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Protein

SCAN domain-containing protein 3

Gene

ZBED9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
SCAN domain-containing protein 3
Alternative name(s):
Transposon-derived Buster4 transposase-like protein
Zinc finger BED domain-containing protein 9
Gene namesi
Name:ZBED9
Synonyms:Buster4, KIAA1925, SCAND3, ZNF305P2, ZNF452
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000232040.2
HGNCiHGNC:13851 ZBED9
MIMi615254 gene
neXtProtiNX_Q6R2W3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000232040
PharmGKBiPA162402460

Polymorphism and mutation databases

BioMutaiSCAND3
DMDMi74710067

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002458461 – 1325SCAN domain-containing protein 3Add BLAST1325

Proteomic databases

PaxDbiQ6R2W3
PeptideAtlasiQ6R2W3
PRIDEiQ6R2W3

PTM databases

iPTMnetiQ6R2W3
PhosphoSitePlusiQ6R2W3

Expressioni

Gene expression databases

BgeeiENSG00000232040
ExpressionAtlasiQ6R2W3 baseline and differential
GenevisibleiQ6R2W3 HS

Organism-specific databases

HPAiHPA007246

Interactioni

Protein-protein interaction databases

BioGridi125371, 9 interactors
STRINGi9606.ENSP00000395259

Structurei

3D structure databases

ProteinModelPortaliQ6R2W3
SMRiQ6R2W3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 134SCAN boxPROSITE-ProRule annotationAdd BLAST83
Domaini366 – 526Integrase catalyticPROSITE-ProRule annotationAdd BLAST161

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili246 – 275Sequence analysisAdd BLAST30
Coiled coili542 – 568Sequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1265 – 1270Poly-Leu6

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0017 Eukaryota
KOG1721 Eukaryota
ENOG410ZSKF LUCA
GeneTreeiENSGT00860000133692
HOGENOMiHOG000154270
InParanoidiQ6R2W3
OMAiSSQPKEF
OrthoDBiEOG091G09O3
PhylomeDBiQ6R2W3
TreeFamiTF323092

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR001584 Integrase_cat-core
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR003309 SCAN_dom
IPR038269 SCAN_sf
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SUPFAMiSSF53098 SSF53098, 2 hits
PROSITEiView protein in PROSITE
PS50994 INTEGRASE, 1 hit
PS50804 SCAN_BOX, 1 hit

Sequencei

Sequence statusi: Complete.

