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Protein

Type I iodothyronine deiodinase

Gene

DIO1

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine).1 Publication

Catalytic activityi

3,5,3'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1261

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processThyroid hormones biosynthesis

Enzyme and pathway databases

SABIO-RKiQ6QN13.

Names & Taxonomyi

Protein namesi
Recommended name:
Type I iodothyronine deiodinase (EC:1.21.99.4)
Alternative name(s):
5DI
DIOI
Type 1 DI
Type-I 5'-deiodinase
Gene namesi
Name:DIO1
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei13 – 33HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003186381 – 249Type I iodothyronine deiodinaseAdd BLAST249

Proteomic databases

PaxDbiQ6QN13.
PRIDEiQ6QN13.

Expressioni

Gene expression databases

GenevisibleiQ6QN13. SS.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000025038.

Family & Domainsi

Sequence similaritiesi

Belongs to the iodothyronine deiodinase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IWHX. Eukaryota.
ENOG4112999. LUCA.
HOVERGENiHBG000099.
InParanoidiQ6QN13.
KOiK01562.
OrthoDBiEOG091G0V5C.

Family and domain databases

InterProiView protein in InterPro
IPR000643. Iodothyronine_deiodinase.
IPR008261. Iodothyronine_deiodinase_AS.
IPR027252. Iodothyronine_deiodinase_I/III.
IPR012336. Thioredoxin-like_fold.
PANTHERiPTHR11781. PTHR11781. 1 hit.
PfamiView protein in Pfam
PF00837. T4_deiodinase. 1 hit.
PIRSFiPIRSF001330. IOD. 1 hit.
PIRSF500144. IODI_III. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiView protein in PROSITE
PS01205. T4_DEIODINASE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6QN13-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELPLPGLWL KRLWVLFQVA LHVAMGKVLM TLFPGRVKQD ILAMSQKTGM
60 70 80 90 100
AKNPHFSHEN WIPTFFSAQY FWFVLKVRWQ RLEDKTEEGG LAPNCPVVSL
110 120 130 140 150
SGQRCHIWDF MQGNRPLVLN FGSCTUPSFI FKFDQFKRLI EDFSSIADFL
160 170 180 190 200
IIYIEEAHAS DGWAFKNNVD IKNHQNLQDR LRAAHLLLDR SPQCPVVVDT
210 220 230 240
MKNQSSRLYA ALPERLYVLQ AGRILYKGKP GPWNYHPEEV RAVLEKLHS
Length:249
Mass (Da):28,888
Last modified:February 26, 2008 - v2
Checksum:i5D805F25F64B1465
GO

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei126Selenocysteine1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY533206 mRNA. Translation: AAS48447.1.
RefSeqiNP_001001627.1. NM_001001627.1.
UniGeneiSsc.26334.

Genome annotation databases

GeneIDi414380.
KEGGissc:414380.

Keywords - Coding sequence diversityi

Selenocysteine

Similar proteinsi

Entry informationi

Entry nameiIOD1_PIG
AccessioniPrimary (citable) accession number: Q6QN13
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: August 30, 2017
This is version 74 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families