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UniProtKB - Q6R327 (RICTR_HUMAN)

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Protein

Rapamycin-insensitive companion of mTOR

Gene

RICTOR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.3 Publications

GO - Molecular functioni

  • enzyme activator activity Source: GO_Central
  • protein kinase binding Source: ParkinsonsUK-UCL
  • ribosome binding Source: Ensembl
Complete GO annotation...

GO - Biological processi

Complete GO annotation...

Keywordsi

Molecular functionDevelopmental protein

Enzyme and pathway databases

ReactomeiR-HSA-1257604. PIP3 activates AKT signaling.
R-HSA-389357. CD28 dependent PI3K/Akt signaling.
R-HSA-5218920. VEGFR2 mediated vascular permeability.
R-HSA-5674400. Constitutive Signaling by AKT1 E17K in Cancer.
R-HSA-6804757. Regulation of TP53 Degradation.
SIGNORiQ6R327.

Names & Taxonomyi

Protein namesi
Recommended name:
Rapamycin-insensitive companion of mTOR
Alternative name(s):
AVO3 homolog
Short name:
hAVO3
Gene namesi
Name:RICTORImported
Synonyms:KIAA1999Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000164327.12.
HGNCiHGNC:28611. RICTOR.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi253260.
OpenTargetsiENSG00000164327.
PharmGKBiPA165660455.

Chemistry databases

ChEMBLiCHEMBL1795179.

Polymorphism and mutation databases

BioMutaiRICTOR.
DMDMi74710068.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003081791 – 1708Rapamycin-insensitive companion of mTORAdd BLAST1708

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphoserineCombined sources1
Modified residuei1103PhosphothreonineCombined sources1
Modified residuei1135Phosphothreonine; by RPS6KB1Combined sources1 Publication1
Modified residuei1162PhosphoserineCombined sources1
Modified residuei1235PhosphoserineBy similarity1
Modified residuei1278PhosphoserineCombined sources1
Modified residuei1282PhosphoserineCombined sources1
Modified residuei1284PhosphoserineCombined sources1
Modified residuei1295PhosphothreonineCombined sources1
Modified residuei1302PhosphoserineCombined sources1
Modified residuei1313PhosphoserineCombined sources1
Modified residuei1332PhosphothreonineCombined sources1
Modified residuei1346PhosphoserineCombined sources1
Modified residuei1353PhosphoserineCombined sources1
Modified residuei1385PhosphoserineCombined sources1
Modified residuei1388PhosphoserineCombined sources1
Modified residuei1396PhosphoserineCombined sources1
Modified residuei1411PhosphoserineCombined sources1
Modified residuei1591PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylated by MTOR; when part of mTORC2. Phosphorylated at Thr-1135 by RPS6KB1; phosphorylation of RICTOR inhibits mTORC2 and AKT1 signaling.2 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ6R327.
MaxQBiQ6R327.
PaxDbiQ6R327.
PeptideAtlasiQ6R327.
PRIDEiQ6R327.

PTM databases

iPTMnetiQ6R327.
PhosphoSitePlusiQ6R327.

Expressioni

Gene expression databases

BgeeiENSG00000164327.
ExpressionAtlasiQ6R327. baseline and differential.
GenevisibleiQ6R327. HS.

Organism-specific databases

HPAiHPA037802.
HPA037803.

Interactioni

Subunit structurei

Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR (PubMed:15268862, PubMed:15467718, PubMed:17461779, PubMed:17599906). Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to MTOR and PRR5 within the TORC2 complex (PubMed:15268862, PubMed:17461779, PubMed:17599906). Interacts with CCDC28B (PubMed:23727834). Interacts with NBN (PubMed:23762398). Interacts with PRR5L (PubMed:17461779, PubMed:21964062).7 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein kinase binding Source: ParkinsonsUK-UCL
Complete GO annotation...

Protein-protein interaction databases

BioGridi128962. 87 interactors.
CORUMiQ6R327.
DIPiDIP-39479N.
IntActiQ6R327. 44 interactors.
MINTiMINT-3976651.
STRINGi9606.ENSP00000349959.

Structurei

3D structure databases

ProteinModelPortaliQ6R327.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 789Interaction with NBN1 PublicationAdd BLAST789

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1016 – 1058Ser-richSequence analysisAdd BLAST43

Sequence similaritiesi

Belongs to the RICTOR family.Curated

Phylogenomic databases

eggNOGiKOG3694. Eukaryota.
ENOG410XQ5Z. LUCA.
GeneTreeiENSGT00390000002096.
HOGENOMiHOG000154126.
HOVERGENiHBG060827.
InParanoidiQ6R327.
KOiK08267.
OMAiIGTILKW.
OrthoDBiEOG091G01CV.
PhylomeDBiQ6R327.
TreeFamiTF343656.

