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Protein

Protein dispatched homolog 1

Gene

disp1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal.1 Publication

GO - Biological processi

  • adenohypophysis development Source: ZFIN
  • anterior/posterior pattern specification Source: ZFIN
  • blood circulation Source: ZFIN
  • embryonic cranial skeleton morphogenesis Source: ZFIN
  • inner ear development Source: ZFIN
  • muscle cell fate specification Source: ZFIN
  • organ morphogenesis Source: ZFIN
  • retinal ganglion cell axon guidance Source: ZFIN
  • skeletal muscle tissue development Source: ZFIN
  • smoothened signaling pathway Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
Protein dispatched homolog 1
Alternative name(s):
Protein chameleon
Gene namesi
Name:disp1
Synonyms:con
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-030911-7. disp1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei173 – 19321HelicalSequence analysisAdd
BLAST
Transmembranei482 – 50221HelicalSequence analysisAdd
BLAST
Transmembranei507 – 52721HelicalSequence analysisAdd
BLAST
Transmembranei531 – 55121HelicalSequence analysisAdd
BLAST
Transmembranei586 – 60621HelicalSequence analysisAdd
BLAST
Transmembranei620 – 64021HelicalSequence analysisAdd
BLAST
Transmembranei701 – 72121HelicalSequence analysisAdd
BLAST
Transmembranei970 – 99021HelicalSequence analysisAdd
BLAST
Transmembranei992 – 101221HelicalSequence analysisAdd
BLAST
Transmembranei1022 – 104221HelicalSequence analysisAdd
BLAST
Transmembranei1065 – 108521HelicalSequence analysisAdd
BLAST
Transmembranei1089 – 110921HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 14641464Protein dispatched homolog 1PRO_0000310695Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi346 – 3461N-linked (GlcNAc...)Sequence analysis
Glycosylationi374 – 3741N-linked (GlcNAc...)Sequence analysis
Glycosylationi458 – 4581N-linked (GlcNAc...)Sequence analysis
Glycosylationi564 – 5641N-linked (GlcNAc...)Sequence analysis
Glycosylationi608 – 6081N-linked (GlcNAc...)Sequence analysis
Glycosylationi818 – 8181N-linked (GlcNAc...)Sequence analysis
Glycosylationi899 – 8991N-linked (GlcNAc...)Sequence analysis
Glycosylationi1140 – 11401N-linked (GlcNAc...)Sequence analysis
Glycosylationi1190 – 11901N-linked (GlcNAc...)Sequence analysis
Glycosylationi1394 – 13941N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6R5J2.
PRIDEiQ6R5J2.

Expressioni

Developmental stagei

Ubiquitously expressed throughout the embryo from fertilization onward. Accumulates at higher levels in the notochord, the ventral floor of the brain as well as dorsal and ventral margins of the myotome.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000065230.

