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Protein
Submitted name:

5-aminoevulinate synthase 2

Gene

ALAS2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. 5-aminolevulinate synthase activity Source: InterPro
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. cellular iron ion homeostasis Source: Ensembl
  2. erythrocyte differentiation Source: Ensembl
  3. heme biosynthetic process Source: Ensembl
  4. hemoglobin biosynthetic process Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
5-aminoevulinate synthase 2Imported
Gene namesi
Name:ALAS2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial matrix Source: InterPro
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ6QNT2.
ExpressionAtlasiQ6QNT2. baseline and differential.

Structurei

3D structure databases

ProteinModelPortaliQ6QNT2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

InterProiIPR015118. 5aminolev_synth_preseq.
[Graphical view]
PfamiPF09029. Preseq_ALAS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q6QNT2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVTAAMLLQC CPVLARGPTS LLGKVVKTHQ FLFGIGRCPI LATQGPNCSQ
60 70 80 90 100
IHLKATKAGG DSPSWAKGHC PFMLSELQDG KSKIVQKAAP EVQEDVKAFK

T
Length:101
Mass (Da):10,763
Last modified:July 5, 2004 - v1
Checksum:i171408F0B6ACC864
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei101 – 1011Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY532069 Genomic DNA. Translation: AAT09371.1.
AY532070 Genomic DNA. Translation: AAT09372.1.
AY532071 Genomic DNA. Translation: AAT09373.1.
AY532072 Genomic DNA. Translation: AAT09374.1.
AY532073 Genomic DNA. Translation: AAT09375.1.
AY532074 Genomic DNA. Translation: AAT09376.1.
AY532075 Genomic DNA. Translation: AAT09377.1.
AY532076 Genomic DNA. Translation: AAT09378.1.
AY532077 Genomic DNA. Translation: AAT09379.1.
AY532078 Genomic DNA. Translation: AAT09380.1.
AY532079 Genomic DNA. Translation: AAT09381.1.
AY532080 Genomic DNA. Translation: AAT09382.1.
AY532081 Genomic DNA. Translation: AAT09383.1.
AY532082 Genomic DNA. Translation: AAT09384.1.
AY532083 Genomic DNA. Translation: AAT09385.1.
AY532084 Genomic DNA. Translation: AAT09386.1.
AY532085 Genomic DNA. Translation: AAT09387.1.
AY532086 Genomic DNA. Translation: AAT09388.1.
AY532087 Genomic DNA. Translation: AAT09389.1.
AY532088 Genomic DNA. Translation: AAT09390.1.
AY532089 Genomic DNA. Translation: AAT09391.1.
AY532091 Genomic DNA. Translation: AAT09393.1.
AY532092 Genomic DNA. Translation: AAT09394.1.
AY532093 Genomic DNA. Translation: AAT09395.1.
AY532094 Genomic DNA. Translation: AAT09396.1.
AY532095 Genomic DNA. Translation: AAT09397.1.
AY532096 Genomic DNA. Translation: AAT09398.1.
AY532097 Genomic DNA. Translation: AAT09399.1.
AY532098 Genomic DNA. Translation: AAT09400.1.
AY532099 Genomic DNA. Translation: AAT09401.1.
AY532100 Genomic DNA. Translation: AAT09402.1.
AY532101 Genomic DNA. Translation: AAT09403.1.
AY532102 Genomic DNA. Translation: AAT09404.1.
AY532103 Genomic DNA. Translation: AAT09405.1.
AY532104 Genomic DNA. Translation: AAT09406.1.
AY532105 Genomic DNA. Translation: AAT09407.1.
AY532106 Genomic DNA. Translation: AAT09408.1.
AY532107 Genomic DNA. Translation: AAT09409.1.
AY532108 Genomic DNA. Translation: AAT09410.1.
AY532109 Genomic DNA. Translation: AAT09411.1.
UniGeneiHs.522666.
Hs.555936.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY532069 Genomic DNA. Translation: AAT09371.1.
AY532070 Genomic DNA. Translation: AAT09372.1.
AY532071 Genomic DNA. Translation: AAT09373.1.
AY532072 Genomic DNA. Translation: AAT09374.1.
AY532073 Genomic DNA. Translation: AAT09375.1.
AY532074 Genomic DNA. Translation: AAT09376.1.
AY532075 Genomic DNA. Translation: AAT09377.1.
AY532076 Genomic DNA. Translation: AAT09378.1.
AY532077 Genomic DNA. Translation: AAT09379.1.
AY532078 Genomic DNA. Translation: AAT09380.1.
AY532079 Genomic DNA. Translation: AAT09381.1.
AY532080 Genomic DNA. Translation: AAT09382.1.
AY532081 Genomic DNA. Translation: AAT09383.1.
AY532082 Genomic DNA. Translation: AAT09384.1.
AY532083 Genomic DNA. Translation: AAT09385.1.
AY532084 Genomic DNA. Translation: AAT09386.1.
AY532085 Genomic DNA. Translation: AAT09387.1.
AY532086 Genomic DNA. Translation: AAT09388.1.
AY532087 Genomic DNA. Translation: AAT09389.1.
AY532088 Genomic DNA. Translation: AAT09390.1.
AY532089 Genomic DNA. Translation: AAT09391.1.
AY532091 Genomic DNA. Translation: AAT09393.1.
AY532092 Genomic DNA. Translation: AAT09394.1.
AY532093 Genomic DNA. Translation: AAT09395.1.
AY532094 Genomic DNA. Translation: AAT09396.1.
AY532095 Genomic DNA. Translation: AAT09397.1.
AY532096 Genomic DNA. Translation: AAT09398.1.
AY532097 Genomic DNA. Translation: AAT09399.1.
AY532098 Genomic DNA. Translation: AAT09400.1.
AY532099 Genomic DNA. Translation: AAT09401.1.
AY532100 Genomic DNA. Translation: AAT09402.1.
AY532101 Genomic DNA. Translation: AAT09403.1.
AY532102 Genomic DNA. Translation: AAT09404.1.
AY532103 Genomic DNA. Translation: AAT09405.1.
AY532104 Genomic DNA. Translation: AAT09406.1.
AY532105 Genomic DNA. Translation: AAT09407.1.
AY532106 Genomic DNA. Translation: AAT09408.1.
AY532107 Genomic DNA. Translation: AAT09409.1.
AY532108 Genomic DNA. Translation: AAT09410.1.
AY532109 Genomic DNA. Translation: AAT09411.1.
UniGeneiHs.522666.
Hs.555936.

