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Q6QNT2

- Q6QNT2_HUMAN

UniProt

Q6QNT2 - Q6QNT2_HUMAN

Protein
Submitted name:

5-aminoevulinate synthase 2

Gene

ALAS2

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 1 out of 5- Protein predictedi
  1. Functioni

    GO - Molecular functioni

    1. 5-aminolevulinate synthase activity Source: InterPro
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. cellular iron ion homeostasis Source: Ensembl
    2. erythrocyte differentiation Source: Ensembl
    3. heme biosynthetic process Source: Ensembl
    4. hemoglobin biosynthetic process Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    5-aminoevulinate synthase 2Imported
    Gene namesi
    Name:ALAS2Imported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial matrix Source: InterPro

    Expressioni

    Gene expression databases

    ArrayExpressiQ6QNT2.
    BgeeiQ6QNT2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6QNT2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Family and domain databases

    InterProiIPR015118. 5aminolev_synth_preseq.
    [Graphical view]
    PfamiPF09029. Preseq_ALAS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q6QNT2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVTAAMLLQC CPVLARGPTS LLGKVVKTHQ FLFGIGRCPI LATQGPNCSQ    50
    IHLKATKAGG DSPSWAKGHC PFMLSELQDG KSKIVQKAAP EVQEDVKAFK 100
    T 101
    Length:101
    Mass (Da):10,763
    Last modified:July 5, 2004 - v1
    Checksum:i171408F0B6ACC864
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei101 – 1011Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY532069 Genomic DNA. Translation: AAT09371.1.
    AY532070 Genomic DNA. Translation: AAT09372.1.
    AY532071 Genomic DNA. Translation: AAT09373.1.
    AY532072 Genomic DNA. Translation: AAT09374.1.
    AY532073 Genomic DNA. Translation: AAT09375.1.
    AY532074 Genomic DNA. Translation: AAT09376.1.
    AY532075 Genomic DNA. Translation: AAT09377.1.
    AY532076 Genomic DNA. Translation: AAT09378.1.
    AY532077 Genomic DNA. Translation: AAT09379.1.
    AY532078 Genomic DNA. Translation: AAT09380.1.
    AY532079 Genomic DNA. Translation: AAT09381.1.
    AY532080 Genomic DNA. Translation: AAT09382.1.
    AY532081 Genomic DNA. Translation: AAT09383.1.
    AY532082 Genomic DNA. Translation: AAT09384.1.
    AY532083 Genomic DNA. Translation: AAT09385.1.
    AY532084 Genomic DNA. Translation: AAT09386.1.
    AY532085 Genomic DNA. Translation: AAT09387.1.
    AY532086 Genomic DNA. Translation: AAT09388.1.
    AY532087 Genomic DNA. Translation: AAT09389.1.
    AY532088 Genomic DNA. Translation: AAT09390.1.
    AY532089 Genomic DNA. Translation: AAT09391.1.
    AY532091 Genomic DNA. Translation: AAT09393.1.
    AY532092 Genomic DNA. Translation: AAT09394.1.
    AY532093 Genomic DNA. Translation: AAT09395.1.
    AY532094 Genomic DNA. Translation: AAT09396.1.
    AY532095 Genomic DNA. Translation: AAT09397.1.
    AY532096 Genomic DNA. Translation: AAT09398.1.
    AY532097 Genomic DNA. Translation: AAT09399.1.
    AY532098 Genomic DNA. Translation: AAT09400.1.
    AY532099 Genomic DNA. Translation: AAT09401.1.
    AY532100 Genomic DNA. Translation: AAT09402.1.
    AY532101 Genomic DNA. Translation: AAT09403.1.
    AY532102 Genomic DNA. Translation: AAT09404.1.
    AY532103 Genomic DNA. Translation: AAT09405.1.
    AY532104 Genomic DNA. Translation: AAT09406.1.
    AY532105 Genomic DNA. Translation: AAT09407.1.
    AY532106 Genomic DNA. Translation: AAT09408.1.
    AY532107 Genomic DNA. Translation: AAT09409.1.
    AY532108 Genomic DNA. Translation: AAT09410.1.
    AY532109 Genomic DNA. Translation: AAT09411.1.
    UniGeneiHs.522666.
    Hs.555936.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY532069 Genomic DNA. Translation: AAT09371.1 .
    AY532070 Genomic DNA. Translation: AAT09372.1 .
    AY532071 Genomic DNA. Translation: AAT09373.1 .
    AY532072 Genomic DNA. Translation: AAT09374.1 .
    AY532073 Genomic DNA. Translation: AAT09375.1 .
    AY532074 Genomic DNA. Translation: AAT09376.1 .
    AY532075 Genomic DNA. Translation: AAT09377.1 .
    AY532076 Genomic DNA. Translation: AAT09378.1 .
    AY532077 Genomic DNA. Translation: AAT09379.1 .
    AY532078 Genomic DNA. Translation: AAT09380.1 .
    AY532079 Genomic DNA. Translation: AAT09381.1 .
    AY532080 Genomic DNA. Translation: AAT09382.1 .
    AY532081 Genomic DNA. Translation: AAT09383.1 .
    AY532082 Genomic DNA. Translation: AAT09384.1 .
    AY532083 Genomic DNA. Translation: AAT09385.1 .
    AY532084 Genomic DNA. Translation: AAT09386.1 .
    AY532085 Genomic DNA. Translation: AAT09387.1 .
    AY532086 Genomic DNA. Translation: AAT09388.1 .
    AY532087 Genomic DNA. Translation: AAT09389.1 .
    AY532088 Genomic DNA. Translation: AAT09390.1 .
    AY532089 Genomic DNA. Translation: AAT09391.1 .
    AY532091 Genomic DNA. Translation: AAT09393.1 .
    AY532092 Genomic DNA. Translation: AAT09394.1 .
    AY532093 Genomic DNA. Translation: AAT09395.1 .
    AY532094 Genomic DNA. Translation: AAT09396.1 .
    AY532095 Genomic DNA. Translation: AAT09397.1 .
    AY532096 Genomic DNA. Translation: AAT09398.1 .
    AY532097 Genomic DNA. Translation: AAT09399.1 .
    AY532098 Genomic DNA. Translation: AAT09400.1 .
    AY532099 Genomic DNA. Translation: AAT09401.1 .
    AY532100 Genomic DNA. Translation: AAT09402.1 .
    AY532101 Genomic DNA. Translation: AAT09403.1 .
    AY532102 Genomic DNA. Translation: AAT09404.1 .
    AY532103 Genomic DNA. Translation: AAT09405.1 .
    AY532104 Genomic DNA. Translation: AAT09406.1 .
    AY532105 Genomic DNA. Translation: AAT09407.1 .
    AY532106 Genomic DNA. Translation: AAT09408.1 .
    AY532107 Genomic DNA. Translation: AAT09409.1 .
    AY532108 Genomic DNA. Translation: AAT09410.1 .
    AY532109 Genomic DNA. Translation: AAT09411.1 .
    UniGenei Hs.522666.
    Hs.555936.