Structurei

3D structure databases

ProteinModelPortaliQ6R5J2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini468 – 640173SSDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the dispatched family.Curated
Contains 1 SSD (sterol-sensing) domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3664. Eukaryota.
ENOG410XT7M. LUCA.
HOGENOMiHOG000112218.
HOVERGENiHBG101595.
InParanoidiQ6R5J2.
PhylomeDBiQ6R5J2.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR003392. Ptc/Disp.
IPR000731. SSD.
[Graphical view]
PfamiPF02460. Patched. 2 hits.
[Graphical view]
PROSITEiPS50156. SSD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6R5J2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSEDFTEL QTLSNGRSSS IFPTTNTPVD PEEEEEQSVS ACTQPNEHTQ
60 70 80 90 100
MMQTGQNGGL KSTRLSSSSS SSSQLTDAQR LAVLLPNALP PGFCVCCSLC
110 120 130 140 150
CNGNQQDCAL FQSAVPSAAL HMGSCCVQGV PCFCMQHHWP EHLQNQPNMA
160 170 180 190 200
TLSPPRPFRF PKNYAELIAD WPVVVLGICT VLIVVCALVG ILVPDLPDFS
210 220 230 240 250
NPLQGFEPRG TAIGQRLVTW NNMVKNTGYK ATLANYPFKY ADEQAKSHQD
260 270 280 290 300
DRWSKDHYDR KKRQAEWDFS KDSFFCDVPG DSYSRIVFAS AEGKNLWNIQ
310 320 330 340 350
AIKSMCNFDN TRVRSHPQYL DLCQRTTAAS CCPSWTLGNY IAVLTNKSSC
360 370 380 390 400
QKITERDVSH TLNILRSCAK FYHNGTLGPE CWDMTTRKKD LKCGNLPRKC
410 420 430 440 450
TKYNAVYQIF HFLVDKDFLN PKNTDYLPPN LKYSMLFAPT EKGETMMNIY
460 470 480 490 500
LDNFENRNSS DGITTITGIE FGIKHSLFQD YLLTDTMYPA IAIVIVLVVM
510 520 530 540 550
CVYTRSMFIT LMTMFAIISS LIVSYFLYRV VFNFDFFPFM NLTALIILVG
560 570 580 590 600
IGADDAFVLC DVWNYTKFDK PNSELSETVS ITLQHAALSM FVTSFTTAAA
610 620 630 640 650
FYANYVSNIT AIRCFGVYAG TAILVNYILM VTWLPAVVVL HERYLVNLLT
660 670 680 690 700
CSRTQNHQSQ GAATFWTSLC QVVNKCLFSI SEASRIFFEK VLPCVVIKLR
710 720 730 740 750
YLWLLWFLAL TVGGAYVVCV NPKMKLPSLE LSEFQVFRSS HPFERYDAEY
760 770 780 790 800
KKLFMFERVN HGEDLHMPIT IIWGVTPIDS GDPLNPKNKG KLTLDTTFNI
810 820 830 840 850
ASPASQVWIL NFCQKLRNQS FVYQSEEQDF TSCFMETFKQ WMENQDCEEA
860 870 880 890 900
SVYPCCSQST FPYRQDVFEL CIKRAIMELD RSTIYHLDSK TPGPRFDIND
910 920 930 940 950
TIRAIVLEFQ STYHFTLAYE KMHQFYREVD TWIQEELRDA PEGLSYGWFV
960 970 980 990 1000
SNLEFYDLQD SLSDGTLIAM ALSVVVAFSV MLLTTWNIII SLYAIISIAG
1010 1020 1030 1040 1050
TIFVTVGSLV LLGWELNVLE SVTISVAVGL SVDFAVHYGV AYRLAPEPDR
1060 1070 1080 1090 1100
EGKVVFSLSR MGSAIAMAAL TTFVAGAMMM PSTVLAYTQL GTFLMLIMCI
1110 1120 1130 1140 1150
SWAFATFFFQ CMCRLLGPQG TCGQIPLPKK LQCAERTSEN QSTVNNQGKA
1160 1170 1180 1190 1200
GACYTTKHEH YELEPLAANV RNEGKASDEE QEACTQLQNN ITSLHDDATL
1210 1220 1230 1240 1250
CASHEEPKHE FENGVQATEH SHLHQYAFNT RCTCENSMHQ YIRERQRTAC
1260 1270 1280 1290 1300
HPCGQSRETQ CATKQSNHLP VCLNRDMIHA PTNSGHFQHC TPSQISRPAA
1310 1320 1330 1340 1350
HRCFSGGCGM HAVHISQQQT ETESYISACV PSSSPQESQN RPAHLQFPDV
1360 1370 1380 1390 1400
QRCSSPDTTG VCTLNHDTQN AGELAINSQS PQKIPWNHLK TKANGTCVLQ
1410 1420 1430 1440 1450
DCREVVPEDS IGCRVDKEKT VSPKKFNCFK KNVNAKCNSV EFHKTRTSVP
1460
TIAINSKASS ESLC
Length:1,464
Mass (Da):164,535
Last modified:July 5, 2004 - v1
Checksum:iDBFF4B1849702DFD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY512779 mRNA. Translation: AAR99503.1.
RefSeqiNP_997965.1. NM_212800.1.
UniGeneiDr.48573.

Genome annotation databases

GeneIDi619201.
KEGGidre:619201.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY512779 mRNA. Translation: AAR99503.1.
RefSeqiNP_997965.1. NM_212800.1.
UniGeneiDr.48573.

3D structure databases

ProteinModelPortaliQ6R5J2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000065230.

Proteomic databases

PaxDbiQ6R5J2.
PRIDEiQ6R5J2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi619201.
KEGGidre:619201.

Organism-specific databases

CTDi84976.
ZFINiZDB-GENE-030911-7. disp1.

Phylogenomic databases

eggNOGiKOG3664. Eukaryota.
ENOG410XT7M. LUCA.
HOGENOMiHOG000112218.
HOVERGENiHBG101595.
InParanoidiQ6R5J2.
PhylomeDBiQ6R5J2.

Miscellaneous databases

PROiQ6R5J2.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR003392. Ptc/Disp.
IPR000731. SSD.
[Graphical view]
PfamiPF02460. Patched. 2 hits.
[Graphical view]
PROSITEiPS50156. SSD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Inactivation of dispatched 1 by the chameleon mutation disrupts hedgehog signalling in the zebrafish embryo."
    Nakano Y., Kim H.R., Kawakami A., Roy S., Schier A.F., Ingham P.W.
    Dev. Biol. 269:381-392(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, DEVELOPMENTAL STAGE.
    Tissue: Embryo.

Entry informationi

Entry nameiDISP1_DANRE
AccessioniPrimary (citable) accession number: Q6R5J2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.