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Q6QN12 (IOD2_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Type II iodothyronine deiodinase

EC=1.97.1.10
Alternative name(s):
5DII
DIOII
Type 2 DI
Type-II 5'-deiodinase
Gene names
Name:DIO2
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length269 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development. Ref.1

Catalytic activity

3,5,3'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.

Subunit structure

Interacts with USP20 and USP33. Interacts with MARCH6 By similarity.

Subcellular location

Membrane; Single-pass membrane protein Potential.

Tissue specificity

More expressed in pituitary than in brain, low to undetectable levels in thyroid and skeletal muscle. Ref.1

Post-translational modification

Ubiquitinated by MARCH6, leading to its degradation by the proteasome. Deubiquitinated by USP20 and USP33 By similarity.

Sequence similarities

Belongs to the iodothyronine deiodinase family.

Sequence caution

The sequence AAS48448.1 differs from that shown. Reason: Erroneous termination at position 266. Translated as Sec.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 269269Type II iodothyronine deiodinase
PRO_0000223866

Regions

Transmembrane10 – 3425Helical; Potential

Sites

Active site1331

Amino acid modifications

Non-standard residue1331Selenocysteine
Non-standard residue2661Selenocysteine

Sequences

Sequence LengthMass (Da)Tools
Q6QN12 [UniParc].

Last modified February 26, 2008. Version 3.
Checksum: FF68E3ABABBF06A9

FASTA26930,376
        10         20         30         40         50         60 
MGILSVDLLI TLQILPVFFS NCLFLALYDS VILLKHVVLL LSRSKSTRGE WRRMLTSEGM 

        70         80         90        100        110        120 
RCIWKSFLLD AYKQVKLGED APNSSVVHVS NPEGSNNHGH GTQEKTVDGA ECHLLDFANP 

       130        140        150        160        170        180 
ERPLVVNFGS ATUPPFTSQL PAFSKLVEEF SSVADFLLVY IDEAHPSDGW AVPGDSSLSF 

       190        200        210        220        230        240 
EVKKHQNQED RCAAAHQLLE RFSLPPQCRV VADRMDNNAN VAYGVAFERV CIVQRQKIAY 

       250        260 
LGGKGPFYYN LQEVRRWLEK NFSKRUKKT 

« Hide

References

[1]"Characteristics and thyroid state-dependent regulation of iodothyronine deiodinases in pigs."
Wassen F.W.J.S., Klootwijk W., Kaptein E., Duncker D.J., Visser T.J., Kuiper G.G.J.M.
Endocrinology 145:4251-4263(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
Strain: Landrace X Yorkshire.
Tissue: Pituitary.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY533207 mRNA. Translation: AAS48448.1. Sequence problems.
RefSeqNP_001001626.1. NM_001001626.1.
UniGeneSsc.26333.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID414379.
KEGGssc:414379.

Organism-specific databases

CTD1734.

Phylogenomic databases

HOVERGENHBG000099.
KOK17904.

Family and domain databases

Gene3D3.40.30.10. 1 hit.
InterProIPR000643. Iodothyronine_deiodinase.
IPR008261. Iodothyronine_deiodinase_AS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERPTHR11781. PTHR11781. 1 hit.
PfamPF00837. T4_deiodinase. 1 hit.
[Graphical view]
SUPFAMSSF52833. SSF52833. 1 hit.
PROSITEPS01205. T4_DEIODINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameIOD2_PIG
AccessionPrimary (citable) accession number: Q6QN12
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: February 26, 2008
Last modified: May 14, 2014
This is version 60 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families