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Protein

Relaxin receptor 1

Gene

Rxfp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi45 – 451Calcium; via carbonyl oxygenBy similarity
Metal bindingi48 – 481CalciumBy similarity
Metal bindingi50 – 501Calcium; via carbonyl oxygenBy similarity
Metal bindingi52 – 521CalciumBy similarity
Metal bindingi58 – 581CalciumBy similarity
Metal bindingi59 – 591CalciumBy similarity

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: MGI
  2. hormone binding Source: MGI
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: MGI
  2. cell differentiation Source: MGI
  3. extracellular matrix organization Source: MGI
  4. lung connective tissue development Source: MGI
  5. nipple morphogenesis Source: MGI
  6. parturition Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_198713. Relaxin receptors.
REACT_242871. G alpha (s) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Relaxin receptor 1
Alternative name(s):
Leucine-rich repeat-containing G-protein coupled receptor 7
Relaxin family peptide receptor 1
Gene namesi
Name:Rxfp1
Synonyms:Gm1018, Lgr7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:2682211. Rxfp1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 409409ExtracellularSequence AnalysisAdd
BLAST
Transmembranei410 – 43021Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini431 – 44313CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei444 – 46421Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini465 – 48622ExtracellularSequence AnalysisAdd
BLAST
Transmembranei487 – 50721Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini508 – 52720CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei528 – 54821Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini549 – 57729ExtracellularSequence AnalysisAdd
BLAST
Transmembranei578 – 59821Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini599 – 62931CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei630 – 65021Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini651 – 6511ExtracellularSequence Analysis
Transmembranei652 – 67221Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini673 – 75886CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 758758Relaxin receptor 1PRO_0000303887Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 40By similarity
Disulfide bondi34 ↔ 53By similarity
Glycosylationi36 – 361N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi47 ↔ 62By similarity
Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence Analysis
Glycosylationi272 – 2721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi325 – 3251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi368 – 3681N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi485 ↔ 563By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ6R6I7.
PRIDEiQ6R6I7.

PTM databases

PhosphoSiteiQ6R6I7.

Expressioni

Gene expression databases

BgeeiQ6R6I7.
CleanExiMM_RXFP1.
ExpressionAtlasiQ6R6I7. baseline and differential.
GenevestigatoriQ6R6I7.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077611.

Structurei

3D structure databases

ProteinModelPortaliQ6R6I7.
SMRiQ6R6I7. Positions 22-63, 66-714.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 6338LDL-receptor class APROSITE-ProRule annotationAdd
BLAST
Repeati127 – 14822LRR 1Add
BLAST
Repeati151 – 17222LRR 2Add
BLAST
Repeati175 – 19622LRR 3Add
BLAST
Repeati199 – 22022LRR 4Add
BLAST
Repeati223 – 24422LRR 5Add
BLAST
Repeati248 – 26922LRR 6Add
BLAST
Repeati272 – 29322LRR 7Add
BLAST
Repeati296 – 31722LRR 8Add
BLAST
Repeati320 – 34122LRR 9Add
BLAST
Repeati344 – 36522LRR 10Add
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Contains 1 LDL-receptor class A domain.PROSITE-ProRule annotation
Contains 10 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00760000119088.
HOGENOMiHOG000049056.
HOVERGENiHBG026354.
InParanoidiQ6R6I7.
KOiK04306.
OMAiTRPFKEM.
OrthoDBiEOG77DJ5W.
PhylomeDBiQ6R6I7.
TreeFamiTF326185.

