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Q6QN12

- IOD2_PIG

UniProt

Q6QN12 - IOD2_PIG

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Protein

Type II iodothyronine deiodinase

Gene

DIO2

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.1 Publication

Catalytic activityi

3,5,3'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei133 – 1331

GO - Molecular functioni

  1. thyroxine 5'-deiodinase activity Source: UniProtKB

GO - Biological processi

  1. hormone biosynthetic process Source: UniProtKB-KW
  2. thyroid hormone catabolic process Source: Ensembl
  3. thyroid hormone metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Thyroid hormones biosynthesis

Enzyme and pathway databases

ReactomeiREACT_218253. Regulation of thyroid hormone activity.

Names & Taxonomyi

Protein namesi
Recommended name:
Type II iodothyronine deiodinase (EC:1.97.1.10)
Alternative name(s):
5DII
DIOII
Type 2 DI
Type-II 5'-deiodinase
Gene namesi
Name:DIO2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 3425HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Type II iodothyronine deiodinasePRO_0000223866Add
BLAST

Post-translational modificationi

Ubiquitinated by MARCH6, leading to its degradation by the proteasome. Deubiquitinated by USP20 and USP33 (By similarity).By similarity

Keywords - PTMi

Ubl conjugation

Expressioni

Tissue specificityi

More expressed in pituitary than in brain, low to undetectable levels in thyroid and skeletal muscle.1 Publication

Interactioni

Subunit structurei

Interacts with USP20 and USP33. Interacts with MARCH6 (By similarity).By similarity

Family & Domainsi

Sequence similaritiesi

Belongs to the iodothyronine deiodinase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG000099.
InParanoidiQ6QN12.
KOiK17904.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000643. Iodothyronine_deiodinase.
IPR008261. Iodothyronine_deiodinase_AS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11781. PTHR11781. 1 hit.
PfamiPF00837. T4_deiodinase. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS01205. T4_DEIODINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6QN12-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGILSVDLLI TLQILPVFFS NCLFLALYDS VILLKHVVLL LSRSKSTRGE
60 70 80 90 100
WRRMLTSEGM RCIWKSFLLD AYKQVKLGED APNSSVVHVS NPEGSNNHGH
110 120 130 140 150
GTQEKTVDGA ECHLLDFANP ERPLVVNFGS ATUPPFTSQL PAFSKLVEEF
160 170 180 190 200
SSVADFLLVY IDEAHPSDGW AVPGDSSLSF EVKKHQNQED RCAAAHQLLE
210 220 230 240 250
RFSLPPQCRV VADRMDNNAN VAYGVAFERV CIVQRQKIAY LGGKGPFYYN
260
LQEVRRWLEK NFSKRUKKT
Length:269
Mass (Da):30,376
Last modified:February 26, 2008 - v3
Checksum:iFF68E3ABABBF06A9
GO

Sequence cautioni

The sequence AAS48448.1 differs from that shown. Reason: Erroneous termination at position 266. Translated as Sec.Curated

Non-standard residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-standard residuei133 – 1331Selenocysteine
Non-standard residuei266 – 2661Selenocysteine

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY533207 mRNA. Translation: AAS48448.1. Sequence problems.
RefSeqiNP_001001626.1. NM_001001626.1.
UniGeneiSsc.26333.

Genome annotation databases

GeneIDi414379.
KEGGissc:414379.

Keywords - Coding sequence diversityi

Selenocysteine

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY533207 mRNA. Translation: AAS48448.1 . Sequence problems.
RefSeqi NP_001001626.1. NM_001001626.1.
UniGenei Ssc.26333.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 414379.
KEGGi ssc:414379.

Organism-specific databases

CTDi 1734.

Phylogenomic databases

HOVERGENi HBG000099.
InParanoidi Q6QN12.
KOi K17904.

Enzyme and pathway databases

Reactomei REACT_218253. Regulation of thyroid hormone activity.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR000643. Iodothyronine_deiodinase.
IPR008261. Iodothyronine_deiodinase_AS.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
PANTHERi PTHR11781. PTHR11781. 1 hit.
Pfami PF00837. T4_deiodinase. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
PROSITEi PS01205. T4_DEIODINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characteristics and thyroid state-dependent regulation of iodothyronine deiodinases in pigs."
    Wassen F.W.J.S., Klootwijk W., Kaptein E., Duncker D.J., Visser T.J., Kuiper G.G.J.M.
    Endocrinology 145:4251-4263(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: Landrace X Yorkshire.
    Tissue: Pituitary.

Entry informationi

Entry nameiIOD2_PIG
AccessioniPrimary (citable) accession number: Q6QN12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: February 26, 2008
Last modified: November 26, 2014
This is version 63 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3