Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Type II iodothyronine deiodinase

Gene

DIO2

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.1 Publication

Catalytic activityi

3,5,3'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei1331

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Thyroid hormones biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Type II iodothyronine deiodinase (EC:1.21.99.4)
Alternative name(s):
5DII
DIOII
Type 2 DI
Type-II 5'-deiodinase
Gene namesi
Name:DIO2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei10 – 34HelicalSequence analysisAdd BLAST25

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002238661 – 269Type II iodothyronine deiodinaseAdd BLAST269

Post-translational modificationi

Ubiquitinated by MARCH6, leading to its degradation by the proteasome. Deubiquitinated by USP20 and USP33 (By similarity).By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ6QN12.
PRIDEiQ6QN12.

Expressioni

Tissue specificityi

More expressed in pituitary than in brain, low to undetectable levels in thyroid and skeletal muscle.1 Publication

Gene expression databases

BgeeiENSSSCG00000027643.
GenevisibleiQ6QN12. SS.

Interactioni

Subunit structurei

Interacts with USP20 and USP33. Interacts with MARCH6 (By similarity).By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000025124.

Family & Domainsi

Sequence similaritiesi

Belongs to the iodothyronine deiodinase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXX0. Eukaryota.
ENOG4111SVE. LUCA.
HOVERGENiHBG000099.
InParanoidiQ6QN12.
KOiK17904.
OrthoDBiEOG091G0V5C.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000643. Iodothyronine_deiodinase.
IPR008261. Iodothyronine_deiodinase_AS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11781. PTHR11781. 1 hit.
PfamiPF00837. T4_deiodinase. 1 hit.
[Graphical view]
PIRSFiPIRSF001330. IOD. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS01205. T4_DEIODINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6QN12-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGILSVDLLI TLQILPVFFS NCLFLALYDS VILLKHVVLL LSRSKSTRGE
60 70 80 90 100
WRRMLTSEGM RCIWKSFLLD AYKQVKLGED APNSSVVHVS NPEGSNNHGH
110 120 130 140 150
GTQEKTVDGA ECHLLDFANP ERPLVVNFGS ATUPPFTSQL PAFSKLVEEF
160 170 180 190 200
SSVADFLLVY IDEAHPSDGW AVPGDSSLSF EVKKHQNQED RCAAAHQLLE
210 220 230 240 250
RFSLPPQCRV VADRMDNNAN VAYGVAFERV CIVQRQKIAY LGGKGPFYYN
260
LQEVRRWLEK NFSKRUKKT
Length:269
Mass (Da):30,376
Last modified:February 26, 2008 - v3
Checksum:iFF68E3ABABBF06A9
GO

Sequence cautioni

The sequence AAS48448 differs from that shown. Reason: Erroneous termination at position 266. Translated as Sec.Curated

Non-standard residue

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-standard residuei133Selenocysteine1
Non-standard residuei266Selenocysteine1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY533207 mRNA. Translation: AAS48448.1. Sequence problems.
RefSeqiNP_001001626.1. NM_001001626.1.
UniGeneiSsc.26333.

Genome annotation databases

GeneIDi414379.
KEGGissc:414379.

Keywords - Coding sequence diversityi

Selenocysteine

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY533207 mRNA. Translation: AAS48448.1. Sequence problems.
RefSeqiNP_001001626.1. NM_001001626.1.
UniGeneiSsc.26333.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000025124.

Proteomic databases

PaxDbiQ6QN12.
PRIDEiQ6QN12.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi414379.
KEGGissc:414379.

Organism-specific databases

CTDi1734.

Phylogenomic databases

eggNOGiENOG410IXX0. Eukaryota.
ENOG4111SVE. LUCA.
HOVERGENiHBG000099.
InParanoidiQ6QN12.
KOiK17904.
OrthoDBiEOG091G0V5C.

Gene expression databases

BgeeiENSSSCG00000027643.
GenevisibleiQ6QN12. SS.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000643. Iodothyronine_deiodinase.
IPR008261. Iodothyronine_deiodinase_AS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11781. PTHR11781. 1 hit.
PfamiPF00837. T4_deiodinase. 1 hit.
[Graphical view]
PIRSFiPIRSF001330. IOD. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS01205. T4_DEIODINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIOD2_PIG
AccessioniPrimary (citable) accession number: Q6QN12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: February 26, 2008
Last modified: October 5, 2016
This is version 78 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.