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Protein

Relaxin receptor 1

Gene

Rxfp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi45 – 451Calcium; via carbonyl oxygenBy similarity
Metal bindingi48 – 481CalciumBy similarity
Metal bindingi50 – 501Calcium; via carbonyl oxygenBy similarity
Metal bindingi52 – 521CalciumBy similarity
Metal bindingi58 – 581CalciumBy similarity
Metal bindingi59 – 591CalciumBy similarity

GO - Molecular functioni

  • G-protein coupled receptor activity Source: RGD
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Relaxin receptor 1
Alternative name(s):
Leucine-rich repeat-containing G-protein coupled receptor 7
Relaxin family peptide receptor 1
Gene namesi
Name:Rxfp1
Synonyms:Lgr7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1302973. Rxfp1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 408408ExtracellularSequence analysisAdd
BLAST
Transmembranei409 – 42921Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini430 – 44314CytoplasmicSequence analysisAdd
BLAST
Transmembranei444 – 46421Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini465 – 48622ExtracellularSequence analysisAdd
BLAST
Transmembranei487 – 50721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini508 – 52720CytoplasmicSequence analysisAdd
BLAST
Transmembranei528 – 54821Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini549 – 57729ExtracellularSequence analysisAdd
BLAST
Transmembranei578 – 59821Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini599 – 62931CytoplasmicSequence analysisAdd
BLAST
Transmembranei630 – 65021Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini651 – 66010ExtracellularSequence analysis
Transmembranei661 – 68121Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini682 – 75877CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 758758Relaxin receptor 1PRO_0000312669Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi27 ↔ 40By similarity
Disulfide bondi34 ↔ 53By similarity
Glycosylationi36 – 361N-linked (GlcNAc...)Sequence analysis
Disulfide bondi47 ↔ 62By similarity
Glycosylationi127 – 1271N-linked (GlcNAc...)Sequence analysis
Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence analysis
Glycosylationi272 – 2721N-linked (GlcNAc...)Sequence analysis
Glycosylationi325 – 3251N-linked (GlcNAc...)Sequence analysis
Glycosylationi368 – 3681N-linked (GlcNAc...)Sequence analysis
Disulfide bondi485 ↔ 563By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6R6I6.
PRIDEiQ6R6I6.

PTM databases

PhosphoSiteiQ6R6I6.

Expressioni

Tissue specificityi

Detected in brain cortex, and at low levels in testis.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000033541.

Structurei

3D structure databases

ProteinModelPortaliQ6R6I6.
SMRiQ6R6I6. Positions 22-63.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 6338LDL-receptor class APROSITE-ProRule annotationAdd
BLAST
Repeati105 – 12521LRR 1Add
BLAST
Repeati126 – 14823LRR 2Add
BLAST
Repeati149 – 17224LRR 3Add
BLAST
Repeati173 – 19624LRR 4Add
BLAST
Repeati198 – 22023LRR 5Add
BLAST
Repeati221 – 24424LRR 6Add
BLAST
Repeati246 – 26924LRR 7Add
BLAST
Repeati270 – 29324LRR 8Add
BLAST
Repeati294 – 31724LRR 9Add
BLAST
Repeati319 – 34123LRR 10Add
BLAST
Repeati342 – 36524LRR 11Add
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Contains 1 LDL-receptor class A domain.PROSITE-ProRule annotation
Contains 11 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
KOG2087. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000049056.
HOVERGENiHBG026354.
InParanoidiQ6R6I6.
KOiK04306.
PhylomeDBiQ6R6I6.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
4.10.400.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR032675. L_dom-like.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR008112. Relaxin_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF00057. Ldl_recept_a. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01739. RELAXINR.
SMARTiSM00192. LDLa. 1 hit.
SM00369. LRR_TYP. 10 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF57424. SSF57424. 1 hit.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS51450. LRR. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6R6I6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSGPFFFCV FIIGRYFTLG NAQDVSCPLG SFPCGNISKC LPQLLHCNGV
60 70 80 90 100
DDCGNQADED NCGDNNGWSL QLDKYFANYY KLTSTNSIEA ETSECLVGSV
110 120 130 140 150
PMHCLCRDLE LDCDEANLRA VPSVSSNVTV MSLQWNFIRT LPPNSFRKYH
160 170 180 190 200
DLQKLCLQNN KIRSVSVSAF RGLHSLTKLY LSHNRITFLK PGVFEDLHRL
210 220 230 240 250
EWLIIEDNHL SRISPLTFYG LNSLILLVLM NNALTRLPDK PLCQHMPRLH
260 270 280 290 300
WLDFEGNRIH NLRNLTFISC NNLTVLVMRK NKINHLNEHA FTHLQKLDEL
310 320 330 340 350
DLGSNKIENL PPNIFKDLKE LSQLNISYNP IQKIEVNQFD YLAKLKSLSL
360 370 380 390 400
EGIEISNIQQ RMFRPLINLS HIYFKKFQYC GYAPHVRSCK PNTDGISSLE
410 420 430 440 450
NLLASIIQRV FVWVVSAITC FGNIFVICMR PYIRSENKLH AMSIMSLCCA
460 470 480 490 500
DCLMGVYLFV IGAFDLKFRG EYRKHAQPWM ESVHCQFMGS LAVLSTEVSV
510 520 530 540 550
LLLTFLTLEK YICIVYPFRC LRPRKCRTVA VLIFIWITGF IVAFAPLGNK
560 570 580 590 600
EFFKNYYGTN GVCFPLHSED TGSTGAQIYS VVIFLGINLV AFIIIVFSYG
610 620 630 640 650
SMFYSVHQST ITATEIQKQV KKEMILAKRF FFIVFTDALC WIPIFILKFL
660 670 680 690 700
SLIRVEIPDT ITSWVVIFIL PINSALNPII YTLTTRPFKE MIHQLWYNYR
710 720 730 740 750
QRRSVDRKGT QKAYTPSFIW VEMWPLQEMS TEFMKPDAFT DPCDLSLVSR

SSRLNSYS
Length:758
Mass (Da):87,183
Last modified:July 5, 2004 - v1
Checksum:i85C2A295A5C0195B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY509976 mRNA. Translation: AAR97516.1.
RefSeqiNP_958820.1. NM_201417.1.
UniGeneiRn.109230.

Genome annotation databases

GeneIDi295144.
KEGGirno:295144.
UCSCiRGD:1302973. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY509976 mRNA. Translation: AAR97516.1.
RefSeqiNP_958820.1. NM_201417.1.
UniGeneiRn.109230.

3D structure databases

ProteinModelPortaliQ6R6I6.
SMRiQ6R6I6. Positions 22-63.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000033541.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSiteiQ6R6I6.

Proteomic databases

PaxDbiQ6R6I6.
PRIDEiQ6R6I6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi295144.
KEGGirno:295144.
UCSCiRGD:1302973. rat.

Organism-specific databases

CTDi59350.
RGDi1302973. Rxfp1.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
KOG2087. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000049056.
HOVERGENiHBG026354.
InParanoidiQ6R6I6.
KOiK04306.
PhylomeDBiQ6R6I6.

Miscellaneous databases

PROiQ6R6I6.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
4.10.400.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR032675. L_dom-like.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR008112. Relaxin_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF00057. Ldl_recept_a. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01739. RELAXINR.
SMARTiSM00192. LDLa. 1 hit.
SM00369. LRR_TYP. 10 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF57424. SSF57424. 1 hit.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS51450. LRR. 10 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRXFP1_RAT
AccessioniPrimary (citable) accession number: Q6R6I6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.