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Q6QMY5 (ERR1_CANFA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Steroid hormone receptor ERR1
Alternative name(s):
Estrogen-related receptor alpha
Short name=ERR-alpha
Nuclear receptor subfamily 3 group B member 1
Gene names
Name:ESRRA
Synonyms:NR3B1
OrganismCanis familiaris (Dog) (Canis lupus familiaris) [Reference proteome]
Taxonomic identifier9615 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis

Protein attributes

Sequence length422 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. May function as a modulator of the estrogen signaling pathway in the uterus. Induces the expression of PERM1 in the skeletal muscle By similarity.

Subunit structure

Binds DNA as a monomer Probable.

Subcellular location

Nucleus By similarity.

Post-translational modification

Phosphorylation on Ser-19 enhances sumoylation on Lys-14 increasing repression of transcriptional activity By similarity.

Sumoylated with SUMO2. Main site is Lys-14 which is enhanced by phosphorylation on Ser-19, cofactor activation, and by interaction with PIAS4. Sumoylation enhances repression of transcriptional activity, but has no effect on subcellular location nor on DNA binding By similarity.

Reversibly acetylated. Acetylation by PCAF/KAT2 at Lys-129, Lys-138, Lys-160 and Lys-162 and PCAF/KAT2 decreases transcriptional activity probably by inhibiting DNA-binding activity; deacetylation involves SIRT1 and HDAC8 and increases DNA-binding By similarity.

Sequence similarities

Belongs to the nuclear hormone receptor family. NR3 subfamily.

Contains 1 nuclear receptor DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 422422Steroid hormone receptor ERR1
PRO_0000295231

Regions

DNA binding76 – 15176Nuclear receptor
Zinc finger79 – 9921NR C4-type
Zinc finger115 – 13420NR C4-type

Amino acid modifications

Modified residue191Phosphoserine By similarity
Modified residue221Phosphoserine By similarity
Modified residue1291N6-acetyllysine; by PCAF/KAT2B By similarity
Modified residue1381N6-acetyllysine; by PCAF/KAT2B By similarity
Modified residue1601N6-acetyllysine; by PCAF/KAT2B By similarity
Modified residue1621N6-acetyllysine; by PCAF/KAT2B By similarity

Sequences

Sequence LengthMass (Da)Tools
Q6QMY5 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 2739152CA0B355F4

FASTA42245,457
        10         20         30         40         50         60 
MSSQVVGIEP LYIKAEPASP DSPKGSSETE TEPPVALAPG PAPTRCLPGH KEEEDGEGAG 

        70         80         90        100        110        120 
PGEQGGGKLV LSSLPKRLCL VCGDVASGYH YGVASCEACK AFFKRTIQGS IEYSCPASNE 

       130        140        150        160        170        180 
CEITKRRRKA CQACRFTKCL RVGMLKEGVR LDRVRGGRQK YKRRPEVDPL PFPGSFPAGP 

       190        200        210        220        230        240 
LAVAGGPRKT APVNALVSHL LVVEPEKLYA MPDPAGPDGH LPAVATLCDL FDREIVVTIS 

       250        260        270        280        290        300 
WAKSIPGFSS LSLSDQMSVL QSVWMEVLVL GVAQRSLPLQ DELAFAEDLV LDEEGARAAG 

       310        320        330        340        350        360 
LGELGAVLLQ LVRRLQALRL EREEYVLLKA LALANSDSVH IEDAEAVEQL REALHEALLE 

       370        380        390        400        410        420 
YEAGRAGPGG GAERRRAGRL LLTLPLLRQT AGKVLAHFYG VKLEGKVPMH KLFLEMLEAM 


MD 

« Hide

References

[1]"Dog estrogen related receptor alpha (Estrra) mRNA."
Lu P., Colitz C.
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY533243 mRNA. Translation: AAS20260.1.
RefSeqNP_001002936.1. NM_001002936.1.
UniGeneCfa.3916.

3D structure databases

ProteinModelPortalQ6QMY5.
SMRQ6QMY5. Positions 73-162, 191-420.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9615.ENSCAFP00000021334.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID403169.
KEGGcfa:403169.

Organism-specific databases

CTD2101.

Phylogenomic databases

eggNOGNOG282629.
HOGENOMHOG000233467.
HOVERGENHBG108344.
InParanoidQ6QMY5.
KOK08552.

Family and domain databases

Gene3D1.10.565.10. 1 hit.
3.30.50.10. 1 hit.
InterProIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR027289. Oest-rel_rcp.
IPR024178. Oest_rcpt/oest-rel_rcp.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PIRSFPIRSF002527. ER-like_NR. 1 hit.
PIRSF500939. ERR1-2-3. 1 hit.
PRINTSPR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMSSF48508. SSF48508. 2 hits.
PROSITEPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio20816913.

Entry information

Entry nameERR1_CANFA
AccessionPrimary (citable) accession number: Q6QMY5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 5, 2004
Last modified: February 19, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families