Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas

Gene

Gnas

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP. GNAS functions downstream of several GPCRs, including beta-adrenergic receptors. XLas isoforms interact with the same set of receptors as Gnas isoforms.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi793MagnesiumBy similarity1
Metal bindingi943MagnesiumBy similarity1
Binding sitei1105GTP; via amide nitrogenBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi786 – 794GTPBy similarity9
Nucleotide bindingi936 – 943GTPBy similarity8
Nucleotide bindingi962 – 966GTPBy similarity5
Nucleotide bindingi1031 – 1034GTPBy similarity4

GO - Molecular functioni

GO - Biological processi

  • adenylate cyclase-activating adrenergic receptor signaling pathway Source: MGI
  • adenylate cyclase-activating dopamine receptor signaling pathway Source: MGI
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
  • bone development Source: MGI
  • cartilage development Source: MGI
  • cognition Source: MGI
  • developmental growth Source: MGI
  • DNA methylation Source: MGI
  • embryonic cranial skeleton morphogenesis Source: MGI
  • embryonic hindlimb morphogenesis Source: MGI
  • endochondral ossification Source: MGI
  • energy reserve metabolic process Source: MGI
  • genetic imprinting Source: MGI
  • G-protein coupled receptor signaling pathway Source: MGI
  • hair follicle placode formation Source: MGI
  • multicellular organism growth Source: MGI
  • platelet aggregation Source: MGI
  • positive regulation of cAMP biosynthetic process Source: MGI
  • positive regulation of cAMP-mediated signaling Source: MGI
  • positive regulation of GTPase activity Source: MGI
  • positive regulation of osteoblast differentiation Source: MGI
  • positive regulation of osteoclast differentiation Source: MGI
  • post-embryonic body morphogenesis Source: MGI
  • post-embryonic development Source: MGI
  • regulation of parathyroid hormone secretion Source: MGI
  • regulation of signal transduction Source: MGI
  • response to drug Source: MGI
  • response to parathyroid hormone Source: MGI
  • sensory perception of chemical stimulus Source: GO_Central
  • skeletal system development Source: MGI
  • skin development Source: MGI
  • tissue homeostasis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Transducer

Keywords - Ligandi

GTP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-163359. Glucagon signaling in metabolic regulation.
R-MMU-164378. PKA activation in glucagon signalling.
R-MMU-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-MMU-392851. Prostacyclin signalling through prostacyclin receptor.
R-MMU-418555. G alpha (s) signalling events.
R-MMU-420092. Glucagon-type ligand receptors.
R-MMU-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-MMU-5610787. Hedgehog 'off' state.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas
Alternative name(s):
Adenylate cyclase-stimulating G alpha protein
Extra large alphas protein
Short name:
XLalphas
Gene namesi
Name:GnasImported
Synonyms:Gnas1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:95777. Gnas.

Subcellular locationi

  • Cell membrane By similarity; Peripheral membrane protein By similarity
  • Apical cell membrane By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice cells lacking XLas isoforms which are then transfected with these isoforms and a range of receptors demonstrate that the XLas isoforms are capable of functionally coupling to the same receptors as the Gnas isoforms including Adrb2, Crfr1, Pthr1 and Tshr.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002539851 – 1133Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLasAdd BLAST1133

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei940ADP-ribosylarginine; by cholera toxinBy similarity1
Modified residuei1091PhosphoserineBy similarity1

Keywords - PTMi

ADP-ribosylation, Phosphoprotein

Proteomic databases

EPDiQ6R0H7.
PaxDbiQ6R0H7.
PeptideAtlasiQ6R0H7.
PRIDEiQ6R0H7.

PTM databases

iPTMnetiQ6R0H7.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027523.
ExpressionAtlasiQ6R0H7. baseline and differential.
GenevisibleiQ6R0H7. MM.

Interactioni

Subunit structurei

G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts through its N-terminal region with ALEX which is produced from the same locus in a different open reading frame. This interaction may inhibit its adenylyl cyclase-stimulating activity (By similarity). Interacts with MAGED2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199972. 2 interactors.
IntActiQ6R0H7. 1 interactor.
STRINGi10090.ENSMUSP00000079341.

Structurei

3D structure databases

ProteinModelPortaliQ6R0H7.
SMRiQ6R0H7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili737 – 761Sequence analysisAdd BLAST25

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi19 – 303Pro-richSequence analysisAdd BLAST285
Compositional biasi450 – 619Ala-richSequence analysisAdd BLAST170

Sequence similaritiesi

Belongs to the G-alpha family. G(s) subfamily.Sequence analysis

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG0099. Eukaryota.
ENOG410XPC4. LUCA.
GeneTreeiENSGT00770000120503.
HOVERGENiHBG079975.
InParanoidiQ6R0H7.
OMAiNDERPSH.
OrthoDBiEOG091G0CAY.
PhylomeDBiQ6R0H7.
TreeFamiTF300673.