Q6R2W3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEAVSRVFPA LAGQAPEEQG EIIKVKVKEE DHTWDQESAL RRNLSYTREL
60 70 80 90 100
SRQRFRQFCY QETPGPREAL SQLRELCRQW LNPEIHTKEQ ILELLVLEQF
110 120 130 140 150
LTILPEELQS WVREHNPESG EEVVTLLEDL ERELDEPRQQ VSQGTYGQEV
160 170 180 190 200
SMEEMIPLDS AKESLGTQLQ SMEDRMECES PEPHPLQDNG SFLWFSMMSQ
210 220 230 240 250
SMGGDNLSSL DTNEAEIEPE NMREKFFRSL ARLLENKSNN TKIFSKAKYC
260 270 280 290 300
QLIKEVKEAK AKAKKESVDY RRLARFDVIL VQGNEKLIEA VNGETDKIRY
310 320 330 340 350
YLHSEDLFDI LHNTHLSIGH GGRTRMEKEL QAKYKNITKE VIMLYLTLCK
360 370 380 390 400
PCQQKNSKLK KVLTSKSIKE VSSRCQVDLI DMQLNPDGEY RFILHYQDLC
410 420 430 440 450
TKLTFLRSLK SKRPTEVAHA LLDIFTIIGA PSVLQSDNGR EFSSQVVSEL
460 470 480 490 500
SNIWPELKIV HGKSQTCQSQ SSAEQTEDIR KRIFSWMQTN NSSHWTEFLW
510 520 530 540 550
FIQMSQNQPY HRSMQQTPCE SAFSSEAKLG LSHSQLTEEL VASLHTENEL
560 570 580 590 600
DQADKELENT LRAQYEENIE TGTDSSDIEE NLSVTPKVAE KSPPESRLRF
610 620 630 640 650
LSCVVCEKEC TGVNSCISCD GNIHAICGVP SQHGTEGCGR QITCSLCYET
660 670 680 690 700
STMKRKHDEI QRSLPVKPSK MLKPSGTPFS PDKVGDWMAK QASLDFFVKK
710 720 730 740 750
RHAFSEHSSS NKRNVNNRSY PEEGKTKRVH ASFTRKYDPS YIEFGFVAVI
760 770 780 790 800
DGEVLKPQCI ICGDVLANEA MKPSKLKRHL YSKHKEISSQ PKEFFERKSS
810 820 830 840 850
ELKSQPKQVF NVSHINISAL RASYKVALPV AKSKTPYTIA ETLVKDCIKE
860 870 880 890 900
VCLEMLGESA AKKVAQVPLS NDTIARRIQE LANDMEDQLI EQIKLAKYFS
910 920 930 940 950
LQLDECRDIA NMIILLVYVR FEHDDDIKEE FFFSASLPTN TTSSELYEAV
960 970 980 990 1000
KNYIVNKCGL EFKFCVGVCS DGAASMTGKH SEVVTQIKEL APECKTTHCF
1010 1020 1030 1040 1050
IHRESLAMKK ISAELNSVLN DIVKIVNYIK SNSLNSRLFS LLCDNMEADH
1060 1070 1080 1090 1100
KQLLLHAEIR WLSRGKVLSR MFEIRNELLV FLQGKKPMWS QLFKDVNWTA
1110 1120 1130 1140 1150
RLAYLSDIFS IFNDLNASMQ GKNATYFSMA DKVEGQKQKL EAWKNRISTD
1160 1170 1180 1190 1200
CYDMFHNLTT IINEVGNDLD IAHLRKVISE HLTNLLECFE FYFPSKEDPR
1210 1220 1230 1240 1250
IGNLWIQNPF LSSKDNLNLT VTLQDKLLKL ATDEGLKISF ENTASLPSFW
1260 1270 1280 1290 1300
IKAKNDYPEL AEIALKLLLL FPSTYLCETG FSTLSVIKTK HRNSLNIHYP
1310 1320
LRVALSSIQP RLDKLTSKKQ AHLSH
Length:1,325
Mass (Da):151,666
Last modified:July 5, 2004 - v1
Checksum:i637F5B2A42929A01
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti145T → A in BX647791 (PubMed:17974005).Curated1
Sequence conflicti536L → P in BX647791 (PubMed:17974005).Curated1
Sequence conflicti582L → P in BX647791 (PubMed:17974005).Curated1
Sequence conflicti913I → V in BX647791 (PubMed:17974005).Curated1
Sequence conflicti1112F → FF in CAD28490 (PubMed:17974005).Curated1
Sequence conflicti1169L → H in BX647791 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_027012155M → V. Corresponds to variant dbSNP:rs409029Ensembl.1
Natural variantiVAR_061703465Q → K1 PublicationCorresponds to variant dbSNP:rs41270593Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL713690 mRNA Translation: CAD28490.2
BX647791 mRNA No translation available.
AY517631 mRNA Translation: AAS01734.1
AL671879 Genomic DNA No translation available.
BC110834 mRNA Translation: AAI10835.1
BC111741 mRNA Translation: AAI11742.1
BC111742 mRNA Translation: AAI11743.1
AK056369 mRNA Translation: BAB71166.1
AB067512 mRNA Translation: BAB67818.1
CCDSiCCDS34355.1
RefSeqiNP_001316545.1, NM_001329616.1
NP_443155.1, NM_052923.1
UniGeneiHs.176980

Genome annotation databases

EnsembliENST00000452236; ENSP00000395259; ENSG00000232040
ENST00000600483; ENSP00000473230; ENSG00000248496
GeneIDi114821
KEGGihsa:114821
UCSCiuc003nlo.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSCND3_HUMAN
AccessioniPrimary (citable) accession number: Q6R2W3
Secondary accession number(s): Q2NKL9
, Q5SRJ3, Q8TCN2, Q96MV9, Q96PW3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health