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Protein

Calcium/calmodulin-dependent protein kinase II inhibitor 1

Gene

Camk2n1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Potent and specific inhibitor of CaM-kinase II (CAMK2).By similarity

GO - Molecular functioni

Keywordsi

Molecular functionProtein kinase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium/calmodulin-dependent protein kinase II inhibitor 1
Alternative name(s):
calcium/calmodulin-dependent protein kinase II inhibitor alpha
Short name:
mCaMKIINalpha
Gene namesi
Name:Camk2n1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1913509. Camk2n1.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003383941 – 78Calcium/calmodulin-dependent protein kinase II inhibitor 1Add BLAST78

Proteomic databases

MaxQBiQ6QWF9.
PaxDbiQ6QWF9.
PRIDEiQ6QWF9.

PTM databases

iPTMnetiQ6QWF9.
PhosphoSitePlusiQ6QWF9.

Expressioni

Tissue specificityi

Brain specific (at protein level).1 Publication

Inductioni

Up-regulated during consolidation of fear memory. Down-regulated in brain during Japanese encephalitis virus (JEV) and rabies virus infection.2 Publications

Gene expression databases

BgeeiENSMUSG00000046447.
GenevisibleiQ6QWF9. MM.

Interactioni

Subunit structurei

Interacts with CAMK2B; the presence of Ca2+/calmodulin increases the interaction but is not essential. Interacts with CAMK2A; this interaction requires CAMK2A activation by Ca2+ (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060349.

Structurei

3D structure databases

ProteinModelPortaliQ6QWF9.
SMRiQ6QWF9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni41 – 68CAMK2 inhibitory domainBy similarityAdd BLAST28

Sequence similaritiesi

Belongs to the CAMK2N family.Curated

Phylogenomic databases

eggNOGiENOG410J0PZ. Eukaryota.
ENOG410YP01. LUCA.
GeneTreeiENSGT00390000004940.
HOGENOMiHOG000060311.
HOVERGENiHBG104926.
InParanoidiQ6QWF9.
OMAiKLGHYGD.
OrthoDBiEOG091G15S0.
PhylomeDBiQ6QWF9.
TreeFamiTF333175.

Family and domain databases

InterProiView protein in InterPro
IPR026779. Camk2n.
PANTHERiPTHR31007. PTHR31007. 1 hit.
PfamiView protein in Pfam
PF15170. CaM-KIIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6QWF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEVLPYGDE KLSPYGDGGD VGQIFSCRLQ DTNNFFGAGQ SKRPPKLGQI
60 70
GRSKRVVIED DRIDDVLKTM TDKAPPGV
Length:78
Mass (Da):8,513
Last modified:July 5, 2004 - v1
Checksum:iA89A9E5DA11B8E61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY523601 mRNA. Translation: AAS02090.1.
AL807249 Genomic DNA. Translation: CAM18882.1.
CCDSiCCDS38930.1.
RefSeqiNP_079727.1. NM_025451.2.
UniGeneiMm.41603.

Genome annotation databases

EnsembliENSMUST00000050918; ENSMUSP00000060349; ENSMUSG00000046447.
GeneIDi66259.
KEGGimmu:66259.
UCSCiuc008vkz.2. mouse.

Similar proteinsi

Entry informationi

Entry nameiCK2N1_MOUSE
AccessioniPrimary (citable) accession number: Q6QWF9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: July 5, 2004
Last modified: September 27, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families