UniProtKB - Q6R327 (RICTR_HUMAN)
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Protein
Rapamycin-insensitive companion of mTOR
Gene
RICTOR
Organism
Homo sapiens (Human)
Status
Functioni
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development.3 Publications
GO - Molecular functioni
- enzyme activator activity Source: GO_Central
- protein kinase binding Source: ParkinsonsUK-UCL
- ribosome binding Source: Ensembl
GO - Biological processi
- actin cytoskeleton reorganization Source: UniProtKB
- activation of protein kinase B activity Source: Reactome
- embryo development ending in birth or egg hatching Source: UniProtKB
- establishment of cell polarity Source: GO_Central
- establishment or maintenance of actin cytoskeleton polarity Source: GO_Central
- peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
- positive regulation of actin filament polymerization Source: Ensembl
- positive regulation of endothelial cell proliferation Source: Ensembl
- positive regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
- positive regulation of protein kinase B signaling Source: GO_Central
- positive regulation of TOR signaling Source: UniProtKB
- regulation of actin cytoskeleton organization Source: UniProtKB
- regulation of establishment of cell polarity Source: Ensembl
- regulation of gene expression Source: Ensembl
- regulation of GTPase activity Source: Ensembl
- regulation of inflammatory response Source: Ensembl
- regulation of peptidyl-serine phosphorylation Source: Ensembl
- regulation of phosphorylation Source: GO_Central
- regulation of protein kinase B signaling Source: UniProtKB
- TOR signaling Source: InterPro
Keywordsi
Molecular function | Developmental protein |
Enzyme and pathway databases
Reactomei | R-HSA-1257604. PIP3 activates AKT signaling. R-HSA-389357. CD28 dependent PI3K/Akt signaling. R-HSA-5218920. VEGFR2 mediated vascular permeability. R-HSA-5674400. Constitutive Signaling by AKT1 E17K in Cancer. R-HSA-6804757. Regulation of TP53 Degradation. |
SIGNORi | Q6R327. |
Names & Taxonomyi
Protein namesi | Recommended name: Rapamycin-insensitive companion of mTORAlternative name(s): AVO3 homolog Short name: hAVO3 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000164327.12. |
HGNCi | HGNC:28611. RICTOR. |
MIMi | 609022. gene. |
neXtProti | NX_Q6R327. |
Subcellular locationi
Pathology & Biotechi
Organism-specific databases
DisGeNETi | 253260. |
OpenTargetsi | ENSG00000164327. |
PharmGKBi | PA165660455. |
Chemistry databases
ChEMBLi | CHEMBL1795179. |
Polymorphism and mutation databases
BioMutai | RICTOR. |
DMDMi | 74710068. |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000308179 | 1 – 1708 | Rapamycin-insensitive companion of mTORAdd BLAST | 1708 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 21 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1103 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1135 | Phosphothreonine; by RPS6KB1Combined sources1 Publication | 1 | |
Modified residuei | 1162 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1235 | PhosphoserineBy similarity | 1 | |
Modified residuei | 1278 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1282 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1284 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1295 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1302 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1313 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1332 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 1346 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1353 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1385 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1388 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1396 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1411 | PhosphoserineCombined sources | 1 | |
