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Q6R6I7

- RXFP1_MOUSE

UniProt

Q6R6I7 - RXFP1_MOUSE

Protein

Relaxin receptor 1

Gene

Rxfp1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi45 – 451Calcium; via carbonyl oxygenBy similarity
    Metal bindingi48 – 481CalciumBy similarity
    Metal bindingi50 – 501Calcium; via carbonyl oxygenBy similarity
    Metal bindingi52 – 521CalciumBy similarity
    Metal bindingi58 – 581CalciumBy similarity
    Metal bindingi59 – 591CalciumBy similarity

    GO - Molecular functioni

    1. G-protein coupled receptor activity Source: MGI
    2. hormone binding Source: MGI
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: MGI
    2. cell differentiation Source: MGI
    3. extracellular matrix organization Source: MGI
    4. lung connective tissue development Source: MGI
    5. nipple morphogenesis Source: MGI
    6. parturition Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_198713. Relaxin receptors.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Relaxin receptor 1
    Alternative name(s):
    Leucine-rich repeat-containing G-protein coupled receptor 7
    Relaxin family peptide receptor 1
    Gene namesi
    Name:Rxfp1
    Synonyms:Gm1018, Lgr7
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:2682211. Rxfp1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 758758Relaxin receptor 1PRO_0000303887Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi27 ↔ 40By similarity
    Disulfide bondi34 ↔ 53By similarity
    Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi47 ↔ 62By similarity
    Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi272 – 2721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi325 – 3251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi368 – 3681N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi485 ↔ 563By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiQ6R6I7.

    PTM databases

    PhosphoSiteiQ6R6I7.

    Expressioni

    Gene expression databases

    BgeeiQ6R6I7.
    CleanExiMM_RXFP1.
    GenevestigatoriQ6R6I7.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000077611.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6R6I7.
    SMRiQ6R6I7. Positions 22-63, 66-714.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 409409ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini431 – 44313CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini465 – 48622ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini508 – 52720CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini549 – 57729ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini599 – 62931CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini651 – 6511ExtracellularSequence Analysis
    Topological domaini673 – 75886CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei410 – 43021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei444 – 46421Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei487 – 50721Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei528 – 54821Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei578 – 59821Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei630 – 65021Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei652 – 67221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 6338LDL-receptor class APROSITE-ProRule annotationAdd
    BLAST
    Repeati127 – 14822LRR 1Add
    BLAST
    Repeati151 – 17222LRR 2Add
    BLAST
    Repeati175 – 19622LRR 3Add
    BLAST
    Repeati199 – 22022LRR 4Add
    BLAST
    Repeati223 – 24422LRR 5Add
    BLAST
    Repeati248 – 26922LRR 6Add
    BLAST
    Repeati272 – 29322LRR 7Add
    BLAST
    Repeati296 – 31722LRR 8Add
    BLAST
    Repeati320 – 34122LRR 9Add
    BLAST
    Repeati344 – 36522LRR 10Add
    BLAST

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
    Contains 1 LDL-receptor class A domain.PROSITE-ProRule annotation
    Contains 10 LRR (leucine-rich) repeats.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG4886.
    GeneTreeiENSGT00730000110698.
    HOGENOMiHOG000049056.
    HOVERGENiHBG026354.
    InParanoidiQ6R6I7.
    KOiK04306.
    OMAiTRPFKEM.
    OrthoDBiEOG77DJ5W.
    PhylomeDBiQ6R6I7.
    TreeFamiTF326185.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    4.10.400.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR023415. LDLR_class-A_CS.
    IPR002172. LDrepeatLR_classA_rpt.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    IPR008112. Relaxin_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    PF00057. Ldl_recept_a. 1 hit.
    PF13855. LRR_8. 3 hits.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01739. RELAXINR.
    SMARTiSM00192. LDLa. 1 hit.
    SM00369. LRR_TYP. 2 hits.
    SM00013. LRRNT. 1 hit.
    [Graphical view]
    SUPFAMiSSF57424. SSF57424. 1 hit.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    PS01209. LDLRA_1. 1 hit.
    PS50068. LDLRA_2. 1 hit.
    PS51450. LRR. 10 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6R6I7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSGPFFFCI FIIGKYFTLG SAQDVSCPLG SFPCGNMSRC LPQLLHCNGV    50
    DDCGNRADED HCGDNNGWSL QLDKYFANYY KLASTNSFEA ETSECLVGSV 100
    PMHCLCRDLE LDCDEANLRA VPSVSSNVTV MSLQRNFIRT LPPNGFRKYH 150
    ELQKLCLQNN RIHSVSVSAF RGLRSLTKLY LSHNRITFLK PGVFEDLHRL 200
    EWLIIEDNHL SRISPLTFYG LNSLILLVLM NNALTRLPDK PLCQHMPRLH 250
    WLDFEGNRIH NLRNLTFISC NNLTVLVMRK NKINYLNEHA FTHLQKLDEL 300
    DLGSNKIENL PPNIFKDLKE LSQLNISYNP IQKIEVNQFD CLAKLKSLSL 350
    EGIEISNIQQ RMFRPLINLS HIYFKKFQYC GYAPHVRSCK PNTDGISSLE 400
    NLLASIIQRV FVWVVSAITC FGNIFVICMR PYIRSENKLH AMSIISLCCA 450
    DCLMGVYLFV IGAFDLKFRG EYNKHAQPWM ESVHCQFMGS LAILSTEVSV 500
    LLLTFLTLEK YICIVYPFRC LRPRKCRTIT VLIFIWIIGF IVAFAPLGNK 550
    EFFKNYYGTN GVCFPLHSED TGSTGAQIYS VVIFLGINLV AFIIIVFSYG 600
    SMFYSVHQSS VTVTEIQKQV KKEVVLAKRF FFIVFTDALC WIPIFILKFL 650
    SLLQVEIPDS ITSWVVIFIL PINSALNPII YTLTTRPFKE MIHQLWHNYR 700
    QRRSVDRKET QKAYAPSFIW VEMWPLQEMS SGFMKPGAFT DPCDLSLVSQ 750
    SSRLNSYS 758
    Length:758
    Mass (Da):86,957
    Last modified:July 5, 2004 - v1
    Checksum:i10D62BE70EC336E6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY509975 mRNA. Translation: AAR97515.1.
    AY255542 mRNA. Translation: AAO85054.1.
    CCDSiCCDS17420.1.
    RefSeqiNP_997617.1. NM_212452.1.
    UniGeneiMm.331086.

