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Protein

Protein ALEX

Gene

Gnas

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

May inhibit the adenylyl cyclase-stimulating activity of guanine nucleotide-binding protein G(s) subunit alpha which is produced from the same locus in a different open reading frame.By similarity

GO - Molecular functioni

GO - Biological processi

  • adenylate cyclase-activating adrenergic receptor signaling pathway Source: MGI
  • adenylate cyclase-activating dopamine receptor signaling pathway Source: MGI
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
  • bone development Source: MGI
  • cartilage development Source: MGI
  • cognition Source: MGI
  • developmental growth Source: MGI
  • DNA methylation Source: MGI
  • embryonic cranial skeleton morphogenesis Source: MGI
  • embryonic hindlimb morphogenesis Source: MGI
  • endochondral ossification Source: MGI
  • energy reserve metabolic process Source: MGI
  • genetic imprinting Source: MGI
  • G-protein coupled receptor signaling pathway Source: MGI
  • hair follicle placode formation Source: MGI
  • multicellular organism growth Source: MGI
  • platelet aggregation Source: MGI
  • positive regulation of cAMP biosynthetic process Source: MGI
  • positive regulation of cAMP-mediated signaling Source: MGI
  • positive regulation of GTPase activity Source: MGI
  • positive regulation of osteoblast differentiation Source: MGI
  • positive regulation of osteoclast differentiation Source: MGI
  • post-embryonic body morphogenesis Source: MGI
  • post-embryonic development Source: MGI
  • regulation of parathyroid hormone secretion Source: MGI
  • regulation of signal transduction Source: MGI
  • response to drug Source: MGI
  • response to parathyroid hormone Source: MGI
  • skeletal system development Source: MGI
  • skin development Source: MGI
  • tissue homeostasis Source: MGI
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-MMU-163359. Glucagon signaling in metabolic regulation.
R-MMU-164378. PKA activation in glucagon signalling.
R-MMU-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-MMU-392851. Prostacyclin signalling through prostacyclin receptor.
R-MMU-418555. G alpha (s) signalling events.
R-MMU-420092. Glucagon-type ligand receptors.
R-MMU-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-MMU-5610787. Hedgehog 'off' state.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein ALEX
Alternative name(s):
Alternative gene product encoded by XL-exon
Gene namesi
Name:GnasImported
Synonyms:Gnas1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:95777. Gnas.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002539651 – 725Protein ALEXAdd BLAST725

Proteomic databases

PRIDEiQ6R0H6.

2D gel databases

REPRODUCTION-2DPAGEIPI00471141.

PTM databases

SwissPalmiQ6R0H6.

Expressioni

Gene expression databases

BgeeiENSMUSG00000027523.
ExpressionAtlasiQ6R0H6. baseline and differential.
GenevisibleiQ6R0H6. MM.

Interactioni

Subunit structurei

Interacts with the N-terminal region of the XLas isoforms of guanine nucleotide-binding protein G(s) subunit alpha.By similarity

Protein-protein interaction databases

BioGridi199972. 2 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ6R0H6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi310 – 567Pro-richSequence analysisAdd BLAST258

Sequence similaritiesi

Belongs to the ALEX family.Curated

Phylogenomic databases

GeneTreeiENSGT00770000120503.
HOGENOMiHOG000293422.
HOVERGENiHBG080831.

Sequencei

Sequence statusi: Complete.

