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Protein

Calcium/calmodulin-dependent protein kinase II inhibitor 1

Gene

Camk2n1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Potent and specific inhibitor of CaM-kinase II (CAMK2).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Protein kinase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium/calmodulin-dependent protein kinase II inhibitor 1
Alternative name(s):
calcium/calmodulin-dependent protein kinase II inhibitor alpha
Short name:
mCaMKIINalpha
Gene namesi
Name:Camk2n1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:1913509. Camk2n1.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • dendrite Source: Ensembl
  • neuronal cell body Source: Ensembl
  • postsynaptic density Source: MGI
  • postsynaptic membrane Source: UniProtKB-KW
  • synapse Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 7878Calcium/calmodulin-dependent protein kinase II inhibitor 1PRO_0000338394Add
BLAST

Proteomic databases

MaxQBiQ6QWF9.
PaxDbiQ6QWF9.
PRIDEiQ6QWF9.

PTM databases

iPTMnetiQ6QWF9.
PhosphoSiteiQ6QWF9.

Expressioni

Tissue specificityi

Brain specific (at protein level).1 Publication

Inductioni

Up-regulated during consolidation of fear memory. Down-regulated in brain during Japanese encephalitis virus (JEV) and rabies virus infection.2 Publications

Gene expression databases

BgeeiENSMUSG00000046447.
GenevisibleiQ6QWF9. MM.

Interactioni

Subunit structurei

Interacts with CAMK2B; the presence of Ca2+/calmodulin increases the interaction but is not essential. Interacts with CAMK2A; this interaction requires CAMK2A activation by Ca2+ (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060349.

Structurei

3D structure databases

ProteinModelPortaliQ6QWF9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni41 – 6828CAMK2 inhibitory domainBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the CAMK2N family.Curated

Phylogenomic databases

eggNOGiENOG410J0PZ. Eukaryota.
ENOG410YP01. LUCA.
GeneTreeiENSGT00390000004940.
HOGENOMiHOG000060311.
HOVERGENiHBG104926.
InParanoidiQ6QWF9.
OMAiDEGHLSF.
OrthoDBiEOG091G15S0.
PhylomeDBiQ6QWF9.
TreeFamiTF333175.

Family and domain databases

InterProiIPR026779. Camk2n.
[Graphical view]
PfamiPF15170. CaM-KIIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6QWF9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSEVLPYGDE KLSPYGDGGD VGQIFSCRLQ DTNNFFGAGQ SKRPPKLGQI
60 70
GRSKRVVIED DRIDDVLKTM TDKAPPGV
Length:78
Mass (Da):8,513
Last modified:July 5, 2004 - v1
Checksum:iA89A9E5DA11B8E61
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY523601 mRNA. Translation: AAS02090.1.
AL807249 Genomic DNA. Translation: CAM18882.1.
CCDSiCCDS38930.1.
RefSeqiNP_079727.1. NM_025451.2.
UniGeneiMm.41603.

Genome annotation databases

EnsembliENSMUST00000050918; ENSMUSP00000060349; ENSMUSG00000046447.
GeneIDi66259.
KEGGimmu:66259.
UCSCiuc008vkz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY523601 mRNA. Translation: AAS02090.1.
AL807249 Genomic DNA. Translation: CAM18882.1.
CCDSiCCDS38930.1.
RefSeqiNP_079727.1. NM_025451.2.
UniGeneiMm.41603.

3D structure databases

ProteinModelPortaliQ6QWF9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000060349.

PTM databases

iPTMnetiQ6QWF9.
PhosphoSiteiQ6QWF9.

Proteomic databases

MaxQBiQ6QWF9.
PaxDbiQ6QWF9.
PRIDEiQ6QWF9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000050918; ENSMUSP00000060349; ENSMUSG00000046447.
GeneIDi66259.
KEGGimmu:66259.
UCSCiuc008vkz.2. mouse.

Organism-specific databases

CTDi55450.
MGIiMGI:1913509. Camk2n1.

Phylogenomic databases

eggNOGiENOG410J0PZ. Eukaryota.
ENOG410YP01. LUCA.
GeneTreeiENSGT00390000004940.
HOGENOMiHOG000060311.
HOVERGENiHBG104926.
InParanoidiQ6QWF9.
OMAiDEGHLSF.
OrthoDBiEOG091G15S0.
PhylomeDBiQ6QWF9.
TreeFamiTF333175.

Miscellaneous databases

ChiTaRSiCamk2n1. mouse.
PROiQ6QWF9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000046447.
GenevisibleiQ6QWF9. MM.

Family and domain databases

InterProiIPR026779. Camk2n.
[Graphical view]
PfamiPF15170. CaM-KIIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCK2N1_MOUSE
AccessioniPrimary (citable) accession number: Q6QWF9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: July 5, 2004
Last modified: September 7, 2016
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.