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Protein

Toll-like receptor 12

Gene

Tlr12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Plays a role in preventing infection of internal organs of the urogenital system.By similarity1 Publication

GO - Biological processi

  • defense response to protozoan Source: MGI
  • immune response Source: GO_Central
  • inflammatory response Source: UniProtKB-KW
  • innate immune response Source: UniProtKB-KW
  • signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptor 12
Gene namesi
Name:Tlr12
Synonyms:Gm1365
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:3045221. Tlr12.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 709ExtracellularSequence analysisAdd BLAST688
Transmembranei710 – 730HelicalSequence analysisAdd BLAST21
Topological domaini731 – 906CytoplasmicSequence analysisAdd BLAST176

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000004279422 – 906Toll-like receptor 12Add BLAST885

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi59N-linked (GlcNAc...)Sequence analysis1
Glycosylationi336N-linked (GlcNAc...)Sequence analysis1
Glycosylationi505N-linked (GlcNAc...)Sequence analysis1
Glycosylationi552N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ6QNU9.
PaxDbiQ6QNU9.
PRIDEiQ6QNU9.

PTM databases

PhosphoSitePlusiQ6QNU9.

Expressioni

Tissue specificityi

Macrophages, liver, kidney and bladder epithelial cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000062545.
CleanExiMM_TLR12.
ExpressionAtlasiQ6QNU9. baseline and differential.
GenevisibleiQ6QNU9. MM.

Interactioni

Subunit structurei

Binds MYD88 via their respective TIR domains.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074381.

Structurei

3D structure databases

ProteinModelPortaliQ6QNU9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati91 – 114LRR 1Add BLAST24
Repeati115 – 140LRR 2Add BLAST26
Repeati142 – 170LRR 3Add BLAST29
Repeati198 – 222LRR 4Add BLAST25
Repeati224 – 247LRR 5Add BLAST24
Repeati267 – 290LRR 6Add BLAST24
Repeati291 – 314LRR 7Add BLAST24
Repeati316 – 338LRR 8Add BLAST23
Repeati341 – 364LRR 9Add BLAST24
Repeati366 – 388LRR 10Add BLAST23
Repeati389 – 412LRR 11Add BLAST24
Repeati414 – 436LRR 12Add BLAST23
Repeati462 – 484LRR 13Add BLAST23
Repeati485 – 508LRR 14Add BLAST24
Repeati510 – 533LRR 15Add BLAST24
Repeati562 – 586LRR 16Add BLAST25
Repeati591 – 614LRR 17Add BLAST24
Domaini759 – 906TIRPROSITE-ProRule annotationAdd BLAST148

