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Q6R5J1 (DISP2_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Protein dispatched homolog 2
Gene names
Name:disp2
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length1476 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Developmental stage

Ubiquitously expressed throughout the embryo from fertilization onward. Accumulates at higher levels in cells of the telencephalon, the ventral hindbrain and the gut. Ref.1

Sequence similarities

Belongs to the dispatched family.

Contains 1 SSD (sterol-sensing) domain.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processgene silencing by miRNA

Inferred from genetic interaction. Source: ZFIN

   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionhedgehog receptor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14761476Protein dispatched homolog 2
PRO_0000310698

Regions

Transmembrane185 – 20521Helical; Potential
Transmembrane506 – 52621Helical; Potential
Transmembrane528 – 54821Helical; Potential
Transmembrane550 – 57021Helical; Potential
Transmembrane602 – 62221Helical; Potential
Transmembrane635 – 65521Helical; Potential
Transmembrane729 – 74921Helical; Potential
Transmembrane1000 – 102021Helical; Potential
Transmembrane1023 – 104321Helical; Potential
Transmembrane1047 – 106721Helical; Potential
Transmembrane1098 – 111821Helical; Potential
Transmembrane1121 – 114121Helical; Potential
Domain495 – 656162SSD

Amino acid modifications

Glycosylation581N-linked (GlcNAc...) Potential
Glycosylation3661N-linked (GlcNAc...) Potential
Glycosylation4781N-linked (GlcNAc...) Potential
Glycosylation4791N-linked (GlcNAc...) Potential
Glycosylation8171N-linked (GlcNAc...) Potential
Glycosylation8271N-linked (GlcNAc...) Potential
Glycosylation8461N-linked (GlcNAc...) Potential
Glycosylation12451N-linked (GlcNAc...) Potential
Glycosylation13391N-linked (GlcNAc...) Potential
Glycosylation13911N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q6R5J1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: F182C710E5DF61FF

FASTA1,476164,020
        10         20         30         40         50         60 
MESGSISRQR EDAEMPDSST TEGPSLEAPQ SEIPEVSLCP PDSDSTESQM CPVEIEENQT 

        70         80         90        100        110        120 
KSSSPFNSHS STQLERQVSQ GSAYHSPPHK KCPCCGHQQP SQSDVCPGQM NALHQADCAA 

       130        140        150        160        170        180 
SPVKTLYSCS PSRLPSCHTK MQCHWLHGSH DGSNHKPVQH HMVTVRNDGL HRIPRSYSQV 

       190        200        210        220        230        240 
IVEYPMTVLI SCTLVLFACS LAGILTGPLP DFSDPLLGFE PRGTDISVRL ATWTRLKQNT 

       250        260        270        280        290        300 
GPGKPLSPVP WQLTEKTTTG KDTIKSEPQF RERSRRMLHR DNAEHNFFCN APGERYAQLV 

       310        320        330        340        350        360 
FRSGNSASLW SLKAIYSMCQ MEQTQIRSGP QFDKLCQVKS EFYGSMVKNE CCPSWSLGNY 

       370        380        390        400        410        420 
LAVLNNISSC FSLTSQQVSE SLGLLRFCAP YYHDGSLIAS CTERSKFGRC ASVPHRCKLS 

       430        440        450        460        470        480 
SIFQILHYLV DKDFLGPQTV EYKVPSLKYS IVFLPVEKSD SLMNIYLDHL EGHKLTYNNT 

       490        500        510        520        530        540 
TITGMDLGIK QKLFKYYLAR DSIYPVLAAL ALLITIGLYL KSLFIAAMSL VAVILSLSTS 

       550        560        570        580        590        600 
YFFYKVAFRL TFFPLLNLAA VFVLLGSCLN QALTFVDFWK LQLSHNPPAV PEKRMNRVLQ 

       610        620        630        640        650        660 
EMGYLIIVSG LTSSVTFYSG YISSITAVRC YAVYLGSASL INTLFALVWL PCTLILQERY 

