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Protein

Relaxin receptor 1

Gene

Rxfp1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP (By similarity).By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi45Calcium; via carbonyl oxygenBy similarity1
Metal bindingi48CalciumBy similarity1
Metal bindingi50Calcium; via carbonyl oxygenBy similarity1
Metal bindingi52CalciumBy similarity1
Metal bindingi58CalciumBy similarity1
Metal bindingi59CalciumBy similarity1

GO - Molecular functioni

  • G-protein coupled receptor activity Source: RGD
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Relaxin receptor 1
Alternative name(s):
Leucine-rich repeat-containing G-protein coupled receptor 7
Relaxin family peptide receptor 1
Gene namesi
Name:Rxfp1
Synonyms:Lgr7
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1302973. Rxfp1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 408ExtracellularSequence analysisAdd BLAST408
Transmembranei409 – 429Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini430 – 443CytoplasmicSequence analysisAdd BLAST14
Transmembranei444 – 464Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini465 – 486ExtracellularSequence analysisAdd BLAST22
Transmembranei487 – 507Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini508 – 527CytoplasmicSequence analysisAdd BLAST20
Transmembranei528 – 548Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini549 – 577ExtracellularSequence analysisAdd BLAST29
Transmembranei578 – 598Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini599 – 629CytoplasmicSequence analysisAdd BLAST31
Transmembranei630 – 650Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini651 – 660ExtracellularSequence analysis10
Transmembranei661 – 681Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini682 – 758CytoplasmicSequence analysisAdd BLAST77

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003126691 – 758Relaxin receptor 1Add BLAST758

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 40By similarity
Disulfide bondi34 ↔ 53By similarity
Glycosylationi36N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi47 ↔ 62By similarity
Glycosylationi127N-linked (GlcNAc...)Sequence analysis1
Glycosylationi264N-linked (GlcNAc...)Sequence analysis1
Glycosylationi272N-linked (GlcNAc...)Sequence analysis1
Glycosylationi325N-linked (GlcNAc...)Sequence analysis1
Glycosylationi368N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi485 ↔ 563By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ6R6I6.
PRIDEiQ6R6I6.

PTM databases

PhosphoSitePlusiQ6R6I6.

Expressioni

Tissue specificityi

Detected in brain cortex, and at low levels in testis.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000033541.

Structurei

3D structure databases

ProteinModelPortaliQ6R6I6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 63LDL-receptor class APROSITE-ProRule annotationAdd BLAST38
Repeati105 – 125LRR 1Add BLAST21
Repeati126 – 148LRR 2Add BLAST23
Repeati149 – 172LRR 3Add BLAST24
Repeati173 – 196LRR 4Add BLAST24
Repeati198 – 220LRR 5Add BLAST23
Repeati221 – 244LRR 6Add BLAST24
Repeati246 – 269LRR 7Add BLAST24
Repeati270 – 293LRR 8Add BLAST24
Repeati294 – 317LRR 9Add BLAST24
Repeati319 – 341LRR 10Add BLAST23
Repeati342 – 365LRR 11Add BLAST24

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Contains 1 LDL-receptor class A domain.PROSITE-ProRule annotation
Contains 11 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
KOG2087. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000049056.
HOVERGENiHBG026354.
InParanoidiQ6R6I6.
KOiK04306.
PhylomeDBiQ6R6I6.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
4.10.400.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR032675. L_dom-like.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR008112. Relaxin_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF00057. Ldl_recept_a. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01739. RELAXINR.
SMARTiSM00192. LDLa. 1 hit.
SM00369. LRR_TYP. 10 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF57424. SSF57424. 1 hit.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS51450. LRR. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6R6I6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSGPFFFCV FIIGRYFTLG NAQDVSCPLG SFPCGNISKC LPQLLHCNGV
60 70 80 90 100
DDCGNQADED NCGDNNGWSL QLDKYFANYY KLTSTNSIEA ETSECLVGSV
110 120 130 140 150
PMHCLCRDLE LDCDEANLRA VPSVSSNVTV MSLQWNFIRT LPPNSFRKYH
160 170 180 190 200
DLQKLCLQNN KIRSVSVSAF RGLHSLTKLY LSHNRITFLK PGVFEDLHRL
210 220 230 240 250
EWLIIEDNHL SRISPLTFYG LNSLILLVLM NNALTRLPDK PLCQHMPRLH
260 270 280 290 300
WLDFEGNRIH NLRNLTFISC NNLTVLVMRK NKINHLNEHA FTHLQKLDEL
310 320 330 340 350
DLGSNKIENL PPNIFKDLKE LSQLNISYNP IQKIEVNQFD YLAKLKSLSL
360 370 380 390 400
EGIEISNIQQ RMFRPLINLS HIYFKKFQYC GYAPHVRSCK PNTDGISSLE
410 420 430 440 450
NLLASIIQRV FVWVVSAITC FGNIFVICMR PYIRSENKLH AMSIMSLCCA
460 470 480 490 500
DCLMGVYLFV IGAFDLKFRG EYRKHAQPWM ESVHCQFMGS LAVLSTEVSV
510 520 530 540 550
LLLTFLTLEK YICIVYPFRC LRPRKCRTVA VLIFIWITGF IVAFAPLGNK
560 570 580 590 600
EFFKNYYGTN GVCFPLHSED TGSTGAQIYS VVIFLGINLV AFIIIVFSYG
610 620 630 640 650
SMFYSVHQST ITATEIQKQV KKEMILAKRF FFIVFTDALC WIPIFILKFL
660 670 680 690 700
SLIRVEIPDT ITSWVVIFIL PINSALNPII YTLTTRPFKE MIHQLWYNYR
710 720 730 740 750
QRRSVDRKGT QKAYTPSFIW VEMWPLQEMS TEFMKPDAFT DPCDLSLVSR

SSRLNSYS
Length:758
Mass (Da):87,183
Last modified:July 5, 2004 - v1
Checksum:i85C2A295A5C0195B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY509976 mRNA. Translation: AAR97516.1.
RefSeqiNP_958820.1. NM_201417.1.
UniGeneiRn.109230.

Genome annotation databases

GeneIDi295144.
KEGGirno:295144.
UCSCiRGD:1302973. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY509976 mRNA. Translation: AAR97516.1.
RefSeqiNP_958820.1. NM_201417.1.
UniGeneiRn.109230.

3D structure databases

ProteinModelPortaliQ6R6I6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000033541.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiQ6R6I6.

Proteomic databases

PaxDbiQ6R6I6.
PRIDEiQ6R6I6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi295144.
KEGGirno:295144.
UCSCiRGD:1302973. rat.

Organism-specific databases

CTDi59350.
RGDi1302973. Rxfp1.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
KOG2087. Eukaryota.
COG4886. LUCA.
HOGENOMiHOG000049056.
HOVERGENiHBG026354.
InParanoidiQ6R6I6.
KOiK04306.
PhylomeDBiQ6R6I6.

Miscellaneous databases

PROiQ6R6I6.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
4.10.400.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR032675. L_dom-like.
IPR023415. LDLR_class-A_CS.
IPR002172. LDrepeatLR_classA_rpt.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR008112. Relaxin_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
PF00057. Ldl_recept_a. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01739. RELAXINR.
SMARTiSM00192. LDLa. 1 hit.
SM00369. LRR_TYP. 10 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF57424. SSF57424. 1 hit.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
PS01209. LDLRA_1. 1 hit.
PS50068. LDLRA_2. 1 hit.
PS51450. LRR. 10 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRXFP1_RAT
AccessioniPrimary (citable) accession number: Q6R6I6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.