Family and domain databases

Gene3Di1.25.10.10. 2 hits.
InterProiView protein in InterPro
IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR028268. Pianissimo_fam.
IPR028267. Pianissimo_N.
IPR029453. Rictor_IV.
IPR029451. RICTOR_M.
IPR029259. RICTOR_phospho.
IPR029452. RICTOR_V.
PANTHERiPTHR13298. PTHR13298. 1 hit.
PfamiView protein in Pfam
PF14663. RasGEF_N_2. 1 hit.
PF14666. RICTOR_M. 1 hit.
PF14664. RICTOR_N. 1 hit.
PF14665. RICTOR_phospho. 1 hit.
PF14668. RICTOR_V. 1 hit.
SMARTiView protein in SMART
SM01307. RICTOR_M. 1 hit.
SM01308. RICTOR_N. 1 hit.
SM01309. RICTOR_phospho. 1 hit.
SM01310. RICTOR_V. 1 hit.
SUPFAMiSSF48371. SSF48371. 5 hits.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q6R327-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAIGRGRSL KNLRVRGRND SGEENVPLDL TREPSDNLRE ILQNVARLQG 
        60         70         80         90        100
VSNMRKLGHL NNFTKLLCDI GHSEEKLGFH YEDIIICLRL ALLNEAKEVR 
       110        120        130        140        150
AAGLRALRYL IQDSSILQKV LKLKVDYLIA RCIDIQQSNE VERTQALRLV 
       160        170        180        190        200
RKMITVNASL FPSSVTNSLI AVGNDGLQER DRMVRACIAI ICELALQNPE 
       210        220        230        240        250
VVALRGGLNT ILKNVIDCQL SRINEALITT ILHLLNHPKT RQYVRADVEL 
       260        270        280        290        300
ERILAPYTDF HYRHSPDTAE GQLKEDREAR FLASKMGIIA TFRSWAGIIN 
       310        320        330        340        350
LCKPGNSGIQ SLIGVLCIPN MEIRRGLLEV LYDIFRLPLP VVTEEFIEAL 
       360        370        380        390        400
LSVDPGRFQD SWRLSDGFVA AEAKTILPHR ARSRPDLMDN YLALILSAFI 
       410        420        430        440        450
RNGLLEGLVE VITNSDDHIS VRATILLGEL LHMANTILPH SHSHHLHCLP 
       460        470        480        490        500
TLMNMAASFD IPKEKRLRAS AALNCLKRFH EMKKRGPKPY SLHLDHIIQK 
       510        520        530        540        550
AIATHQKRDQ YLRVQKDIFI LKDTEEALLI NLRDSQVLQH KENLEWNWNL 
       560        570        580        590        600
IGTILKWPNV NLRNYKDEQL HRFVRRLLYF YKPSSKLYAN LDLDFAKAKQ 
       610        620        630        640        650
LTVVGCQFTE FLLESEEDGQ GYLEDLVKDI VQWLNASSGM KPERSLQNNG 
       660        670        680        690        700
LLTTLSQHYF LFIGTLSCHP HGVKMLEKCS VFQCLLNLCS LKNQDHLLKL 
       710        720        730        740        750
TVSSLDYSRD GLARVILSKI LTAATDACRL YATKHLRVLL RANVEFFNNW 
       760        770        780        790        800
GIELLVTQLH DKNKTISSEA LDILDEACED KANLHALIQM KPALSHLGDK 
       810        820        830        840        850
GLLLLLRFLS IPKGFSYLNE RGYVAKQLEK WHREYNSKYV DLIEEQLNEA 
       860        870        880        890        900
LTTYRKPVDG DNYVRRSNQR LQRPHVYLPI HLYGQLVHHK TGCHLLEVQN 
       910        920        930        940        950
IITELCRNVR TPDLDKWEEI KKLKASLWAL GNIGSSNWGL NLLQEENVIP 
       960        970        980        990       1000
DILKLAKQCE VLSIRGTCVY VLGLIAKTKQ GCDILKCHNW DAVRHSRKHL 
      1010       1020       1030       1040       1050
WPVVPDDVEQ LCNELSSIPS TLSLNSESTS SRHNSESESV PSSMFILEDD 
      1060       1070       1080       1090       1100
RFGSSSTSTF FLDINEDTEP TFYDRSGPIK DKNSFPFFAS SKLVKNRILN 
      1110       1120       1130       1140       1150
SLTLPNKKHR SSSDPKGGKL SSESKTSNRR IRTLTEPSVD FNHSDDFTPI 
      1160       1170       1180       1190       1200
STVQKTLQLE TSFMGNKHIE DTGSTPSIGE NDLKFTKNFG TENHRENTSR 
      1210       1220       1230       1240       1250
ERLVVESSTS SHMKIRSQSF NTDTTTSGIS SMSSSPSRET VGVDATTMDT 
      1260       1270       1280       1290       1300
DCGSMSTVVS TKTIKTSHYL TPQSNHLSLS KSNSVSLVPP GSSHTLPRRA 
      1310       1320       1330       1340       1350
QSLKAPSIAT IKSLADCNFS YTSSRDAFGY ATLKRLQQQR MHPSLSHSEA 
      1360       1370       1380       1390       1400
LASPAKDVLF TDTITMKANS FESRLTPSRF MKALSYASLD KEDLLSPINQ 
      1410       1420       1430       1440       1450
NTLQRSSSVR SMVSSATYGG SDDYIGLALP VDINDIFQVK DIPYFQTKNI 
      1460       1470       1480       1490       1500
PPHDDRGARA FAHDAGGLPS GTGGLVKNSF HLLRQQMSLT EIMNSIHSDA 
      1510       1520       1530       1540       1550
SLFLESTEDT GLQEHTDDNC LYCVCIEILG FQPSNQLSAI CSHSDFQDIP 
      1560       1570       1580       1590       1600
YSDWCEQTIH NPLEVVPSKF SGISGCSDGV SQEGSASSTK STELLLGVKT 
      1610       1620       1630       1640       1650
IPDDTPMCRI LLRKEVLRLV INLSSSVSTK CHETGLLTIK EKYPQTFDDI 
      1660       1670       1680       1690       1700
CLYSEVSHLL SHCTFRLPCR RFIQELFQDV QFLQMHEEAE AVLATPPKQP 

