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Q6R4B4 (GST_ALTAL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutathione-S-transferase

EC=2.5.1.18
Alternative name(s):
Allergen=Alt a 13
OrganismAlternaria alternata (Alternaria rot fungus) (Torula alternata)
Taxonomic identifier5599 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaPezizomycotinaDothideomycetesPleosporomycetidaePleosporalesPleosporineaePleosporaceaeAlternariaAlternaria alternata group

Protein attributes

Sequence length231 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Ref.1

Catalytic activity

RX + glutathione = HX + R-S-glutathione.

Allergenic properties

Causes an allergic reaction in human. Ref.1

Sequence similarities

Belongs to the GST superfamily.

Contains 1 GST N-terminal domain.

Ontologies

Keywords
   DiseaseAllergen
   Molecular functionTransferase
Gene Ontology (GO)
   Molecular_functionglutathione transferase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 231231Glutathione-S-transferase
PRO_0000345088

Regions

Domain15 – 9884GST N-terminal

Sequences

Sequence LengthMass (Da)Tools
Q6R4B4 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 4320AFD16D5D5699

FASTA23126,562
        10         20         30         40         50         60 
MSDKPSELAV QKLVLFAVKG TATSTHNTVR PLILLDELGV PHEIYVVDRV SAPWFTEINP 

        70         80         90        100        110        120 
HRMVPVILEK SPDGRDTLRA WESTSTLMYI ADAYDKDGTF GGRNVQESSD INNWLTLHTA 

       130        140        150        160        170        180 
ALGPTAKYWL YFYKLHPEKL PKTIEKLRSN ITVQYDILER RLNEPGQQYL AWLNEKFKRS 

       190        200        210        220        230 
SYNRRHCYAS LCYEKYRRVV RAGVKVAQTA RVVCPYGGDT RRGVWPARKS T 

« Hide

References

[1]"Recombinant glutathione-S-transferase a major allergen from Alternaria alternata for clinical use in allergy patients."
Shankar J., Singh B.P., Gaur S.N., Arora N.
Mol. Immunol. 43:1927-1932(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, ALLERGEN.
Strain: ITCC 4789.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY514673 mRNA. Translation: AAR98813.1.

3D structure databases

ProteinModelPortalQ6R4B4.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

Allergome2542. Alt a 13.
3060. Alt a 13.0101.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamPF13409. GST_N_2. 1 hit.
[Graphical view]
SUPFAMSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEPS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGST_ALTAL
AccessionPrimary (citable) accession number: Q6R4B4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Allergens

Nomenclature of allergens and list of entries