Modified residuei | 1591 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Phosphorylated by MTOR; when part of mTORC2. Phosphorylated at Thr-1135 by RPS6KB1; phosphorylation of RICTOR inhibits mTORC2 and AKT1 signaling.2 Publications
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | Q6R327. |
MaxQBi | Q6R327. |
PaxDbi | Q6R327. |
PeptideAtlasi | Q6R327. |
PRIDEi | Q6R327. |
PTM databases
iPTMneti | Q6R327. |
PhosphoSitePlusi | Q6R327. |
Expressioni
Gene expression databases
Bgeei | ENSG00000164327. |
ExpressionAtlasi | Q6R327. baseline and differential. |
Genevisiblei | Q6R327. HS. |
Organism-specific databases
HPAi | HPA037802. HPA037803. |
Interactioni
Subunit structurei
Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR (PubMed:15268862, PubMed:15467718, PubMed:17461779, PubMed:17599906). Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to MTOR and PRR5 within the TORC2 complex (PubMed:15268862, PubMed:17461779, PubMed:17599906). Interacts with CCDC28B (PubMed:23727834). Interacts with NBN (PubMed:23762398). Interacts with PRR5L (PubMed:17461779, PubMed:21964062).7 Publications
Binary interactionsi
GO - Molecular functioni
- protein kinase binding Source: ParkinsonsUK-UCL
Protein-protein interaction databases
BioGridi | 128962. 89 interactors. |
CORUMi | Q6R327. |
DIPi | DIP-39479N. |
IntActi | Q6R327. 47 interactors. |
MINTi | Q6R327. |
STRINGi | 9606.ENSP00000349959. |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 789 | Interaction with NBN1 PublicationAdd BLAST | 789 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1016 – 1058 | Ser-richSequence analysisAdd BLAST | 43 |
Sequence similaritiesi
Belongs to the RICTOR family.Curated
Phylogenomic databases
eggNOGi | KOG3694. Eukaryota. ENOG410XQ5Z. LUCA. |
GeneTreei | ENSGT00390000002096. |
HOGENOMi | HOG000154126. |
HOVERGENi | HBG060827. |
InParanoidi | Q6R327. |
KOi | K08267. |
OMAi | IGTILKW. |
OrthoDBi | EOG091G01CV. |
PhylomeDBi | Q6R327. |
TreeFami | TF343656. |
Family and domain databases
InterProi | View protein in InterPro IPR016024. ARM-type_fold. IPR028268. Pianissimo_fam. IPR028267. Pianissimo_N. IPR029453. Rictor_IV. IPR029451. RICTOR_M. IPR029259. RICTOR_phospho. IPR029452. RICTOR_V. |
PANTHERi | PTHR13298. PTHR13298. 1 hit. |
Pfami | View protein in Pfam PF14663. RasGEF_N_2. 1 hit. PF14666. RICTOR_M. 1 hit. PF14664. RICTOR_N. 1 hit. PF14665. RICTOR_phospho. 1 hit. PF14668. RICTOR_V. 1 hit. |
SMARTi | View protein in SMART SM01307. RICTOR_M. 1 hit. SM01308. RICTOR_N. 1 hit. SM01309. RICTOR_phospho. 1 hit. SM01310. RICTOR_V. 1 hit. |
SUPFAMi | SSF48371. SSF48371. 5 hits. |
s (3)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 11 Publication (identifier: Q6R327-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MAAIGRGRSL KNLRVRGRND SGEENVPLDL TREPSDNLRE ILQNVARLQG
60 70 80 90 100
VSNMRKLGHL NNFTKLLCDI GHSEEKLGFH YEDIIICLRL ALLNEAKEVR
110 120 130 140 150
AAGLRALRYL IQDSSILQKV LKLKVDYLIA RCIDIQQSNE VERTQALRLV
160 170 180 190 200
RKMITVNASL FPSSVTNSLI AVGNDGLQER DRMVRACIAI ICELALQNPE
210 220 230 240 250
VVALRGGLNT ILKNVIDCQL SRINEALITT ILHLLNHPKT RQYVRADVEL
260 270 280 290 300
ERILAPYTDF HYRHSPDTAE GQLKEDREAR FLASKMGIIA TFRSWAGIIN
310 320 330 340 350
LCKPGNSGIQ SLIGVLCIPN MEIRRGLLEV LYDIFRLPLP VVTEEFIEAL
360 370 380 390 400
LSVDPGRFQD SWRLSDGFVA AEAKTILPHR ARSRPDLMDN YLALILSAFI
410 420 430 440 450
RNGLLEGLVE VITNSDDHIS VRATILLGEL LHMANTILPH SHSHHLHCLP
460 470 480 490 500
TLMNMAASFD IPKEKRLRAS AALNCLKRFH EMKKRGPKPY SLHLDHIIQK
510 520 530 540 550
AIATHQKRDQ YLRVQKDIFI LKDTEEALLI NLRDSQVLQH KENLEWNWNL
560 570 580 590 600
IGTILKWPNV NLRNYKDEQL HRFVRRLLYF YKPSSKLYAN LDLDFAKAKQ
610 620 630 640 650
LTVVGCQFTE FLLESEEDGQ GYLEDLVKDI VQWLNASSGM KPERSLQNNG
660 670 680 690 700
LLTTLSQHYF LFIGTLSCHP HGVKMLEKCS VFQCLLNLCS LKNQDHLLKL
710 720 730 740 750
TVSSLDYSRD GLARVILSKI LTAATDACRL YATKHLRVLL RANVEFFNNW
760 770 780 790 800