       670        680        690        700        710        720 
AVLSSNTVGK VAWKPCCSKN AGGFWETSSR KRCLFTFRQK LRTLGRGFSD TSNLLFLKIL 

       730        740        750        760        770        780 
PCGVVKFRYI WICWFAVLAA GGTYISCVDP GMKLPTSDSR TTQLFRSSHP FERYDAEYRH 

       790        800        810        820        830        840 
QFMFERMKDG EDEPMMLTLI WGIVPSDNGD HFDPKSNGSL SVDPGFNMSS LQAQIWLRDL 

       850        860        870        880        890        900 
CGKIQNQTFY SPLSAEQDTA EDNVCFVEHL IHWVSIRRCS ESEDAFSFCC NNIPFPYPPR 

       910        920        930        940        950        960 
VFEQCLSMMV AEQHAEGRLP SAGGLRFDSE GRIAALVVIF KTVQLYSFNY NRMSQFYQEI 

       970        980        990       1000       1010       1020 
LSWFNREISK APAGLQRGWF VSQLGLYDLQ QCLSSETLEV AGFSVALTFA LLLLTTWNIP 

      1030       1040       1050       1060       1070       1080 
LSVYVSIAVA GSVFATVGLL VLLEWQLNGV EALFISAAAG LSVDFVANYC ISYSLAPHSD 

      1090       1100       1110       1120       1130       1140 
RLGRVAHSIK RMGCPVATGA GAYFCVGIIM LPATALLFRK LGIFLLLVKC VACGFATFFF 

      1150       1160       1170       1180       1190       1200 
QSLCCFFGPQ NNCGRITLPC VTQQSTENIL SSCSATEPGT NNPAANGAFG CGKGSRVRRS 

      1210       1220       1230       1240       1250       1260 
FNKENEGFLC PNQQHHRKRQ PVGGREPEQN ELQPLACQLS DSFENSTCTS KLSNRPSVLS 

      1270       1280       1290       1300       1310       1320 
DDIQFCGLSP KQDYDRVSIE ADSTEMCSRH LKGCNPPPAL QTSSPYKENM LRLPQDACKE 

      1330       1340       1350       1360       1370       1380 
KVLCKKCRGQ SRGGLQLWNV SLSSSSSMDE IMITQTTDTV NERSLSMDDH IHKRLLSCQS 

      1390       1400       1410       1420       1430       1440 
QSSIEGLEES NDTCLTEVEA AIPQAGKIED EFQPGHLNGK RDTLRLSLKE TVYDLASPGS 

      1450       1460       1470 
GRVRTAQSDV PVILPNSKPD MPDVWIKREG KGEGGS

« Hide

References

[1]"Inactivation of dispatched 1 by the chameleon mutation disrupts hedgehog signalling in the zebrafish embryo."
Nakano Y., Kim H.R., Kawakami A., Roy S., Schier A.F., Ingham P.W.
Dev. Biol. 269:381-392(2004) [PubMed: 15110707] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY512780 mRNA. Translation: AAR99504.1.
IPIIPI00486205.
RefSeqNP_997599.1. NM_212434.1.
UniGeneDr.88066.

3D structure databases

ProteinModelPortalQ6R5J1.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSDART00000062887; ENSDARP00000062886; ENSDARG00000042846.
GeneID405793.
KEGGdre:405793.

Organism-specific databases

CTD85455.
ZFINZDB-GENE-030915-1. disp2.

Phylogenomic databases

eggNOGfiNOG05279.
GeneTreeENSGT00530000063208.
HOGENOMHBG713127.
HOVERGENHBG094891.
InParanoidQ6R5J1.
OMACTSKLSN.
OrthoDBEOG4HQDHN.
PhylomeDBQ6R5J1.

Gene expression databases

BgeeQ6R5J1.

Family and domain databases

InterProIPR003392. Patched.
IPR000731. SSD.
[Graphical view]
PfamPF02460. Patched. 1 hit.
[Graphical view]
PROSITEPS50156. SSD. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDISP2_DANRE
AccessionPrimary (citable) accession number: Q6R5J1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: July 5, 2004
Last modified: September 21, 2011
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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