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Q6R4B4

- GST_ALTAL

UniProt

Q6R4B4 - GST_ALTAL

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Protein

Glutathione-S-transferase

Gene
N/A
Organism
Alternaria alternata (Alternaria rot fungus) (Torula alternata)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.1 Publication

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione-S-transferase (EC:2.5.1.18)
Alternative name(s):
Allergen: Alt a 13
OrganismiAlternaria alternata (Alternaria rot fungus) (Torula alternata)
Taxonomic identifieri5599 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaeAlternariaAlternaria alternata group

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei2542. Alt a 13.
3060. Alt a 13.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 231231Glutathione-S-transferasePRO_0000345088Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6R4B4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 9884GST N-terminalAdd
BLAST

Sequence similaritiesi

Belongs to the GST superfamily.Curated
Contains 1 GST N-terminal domain.Curated

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF13409. GST_N_2. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6R4B4 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDKPSELAV QKLVLFAVKG TATSTHNTVR PLILLDELGV PHEIYVVDRV
60 70 80 90 100
SAPWFTEINP HRMVPVILEK SPDGRDTLRA WESTSTLMYI ADAYDKDGTF
110 120 130 140 150
GGRNVQESSD INNWLTLHTA ALGPTAKYWL YFYKLHPEKL PKTIEKLRSN
160 170 180 190 200
ITVQYDILER RLNEPGQQYL AWLNEKFKRS SYNRRHCYAS LCYEKYRRVV
210 220 230
RAGVKVAQTA RVVCPYGGDT RRGVWPARKS T
Length:231
Mass (Da):26,562
Last modified:July 5, 2004 - v1
Checksum:i4320AFD16D5D5699
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY514673 mRNA. Translation: AAR98813.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY514673 mRNA. Translation: AAR98813.1 .

3D structure databases

ProteinModelPortali Q6R4B4.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 2542. Alt a 13.
3060. Alt a 13.0101.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF13409. GST_N_2. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Recombinant glutathione-S-transferase a major allergen from Alternaria alternata for clinical use in allergy patients."
    Shankar J., Singh B.P., Gaur S.N., Arora N.
    Mol. Immunol. 43:1927-1932(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, ALLERGEN.
    Strain: ITCC 4789.

Entry informationi

Entry nameiGST_ALTAL
AccessioniPrimary (citable) accession number: Q6R4B4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 5, 2004
Last modified: October 1, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3