Family and domain databases

CDDicd00066. G-alpha. 1 hit.
Gene3Di1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR000367. Gprotein_alpha_S.
IPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10218. PTHR10218. 2 hits.
PfamiPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSiPR00318. GPROTEINA.
PR00443. GPROTEINAS.
SMARTiSM00275. G_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.

Sequences (9)i

Sequence statusi: Complete.

This entry describes 9 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform XLas-1 (identifier: Q6R0H7-1) [UniParc]FASTAAdd to basket
Also known as: XXL1 Publication

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGMFNCLHGN NMSGQHDIPP EVGEQPEQEP LEAPGAAAPG AGAGPAEEMA
60 70 80 90 100
TEPDSEPSNN EPVPDETGSE ISGPPEDSKS DIQSPCQAFE EVRVGGDYSP
110 120 130 140 150
PPEEAMPFET QQPSLGDFWP TLEQPGPSGT PSGLQAFNPA ILEPGTPTGA
160 170 180 190 200
SPGLGAYTPP PEEAMPFEFN EPAQGDHSQP PLQVPDLAPG GPEALVPRAL
210 220 230 240 250
PAEPGNIRFE NAGFREDYSP PPEESVPFQV GGEEFGGDSP PPGLPRVIPQ
260 270 280 290 300
IGIGGEFPTV AVPSALCLAP AENAPPLWVR GAIDRPFREA VRSPPNFACD
310 320 330 340 350
SPPMEITRPL LEIGRASIGV DDDTAVNMDS PPIASDGPPI EVSGAPDKSE
360 370 380 390 400
CAERPPVERE AAEMEGSPTT ATAVEGKVPS PERGDGSSTQ PEAMDAKPAP
410 420 430 440 450
AAQAVSTGSD AGAPTDSAML TDSQSDAGED GTAPGTPSDL QSDPEELEEA
460 470 480 490 500
PAVRADPDGG AAPVAPATPA ESESEGSRDP AAEPASEAVP ATTAESASGA
510 520 530 540 550
APVTQVEPAA AAVSATLAEP AARAAPITPK EPTTRAVPSA RAHPAAGAVP
560 570 580 590 600
GAPAMSASAR AAAARAAYAG PLVWGARSLS ATPAARASLP ARAAAAARAA
610 620 630 640 650
SAARAVAAGR SASAAPSRAH LRPPSPEIQV ADPPTPRPPP RPTAWPDKYE
660 670 680 690 700
RGRSCCRYEA SSGICEIESS SDESEEGATG CFQWLLRRNR RPGLPRSHTV
710 720 730 740 750
GSNPVRNFFT RAFGSCFGLS ECTRSRSLSP GKAKDPMEER RKQMRKEAIE
760 770 780 790 800
MREQKRADKK RSKLIDKQLE EEKMDYMCTH RLLLLGAGES GKSTIVKQMR
810 820 830 840 850
ILHVNGFNGE GGEEDPQAAR SNSDGEKATK VQDIKNNLKE AIETIVAAMS
860 870 880 890 900
NLVPPVELAN PENQFRVDYI LSVMNVPNFD FPPEFYEHAK ALWEDEGVRA
910 920 930 940 950
CYERSNEYQL IDCAQYFLDK IDVIKQADYV PSDQDLLRCR VLTSGIFETK
960 970 980 990 1000
FQVDKVNFHM FDVGGQRDER RKWIQCFNDV TAIIFVVASS SYNMVIREDN
1010 1020 1030 1040 1050
QTNRLQEALN LFKSIWNNRW LRTISVILFL NKQDLLAEKV LAGKSKIEDY
1060 1070 1080 1090 1100
FPEFARYTTP EDATPEPGED PRVTRAKYFI RDEFLRISTA SGDGRHYCYP
1110 1120 1130
HFTCAVDTEN IRRVFNDCRD IIQRMHLRQY ELL
Length:1,133
Mass (Da):121,505
Last modified:July 5, 2004 - v1
Checksum:iC1497D45498172F7
GO
Isoform XLas-2 (identifier: Q6R0H7-2) [UniParc]FASTAAdd to basket
Also known as: XXLb11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     787-876: AGESGKSTIV...VDYILSVMNV → RKVVPSDTEG...WCPFSVFACA
     877-1133: Missing.

Show »
Length:876
Mass (Da):91,094
Checksum:iA5C9C8616F7D5655
GO
Isoform XLas-3 (identifier: Q6R0H7-3) [UniParc]FASTAAdd to basket
Also known as: XXLb21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     787-827: AGESGKSTIV...AARSNSDGEK → RKVVPSDTEG...VLESLAKAPL
     828-1133: Missing.

