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Q6R4B4

- GST_ALTAL

UniProt

Q6R4B4 - GST_ALTAL

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Protein

Glutathione-S-transferase

Gene
N/A
Organism
Alternaria alternata (Alternaria rot fungus) (Torula alternata)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.1 Publication

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

  1. glutathione transferase activity Source: UniProtKB-EC
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione-S-transferase (EC:2.5.1.18)
Alternative name(s):
Allergen: Alt a 13
OrganismiAlternaria alternata (Alternaria rot fungus) (Torula alternata)
Taxonomic identifieri5599 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaeAlternariaAlternaria alternata group

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei2542. Alt a 13.
3060. Alt a 13.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 231231Glutathione-S-transferasePRO_0000345088Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ6R4B4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini15 – 9884GST N-terminalAdd
BLAST

Sequence similaritiesi

Belongs to the GST superfamily.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF13409. GST_N_2. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6R4B4-1 [UniParc]FASTAAdd to Basket

« Hide

MSDKPSELAV QKLVLFAVKG TATSTHNTVR PLILLDELGV PHEIYVVDRV    50
SAPWFTEINP HRMVPVILEK SPDGRDTLRA WESTSTLMYI ADAYDKDGTF 100
GGRNVQESSD INNWLTLHTA ALGPTAKYWL YFYKLHPEKL PKTIEKLRSN 150
ITVQYDILER RLNEPGQQYL AWLNEKFKRS SYNRRHCYAS LCYEKYRRVV 200
RAGVKVAQTA RVVCPYGGDT RRGVWPARKS T 231
Length:231
Mass (Da):26,562
Last modified:July 5, 2004 - v1
Checksum:i4320AFD16D5D5699
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY514673 mRNA. Translation: AAR98813.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY514673 mRNA. Translation: AAR98813.1 .

3D structure databases

ProteinModelPortali Q6R4B4.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

Allergomei 2542. Alt a 13.
3060. Alt a 13.0101.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProi IPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
Pfami PF13409. GST_N_2. 1 hit.
[Graphical view ]
SUPFAMi SSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEi PS50404. GST_NTER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Recombinant glutathione-S-transferase a major allergen from Alternaria alternata for clinical use in allergy patients."
    Shankar J., Singh B.P., Gaur S.N., Arora N.
    Mol. Immunol. 43:1927-1932(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, ALLERGEN.
    Strain: ITCC 4789.

Entry informationi

Entry nameiGST_ALTAL
AccessioniPrimary (citable) accession number: Q6R4B4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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