3D structure databases

ProteinModelPortaliQ6QNT2.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

ChiTaRSiALAS2. human.

Gene expression databases

BgeeiQ6QNT2.
ExpressionAtlasiQ6QNT2. baseline and differential.

Family and domain databases

InterProiIPR015118. 5aminolev_synth_preseq.
[Graphical view]
PfamiPF09029. Preseq_ALAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide variation at Msn and Alas2, two genes flanking the centromere of the X chromosome in humans."
    Nachman M.W., D'Agostino S.L., Tillquist C.R., Mobasher Z., Hammer M.F.
    Genetics 167:423-437(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: YCC10Imported, YCC12Imported, YCC13Imported, YCC14Imported, YCC16Imported, YCC17Imported, YCC2Imported, YCC22Imported, YCC23Imported, YCC24Imported, YCC25Imported, YCC27Imported, YCC32Imported, YCC33Imported, YCC38Imported, YCC4Imported, YCC40Imported, YCC49Imported, YCC51Imported, YCC56Imported, YCC57Imported, YCC59Imported, YCC6Imported, YCC61Imported, YCC62Imported, YCC64Imported, YCC65Imported, YCC66Imported, YCC67Imported, YCC68Imported, YCC69Imported, YCC7Imported, YCC71Imported, YCC72Imported, YCC76Imported, YCC77Imported, YCC78Imported, YCC79Imported, YCC8Imported and YCC9Imported.

Entry informationi

Entry nameiQ6QNT2_HUMAN
AccessioniPrimary (citable) accession number: Q6QNT2
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.