Show »
Length:827
Mass (Da):85,918
Checksum:i212C34DCA37D0D07
GO
Isoform XLas-4 (identifier: Q6R0H7-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     810-825: EGGEEDPQAARSNSDG → DS

Show »
Length:1,119
Mass (Da):120,107
Checksum:i7CE085576EBF061E
GO
Isoform Gnas-1Curated (identifier: P63094-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P63094.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:394
Mass (Da):45,664
GO
Isoform Gnas-2Curated (identifier: P63094-2) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P63094.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:380
Mass (Da):44,265
GO
Isoform Gnas-3Curated (identifier: P63094-3) [UniParc]FASTAAdd to basket
Also known as: NTasCurated
The sequence of this isoform can be found in the external entry P63094.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:362
Mass (Da):41,818
GO
Isoform Nesp55-1Curated (identifier: Q9Z0F1-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q9Z0F1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Shares no sequence similarity with other isoforms (except isoform Nesp55-2) due to a novel first exon containing the entire reading frame spliced to shared exon 2 so that exons 2-13 make up the 3'-UTR.
Length:257
Mass (Da):29,301
GO
Isoform Nesp55-2Curated (identifier: Q9Z0F1-2) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry Q9Z0F1.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Shares no sequence similarity with other isoforms (except isoform Nesp55-1) due to a novel first exon containing the entire reading frame spliced to shared exon 2 so that exons 2-13 make up the 3'-UTR.
Length:253
Mass (Da):28,930
GO

Sequence cautioni

The sequence AAD14686 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAB83219 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti371A → G in CAB83219 (PubMed:10931851).Curated1
Sequence conflicti381P → S in CAB83219 (PubMed:10931851).Curated1
Sequence conflicti578 – 591SLSAT…ASLPA → YSRYSQLLPPLGHPFLPR (PubMed:10749992).CuratedAdd BLAST14
Sequence conflicti595 – 596Missing (PubMed:10749992).Curated2
Sequence conflicti599A → Q (PubMed:10749992).Curated1
Sequence conflicti613 – 617SAAPS → LPPH (PubMed:10749992).Curated5
Sequence conflicti622 – 628RPPSPEI → DPQPRD (PubMed:10749992).Curated7

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_052176787 – 876AGESG…SVMNV → RKVVPSDTEGRYRPEASASA SDRRLDRRGREVSPELLGWA LRGSPGSIVRDRGGLGPSGC APPPRLARLLRLRQLVVGVC WCPFSVFACA in isoform XLas-2. 1 PublicationAdd BLAST90
Alternative sequenceiVSP_052177787 – 827AGESG…SDGEK → RKVVPSDTEGRYRPEASASA SDRRLDRRGREVLESLAKAP L in isoform XLas-3. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_052178810 – 825EGGEE…SNSDG → DS in isoform XLas-4. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_052179828 – 1133Missing in isoform XLas-3. 1 PublicationAdd BLAST306
Alternative sequenceiVSP_052180877 – 1133Missing in isoform XLas-2. 1 PublicationAdd BLAST257

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY518305 Genomic DNA. Translation: AAR99380.1.
AY518306 Genomic DNA. Translation: AAR99381.1.
AY518307 Genomic DNA. Translation: AAR99382.1.
AY518308 Genomic DNA. Translation: AAR99383.1.
AY519501 mRNA. Translation: AAS00601.1.
AY519503 mRNA. Translation: AAS00603.1.
AY519504 mRNA. Translation: AAS00604.1.
AL593857 Genomic DNA. Translation: CAM24406.1.
AL593857 Genomic DNA. Translation: CAM24407.1.
AJ251761 Genomic DNA. Translation: CAB83219.1. Different initiation.
AF116268 mRNA. Translation: AAD14686.1. Different initiation.
CCDSiCCDS17151.1. [Q6R0H7-1]
CCDS38354.1. [Q6R0H7-4]
CCDS38355.1. [Q6R0H7-2]
RefSeqiNP_001070975.1. NM_001077507.2. [Q6R0H7-4]
NP_001297014.1. NM_001310085.1. [Q6R0H7-3]
NP_034439.2. NM_010309.4. [Q6R0H7-1]
NP_963911.1. NM_201617.2. [Q6R0H7-2]
UniGeneiMm.125770.
Mm.394046.

