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Q6R4B4

- GST_ALTAL

UniProt

Q6R4B4 - GST_ALTAL

Protein

Glutathione-S-transferase

Gene
N/A
Organism
Alternaria alternata (Alternaria rot fungus) (Torula alternata)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.1 Publication

    Catalytic activityi

    RX + glutathione = HX + R-S-glutathione.

    GO - Molecular functioni

    1. glutathione transferase activity Source: UniProtKB-EC

    Keywords - Molecular functioni

    Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutathione-S-transferase (EC:2.5.1.18)
    Alternative name(s):
    Allergen: Alt a 13
    OrganismiAlternaria alternata (Alternaria rot fungus) (Torula alternata)
    Taxonomic identifieri5599 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaeAlternariaAlternaria alternata group

    Pathology & Biotechi

    Allergenic propertiesi

    Causes an allergic reaction in human.1 Publication

    Keywords - Diseasei

    Allergen

    Protein family/group databases

    Allergomei2542. Alt a 13.
    3060. Alt a 13.0101.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 231231Glutathione-S-transferasePRO_0000345088Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ6R4B4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini15 – 9884GST N-terminalAdd
    BLAST

    Sequence similaritiesi

    Belongs to the GST superfamily.Curated
    Contains 1 GST N-terminal domain.Curated

    Family and domain databases

    Gene3Di1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProiIPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view]
    PfamiPF13409. GST_N_2. 1 hit.
    [Graphical view]
    SUPFAMiSSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEiPS50404. GST_NTER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6R4B4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSDKPSELAV QKLVLFAVKG TATSTHNTVR PLILLDELGV PHEIYVVDRV    50
    SAPWFTEINP HRMVPVILEK SPDGRDTLRA WESTSTLMYI ADAYDKDGTF 100
    GGRNVQESSD INNWLTLHTA ALGPTAKYWL YFYKLHPEKL PKTIEKLRSN 150
    ITVQYDILER RLNEPGQQYL AWLNEKFKRS SYNRRHCYAS LCYEKYRRVV 200
    RAGVKVAQTA RVVCPYGGDT RRGVWPARKS T 231
    Length:231
    Mass (Da):26,562
    Last modified:July 5, 2004 - v1
    Checksum:i4320AFD16D5D5699
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY514673 mRNA. Translation: AAR98813.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY514673 mRNA. Translation: AAR98813.1 .

    3D structure databases

    ProteinModelPortali Q6R4B4.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    Allergomei 2542. Alt a 13.
    3060. Alt a 13.0101.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    Gene3Di 1.20.1050.10. 1 hit.
    3.40.30.10. 1 hit.
    InterProi IPR010987. Glutathione-S-Trfase_C-like.
    IPR004045. Glutathione_S-Trfase_N.
    IPR012336. Thioredoxin-like_fold.
    [Graphical view ]
    Pfami PF13409. GST_N_2. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47616. SSF47616. 1 hit.
    SSF52833. SSF52833. 1 hit.
    PROSITEi PS50404. GST_NTER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Recombinant glutathione-S-transferase a major allergen from Alternaria alternata for clinical use in allergy patients."
      Shankar J., Singh B.P., Gaur S.N., Arora N.
      Mol. Immunol. 43:1927-1932(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, ALLERGEN.
      Strain: ITCC 4789.

    Entry informationi

    Entry nameiGST_ALTAL
    AccessioniPrimary (citable) accession number: Q6R4B4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 22, 2008
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Documents

    1. Allergens
      Nomenclature of allergens and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3