    3D structure databases

    ProteinModelPortali Q6QNT2.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    ChiTaRSi ALAS2. human.

    Gene expression databases

    ArrayExpressi Q6QNT2.
    Bgeei Q6QNT2.

    Family and domain databases

    InterProi IPR015118. 5aminolev_synth_preseq.
    [Graphical view ]
    Pfami PF09029. Preseq_ALAS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Nucleotide variation at Msn and Alas2, two genes flanking the centromere of the X chromosome in humans."
      Nachman M.W., D'Agostino S.L., Tillquist C.R., Mobasher Z., Hammer M.F.
      Genetics 167:423-437(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: YCC10Imported, YCC12Imported, YCC13Imported, YCC14Imported, YCC16Imported, YCC17Imported, YCC2Imported, YCC22Imported, YCC23Imported, YCC24Imported, YCC25Imported, YCC27Imported, YCC32Imported, YCC33Imported, YCC38Imported, YCC4Imported, YCC40Imported, YCC49Imported, YCC51Imported, YCC56Imported, YCC57Imported, YCC59Imported, YCC6Imported, YCC61Imported, YCC62Imported, YCC64Imported, YCC65Imported, YCC66Imported, YCC67Imported, YCC68Imported, YCC69Imported, YCC7Imported, YCC71Imported, YCC72Imported, YCC76Imported, YCC77Imported, YCC78Imported, YCC79Imported, YCC8Imported and YCC9Imported.

    Entry informationi

    Entry nameiQ6QNT2_HUMAN
    AccessioniPrimary (citable) accession number: Q6QNT2
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.