Genome annotation databases

EnsembliENSMUST00000080493; ENSMUSP00000079341; ENSMUSG00000027523. [Q6R0H7-1]
ENSMUST00000087876; ENSMUSP00000085184; ENSMUSG00000027523. [Q6R0H7-4]
ENSMUST00000087877; ENSMUSP00000085185; ENSMUSG00000027523. [Q6R0H7-2]
ENSMUST00000185956; ENSMUSP00000140174; ENSMUSG00000027523. [Q6R0H7-1]
GeneIDi14683.
UCSCiuc008oet.1. mouse. [Q6R0H7-2]
uc033hrq.1. mouse. [Q6R0H7-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY518305 Genomic DNA. Translation: AAR99380.1.
AY518306 Genomic DNA. Translation: AAR99381.1.
AY518307 Genomic DNA. Translation: AAR99382.1.
AY518308 Genomic DNA. Translation: AAR99383.1.
AY519501 mRNA. Translation: AAS00601.1.
AY519503 mRNA. Translation: AAS00603.1.
AY519504 mRNA. Translation: AAS00604.1.
AL593857 Genomic DNA. Translation: CAM24406.1.
AL593857 Genomic DNA. Translation: CAM24407.1.
AJ251761 Genomic DNA. Translation: CAB83219.1. Different initiation.
AF116268 mRNA. Translation: AAD14686.1. Different initiation.
CCDSiCCDS17151.1. [Q6R0H7-1]
CCDS38354.1. [Q6R0H7-4]
CCDS38355.1. [Q6R0H7-2]
RefSeqiNP_001070975.1. NM_001077507.2. [Q6R0H7-4]
NP_001297014.1. NM_001310085.1. [Q6R0H7-3]
NP_034439.2. NM_010309.4. [Q6R0H7-1]
NP_963911.1. NM_201617.2. [Q6R0H7-2]
UniGeneiMm.125770.
Mm.394046.

3D structure databases

ProteinModelPortaliQ6R0H7.
SMRiQ6R0H7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199972. 2 interactors.
IntActiQ6R0H7. 1 interactor.
STRINGi10090.ENSMUSP00000079341.

PTM databases

iPTMnetiQ6R0H7.

Proteomic databases

EPDiQ6R0H7.
PaxDbiQ6R0H7.
PeptideAtlasiQ6R0H7.
PRIDEiQ6R0H7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000080493; ENSMUSP00000079341; ENSMUSG00000027523. [Q6R0H7-1]
ENSMUST00000087876; ENSMUSP00000085184; ENSMUSG00000027523. [Q6R0H7-4]
ENSMUST00000087877; ENSMUSP00000085185; ENSMUSG00000027523. [Q6R0H7-2]
ENSMUST00000185956; ENSMUSP00000140174; ENSMUSG00000027523. [Q6R0H7-1]
GeneIDi14683.
UCSCiuc008oet.1. mouse. [Q6R0H7-2]
uc033hrq.1. mouse. [Q6R0H7-4]

Organism-specific databases

CTDi2778.
MGIiMGI:95777. Gnas.

Phylogenomic databases

eggNOGiKOG0099. Eukaryota.
ENOG410XPC4. LUCA.
GeneTreeiENSGT00770000120503.
HOVERGENiHBG079975.
InParanoidiQ6R0H7.
OMAiNDERPSH.
OrthoDBiEOG091G0CAY.
PhylomeDBiQ6R0H7.
TreeFamiTF300673.

Enzyme and pathway databases

ReactomeiR-MMU-163359. Glucagon signaling in metabolic regulation.
R-MMU-164378. PKA activation in glucagon signalling.
R-MMU-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-MMU-392851. Prostacyclin signalling through prostacyclin receptor.
R-MMU-418555. G alpha (s) signalling events.
R-MMU-420092. Glucagon-type ligand receptors.
R-MMU-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-MMU-5610787. Hedgehog 'off' state.

Miscellaneous databases

ChiTaRSiGnas. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027523.
ExpressionAtlasiQ6R0H7. baseline and differential.
GenevisibleiQ6R0H7. MM.

Family and domain databases

CDDicd00066. G-alpha. 1 hit.
Gene3Di1.10.400.10. 1 hit.
3.40.50.300. 2 hits.
InterProiIPR000367. Gprotein_alpha_S.
IPR001019. Gprotein_alpha_su.
IPR011025. GproteinA_insert.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR10218. PTHR10218. 2 hits.
PfamiPF00503. G-alpha. 1 hit.
[Graphical view]
PRINTSiPR00318. GPROTEINA.
PR00443. GPROTEINAS.
SMARTiSM00275. G_alpha. 1 hit.
[Graphical view]
SUPFAMiSSF47895. SSF47895. 1 hit.
SSF52540. SSF52540. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiGNAS1_MOUSE
AccessioniPrimary (citable) accession number: Q6R0H7
Secondary accession number(s): A2A607
, A2A608, Q6R0H4, Q6R0H5, Q6R2J5, Q9JJX0, Q9Z1N8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is produced by a bicistronic gene which also produces the ALEX protein from an overlapping reading frame.By similarity
The GNAS locus is imprinted in a complex manner, giving rise to distinct paternally, maternally and biallelically expressed proteins. The XLas isoforms are paternally derived, the Gnas isoforms are biallelically derived and the Nesp55 isoforms are maternally derived.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.