    Genome annotation databases

    EnsembliENSMUST00000078527; ENSMUSP00000077611; ENSMUSG00000034009.
    GeneIDi381489.
    KEGGimmu:381489.
    UCSCiuc008pnv.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY509975 mRNA. Translation: AAR97515.1 .
    AY255542 mRNA. Translation: AAO85054.1 .
    CCDSi CCDS17420.1.
    RefSeqi NP_997617.1. NM_212452.1.
    UniGenei Mm.331086.

    3D structure databases

    ProteinModelPortali Q6R6I7.
    SMRi Q6R6I7. Positions 22-63, 66-714.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000077611.

    Chemistry

    GuidetoPHARMACOLOGYi 351.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q6R6I7.

    Proteomic databases

    PRIDEi Q6R6I7.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000078527 ; ENSMUSP00000077611 ; ENSMUSG00000034009 .
    GeneIDi 381489.
    KEGGi mmu:381489.
    UCSCi uc008pnv.1. mouse.

    Organism-specific databases

    CTDi 59350.
    MGIi MGI:2682211. Rxfp1.

    Phylogenomic databases

    eggNOGi COG4886.
    GeneTreei ENSGT00730000110698.
    HOGENOMi HOG000049056.
    HOVERGENi HBG026354.
    InParanoidi Q6R6I7.
    KOi K04306.
    OMAi TRPFKEM.
    OrthoDBi EOG77DJ5W.
    PhylomeDBi Q6R6I7.
    TreeFami TF326185.

    Enzyme and pathway databases

    Reactomei REACT_198713. Relaxin receptors.

    Miscellaneous databases

    ChiTaRSi RXFP1. mouse.
    NextBioi 402138.
    PROi Q6R6I7.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6R6I7.
    CleanExi MM_RXFP1.
    Genevestigatori Q6R6I7.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    4.10.400.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR023415. LDLR_class-A_CS.
    IPR002172. LDrepeatLR_classA_rpt.
    IPR001611. Leu-rich_rpt.
    IPR003591. Leu-rich_rpt_typical-subtyp.
    IPR000372. LRR-contain_N.
    IPR008112. Relaxin_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    PF00057. Ldl_recept_a. 1 hit.
    PF13855. LRR_8. 3 hits.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01739. RELAXINR.
    SMARTi SM00192. LDLa. 1 hit.
    SM00369. LRR_TYP. 2 hits.
    SM00013. LRRNT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF57424. SSF57424. 1 hit.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    PS01209. LDLRA_1. 1 hit.
    PS50068. LDLRA_2. 1 hit.
    PS51450. LRR. 10 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and characterization of the mouse and rat relaxin receptors as the novel orthologues of human leucine-rich repeat-containing G-protein-coupled receptor 7."
      Scott D.J., Layfield S., Riesewijk A., Morita H., Tregear G.W., Bathgate R.A.D.
      Clin. Exp. Pharmacol. Physiol. 31:828-832(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
      Strain: C57BL/6J.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 389-420.

    Entry informationi

    Entry nameiRXFP1_MOUSE
    AccessioniPrimary (citable) accession number: Q6R6I7
    Secondary accession number(s): Q80UD3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 11, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 86 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3