Sequence similaritiesi

Belongs to the Toll-like receptor family.Curated
Contains 17 LRR (leucine-rich) repeats.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4641. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119006.
HOGENOMiHOG000236285.
HOVERGENiHBG080130.
InParanoidiQ6QNU9.
KOiK18807.
OMAiLACQCAN.
OrthoDBiEOG091G03AC.
PhylomeDBiQ6QNU9.
TreeFamiTF351113.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 3 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 7 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6QNU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRYWLLPGL LLSLPLVTGW STSNCLVTEG SRLPLVSRYF TFCRHSKLSF
60 70 80 90 100
LAACLSVSNL TQTLEVVPRT VEGLCLGGTV STLLPDAFSA FPGLKVLALS
110 120 130 140 150
LHLTQLLPGA LRGLGQLQSL SFFDSPLRRS LFLPPDAFSD LISLQRLHIS
160 170 180 190 200
GPCLDKKAGI RLPPGLQWLG VTLSCIQDVG ELAGMFPDLV QGSSSRVSWT
210 220 230 240 250
LQKLDLSSNW KLKMASPGSL QGLQVEILDL TRTPLDAVWL KGLGLQKLDV
260 270 280 290 300
LYAQTATAEL AAEAVAHFEL QGLIVKESKI GSISQEALAS CHSLKTLGLS
310 320 330 340 350
STGLTKLPPG FLTAMPRLQR LELSGNQLQS AVLCMNETGD VSGLTTLDLS
360 370 380 390 400
GNRLRILPPA AFSCLPHLRE LLLRYNQLLS LEGYLFQELQ QLETLKLDGN
410 420 430 440 450
PLLHLGKNWL AALPALTTLS LLDTQIRMSP EPGFWGAKNL HTLSLKLPAL
460 470 480 490 500
PAPAVLFLPM YLTSLELHIA SGTTEHWTLS PAIFPSLETL TISGGGLKLK
510 520 530 540 550
LGSQNASGVF PALQKLSLLK NSLDAFCSQG TSNLFLWQLP KLQSLRVWGA
560 570 580 590 600
GNSSRPCLIT GLPSLRELKL ASLQSITQPR SVQLEELVGD LPQLQALVLS
610 620 630 640 650
STGLKSLSAA AFQRLHSLQV LVLEYEKDLM LQDSLREYSP QMPHYIYILE
660 670 680 690 700
SNLACHCANA WMEPWVKRST KTYIYIRDNR LCPGQDRLSA RGSLPSFLWD
710 720 730 740 750
HCPQTLELKL FLASSALVFM LIALPLLQEA RNSWIPYLQA LFRVWLQGLR
760 770 780 790 800
GKGDKGKRFL FDVFVSHCRQ DQGWVIEELL PALEGFLPAG LGLRLCLPER
810 820 830 840 850
DFEPGKDVVD NVVDSMLSSR TTLCVLSGQA LCNPRCRLEL RLATSLLLAA
860 870 880 890 900
PSPPVLLLVF LEPISRHQLP GYHRLARLLR RGDYCLWPEE EERKSGFWTW

LRSRLG
Length:906
Mass (Da):99,945
Last modified:July 5, 2004 - v1
Checksum:i9D6372CCB42DFA14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY531552 mRNA. Translation: AAS83531.1.
AY510705 mRNA. Translation: AAS37673.1.
AK137624 mRNA. Translation: BAE23434.1.
CCDSiCCDS18673.1.
RefSeqiNP_991392.1. NM_205823.2.
UniGeneiMm.331901.

Genome annotation databases

EnsembliENSMUST00000074829; ENSMUSP00000074381; ENSMUSG00000062545.
GeneIDi384059.
KEGGimmu:384059.
UCSCiuc008uvf.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY531552 mRNA. Translation: AAS83531.1.
AY510705 mRNA. Translation: AAS37673.1.
AK137624 mRNA. Translation: BAE23434.1.
CCDSiCCDS18673.1.
RefSeqiNP_991392.1. NM_205823.2.
UniGeneiMm.331901.

3D structure databases

ProteinModelPortaliQ6QNU9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074381.

PTM databases

PhosphoSitePlusiQ6QNU9.

Proteomic databases

MaxQBiQ6QNU9.
PaxDbiQ6QNU9.
PRIDEiQ6QNU9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000074829; ENSMUSP00000074381; ENSMUSG00000062545.
GeneIDi384059.
KEGGimmu:384059.
UCSCiuc008uvf.1. mouse.

Organism-specific databases

CTDi384059.
MGIiMGI:3045221. Tlr12.

Phylogenomic databases

eggNOGiKOG4641. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119006.
HOGENOMiHOG000236285.
HOVERGENiHBG080130.
InParanoidiQ6QNU9.
KOiK18807.
OMAiLACQCAN.
OrthoDBiEOG091G03AC.
PhylomeDBiQ6QNU9.
TreeFamiTF351113.

Miscellaneous databases

PROiQ6QNU9.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000062545.
CleanExiMM_TLR12.
ExpressionAtlasiQ6QNU9. baseline and differential.
GenevisibleiQ6QNU9. MM.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 3 hits.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
PF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 7 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTLR12_MOUSE
AccessioniPrimary (citable) accession number: Q6QNU9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2004
Last modified: November 2, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

Was originally referred to as Tlr11.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.