GIELLVTQLH DKNKTISSEA LDILDEACED KANLHALIQM KPALSHLGDK
810 820 830 840 850
GLLLLLRFLS IPKGFSYLNE RGYVAKQLEK WHREYNSKYV DLIEEQLNEA
860 870 880 890 900
LTTYRKPVDG DNYVRRSNQR LQRPHVYLPI HLYGQLVHHK TGCHLLEVQN
910 920 930 940 950
IITELCRNVR TPDLDKWEEI KKLKASLWAL GNIGSSNWGL NLLQEENVIP
960 970 980 990 1000
DILKLAKQCE VLSIRGTCVY VLGLIAKTKQ GCDILKCHNW DAVRHSRKHL
1010 1020 1030 1040 1050
WPVVPDDVEQ LCNELSSIPS TLSLNSESTS SRHNSESESV PSSMFILEDD
1060 1070 1080 1090 1100
RFGSSSTSTF FLDINEDTEP TFYDRSGPIK DKNSFPFFAS SKLVKNRILN
1110 1120 1130 1140 1150
SLTLPNKKHR SSSDPKGGKL SSESKTSNRR IRTLTEPSVD FNHSDDFTPI
1160 1170 1180 1190 1200
STVQKTLQLE TSFMGNKHIE DTGSTPSIGE NDLKFTKNFG TENHRENTSR
1210 1220 1230 1240 1250
ERLVVESSTS SHMKIRSQSF NTDTTTSGIS SMSSSPSRET VGVDATTMDT
1260 1270 1280 1290 1300
DCGSMSTVVS TKTIKTSHYL TPQSNHLSLS KSNSVSLVPP GSSHTLPRRA
1310 1320 1330 1340 1350
QSLKAPSIAT IKSLADCNFS YTSSRDAFGY ATLKRLQQQR MHPSLSHSEA
1360 1370 1380 1390 1400
LASPAKDVLF TDTITMKANS FESRLTPSRF MKALSYASLD KEDLLSPINQ
1410 1420 1430 1440 1450
NTLQRSSSVR SMVSSATYGG SDDYIGLALP VDINDIFQVK DIPYFQTKNI
1460 1470 1480 1490 1500
PPHDDRGARA FAHDAGGLPS GTGGLVKNSF HLLRQQMSLT EIMNSIHSDA
1510 1520 1530 1540 1550
SLFLESTEDT GLQEHTDDNC LYCVCIEILG FQPSNQLSAI CSHSDFQDIP
1560 1570 1580 1590 1600
YSDWCEQTIH NPLEVVPSKF SGISGCSDGV SQEGSASSTK STELLLGVKT
1610 1620 1630 1640 1650
IPDDTPMCRI LLRKEVLRLV INLSSSVSTK CHETGLLTIK EKYPQTFDDI
1660 1670 1680 1690 1700
CLYSEVSHLL SHCTFRLPCR RFIQELFQDV QFLQMHEEAE AVLATPPKQP
IVDTSAES
Isoform 2 (identifier: Q6R327-4) [UniParc]FASTAAdd to basket
The sequence of this isoform differs from the canonical sequence as follows:
252-257: RILAPY → NFSTLY
258-1708: Missing.
Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 545 | E → G in CAH18135 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 815 | F → L in CAH18135 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 1283 | N → S in CAH18135 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 1699 | Q → R in AAH51729 (PubMed:15489334).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051320 | 837 | S → F2 PublicationsCorresponds to variant dbSNP:rs2043112Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_038362 | 252 – 257 | RILAPY → NFSTLY in isoform 2. 1 Publication | 6 | |
Alternative sequenceiVSP_038363 | 258 – 1708 | Missing in isoform 2. 1 PublicationAdd BLAST | 1451 | |
Alternative sequenceiVSP_052581 | 1379 | R → RIDFKKKHVGGIRSLRPTIT NNLFR in isoform 3. 2 Publications | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY515854 mRNA. Translation: AAS79796.1. AL834497 mRNA. Translation: CAD39155.1. CR749280 mRNA. Translation: CAH18135.1. Sequence problems. AC008964 Genomic DNA. No translation available. AC109467 Genomic DNA. No translation available. CH471119 Genomic DNA. Translation: EAW55980.1. BC051729 mRNA. Translation: AAH51729.1. BC137163 mRNA. Translation: AAI37164.1. BC137164 mRNA. Translation: AAI37165.1. BC144509 mRNA. Translation: AAI44510.1. AB082530 mRNA. Translation: BAC02708.1. |
CCDSi | CCDS34148.1. [Q6R327-1] CCDS68861.1. [Q6R327-3] |
RefSeqi | NP_001272368.1. NM_001285439.1. [Q6R327-3] NP_001272369.1. NM_001285440.1. NP_689969.2. NM_152756.4. [Q6R327-1] |
UniGenei | Hs.407926. |
Genome annotation databases
Ensembli | ENST00000296782; ENSP00000296782; ENSG00000164327. [Q6R327-3] ENST00000357387; ENSP00000349959; ENSG00000164327. [Q6R327-1] ENST00000511516; ENSP00000423019; ENSG00000164327. [Q6R327-4] |
GeneIDi | 253260. |
KEGGi | hsa:253260. |
UCSCi | uc003jlo.4. human. [Q6R327-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Entry informationi
Entry namei | RICTR_HUMAN | |
Accessioni | Q6R327Primary (citable) accession number: Q6R327 Secondary accession number(s): B2RNX0 Q8NCM6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 23, 2007 |
Last sequence update: | July 5, 2004 | |
Last modified: | March 28, 2018 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |