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Q6R6I6 (RXFP1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Relaxin receptor 1
Alternative name(s):
Leucine-rich repeat-containing G-protein coupled receptor 7
Relaxin family peptide receptor 1
Gene names
Name:Rxfp1
Synonyms:Lgr7
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length758 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP By similarity. Ref.1

Subcellular location

Cell membrane; Multi-pass membrane protein Ref.1.

Tissue specificity

Detected in brain cortex, and at low levels in testis. Ref.1

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Contains 1 LDL-receptor class A domain.

Contains 11 LRR (leucine-rich) repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 758758Relaxin receptor 1
PRO_0000312669

Regions

Topological domain1 – 408408Extracellular Potential
Transmembrane409 – 42921Helical; Name=1; Potential
Topological domain430 – 44314Cytoplasmic Potential
Transmembrane444 – 46421Helical; Name=2; Potential
Topological domain465 – 48622Extracellular Potential
Transmembrane487 – 50721Helical; Name=3; Potential
Topological domain508 – 52720Cytoplasmic Potential
Transmembrane528 – 54821Helical; Name=4; Potential
Topological domain549 – 57729Extracellular Potential
Transmembrane578 – 59821Helical; Name=5; Potential
Topological domain599 – 62931Cytoplasmic Potential
Transmembrane630 – 65021Helical; Name=6; Potential
Topological domain651 – 66010Extracellular Potential
Transmembrane661 – 68121Helical; Name=7; Potential
Topological domain682 – 75877Cytoplasmic Potential
Domain26 – 6338LDL-receptor class A
Repeat105 – 12521LRR 1
Repeat126 – 14823LRR 2
Repeat149 – 17224LRR 3
Repeat173 – 19624LRR 4
Repeat198 – 22023LRR 5
Repeat221 – 24424LRR 6
Repeat246 – 26924LRR 7
Repeat270 – 29324LRR 8
Repeat294 – 31724LRR 9
Repeat319 – 34123LRR 10
Repeat342 – 36524LRR 11

Sites

Metal binding451Calcium; via carbonyl oxygen By similarity
Metal binding481Calcium By similarity
Metal binding501Calcium; via carbonyl oxygen By similarity
Metal binding521Calcium By similarity
Metal binding581Calcium By similarity
Metal binding591Calcium By similarity

Amino acid modifications

Glycosylation361N-linked (GlcNAc...) Potential
Glycosylation1271N-linked (GlcNAc...) Potential
Glycosylation2641N-linked (GlcNAc...) Potential
Glycosylation2721N-linked (GlcNAc...) Potential
Glycosylation3251N-linked (GlcNAc...) Potential
Glycosylation3681N-linked (GlcNAc...) Potential
Disulfide bond27 ↔ 40 By similarity
Disulfide bond34 ↔ 53 By similarity
Disulfide bond47 ↔ 62 By similarity
Disulfide bond485 ↔ 563 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6R6I6 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 85C2A295A5C0195B

FASTA75887,183
        10         20         30         40         50         60 
MTSGPFFFCV FIIGRYFTLG NAQDVSCPLG SFPCGNISKC LPQLLHCNGV DDCGNQADED 

        70         80         90        100        110        120 
NCGDNNGWSL QLDKYFANYY KLTSTNSIEA ETSECLVGSV PMHCLCRDLE LDCDEANLRA 

       130        140        150        160        170        180 
VPSVSSNVTV MSLQWNFIRT LPPNSFRKYH DLQKLCLQNN KIRSVSVSAF RGLHSLTKLY 

       190        200        210        220        230        240 
LSHNRITFLK PGVFEDLHRL EWLIIEDNHL SRISPLTFYG LNSLILLVLM NNALTRLPDK 

       250        260        270        280        290        300 
PLCQHMPRLH WLDFEGNRIH NLRNLTFISC NNLTVLVMRK NKINHLNEHA FTHLQKLDEL 

       310        320        330        340        350        360 
DLGSNKIENL PPNIFKDLKE LSQLNISYNP IQKIEVNQFD YLAKLKSLSL EGIEISNIQQ 

       370        380        390        400        410        420 
RMFRPLINLS HIYFKKFQYC GYAPHVRSCK PNTDGISSLE NLLASIIQRV FVWVVSAITC 

       430        440        450        460        470        480 
FGNIFVICMR PYIRSENKLH AMSIMSLCCA DCLMGVYLFV IGAFDLKFRG EYRKHAQPWM 

       490        500        510        520        530        540 
ESVHCQFMGS LAVLSTEVSV LLLTFLTLEK YICIVYPFRC LRPRKCRTVA VLIFIWITGF 

       550        560        570        580        590        600 
IVAFAPLGNK EFFKNYYGTN GVCFPLHSED TGSTGAQIYS VVIFLGINLV AFIIIVFSYG 

       610        620        630        640        650        660 
SMFYSVHQST ITATEIQKQV KKEMILAKRF FFIVFTDALC WIPIFILKFL SLIRVEIPDT 

       670        680        690        700        710        720 
ITSWVVIFIL PINSALNPII YTLTTRPFKE MIHQLWYNYR QRRSVDRKGT QKAYTPSFIW 

       730        740        750 
VEMWPLQEMS TEFMKPDAFT DPCDLSLVSR SSRLNSYS

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References

[1]"Identification and characterization of the mouse and rat relaxin receptors as the novel orthologues of human leucine-rich repeat-containing G-protein-coupled receptor 7."
Scott D.J., Layfield S., Riesewijk A., Morita H., Tregear G.W., Bathgate R.A.D.
Clin. Exp. Pharmacol. Physiol. 31:828-832(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY509976 mRNA. Translation: AAR97516.1.
IPIIPI00409992.
RefSeqNP_958820.1. NM_201417.1.
UniGeneRn.109230.

3D structure databases

HSSPHSSP built from PDB template 1F5Y based on UniProtKB P01130.
ProteinModelPortalQ6R6I6.
SMRQ6R6I6. Positions 22-63.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000033541.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ6R6I6.

Proteomic databases

PaxDbQ6R6I6.
PRIDEQ6R6I6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID295144.
KEGGrno:295144.
UCSCRGD:1302973. rat.

Organism-specific databases

CTD59350.
RGD1302973. Rxfp1.

Phylogenomic databases

eggNOGCOG4886.
HOGENOMHOG000049056.
HOVERGENHBG026354.
InParanoidQ6R6I6.
KOK04306.
OrthoDBEOG4NGGM1.

Gene expression databases

GenevestigatorQ6R6I6.

Family and domain databases

Gene3D4.10.400.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRR-contain_N.
IPR008112. Relaxin_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
PF00057. Ldl_recept_a. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01739. RELAXINR.
SMARTSM00192. LDLa. 1 hit.
SM00369. LRR_TYP. 2 hits.
SM00013. LRRNT. 1 hit.
[Graphical view]
SUPFAMSSF57424. LDL_rcpt_classA_cys-rich. 1 hit.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. False negative.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS51450. LRR. 10 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio639021.

Entry information

Entry nameRXFP1_RAT
AccessionPrimary (citable) accession number: Q6R6I6
Entry history
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 5, 2004
Last modified: April 3, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries

SIMILARITY comments

Index of protein domains and families

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