Q6R0H6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPSPTRLAV RSVDPQKTPN LTSKAPARPS RKSEWVETTA HLRRKPCHSR
60 70 80 90 100
HNSPAWEISG PPWSSQDHLG PHQASKPSTQ RFWSPGPPLA RAQAWEPIPP
110 120 130 140 150
HQKKLCHLSS TSLPRETIAS LPCKSQTLRQ EVRKHWSPEL FPRSPGTSDL
160 170 180 190 200
KTLASEKTTA LPLKNLCHFR SVEKNSGAIA HPQDSRESSH KSALAASSRQ
210 220 230 240 250
SRSRVRSASL PPRTRLPSGS EAPLTDHSAR LSDLLLTSHA TAPRWRSPDP
260 270 280 290 300
CLRLAEPPLG STTTPLSIWT APQSQVMARP SKSREPQIRA SAQRDPQLSE
310 320 330 340 350
KQPRWKEALP PPLRWKEKSP LRREGTDLPP SLKQWMPSQP LLPKPSLPDL
360 370 380 390 400
MLELLRIPRC SQIARAMPEK TGQPQERLQI SSRILKNSKK PQLSAPILTE
410 420 430 440 450
GQPQSPQPLL PSPSLKAAEI QPPSQPPRQS LPPRPSLPPG QPLSPRWSPQ
460 470 480 490 500
PRQSLPPWRS LPPGQPLSPP RSPLPGQSPL LEPIRPLEQS LAPQQCQPLL
510 520 530 540 550
GQLPLGQPMQ VHWSGEPGHS QLLPPLGHPF LPAQQLPPGQ PLLPAQSLLA
560 570 580 590 600
GQPLPPPAGP ILDPPAPRSR LLTRLLRGLL RGRLPGLTST SGAEAAAGTR
610 620 630 640 650
HRLASARSSP PVMSRKKGPP AASSGFCGET AALACPGATR SGATQSATSS
660 670 680 690 700
PEPSEAASVY PSVPDHDPSA PGRPRILWRR GANRCAKKPL RCESRSAQIR
710 720
NAASSSTSNW RRRRWTTCVH TACCF
Length:725
Mass (Da):79,084
Last modified:July 5, 2004 - v1
Checksum:i273F2244509B1573
GO

Sequence cautioni

The sequence BAC26987 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti297Q → E (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY519502 mRNA. Translation: AAS00602.1.
AL593857 Genomic DNA. Translation: CAO78033.1.
AK030489 mRNA. Translation: BAC26987.1. Different initiation.
CCDSiCCDS50817.1.
RefSeqiNP_001070975.1. NM_001077507.2.
NP_001297014.1. NM_001310085.1.
NP_963911.1. NM_201617.2.
NP_963912.1. NM_201618.2.
UniGeneiMm.125770.
Mm.394046.

Genome annotation databases

EnsembliENSMUST00000109088; ENSMUSP00000104716; ENSMUSG00000027523.
ENSMUST00000186907; ENSMUSP00000139839; ENSMUSG00000027523.
GeneIDi14683.
UCSCiuc008oeu.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY519502 mRNA. Translation: AAS00602.1.
AL593857 Genomic DNA. Translation: CAO78033.1.
AK030489 mRNA. Translation: BAC26987.1. Different initiation.
CCDSiCCDS50817.1.
RefSeqiNP_001070975.1. NM_001077507.2.
NP_001297014.1. NM_001310085.1.
NP_963911.1. NM_201617.2.
NP_963912.1. NM_201618.2.
UniGeneiMm.125770.
Mm.394046.

3D structure databases

ProteinModelPortaliQ6R0H6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199972. 2 interactors.

PTM databases

SwissPalmiQ6R0H6.

2D gel databases

REPRODUCTION-2DPAGEIPI00471141.

Proteomic databases

PRIDEiQ6R0H6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000109088; ENSMUSP00000104716; ENSMUSG00000027523.
ENSMUST00000186907; ENSMUSP00000139839; ENSMUSG00000027523.
GeneIDi14683.
UCSCiuc008oeu.2. mouse.

Organism-specific databases

CTDi2778.
MGIiMGI:95777. Gnas.

Phylogenomic databases

GeneTreeiENSGT00770000120503.
HOGENOMiHOG000293422.
HOVERGENiHBG080831.

Enzyme and pathway databases

ReactomeiR-MMU-163359. Glucagon signaling in metabolic regulation.
R-MMU-164378. PKA activation in glucagon signalling.
R-MMU-381676. Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.
R-MMU-392851. Prostacyclin signalling through prostacyclin receptor.
R-MMU-418555. G alpha (s) signalling events.
R-MMU-420092. Glucagon-type ligand receptors.
R-MMU-432040. Vasopressin regulates renal water homeostasis via Aquaporins.
R-MMU-5610787. Hedgehog 'off' state.

Miscellaneous databases

ChiTaRSiGnas. mouse.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027523.
ExpressionAtlasiQ6R0H6. baseline and differential.
GenevisibleiQ6R0H6. MM.

Family and domain databases

ProtoNetiSearch...

Entry informationi

Entry nameiALEX_MOUSE
AccessioniPrimary (citable) accession number: Q6R0H6
Secondary accession number(s): A6PW72, Q8BIR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

This protein is produced by a bicistronic gene which also produces guanine nucleotide-binding protein G(s) subunit alpha from an overlapping reading frame.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.