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Protein

Toll-like receptor 11

Gene

Tlr11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptor 11
Gene namesi
Name:Tlr11
Synonyms:Gm287
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:3045226. Tlr11.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini31 – 721691ExtracellularSequence analysisAdd
BLAST
Transmembranei722 – 74221HelicalSequence analysisAdd
BLAST
Topological domaini743 – 926184CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Sequence analysisAdd
BLAST
Chaini31 – 926896Toll-like receptor 11PRO_0000042793Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi46 – 461N-linked (GlcNAc...)Sequence analysis
Glycosylationi73 – 731N-linked (GlcNAc...)Sequence analysis
Glycosylationi342 – 3421N-linked (GlcNAc...)Sequence analysis
Glycosylationi396 – 3961N-linked (GlcNAc...)Sequence analysis
Glycosylationi402 – 4021N-linked (GlcNAc...)Sequence analysis
Glycosylationi506 – 5061N-linked (GlcNAc...)Sequence analysis
Glycosylationi520 – 5201N-linked (GlcNAc...)Sequence analysis
Glycosylationi620 – 6201N-linked (GlcNAc...)Sequence analysis
Glycosylationi699 – 6991N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6R5P0.
PRIDEiQ6R5P0.

Expressioni

Gene expression databases

BgeeiQ6R5P0.
CleanExiMM_TLR11.
ExpressionAtlasiQ6R5P0. baseline and differential.

Interactioni

Subunit structurei

Binds MYD88 via their respective TIR domains (By similarity). Interacts with HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
fliCA0A0H3NMJ62EBI-6548549,EBI-6548383From a different organism.

Protein-protein interaction databases

IntActiQ6R5P0. 4 interactions.
STRINGi10090.ENSMUSP00000068906.

Structurei

3D structure databases

ProteinModelPortaliQ6R5P0.
SMRiQ6R5P0. Positions 64-915.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati240 – 26324LRR 1Add
BLAST
Repeati264 – 28623LRR 2Add
BLAST
Repeati288 – 30922LRR 3Add
BLAST
Repeati313 – 33422LRR 4Add
BLAST
Repeati337 – 35822LRR 5Add
BLAST
Repeati362 – 38322LRR 6Add
BLAST
Repeati386 – 40722LRR 7Add
BLAST
Repeati410 – 43324LRR 8Add
BLAST
Repeati434 – 45522LRR 9Add
BLAST
Repeati458 – 47922LRR 10Add
BLAST
Domaini772 – 918147TIRPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the Toll-like receptor family.Curated
Contains 10 LRR (leucine-rich) repeats.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119006.
HOGENOMiHOG000236285.
HOVERGENiHBG080130.
InParanoidiQ6R5P0.
KOiK14142.
OrthoDBiEOG7Q5HCK.
PhylomeDBiQ6R5P0.
TreeFamiTF351113.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 4 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027194. TLR11.
[Graphical view]
PANTHERiPTHR24365:SF370. PTHR24365:SF370. 5 hits.
PfamiPF13855. LRR_8. 1 hit.
PF13676. TIR_2. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 6 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 10 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6R5P0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPRMERHQFC SVLLILILLT LVSLTLTGWA WTIPDCIIAD SLLFPNLSYY
60 70 80 90 100
IPFCTSAPGL HLLASCSNVK NLNQTLKRVP RNTEVLCLQG MVPTLPAKAF
110 120 130 140 150
IRFHSLQLLR LQLRTTSVTS RTFQGLDQLQ YLFFDHHAPC CLSLFLSPNC
160 170 180 190 200
FESLRSLSSL SFQGYCLTYS QSIYLPTSLR HLTLRNSCLT KFQDLQRLFP
210 220 230 240 250
DLLLSTSSTP NIKPGAPFLE TLDLSYNLQL KQAGVRDLYG LTLHSLILDG
260 270 280 290 300
TPLKALDLTD SGLLHLHFLS LVGTGIEKVP ASLTGYSELR ALDLGKNQIQ
310 320 330 340 350
NILENGEIPG YKALEFLSLH DNHLQTLPTR FLHTLPQLQK LNLSMNKLGP
360 370 380 390 400
ILELPEGLFS TNLKVLDLSY NQLCDVPHGA LSLLSQLQEL WLSGNNISSL
410 420 430 440 450
SNESLQGLRQ LRTLDLSWNQ IKVLKPGWLS HLPALTTLNL LGTYLEYILG
460 470 480 490 500
IQLQGPKMLR HLQLGSYPIL DIYPPWPPTL LSLEIQAESC IQFMIHSGQP
510 520 530 540 550
FLFLENLTLE TSILLLKPDN ITIHFPSLRR LTLRGYSFIF STSQLQRFFP
560 570 580 590 600
QQLPLLEHFF IWCENSYAVD LYLFGMPRLR VLELGYLNFF YESSTMKLEM
610 620 630 640 650
LLKEVPQLQV LALSHLNLRN LSVSSFKSLQ DLKLLLFNSE RALEMNSNLQ
660 670 680 690 700
EFIPQMPQYV YFSDVTFTCQ CEASWLESWA TRAPNTFVYG LEKSICIANA
710 720 730 740 750
SDYSKTLLFS FLATNCPHGT EFWGFLTSFI LLLLLIILPL ISCPKWSWLH
760 770 780 790 800
HLWTLFHTCW WKLCGHRLRG QFNYDVFISY CEEDQAWVLE ELVPVLEKAP
810 820 830 840 850
PEGEGLRLCL PARDFGIGND RMESMIASMG KSRATLCVLT GQALASPWCN
860 870 880 890 900
LELRLATYHL VARPGTTHLL LLFLEPLDRQ RLHSYHRLSR WLQKEDYFDL
910 920
SQGKVEWNSF CEQLKRRLSK AGQERD
Length:926
Mass (Da):105,873
Last modified:July 5, 2004 - v1
Checksum:iDF86FED308671285
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY510704 mRNA. Translation: AAS37672.1.
RefSeqiNP_991388.2. NM_205819.3.
UniGeneiMm.291512.