IVDTSAES
Length:1,708
Mass (Da):192,218
Last modified:July 5, 2004 - v1
Checksum:iDB7B1E4A45DAE2AB
GO
Isoform 2 (identifier: Q6R327-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     252-257: RILAPY → NFSTLY
     258-1708: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:257
Mass (Da):28,988
Checksum:i57DCA4610207FA94
GO
Isoform 3 (identifier: Q6R327-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1379-1379: R → RIDFKKKHVGGIRSLRPTITNNLFR

Note: No experimental confirmation available.Curated
Show »
Length:1,732
Mass (Da):195,011
Checksum:i984F516A908EEC3A
GO

Sequence cautioni

The sequence CAH18135 differs from that shown. Wrong choice of CDS.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti545E → G in CAH18135 (PubMed:17974005).Curated1
Sequence conflicti815F → L in CAH18135 (PubMed:17974005).Curated1
Sequence conflicti1283N → S in CAH18135 (PubMed:17974005).Curated1
Sequence conflicti1699Q → R in AAH51729 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051320837S → F2 PublicationsCorresponds to variant dbSNP:rs2043112Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_038362252 – 257RILAPY → NFSTLY in isoform 2. 1 Publication6
Alternative sequenceiVSP_038363258 – 1708Missing in isoform 2. 1 PublicationAdd BLAST1451
Alternative sequenceiVSP_0525811379R → RIDFKKKHVGGIRSLRPTIT NNLFR in isoform 3. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY515854 mRNA. Translation: AAS79796.1.
AL834497 mRNA. Translation: CAD39155.1.
CR749280 mRNA. Translation: CAH18135.1. Sequence problems.
AC008964 Genomic DNA. No translation available.
AC109467 Genomic DNA. No translation available.
CH471119 Genomic DNA. Translation: EAW55980.1.
BC051729 mRNA. Translation: AAH51729.1.
BC137163 mRNA. Translation: AAI37164.1.
BC137164 mRNA. Translation: AAI37165.1.
BC144509 mRNA. Translation: AAI44510.1.
AB082530 mRNA. Translation: BAC02708.1.
CCDSiCCDS34148.1. [Q6R327-1]
CCDS68861.1. [Q6R327-3]
RefSeqiNP_001272368.1. NM_001285439.1. [Q6R327-3]
NP_001272369.1. NM_001285440.1.
NP_689969.2. NM_152756.4. [Q6R327-1]
UniGeneiHs.407926.

Genome annotation databases

EnsembliENST00000296782; ENSP00000296782; ENSG00000164327. [Q6R327-3]
ENST00000357387; ENSP00000349959; ENSG00000164327. [Q6R327-1]
ENST00000511516; ENSP00000423019; ENSG00000164327. [Q6R327-4]
GeneIDi253260.
KEGGihsa:253260.
UCSCiuc003jlo.4. human. [Q6R327-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRICTR_HUMAN
AccessioniPrimary (citable) accession number: Q6R327
Secondary accession number(s): B2RNX0
, B7ZMF7, Q68DT5, Q86UB7, Q8N3A0, Q8NCM6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: July 5, 2004
Last modified: September 27, 2017
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families