Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Relaxin receptor 1

Gene

Rxfp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi45Calcium; via carbonyl oxygenBy similarity1
Metal bindingi48CalciumBy similarity1
Metal bindingi50Calcium; via carbonyl oxygenBy similarity1
Metal bindingi52CalciumBy similarity1
Metal bindingi58CalciumBy similarity1
Metal bindingi59CalciumBy similarity1

GO - Molecular functioni

  • G-protein coupled receptor activity Source: RGD
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: RGD

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Relaxin receptor 1
Alternative name(s):
Leucine-rich repeat-containing G-protein coupled receptor 7
Relaxin family peptide receptor 1
Gene namesi
Name:Rxfp1
Synonyms:Lgr7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1302973 Rxfp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 408ExtracellularSequence analysisAdd BLAST408
Transmembranei409 – 429Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini430 – 443CytoplasmicSequence analysisAdd BLAST14
Transmembranei444 – 464Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini465 – 486ExtracellularSequence analysisAdd BLAST22
Transmembranei487 – 507Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini508 – 527CytoplasmicSequence analysisAdd BLAST20
Transmembranei528 – 548Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini549 – 577ExtracellularSequence analysisAdd BLAST29
Transmembranei578 – 598Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini599 – 629CytoplasmicSequence analysisAdd BLAST31
Transmembranei630 – 650Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini651 – 660ExtracellularSequence analysis10
Transmembranei661 – 681Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini682 – 758CytoplasmicSequence analysisAdd BLAST77

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003126691 – 758Relaxin receptor 1Add BLAST758

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 40By similarity
Disulfide bondi34 ↔ 53By similarity
Glycosylationi36N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi47 ↔ 62By similarity
Glycosylationi127N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi264N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi272N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi325N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi368N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi485 ↔ 563By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6R6I6
PRIDEiQ6R6I6

PTM databases

PhosphoSitePlusiQ6R6I6

Expressioni

Tissue specificityi

Detected in brain cortex, and at low levels in testis.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000033541

Structurei

3D structure databases

ProteinModelPortaliQ6R6I6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 63LDL-receptor class APROSITE-ProRule annotationAdd BLAST38
Repeati105 – 125LRR 1Add BLAST21
Repeati126 – 148LRR 2Add BLAST23
Repeati149 – 172LRR 3Add BLAST24
Repeati173 – 196LRR 4Add BLAST24
Repeati198 – 220LRR 5Add BLAST23
Repeati221 – 244LRR 6Add BLAST24
Repeati246 – 269LRR 7Add BLAST24
Repeati270 – 293LRR 8Add BLAST24
Repeati294 – 317LRR 9Add BLAST24
Repeati319 – 341LRR 10Add BLAST23
Repeati342 – 365LRR 11Add BLAST24

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
KOG2087 Eukaryota
COG4886 LUCA
HOGENOMiHOG000049056
HOVERGENiHBG026354
InParanoidiQ6R6I6
KOiK04306
PhylomeDBiQ6R6I6

Family and domain databases

CDDicd00112 LDLa, 1 hit
Gene3Di3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR036055 LDL_receptor-like_sf
IPR023415 LDLR_class-A_CS
IPR002172 LDrepeatLR_classA_rpt
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR008112 Relaxin_rcpt
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PF00057 Ldl_recept_a, 1 hit
PF13855 LRR_8, 2 hits
PRINTSiPR00237 GPCRRHODOPSN
PR01739 RELAXINR
SMARTiView protein in SMART
SM00192 LDLa, 1 hit
SM00369 LRR_TYP, 10 hits
SUPFAMiSSF57424 SSF57424, 1 hit
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
PS01209 LDLRA_1, 1 hit
PS50068 LDLRA_2, 1 hit
PS51450 LRR, 10 hits

Sequencei

Sequence statusi: Complete.

Q6R6I6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSGPFFFCV FIIGRYFTLG NAQDVSCPLG SFPCGNISKC LPQLLHCNGV
60 70 80 90 100
DDCGNQADED NCGDNNGWSL QLDKYFANYY KLTSTNSIEA ETSECLVGSV
110 120 130 140 150
PMHCLCRDLE LDCDEANLRA VPSVSSNVTV MSLQWNFIRT LPPNSFRKYH
160 170 180 190 200
DLQKLCLQNN KIRSVSVSAF RGLHSLTKLY LSHNRITFLK PGVFEDLHRL
210 220 230 240 250
EWLIIEDNHL SRISPLTFYG LNSLILLVLM NNALTRLPDK PLCQHMPRLH
260 270 280 290 300
WLDFEGNRIH NLRNLTFISC NNLTVLVMRK NKINHLNEHA FTHLQKLDEL
310 320 330 340 350
DLGSNKIENL PPNIFKDLKE LSQLNISYNP IQKIEVNQFD YLAKLKSLSL
360 370 380 390 400
EGIEISNIQQ RMFRPLINLS HIYFKKFQYC GYAPHVRSCK PNTDGISSLE
410 420 430 440 450
NLLASIIQRV FVWVVSAITC FGNIFVICMR PYIRSENKLH AMSIMSLCCA
460 470 480 490 500
DCLMGVYLFV IGAFDLKFRG EYRKHAQPWM ESVHCQFMGS LAVLSTEVSV
510 520 530 540 550
LLLTFLTLEK YICIVYPFRC LRPRKCRTVA VLIFIWITGF IVAFAPLGNK
560 570 580 590 600
EFFKNYYGTN GVCFPLHSED TGSTGAQIYS VVIFLGINLV AFIIIVFSYG
610 620 630 640 650
SMFYSVHQST ITATEIQKQV KKEMILAKRF FFIVFTDALC WIPIFILKFL
660 670 680 690 700
SLIRVEIPDT ITSWVVIFIL PINSALNPII YTLTTRPFKE MIHQLWYNYR
710 720 730 740 750
QRRSVDRKGT QKAYTPSFIW VEMWPLQEMS TEFMKPDAFT DPCDLSLVSR

SSRLNSYS
Length:758
Mass (Da):87,183
Last modified:July 5, 2004 - v1
Checksum:i85C2A295A5C0195B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY509976 mRNA Translation: AAR97516.1
RefSeqiNP_958820.1, NM_201417.1
UniGeneiRn.109230

Genome annotation databases

GeneIDi295144
KEGGirno:295144
UCSCiRGD:1302973 rat

Similar proteinsi

Entry informationi

Entry nameiRXFP1_RAT
AccessioniPrimary (citable) accession number: Q6R6I6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health