Genome annotation databases

EnsembliENSMUST00000063570; ENSMUSP00000068906; ENSMUSG00000051969.
GeneIDi239081.
KEGGimmu:239081.
UCSCiuc007tkz.3. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY510704 mRNA. Translation: AAS37672.1.
RefSeqiNP_991388.2. NM_205819.3.
UniGeneiMm.291512.

3D structure databases

ProteinModelPortaliQ6R5P0.
SMRiQ6R5P0. Positions 64-915.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6R5P0. 4 interactions.
STRINGi10090.ENSMUSP00000068906.

Proteomic databases

PaxDbiQ6R5P0.
PRIDEiQ6R5P0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063570; ENSMUSP00000068906; ENSMUSG00000051969.
GeneIDi239081.
KEGGimmu:239081.
UCSCiuc007tkz.3. mouse.

Organism-specific databases

CTDi239081.
MGIiMGI:3045226. Tlr11.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119006.
HOGENOMiHOG000236285.
HOVERGENiHBG080130.
InParanoidiQ6R5P0.
KOiK14142.
OrthoDBiEOG7Q5HCK.
PhylomeDBiQ6R5P0.
TreeFamiTF351113.

Miscellaneous databases

NextBioi383971.
PROiQ6R5P0.
SOURCEiSearch...

Gene expression databases

BgeeiQ6R5P0.
CleanExiMM_TLR11.
ExpressionAtlasiQ6R5P0. baseline and differential.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 4 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027194. TLR11.
[Graphical view]
PANTHERiPTHR24365:SF370. PTHR24365:SF370. 5 hits.
PfamiPF13855. LRR_8. 1 hit.
PF13676. TIR_2. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 6 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 10 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection."
    Tabeta K., Georgel P., Janssen E., Du X., Hoebe K., Crozat K., Mudd S., Shamel L., Sovath S., Goode J., Alexopoulou L., Flavell R.A., Beutler B.
    Proc. Natl. Acad. Sci. U.S.A. 101:3516-3521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  2. "Folding of Toll-like receptors by the HSP90 paralogue gp96 requires a substrate-specific cochaperone."
    Liu B., Yang Y., Qiu Z., Staron M., Hong F., Li Y., Wu S., Li Y., Hao B., Bona R., Han D., Li Z.
    Nat. Commun. 1:79-79(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HSP90B1.
  3. Erratum
    Liu B., Yang Y., Qiu Z., Staron M., Hong F., Li Y., Wu S., Li Y., Hao B., Bona R., Han D., Li Z.
    Nat. Commun. 3:653-653(2012)

Entry informationi

Entry nameiTLR11_MOUSE
AccessioniPrimary (citable) accession number: Q6R5P0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.