Family and domain databases

Gene3Di4.10.400.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
IPR008112. Relaxin_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF00057. Ldl_recept_a. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01739. RELAXINR.
SMARTiSM00192. LDLa. 1 hit.
SM00369. LRR_TYP. 2 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF57424. SSF57424. 1 hit.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS51450. LRR. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6R6I7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSGPFFFCI FIIGKYFTLG SAQDVSCPLG SFPCGNMSRC LPQLLHCNGV
60 70 80 90 100
DDCGNRADED HCGDNNGWSL QLDKYFANYY KLASTNSFEA ETSECLVGSV
110 120 130 140 150
PMHCLCRDLE LDCDEANLRA VPSVSSNVTV MSLQRNFIRT LPPNGFRKYH
160 170 180 190 200
ELQKLCLQNN RIHSVSVSAF RGLRSLTKLY LSHNRITFLK PGVFEDLHRL
210 220 230 240 250
EWLIIEDNHL SRISPLTFYG LNSLILLVLM NNALTRLPDK PLCQHMPRLH
260 270 280 290 300
WLDFEGNRIH NLRNLTFISC NNLTVLVMRK NKINYLNEHA FTHLQKLDEL
310 320 330 340 350
DLGSNKIENL PPNIFKDLKE LSQLNISYNP IQKIEVNQFD CLAKLKSLSL
360 370 380 390 400
EGIEISNIQQ RMFRPLINLS HIYFKKFQYC GYAPHVRSCK PNTDGISSLE
410 420 430 440 450
NLLASIIQRV FVWVVSAITC FGNIFVICMR PYIRSENKLH AMSIISLCCA
460 470 480 490 500
DCLMGVYLFV IGAFDLKFRG EYNKHAQPWM ESVHCQFMGS LAILSTEVSV
510 520 530 540 550
LLLTFLTLEK YICIVYPFRC LRPRKCRTIT VLIFIWIIGF IVAFAPLGNK
560 570 580 590 600
EFFKNYYGTN GVCFPLHSED TGSTGAQIYS VVIFLGINLV AFIIIVFSYG
610 620 630 640 650
SMFYSVHQSS VTVTEIQKQV KKEVVLAKRF FFIVFTDALC WIPIFILKFL
660 670 680 690 700
SLLQVEIPDS ITSWVVIFIL PINSALNPII YTLTTRPFKE MIHQLWHNYR
710 720 730 740 750
QRRSVDRKET QKAYAPSFIW VEMWPLQEMS SGFMKPGAFT DPCDLSLVSQ

SSRLNSYS
Length:758
Mass (Da):86,957
Last modified:July 5, 2004 - v1
Checksum:i10D62BE70EC336E6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY509975 mRNA. Translation: AAR97515.1.
AY255542 mRNA. Translation: AAO85054.1.
CCDSiCCDS17420.1.
RefSeqiNP_997617.1. NM_212452.1.
UniGeneiMm.331086.

Genome annotation databases

EnsembliENSMUST00000078527; ENSMUSP00000077611; ENSMUSG00000034009.
GeneIDi381489.
KEGGimmu:381489.
UCSCiuc008pnv.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY509975 mRNA. Translation: AAR97515.1.
AY255542 mRNA. Translation: AAO85054.1.
CCDSiCCDS17420.1.
RefSeqiNP_997617.1. NM_212452.1.
UniGeneiMm.331086.

3D structure databases

ProteinModelPortaliQ6R6I7.
SMRiQ6R6I7. Positions 22-63, 66-714.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000077611.

Chemistry

GuidetoPHARMACOLOGYi351.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ6R6I7.

Proteomic databases

MaxQBiQ6R6I7.
PRIDEiQ6R6I7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000078527; ENSMUSP00000077611; ENSMUSG00000034009.
GeneIDi381489.
KEGGimmu:381489.
UCSCiuc008pnv.1. mouse.

Organism-specific databases

CTDi59350.
MGIiMGI:2682211. Rxfp1.

Phylogenomic databases

eggNOGiCOG4886.
GeneTreeiENSGT00760000119088.
HOGENOMiHOG000049056.
HOVERGENiHBG026354.
InParanoidiQ6R6I7.
KOiK04306.
OMAiTRPFKEM.
OrthoDBiEOG77DJ5W.
PhylomeDBiQ6R6I7.
TreeFamiTF326185.

Enzyme and pathway databases

ReactomeiREACT_198713. Relaxin receptors.
REACT_242871. G alpha (s) signalling events.

Miscellaneous databases

ChiTaRSiRxfp1. mouse.
NextBioi402138.
PROiQ6R6I7.
SOURCEiSearch...

Gene expression databases

BgeeiQ6R6I7.
CleanExiMM_RXFP1.
ExpressionAtlasiQ6R6I7. baseline and differential.
GenevestigatoriQ6R6I7.

Family and domain databases

Gene3Di4.10.400.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
IPR008112. Relaxin_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF00057. Ldl_recept_a. 1 hit.
PF13855. LRR_8. 3 hits.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01739. RELAXINR.
SMARTiSM00192. LDLa. 1 hit.
SM00369. LRR_TYP. 2 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMiSSF57424. SSF57424. 1 hit.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS51450. LRR. 10 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and characterization of the mouse and rat relaxin receptors as the novel orthologues of human leucine-rich repeat-containing G-protein-coupled receptor 7."
    Scott D.J., Layfield S., Riesewijk A., Morita H., Tregear G.W., Bathgate R.A.D.
    Clin. Exp. Pharmacol. Physiol. 31:828-832(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: C57BL/6J.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 389-420.

Entry informationi

Entry nameiRXFP1_MOUSE
AccessioniPrimary (citable) accession number: Q6R6I7
Secondary accession number(s): Q80UD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: July 5, 2004
Last modified: January 7, 2015
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.