Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei444 – 46421Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini465 – 48622Extracellular Reviewed predictionAdd
BLAST
Transmembranei487 – 50721Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini508 – 52720Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei528 – 54821Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini549 – 57729Extracellular Reviewed predictionAdd
BLAST
Transmembranei578 – 59821Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini599 – 62931Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei630 – 65021Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini651 – 6511Extracellular Reviewed prediction
Transmembranei652 – 67221Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini673 – 75886Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 758758Relaxin receptor 1PRO_0000303887Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 40 By similarity
Disulfide bondi34 ↔ 53 By similarity
Glycosylationi36 – 361N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi47 ↔ 62 By similarity
Glycosylationi127 – 1271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi264 – 2641N-linked (GlcNAc...) Reviewed prediction
Glycosylationi272 – 2721N-linked (GlcNAc...) Reviewed prediction
Glycosylationi325 – 3251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi368 – 3681N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi485 ↔ 563 By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ6R6I7.

PTM databases

PhosphoSiteiQ6R6I7.

Expressioni

Gene expression databases

BgeeiQ6R6I7.
CleanExiMM_RXFP1.
GenevestigatoriQ6R6I7.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077611.

Structurei

3D structure databases

ProteinModelPortaliQ6R6I7.
SMRiQ6R6I7. Positions 22-63, 66-714.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 6338LDL-receptor class AAdd
BLAST
Repeati127 – 14822LRR 1Add
BLAST
Repeati151 – 17222LRR 2Add
BLAST
Repeati175 – 19622LRR 3Add
BLAST
Repeati199 – 22022LRR 4Add
BLAST
Repeati223 – 24422LRR 5Add
BLAST
Repeati248 – 26922LRR 6Add
BLAST
Repeati272 – 29322LRR 7Add
BLAST
Repeati296 – 31722LRR 8Add
BLAST
Repeati320 – 34122LRR 9Add
BLAST
Repeati344 – 36522LRR 10Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00730000110698.
HOGENOMiHOG000049056.
HOVERGENiHBG026354.
InParanoidiQ6R6I7.
KOiK04306.
OMAiTRPFKEM.
OrthoDBiEOG77DJ5W.
PhylomeDBiQ6R6I7.
TreeFamiTF326185.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
4.10.400.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
IPR008112. Relaxin_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF00057. Ldl_recept_a. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01739. RELAXINR.
SMARTiSM00192. LDLa. 1 hit.
SM00369. LRR_TYP. 2 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF57424. SSF57424. 1 hit.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS51450. LRR. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6R6I7-1 [UniParc]FASTAAdd to Basket

« Hide

MTSGPFFFCI FIIGKYFTLG SAQDVSCPLG SFPCGNMSRC LPQLLHCNGV    50
DDCGNRADED HCGDNNGWSL QLDKYFANYY KLASTNSFEA ETSECLVGSV 100
PMHCLCRDLE LDCDEANLRA VPSVSSNVTV MSLQRNFIRT LPPNGFRKYH 150
ELQKLCLQNN RIHSVSVSAF RGLRSLTKLY LSHNRITFLK PGVFEDLHRL 200
EWLIIEDNHL SRISPLTFYG LNSLILLVLM NNALTRLPDK PLCQHMPRLH 250
WLDFEGNRIH NLRNLTFISC NNLTVLVMRK NKINYLNEHA FTHLQKLDEL 300
DLGSNKIENL PPNIFKDLKE LSQLNISYNP IQKIEVNQFD CLAKLKSLSL 350
EGIEISNIQQ RMFRPLINLS HIYFKKFQYC GYAPHVRSCK PNTDGISSLE 400
NLLASIIQRV FVWVVSAITC FGNIFVICMR PYIRSENKLH AMSIISLCCA 450
DCLMGVYLFV IGAFDLKFRG EYNKHAQPWM ESVHCQFMGS LAILSTEVSV 500
LLLTFLTLEK YICIVYPFRC LRPRKCRTIT VLIFIWIIGF IVAFAPLGNK 550
EFFKNYYGTN GVCFPLHSED TGSTGAQIYS VVIFLGINLV AFIIIVFSYG 600
SMFYSVHQSS VTVTEIQKQV KKEVVLAKRF FFIVFTDALC WIPIFILKFL 650
SLLQVEIPDS ITSWVVIFIL PINSALNPII YTLTTRPFKE MIHQLWHNYR 700
QRRSVDRKET QKAYAPSFIW VEMWPLQEMS SGFMKPGAFT DPCDLSLVSQ 750
SSRLNSYS 758
Length:758
Mass (Da):86,957
Last modified:July 5, 2004 - v1
Checksum:i10D62BE70EC336E6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY509975 mRNA. Translation: AAR97515.1.
AY255542 mRNA. Translation: AAO85054.1.
CCDSiCCDS17420.1.
RefSeqiNP_997617.1. NM_212452.1.
UniGeneiMm.331086.

Genome annotation databases

EnsembliENSMUST00000078527; ENSMUSP00000077611; ENSMUSG00000034009.
GeneIDi381489.
KEGGimmu:381489.
UCSCiuc008pnv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY509975 mRNA. Translation: AAR97515.1 .
AY255542 mRNA. Translation: AAO85054.1 .
CCDSi CCDS17420.1.
RefSeqi NP_997617.1. NM_212452.1.
UniGenei Mm.331086.

3D structure databases

ProteinModelPortali Q6R6I7.
SMRi Q6R6I7. Positions 22-63, 66-714.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000077611.

Chemistry

GuidetoPHARMACOLOGYi 351.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q6R6I7.

Proteomic databases

PRIDEi Q6R6I7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000078527 ; ENSMUSP00000077611 ; ENSMUSG00000034009 .
GeneIDi 381489.
KEGGi mmu:381489.
UCSCi uc008pnv.1. mouse.

Organism-specific databases

CTDi 59350.
MGIi MGI:2682211. Rxfp1.

Phylogenomic databases

eggNOGi COG4886.
GeneTreei ENSGT00730000110698.
HOGENOMi HOG000049056.
HOVERGENi HBG026354.
InParanoidi Q6R6I7.
KOi K04306.
OMAi TRPFKEM.
OrthoDBi EOG77DJ5W.
PhylomeDBi Q6R6I7.
TreeFami TF326185.

Enzyme and pathway databases

Reactomei REACT_198713. Relaxin receptors.

Miscellaneous databases

ChiTaRSi RXFP1. mouse.
NextBioi 402138.
PROi Q6R6I7.
SOURCEi Search...

Gene expression databases

Bgeei Q6R6I7.
CleanExi MM_RXFP1.
Genevestigatori Q6R6I7.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
4.10.400.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
IPR008112. Relaxin_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
PF00057. Ldl_recept_a. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01739. RELAXINR.
SMARTi SM00192. LDLa. 1 hit.
SM00369. LRR_TYP. 2 hits.
SM00013. LRRNT. 1 hit.
[Graphical view ]
SUPFAMi SSF57424. SSF57424. 1 hit.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS51450. LRR. 10 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of the mouse and rat relaxin receptors as the novel orthologues of human leucine-rich repeat-containing G-protein-coupled receptor 7."
    Scott D.J., Layfield S., Riesewijk A., Morita H., Tregear G.W., Bathgate R.A.D.
    Clin. Exp. Pharmacol. Physiol. 31:828-832(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: C57BL/6J.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 389-420.

Entry informationi

Entry nameiRXFP1_MOUSE
AccessioniPrimary (citable) accession number: Q6R6I7
Secondary accession number(s): Q80UD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 5, 2004
Last modified: September 3, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi