Reviewed, UniProtKB/Swiss-Prot Q6R4B4 (GST_ALTAL)

Names and origin

Protein names	Recommended name:     Glutathione-S-transferase     EC=2.5.1.18 Alternative name(s):     Allergen=Alt a 13
Organism	Alternaria alternata (Alternaria rot fungus)
Taxonomic identifier	5599 [NCBI]
Taxonomic lineage	Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Dothideomycetes › Pleosporomycetidae › Pleosporales › Pleosporaceae › mitosporic Pleosporaceae › Alternaria › Alternaria alternata group

Protein attributes

Sequence length	231 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Ref.1
Catalytic activity	RX + glutathione = HX + R-S-glutathione.
Allergenic properties	Causes an allergic reaction in human. Ref.1
Sequence similarities	Belongs to the GST superfamily. Contains 1 GST N-terminal domain.

Ontologies

Keywords
Disease	Allergen
Molecular function	Transferase
Gene Ontology (GO)
Molecular function	glutathione transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 231	231	Glutathione-S-transferase		PRO_0000345088
Regions
	Domain	15 – 98	84	GST N-terminal

Sequences

	Sequence		Length	Mass (Da)
	Q6R4B4-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 4320AFD16D5D5699	FASTA	231	26,562
	10 20 30 40 50 60 MSDKPSELAV QKLVLFAVKG TATSTHNTVR PLILLDELGV PHEIYVVDRV SAPWFTEINP 70 80 90 100 110 120 HRMVPVILEK SPDGRDTLRA WESTSTLMYI ADAYDKDGTF GGRNVQESSD INNWLTLHTA 130 140 150 160 170 180 ALGPTAKYWL YFYKLHPEKL PKTIEKLRSN ITVQYDILER RLNEPGQQYL AWLNEKFKRS 190 200 210 220 230 SYNRRHCYAS LCYEKYRRVV RAGVKVAQTA RVVCPYGGDT RRGVWPARKS T

References

[1]

"Recombinant glutathione-S-transferase a major allergen from Alternaria alternata for clinical use in allergy patients." Shankar J., Singh B.P., Gaur S.N., Arora N. Mol. Immunol. 43:1927-1932(2006) [PubMed: 16430961] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, ALLERGENICITY. Strain: ITCC 4789.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AY514673 mRNA. Translation: AAR98813.1.
3D structure databases
ModBase	Search...
Family and domain databases
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR012336. Thioredoxin-like_fold. IPR012335. Thioredoxin_fold. [Graphical view]
Gene3D	G3DSA:3.40.30.10. Thioredoxin_fold. 1 hit.
PROSITE	PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GST_ALTAL

Accession

Primary (citable) accession number: Q6R4B4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 22, 2008
Last sequence update:	July 5, 2004
Last modified:	November 24, 2009
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

FPAP (Fungal Proteome Annotation Project)