Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein STRUBBELIG-RECEPTOR FAMILY 3

Gene

SRF3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Not essential for epidermal patterning and not redundant with STRUBBELIG.2 Publications

Miscellaneous

Over-expression of SRF3 led to male-sterility in both cv. Landsberg and cv. Columbia.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei513ATPPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi491 – 499ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • cell surface receptor signaling pathway Source: GO_Central
  • circadian rhythm Source: TAIR
  • protein phosphorylation Source: GO_Central

Keywordsi

Molecular functionReceptor
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-446652. Interleukin-1 family signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein STRUBBELIG-RECEPTOR FAMILY 3
Alternative name(s):
Leucine-rich repeat receptor kinase-like protein SRF3
Gene namesi
Name:SRF3
Ordered Locus Names:At4g03390
ORF Names:F4C21.35
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G03390.
TAIRilocus:2125566. AT4G03390.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini30 – 35CytoplasmicSequence analysis6
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Topological domaini57 – 316ExtracellularSequence analysisAdd BLAST260
Transmembranei317 – 337HelicalSequence analysisAdd BLAST21
Topological domaini338 – 776CytoplasmicSequence analysisAdd BLAST439

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Plants do not show root phenotype alteration.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000031184330 – 776Protein STRUBBELIG-RECEPTOR FAMILY 3Add BLAST747

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi72N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi179N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi248N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi253N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi310N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ6R2K3.

PTM databases

iPTMnetiQ6R2K3.
SwissPalmiQ6R2K3.

Expressioni

Tissue specificityi

Expressed in seedlings, roots, stems, leaves, flowers and siliques.1 Publication

Gene expression databases

ExpressionAtlasiQ6R2K3. baseline and differential.
GenevisibleiQ6R2K3. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G03390.1.

Structurei

3D structure databases

ProteinModelPortaliQ6R2K3.
SMRiQ6R2K3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati99 – 120LRR 1Add BLAST22
Repeati121 – 143LRR 2Add BLAST23
Repeati145 – 167LRR 3Add BLAST23
Repeati169 – 191LRR 4Add BLAST23
Repeati193 – 215LRR 5Add BLAST23
Repeati216 – 236LRR 6Add BLAST21
Domaini485 – 763Protein kinasePROSITE-ProRule annotationAdd BLAST279

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi280 – 283Poly-Pro4
Compositional biasi336 – 339Poly-Leu4
Compositional biasi427 – 466Pro-richAdd BLAST40

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IM0F. Eukaryota.
COG0515. LUCA.
HOGENOMiHOG000239794.
InParanoidiQ6R2K3.
OMAiHEAGTFT.
OrthoDBiEOG093604AP.
PhylomeDBiQ6R2K3.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiView protein in InterPro
IPR011009. Kinase-like_dom_sf.
IPR032675. LRR_dom_sf.
IPR013210. LRR_N_plant-typ.
IPR000719. Prot_kinase_dom.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
PfamiView protein in Pfam
PF08263. LRRNT_2. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiView protein in PROSITE
PS50011. PROTEIN_KINASE_DOM. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6R2K3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAKRSIYCL LLLPLLLSLL IWIPSISLAA TNPDDVAAIN GLFAALGAPV
60 70 80 90 100
LPGWIASGGD PCGEAWQGII CNVSDIISIT VNAANLQGEL GDNLAKFTSI
110 120 130 140 150
RGIDFSNNRI GGSIPSTLPV TLQHFFLSAN QFTGSIPESL GTLSFLNDMS
160 170 180 190 200
LNDNLLSGEL PDVFQNLVGL INLDISSNNI SGTLPPSMEN LLTLTTLRVQ
210 220 230 240 250
NNQLSGTLDV LQGLPLQDLN IENNLFSGPI PDKLLSIPKF LHEGNPFNAT
260 270 280 290 300
MINSTSTAPS LSPSLSPTKP APTRPFSGVP PPPNERNRGK VADGPSDSEG
310 320 330 340 350
SSSENSKGKN SSHTKKIILI AFAGVLVFII LVLAILLLLP KCARRREHAN
360 370 380 390 400
RVFKPHQVGA DRGSRENALE NGTPVLPPPG RSEKVQREPF KKAGEEPKVL
410 420 430 440 450
HDLERLRRPA PISRQESQDI DFSMLMPPPP PPPPPPPPPP LDEKVTVMPI
460 470 480 490 500
ISPERPVKKT SPKRLPLTSV KHYSIASLQQ YTESFAQENL IGSGMLGSVY
510 520 530 540 550
RARLPNGKLF AVKKLDKRAS EQQQDHEFIE LVNNIDMIRH SNIVELVGYC
560 570 580 590 600
AEHDQRLLVY EYCSNGTLQD GLHSDDEFKK KLSWNTRVSM ALGAARALEY
610 620 630 640 650
LHEVCEPPII HRNFKSANVL LDDDLSVLVS DCGLAPLISS GSVSQLSGQL
660 670 680 690 700
LAAYGYGAPE FDSGIYTWQS DVYSFGVVML ELLTGRMSYD RDRSRGEQFL
710 720 730 740 750
VRWAIPQLHD IDALGKMVDP SLNGQYPAKS LSHFADIISR CVQSEPEFRP
760 770
LMSEVVQDLL DMIRRERHGS GDSTAD
Length:776
Mass (Da):84,720
Last modified:July 5, 2004 - v1
Checksum:i566E9F703A9D3773
GO
Isoform 2 (identifier: Q6R2K3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     258-265: APSLSPSL → TTTTSSFG
     266-776: Missing.

Note: No experimental confirmation available.
Show »
Length:265
Mass (Da):28,034
Checksum:i8DBB522F0AC907D7
GO

Sequence cautioni

The sequence AAD14467 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence BAF00067 differs from that shown. Reason: Erroneous translation. Wrong choice of CDS.Curated
The sequence CAB77824 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_029610258 – 265APSLSPSL → TTTTSSFG in isoform 2. 1 Publication8
Alternative sequenceiVSP_029611266 – 776Missing in isoform 2. 1 PublicationAdd BLAST511

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY518288 mRNA. Translation: AAR99871.1.
AC005275 Genomic DNA. Translation: AAD14467.1. Sequence problems.
AL161496 Genomic DNA. Translation: CAB77824.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE82313.1.
CP002687 Genomic DNA. Translation: ANM67568.1.
AK228109 mRNA. Translation: BAF00067.1. Sequence problems.
PIRiA85043.
RefSeqiNP_001329389.1. NM_001340445.1. [Q6R2K3-1]
NP_192248.2. NM_116577.5. [Q6R2K3-1]
UniGeneiAt.27919.

Genome annotation databases

EnsemblPlantsiAT4G03390.1; AT4G03390.1; AT4G03390. [Q6R2K3-1]
AT4G03390.2; AT4G03390.2; AT4G03390. [Q6R2K3-1]
GeneIDi827941.
GrameneiAT4G03390.1; AT4G03390.1; AT4G03390.
AT4G03390.2; AT4G03390.2; AT4G03390.
KEGGiath:AT4G03390.

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSRF3_ARATH
AccessioniPrimary (citable) accession number: Q6R2K3
Secondary accession number(s): Q0WS32, Q9ZQZ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: July 5, 2004
Last modified: November 22, 2017
This is version 109 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Caution

An alternative isoform might be encoded by the 3'part of the transcript derived from AK228109.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families