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Protein

Toll-like receptor 11

Gene

Tlr11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.By similarity

Caution

There is some confusion regarding the nomenclature of this gene. In the literature, Tlr11 is frequently referred to as Tlr12 and vice-versa.Curated

GO - Biological processi

  • inflammatory response Source: UniProtKB-KW
  • innate immune response Source: UniProtKB-KW
  • response to bacterium Source: MGI
  • signal transduction Source: InterPro

Keywordsi

Molecular functionReceptor
Biological processImmunity, Inflammatory response, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptor 111 Publication
Alternative name(s):
Toll-like receptor 12Curated
Gene namesi
Name:Tlr111 PublicationImported
Synonyms:Gm287Imported, Tlr12Curated
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:3045226 Tlr11

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini31 – 721ExtracellularSequence analysisAdd BLAST691
Transmembranei722 – 742HelicalSequence analysisAdd BLAST21
Topological domaini743 – 926CytoplasmicSequence analysisAdd BLAST184

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Sequence analysisAdd BLAST30
ChainiPRO_000004279331 – 926Toll-like receptor 11Add BLAST896

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi46N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi73N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi342N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi396N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi402N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi506N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi520N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi620N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi699N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6R5P0
PRIDEiQ6R5P0

Expressioni

Gene expression databases

BgeeiENSMUSG00000051969
CleanExiMM_TLR11
ExpressionAtlasiQ6R5P0 baseline and differential

Interactioni

Subunit structurei

Binds MYD88 via their respective TIR domains (By similarity). Interacts with HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum (PubMed:20865800).By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
fliCA0A0H3NMJ62EBI-6548549,EBI-6548383From Salmonella typhimurium (strain SL1344).

Protein-protein interaction databases

IntActiQ6R5P0, 4 interactors
STRINGi10090.ENSMUSP00000068906

Structurei

3D structure databases

ProteinModelPortaliQ6R5P0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati240 – 263LRR 1Add BLAST24
Repeati264 – 286LRR 2Add BLAST23
Repeati288 – 309LRR 3Add BLAST22
Repeati313 – 334LRR 4Add BLAST22
Repeati337 – 358LRR 5Add BLAST22
Repeati362 – 383LRR 6Add BLAST22
Repeati386 – 407LRR 7Add BLAST22
Repeati410 – 433LRR 8Add BLAST24
Repeati434 – 455LRR 9Add BLAST22
Repeati458 – 479LRR 10Add BLAST22
Domaini772 – 918TIRPROSITE-ProRule annotationAdd BLAST147

Sequence similaritiesi

Belongs to the Toll-like receptor family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00900000141236
HOGENOMiHOG000236285
HOVERGENiHBG080130
InParanoidiQ6R5P0
KOiK14142
PhylomeDBiQ6R5P0
TreeFamiTF351113

Family and domain databases

Gene3Di3.40.50.10140, 1 hit
3.80.10.10, 4 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 1 hit
PF13676 TIR_2, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 6 hits
SM00255 TIR, 1 hit
SUPFAMiSSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 10 hits
PS50104 TIR, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6R5P0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRMERHQFC SVLLILILLT LVSLTLTGWA WTIPDCIIAD SLLFPNLSYY
60 70 80 90 100
IPFCTSAPGL HLLASCSNVK NLNQTLKRVP RNTEVLCLQG MVPTLPAKAF
110 120 130 140 150
IRFHSLQLLR LQLRTTSVTS RTFQGLDQLQ YLFFDHHAPC CLSLFLSPNC
160 170 180 190 200
FESLRSLSSL SFQGYCLTYS QSIYLPTSLR HLTLRNSCLT KFQDLQRLFP
210 220 230 240 250
DLLLSTSSTP NIKPGAPFLE TLDLSYNLQL KQAGVRDLYG LTLHSLILDG
260 270 280 290 300
TPLKALDLTD SGLLHLHFLS LVGTGIEKVP ASLTGYSELR ALDLGKNQIQ
310 320 330 340 350
NILENGEIPG YKALEFLSLH DNHLQTLPTR FLHTLPQLQK LNLSMNKLGP
360 370 380 390 400
ILELPEGLFS TNLKVLDLSY NQLCDVPHGA LSLLSQLQEL WLSGNNISSL
410 420 430 440 450
SNESLQGLRQ LRTLDLSWNQ IKVLKPGWLS HLPALTTLNL LGTYLEYILG
460 470 480 490 500
IQLQGPKMLR HLQLGSYPIL DIYPPWPPTL LSLEIQAESC IQFMIHSGQP
510 520 530 540 550
FLFLENLTLE TSILLLKPDN ITIHFPSLRR LTLRGYSFIF STSQLQRFFP
560 570 580 590 600
QQLPLLEHFF IWCENSYAVD LYLFGMPRLR VLELGYLNFF YESSTMKLEM
610 620 630 640 650
LLKEVPQLQV LALSHLNLRN LSVSSFKSLQ DLKLLLFNSE RALEMNSNLQ
660 670 680 690 700
EFIPQMPQYV YFSDVTFTCQ CEASWLESWA TRAPNTFVYG LEKSICIANA
710 720 730 740 750
SDYSKTLLFS FLATNCPHGT EFWGFLTSFI LLLLLIILPL ISCPKWSWLH
760 770 780 790 800
HLWTLFHTCW WKLCGHRLRG QFNYDVFISY CEEDQAWVLE ELVPVLEKAP
810 820 830 840 850
PEGEGLRLCL PARDFGIGND RMESMIASMG KSRATLCVLT GQALASPWCN
860 870 880 890 900
LELRLATYHL VARPGTTHLL LLFLEPLDRQ RLHSYHRLSR WLQKEDYFDL
910 920
SQGKVEWNSF CEQLKRRLSK AGQERD
Length:926
Mass (Da):105,873
Last modified:July 5, 2004 - v1
Checksum:iDF86FED308671285
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY510704 mRNA Translation: AAS37672.1
RefSeqiNP_991388.2, NM_205819.3
UniGeneiMm.291512

Genome annotation databases

EnsembliENSMUST00000063570; ENSMUSP00000068906; ENSMUSG00000051969
GeneIDi239081
KEGGimmu:239081
UCSCiuc007tkz.3 mouse

Similar proteinsi

Entry informationi

Entry nameiTLR11_MOUSE
AccessioniPrimary (citable) accession number: Q6R5P0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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