SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q6QN12

- IOD2_PIG

UniProt

Q6QN12 - IOD2_PIG

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Type II iodothyronine deiodinase
Gene
DIO2
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development.1 Publication

Catalytic activityi

3,5,3'-triiodo-L-thyronine + iodide + A + H+ = L-thyroxine + AH2.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei133 – 1331

GO - Molecular functioni

  1. thyroxine 5'-deiodinase activity Source: UniProtKB
Complete GO annotation...

GO - Biological processi

  1. hormone biosynthetic process Source: UniProtKB-KW
  2. thyroid hormone catabolic process Source: Ensembl
  3. thyroid hormone metabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Thyroid hormones biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Type II iodothyronine deiodinase (EC:1.97.1.10)
Alternative name(s):
5DII
DIOII
Type 2 DI
Type-II 5'-deiodinase
Gene namesi
Name:DIO2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei10 – 3425Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Type II iodothyronine deiodinase
PRO_0000223866Add
BLAST

Post-translational modificationi

Ubiquitinated by MARCH6, leading to its degradation by the proteasome. Deubiquitinated by USP20 and USP33 By similarity.

Keywords - PTMi

Ubl conjugation

Expressioni

Tissue specificityi

More expressed in pituitary than in brain, low to undetectable levels in thyroid and skeletal muscle.1 Publication

Interactioni

Subunit structurei

Interacts with USP20 and USP33. Interacts with MARCH6 By similarity.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENiHBG000099.
KOiK17904.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR000643. Iodothyronine_deiodinase.
IPR008261. Iodothyronine_deiodinase_AS.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PANTHERiPTHR11781. PTHR11781. 1 hit.
PfamiPF00837. T4_deiodinase. 1 hit.
[Graphical view]
SUPFAMiSSF52833. SSF52833. 1 hit.
PROSITEiPS01205. T4_DEIODINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6QN12-1 [UniParc]FASTAAdd to Basket

« Hide

MGILSVDLLI TLQILPVFFS NCLFLALYDS VILLKHVVLL LSRSKSTRGE    50
WRRMLTSEGM RCIWKSFLLD AYKQVKLGED APNSSVVHVS NPEGSNNHGH 100
GTQEKTVDGA ECHLLDFANP ERPLVVNFGS ATUPPFTSQL PAFSKLVEEF 150
SSVADFLLVY IDEAHPSDGW AVPGDSSLSF EVKKHQNQED RCAAAHQLLE 200
RFSLPPQCRV VADRMDNNAN VAYGVAFERV CIVQRQKIAY LGGKGPFYYN 250
LQEVRRWLEK NFSKRUKKT 269
Length:269
Mass (Da):30,376
Last modified:February 26, 2008 - v3
Checksum:iFF68E3ABABBF06A9
GO

Sequence cautioni

The sequence AAS48448.1 differs from that shown. Reason: Erroneous termination at position 266. Translated as Sec.

Non-standard residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-standard residuei133 – 1331Selenocysteine
Non-standard residuei266 – 2661Selenocysteine

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY533207 mRNA. Translation: AAS48448.1. Sequence problems.
RefSeqiNP_001001626.1. NM_001001626.1.
UniGeneiSsc.26333.

Genome annotation databases

GeneIDi414379.
KEGGissc:414379.

Keywords - Coding sequence diversityi

Selenocysteine

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY533207 mRNA. Translation: AAS48448.1 . Sequence problems.
RefSeqi NP_001001626.1. NM_001001626.1.
UniGenei Ssc.26333.

3D structure databases

ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 414379.
KEGGi ssc:414379.

Organism-specific databases

CTDi 1734.

Phylogenomic databases

HOVERGENi HBG000099.
KOi K17904.

Family and domain databases

Gene3Di 3.40.30.10. 1 hit.
InterProi IPR000643. Iodothyronine_deiodinase.
IPR008261. Iodothyronine_deiodinase_AS.
IPR012336. Thioredoxin-like_fold.
[Graphical view ]
PANTHERi PTHR11781. PTHR11781. 1 hit.
Pfami PF00837. T4_deiodinase. 1 hit.
[Graphical view ]
SUPFAMi SSF52833. SSF52833. 1 hit.
PROSITEi PS01205. T4_DEIODINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characteristics and thyroid state-dependent regulation of iodothyronine deiodinases in pigs."
    Wassen F.W.J.S., Klootwijk W., Kaptein E., Duncker D.J., Visser T.J., Kuiper G.G.J.M.
    Endocrinology 145:4251-4263(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Strain: Landrace X Yorkshire.
    Tissue: Pituitary.

Entry informationi

Entry nameiIOD2_PIG
AccessioniPrimary (citable) accession number: Q6QN12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: February 26, 2008
Last modified: May 14, 2014
This is version 60 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi