Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6QN13

- IOD1_PIG

UniProt

Q6QN13 - IOD1_PIG

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Type I iodothyronine deiodinase

Gene

DIO1

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).1 Publication

Catalytic activityi

3,5,3'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei126 – 1261

GO - Molecular functioni

  1. selenium binding Source: Ensembl
  2. thyroxine 5'-deiodinase activity Source: UniProtKB-EC

GO - Biological processi

  1. hormone biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Thyroid hormones biosynthesis

Enzyme and pathway databases

ReactomeiREACT_218253. Regulation of thyroid hormone activity.
SABIO-RKQ6QN13.

Names & Taxonomyi

Protein namesi
Recommended name:
Type I iodothyronine deiodinase (EC:1.97.1.10)
Alternative name(s):
5DI
DIOI
Type 1 DI
Type-I 5'-deiodinase
Gene namesi
Name:DIO1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei13 – 3321HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 249249Type I iodothyronine deiodinasePRO_0000318638Add
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the iodothyronine deiodinase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG000099.
InParanoidiQ6QN13.
KOiK01562.

Family and domain databases

InterProiIPR000643. Iodothyronine_deiodinase.
IPR008261. Iodothyronine_deiodinase_AS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11781. PTHR11781. 1 hit.
PfamiPF00837. T4_deiodinase. 1 hit.
[Graphical view]
PIRSFiPIRSF001330. IOD. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS01205. T4_DEIODINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6QN13-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELPLPGLWL KRLWVLFQVA LHVAMGKVLM TLFPGRVKQD ILAMSQKTGM
60 70 80 90 100
AKNPHFSHEN WIPTFFSAQY FWFVLKVRWQ RLEDKTEEGG LAPNCPVVSL
110 120 130 140 150
SGQRCHIWDF MQGNRPLVLN FGSCTUPSFI FKFDQFKRLI EDFSSIADFL
160 170 180 190 200
IIYIEEAHAS DGWAFKNNVD IKNHQNLQDR LRAAHLLLDR SPQCPVVVDT
210 220 230 240
MKNQSSRLYA ALPERLYVLQ AGRILYKGKP GPWNYHPEEV RAVLEKLHS
Length:249
Mass (Da):28,888
Last modified:February 26, 2008 - v2
Checksum:i5D805F25F64B1465
GO

Non-standard residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-standard residuei126 – 1261Selenocysteine

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY533206 mRNA. Translation: AAS48447.1.
RefSeqiNP_001001627.1. NM_001001627.1.
UniGeneiSsc.26334.

Genome annotation databases

GeneIDi414380.
KEGGissc:414380.

Keywords - Coding sequence diversityi

Selenocysteine

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY533206 mRNA. Translation: AAS48447.1 .
RefSeqi NP_001001627.1. NM_001001627.1.
UniGenei Ssc.26334.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 414380.
KEGGi ssc:414380.

Organism-specific databases

CTDi 1733.

Phylogenomic databases

HOVERGENi HBG000099.
InParanoidi Q6QN13.
KOi K01562.

Enzyme and pathway databases

Reactomei REACT_218253. Regulation of thyroid hormone activity.
SABIO-RK Q6QN13.

Family and domain databases

InterProi IPR000643. Iodothyronine_deiodinase.
IPR008261. Iodothyronine_deiodinase_AS.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
PANTHERi PTHR11781. PTHR11781. 1 hit.
Pfami PF00837. T4_deiodinase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001330. IOD. 1 hit.
SUPFAMi SSF52833. SSF52833. 1 hit.
PROSITEi PS01205. T4_DEIODINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characteristics and thyroid state-dependent regulation of iodothyronine deiodinases in pigs."
    Wassen F.W.J.S., Klootwijk W., Kaptein E., Duncker D.J., Visser T.J., Kuiper G.G.J.M.
    Endocrinology 145:4251-4263(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
    Strain: Landrace X Yorkshire.

Entry informationi

Entry nameiIOD1_PIG
AccessioniPrimary (citable) accession number: Q6QN13
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: November 26, 2014
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3