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Protein

Toll-like receptor 12

Gene

Tlr12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Plays a role in preventing infection of internal organs of the urogenital system.By similarity1 Publication

GO - Biological processi

  • defense response to protozoan Source: MGI
  • inflammatory response Source: UniProtKB-KW
  • innate immune response Source: UniProtKB-KW
  • signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptor 12
Gene namesi
Name:Tlr12
Synonyms:Gm1365
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:3045221. Tlr12.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 709688ExtracellularSequence analysisAdd
BLAST
Transmembranei710 – 73021HelicalSequence analysisAdd
BLAST
Topological domaini731 – 906176CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Chaini22 – 906885Toll-like receptor 12PRO_0000042794Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi59 – 591N-linked (GlcNAc...)Sequence analysis
Glycosylationi336 – 3361N-linked (GlcNAc...)Sequence analysis
Glycosylationi505 – 5051N-linked (GlcNAc...)Sequence analysis
Glycosylationi552 – 5521N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ6QNU9.
PaxDbiQ6QNU9.
PRIDEiQ6QNU9.

Expressioni

Tissue specificityi

Macrophages, liver, kidney and bladder epithelial cells.1 Publication

Gene expression databases

BgeeiQ6QNU9.
CleanExiMM_TLR12.
ExpressionAtlasiQ6QNU9. baseline and differential.
GenevisibleiQ6QNU9. MM.

Interactioni

Subunit structurei

Binds MYD88 via their respective TIR domains.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074381.

Structurei

3D structure databases

ProteinModelPortaliQ6QNU9.
SMRiQ6QNU9. Positions 55-620, 761-905.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati91 – 11424LRR 1Add
BLAST
Repeati115 – 14026LRR 2Add
BLAST
Repeati142 – 17029LRR 3Add
BLAST
Repeati198 – 22225LRR 4Add
BLAST
Repeati224 – 24724LRR 5Add
BLAST
Repeati267 – 29024LRR 6Add
BLAST
Repeati291 – 31424LRR 7Add
BLAST
Repeati316 – 33823LRR 8Add
BLAST
Repeati341 – 36424LRR 9Add
BLAST
Repeati366 – 38823LRR 10Add
BLAST
Repeati389 – 41224LRR 11Add
BLAST
Repeati414 – 43623LRR 12Add
BLAST
Repeati462 – 48423LRR 13Add
BLAST
Repeati485 – 50824LRR 14Add
BLAST
Repeati510 – 53324LRR 15Add
BLAST
Repeati562 – 58625LRR 16Add
BLAST
Repeati591 – 61424LRR 17Add
BLAST
Domaini759 – 906148TIRPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the Toll-like receptor family.Curated
Contains 17 LRR (leucine-rich) repeats.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4641. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119006.
HOGENOMiHOG000236285.
HOVERGENiHBG080130.
InParanoidiQ6QNU9.
KOiK18807.
OMAiLACQCAN.
OrthoDBiEOG7R56S0.
PhylomeDBiQ6QNU9.
TreeFamiTF351113.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 3 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 7 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6QNU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRYWLLPGL LLSLPLVTGW STSNCLVTEG SRLPLVSRYF TFCRHSKLSF
60 70 80 90 100
LAACLSVSNL TQTLEVVPRT VEGLCLGGTV STLLPDAFSA FPGLKVLALS
110 120 130 140 150
LHLTQLLPGA LRGLGQLQSL SFFDSPLRRS LFLPPDAFSD LISLQRLHIS
160 170 180 190 200
GPCLDKKAGI RLPPGLQWLG VTLSCIQDVG ELAGMFPDLV QGSSSRVSWT
210 220 230 240 250
LQKLDLSSNW KLKMASPGSL QGLQVEILDL TRTPLDAVWL KGLGLQKLDV
260 270 280 290 300
LYAQTATAEL AAEAVAHFEL QGLIVKESKI GSISQEALAS CHSLKTLGLS
310 320 330 340 350
STGLTKLPPG FLTAMPRLQR LELSGNQLQS AVLCMNETGD VSGLTTLDLS
360 370 380 390 400
GNRLRILPPA AFSCLPHLRE LLLRYNQLLS LEGYLFQELQ QLETLKLDGN
410 420 430 440 450
PLLHLGKNWL AALPALTTLS LLDTQIRMSP EPGFWGAKNL HTLSLKLPAL
460 470 480 490 500
PAPAVLFLPM YLTSLELHIA SGTTEHWTLS PAIFPSLETL TISGGGLKLK
510 520 530 540 550
LGSQNASGVF PALQKLSLLK NSLDAFCSQG TSNLFLWQLP KLQSLRVWGA
560 570 580 590 600
GNSSRPCLIT GLPSLRELKL ASLQSITQPR SVQLEELVGD LPQLQALVLS
610 620 630 640 650
STGLKSLSAA AFQRLHSLQV LVLEYEKDLM LQDSLREYSP QMPHYIYILE
660 670 680 690 700
SNLACHCANA WMEPWVKRST KTYIYIRDNR LCPGQDRLSA RGSLPSFLWD
710 720 730 740 750
HCPQTLELKL FLASSALVFM LIALPLLQEA RNSWIPYLQA LFRVWLQGLR
760 770 780 790 800
GKGDKGKRFL FDVFVSHCRQ DQGWVIEELL PALEGFLPAG LGLRLCLPER
810 820 830 840 850
DFEPGKDVVD NVVDSMLSSR TTLCVLSGQA LCNPRCRLEL RLATSLLLAA
860 870 880 890 900
PSPPVLLLVF LEPISRHQLP GYHRLARLLR RGDYCLWPEE EERKSGFWTW

