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Protein

Toll-like receptor 12

Gene

Tlr12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Plays a role in preventing infection of internal organs of the urogenital system.1 Publication

Caution

There is some confusion regarding the nomenclature of this gene. In the literature, Tlr12 is frequently referred to as Tlr11 and vice-versa.1 Publication

GO - Biological processi

  • defense response to protozoan Source: MGI
  • inflammatory response Source: UniProtKB-KW
  • innate immune response Source: UniProtKB-KW
  • signal transduction Source: InterPro

Keywordsi

Molecular functionReceptor
Biological processImmunity, Inflammatory response, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptor 121 Publication
Alternative name(s):
Toll-like receptor 111 Publication
Gene namesi
Name:Tlr121 PublicationImported
Synonyms:Gm1365Imported, Tlr111 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:3045221 Tlr12

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 709ExtracellularSequence analysisAdd BLAST688
Transmembranei710 – 730HelicalSequence analysisAdd BLAST21
Topological domaini731 – 906CytoplasmicSequence analysisAdd BLAST176

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Disruption phenotypei

Has increased susceptibility to the uropathogenic E.coli strain 8NU. Following infection, kidneys show a significantly increased bacterial load and increased inflammatory response, whereas bladder shows a similar response to wild type.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi804P → H: Fails to activate NF-kappa-B. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000004279422 – 906Toll-like receptor 12Add BLAST885

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi59N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi336N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi505N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi552N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ6QNU9
PaxDbiQ6QNU9
PRIDEiQ6QNU9

PTM databases

iPTMnetiQ6QNU9
PhosphoSitePlusiQ6QNU9

Expressioni

Tissue specificityi

Macrophages, liver, kidney and bladder epithelial cells.1 Publication

Gene expression databases

BgeeiENSMUSG00000062545
CleanExiMM_TLR12
ExpressionAtlasiQ6QNU9 baseline and differential
GenevisibleiQ6QNU9 MM

Interactioni

Subunit structurei

Binds MYD88 via their respective TIR domains.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000074381

Structurei

3D structure databases

ProteinModelPortaliQ6QNU9
SMRiQ6QNU9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati91 – 114LRR 1Add BLAST24
Repeati115 – 140LRR 2Add BLAST26
Repeati142 – 170LRR 3Add BLAST29
Repeati198 – 222LRR 4Add BLAST25
Repeati224 – 247LRR 5Add BLAST24
Repeati267 – 290LRR 6Add BLAST24
Repeati291 – 314LRR 7Add BLAST24
Repeati316 – 338LRR 8Add BLAST23
Repeati341 – 364LRR 9Add BLAST24
Repeati366 – 388LRR 10Add BLAST23
Repeati389 – 412LRR 11Add BLAST24
Repeati414 – 436LRR 12Add BLAST23
Repeati462 – 484LRR 13Add BLAST23
Repeati485 – 508LRR 14Add BLAST24
Repeati510 – 533LRR 15Add BLAST24
Repeati562 – 586LRR 16Add BLAST25
Repeati591 – 614LRR 17Add BLAST24
Domaini759 – 906TIRPROSITE-ProRule annotationAdd BLAST148

Sequence similaritiesi

Belongs to the Toll-like receptor family.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4641 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00900000141236
HOGENOMiHOG000236285
HOVERGENiHBG080130
InParanoidiQ6QNU9
KOiK18807
OMAiLACQCAN
OrthoDBiEOG091G03AC
PhylomeDBiQ6QNU9
TreeFamiTF351113

Family and domain databases

Gene3Di3.40.50.10140, 1 hit
3.80.10.10, 4 hits
InterProiView protein in InterPro
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf
PfamiView protein in Pfam
PF13855 LRR_8, 2 hits
PF01582 TIR, 1 hit
SMARTiView protein in SMART
SM00369 LRR_TYP, 7 hits
SM00255 TIR, 1 hit
SUPFAMiSSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS51450 LRR, 7 hits
PS50104 TIR, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6QNU9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRYWLLPGL LLSLPLVTGW STSNCLVTEG SRLPLVSRYF TFCRHSKLSF
60 70 80 90 100
LAACLSVSNL TQTLEVVPRT VEGLCLGGTV STLLPDAFSA FPGLKVLALS
110 120 130 140 150
LHLTQLLPGA LRGLGQLQSL SFFDSPLRRS LFLPPDAFSD LISLQRLHIS
160 170 180 190 200
GPCLDKKAGI RLPPGLQWLG VTLSCIQDVG ELAGMFPDLV QGSSSRVSWT
210 220 230 240 250
LQKLDLSSNW KLKMASPGSL QGLQVEILDL TRTPLDAVWL KGLGLQKLDV
260 270 280 290 300
LYAQTATAEL AAEAVAHFEL QGLIVKESKI GSISQEALAS CHSLKTLGLS
310 320 330 340 350
STGLTKLPPG FLTAMPRLQR LELSGNQLQS AVLCMNETGD VSGLTTLDLS
360 370 380 390 400
GNRLRILPPA AFSCLPHLRE LLLRYNQLLS LEGYLFQELQ QLETLKLDGN
410 420 430 440 450
PLLHLGKNWL AALPALTTLS LLDTQIRMSP EPGFWGAKNL HTLSLKLPAL
460 470 480 490 500
PAPAVLFLPM YLTSLELHIA SGTTEHWTLS PAIFPSLETL TISGGGLKLK
510 520 530 540 550
LGSQNASGVF PALQKLSLLK NSLDAFCSQG TSNLFLWQLP KLQSLRVWGA
560 570 580 590 600
GNSSRPCLIT GLPSLRELKL ASLQSITQPR SVQLEELVGD LPQLQALVLS
610 620 630 640 650
STGLKSLSAA AFQRLHSLQV LVLEYEKDLM LQDSLREYSP QMPHYIYILE
660 670 680 690 700
SNLACHCANA WMEPWVKRST KTYIYIRDNR LCPGQDRLSA RGSLPSFLWD
710 720 730 740 750
HCPQTLELKL FLASSALVFM LIALPLLQEA RNSWIPYLQA LFRVWLQGLR
760 770 780 790 800
GKGDKGKRFL FDVFVSHCRQ DQGWVIEELL PALEGFLPAG LGLRLCLPER
810 820 830 840 850
DFEPGKDVVD NVVDSMLSSR TTLCVLSGQA LCNPRCRLEL RLATSLLLAA
860 870 880 890 900
PSPPVLLLVF LEPISRHQLP GYHRLARLLR RGDYCLWPEE EERKSGFWTW

LRSRLG
Length:906
Mass (Da):99,945
Last modified:July 5, 2004 - v1
Checksum:i9D6372CCB42DFA14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY531552 mRNA Translation: AAS83531.1
AY510705 mRNA Translation: AAS37673.1
AK137624 mRNA Translation: BAE23434.1
CCDSiCCDS18673.1
RefSeqiNP_991392.1, NM_205823.2
UniGeneiMm.331901

Genome annotation databases

EnsembliENSMUST00000074829; ENSMUSP00000074381; ENSMUSG00000062545
GeneIDi384059
KEGGimmu:384059
UCSCiuc008uvf.1 mouse

Similar proteinsi

Entry informationi

Entry nameiTLR12_MOUSE
AccessioniPrimary (citable) accession number: Q6QNU9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: July 5, 2004
Last modified: March 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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