LRSRLG
Length:906
Mass (Da):99,945
Last modified:July 5, 2004 - v1
Checksum:i9D6372CCB42DFA14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY531552 mRNA. Translation: AAS83531.1.
AY510705 mRNA. Translation: AAS37673.1.
AK137624 mRNA. Translation: BAE23434.1.
CCDSiCCDS18673.1.
RefSeqiNP_991392.1. NM_205823.2.
UniGeneiMm.331901.

Genome annotation databases

EnsembliENSMUST00000074829; ENSMUSP00000074381; ENSMUSG00000062545.
GeneIDi384059.
KEGGimmu:384059.
UCSCiuc008uvf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY531552 mRNA. Translation: AAS83531.1.
AY510705 mRNA. Translation: AAS37673.1.
AK137624 mRNA. Translation: BAE23434.1.
CCDSiCCDS18673.1.
RefSeqiNP_991392.1. NM_205823.2.
UniGeneiMm.331901.

3D structure databases

ProteinModelPortaliQ6QNU9.
SMRiQ6QNU9. Positions 55-620, 761-905.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074381.

Proteomic databases

MaxQBiQ6QNU9.
PaxDbiQ6QNU9.
PRIDEiQ6QNU9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000074829; ENSMUSP00000074381; ENSMUSG00000062545.
GeneIDi384059.
KEGGimmu:384059.
UCSCiuc008uvf.1. mouse.

Organism-specific databases

CTDi384059.
MGIiMGI:3045221. Tlr12.

Phylogenomic databases

eggNOGiKOG4641. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119006.
HOGENOMiHOG000236285.
HOVERGENiHBG080130.
InParanoidiQ6QNU9.
KOiK18807.
OMAiLACQCAN.
OrthoDBiEOG7R56S0.
PhylomeDBiQ6QNU9.
TreeFamiTF351113.

Miscellaneous databases

PROiQ6QNU9.
SOURCEiSearch...

Gene expression databases

BgeeiQ6QNU9.
CleanExiMM_TLR12.
ExpressionAtlasiQ6QNU9. baseline and differential.
GenevisibleiQ6QNU9. MM.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 3 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 7 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A toll-like receptor that prevents infection by uropathogenic bacteria."
    Zhang D., Zhang G., Hayden M.S., Greenblatt M.B., Bussey C., Flavell R.A., Ghosh S.
    Science 303:1522-1526(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: C57BL/6J.
  2. "Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection."
    Tabeta K., Georgel P., Janssen E., Du X., Hoebe K., Crozat K., Mudd S., Shamel L., Sovath S., Goode J., Alexopoulou L., Flavell R.A., Beutler B.
    Proc. Natl. Acad. Sci. U.S.A. 101:3516-3521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: C57BL/6J.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Bone.

Entry informationi

Entry nameiTLR12_MOUSE
AccessioniPrimary (citable) accession number: Q6QNU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2004
Last modified: June 8, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was originally referred to as Tlr11.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.