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Q6QMY5

- ERR1_CANFA

UniProt

Q6QMY5 - ERR1_CANFA

Protein

Steroid hormone receptor ERR1

Gene

ESRRA

Organism
Canis familiaris (Dog) (Canis lupus familiaris)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 76 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. May function as a modulator of the estrogen signaling pathway in the uterus. Induces the expression of PERM1 in the skeletal muscle By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi76 – 15176Nuclear receptorPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri79 – 9921NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri115 – 13420NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: UniProtKB
    2. sequence-specific DNA binding transcription factor activity Source: InterPro
    3. steroid binding Source: InterPro
    4. steroid hormone receptor activity Source: InterPro
    5. zinc ion binding Source: InterPro

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Steroid hormone receptor ERR1
    Alternative name(s):
    Estrogen-related receptor alpha
    Short name:
    ERR-alpha
    Nuclear receptor subfamily 3 group B member 1
    Gene namesi
    Name:ESRRA
    Synonyms:NR3B1
    OrganismiCanis familiaris (Dog) (Canis lupus familiaris)
    Taxonomic identifieri9615 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraCaniformiaCanidaeCanis
    ProteomesiUP000002254: Unplaced

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 422422Steroid hormone receptor ERR1PRO_0000295231Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei19 – 191PhosphoserineBy similarity
    Modified residuei22 – 221PhosphoserineBy similarity
    Modified residuei129 – 1291N6-acetyllysine; by PCAF/KAT2BBy similarity
    Modified residuei138 – 1381N6-acetyllysine; by PCAF/KAT2BBy similarity
    Modified residuei160 – 1601N6-acetyllysine; by PCAF/KAT2BBy similarity
    Modified residuei162 – 1621N6-acetyllysine; by PCAF/KAT2BBy similarity

    Post-translational modificationi

    Phosphorylation on Ser-19 enhances sumoylation on Lys-14 increasing repression of transcriptional activity.By similarity
    Sumoylated with SUMO2. Main site is Lys-14 which is enhanced by phosphorylation on Ser-19, cofactor activation, and by interaction with PIAS4. Sumoylation enhances repression of transcriptional activity, but has no effect on subcellular location nor on DNA binding By similarity.By similarity
    Reversibly acetylated. Acetylation by PCAF/KAT2 at Lys-129, Lys-138, Lys-160 and Lys-162 and PCAF/KAT2 decreases transcriptional activity probably by inhibiting DNA-binding activity; deacetylation involves SIRT1 and HDAC8 and increases DNA-binding By similarity.By similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein, Ubl conjugation

    Interactioni

    Subunit structurei

    Binds DNA as a monomer.Curated

    Protein-protein interaction databases

    STRINGi9615.ENSCAFP00000021334.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6QMY5.
    SMRiQ6QMY5. Positions 73-162, 191-420.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri79 – 9921NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri115 – 13420NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG282629.
    HOGENOMiHOG000233467.
    HOVERGENiHBG108344.
    InParanoidiQ6QMY5.
    KOiK08552.

    Family and domain databases

    Gene3Di1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR027289. Oest-rel_rcp.
    IPR024178. Oest_rcpt/oest-rel_rcp.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PIRSFiPIRSF002527. ER-like_NR. 1 hit.
    PIRSF500939. ERR1-2-3. 1 hit.
    PRINTSiPR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTiSM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 2 hits.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6QMY5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSQVVGIEP LYIKAEPASP DSPKGSSETE TEPPVALAPG PAPTRCLPGH    50
    KEEEDGEGAG PGEQGGGKLV LSSLPKRLCL VCGDVASGYH YGVASCEACK 100
    AFFKRTIQGS IEYSCPASNE CEITKRRRKA CQACRFTKCL RVGMLKEGVR 150
    LDRVRGGRQK YKRRPEVDPL PFPGSFPAGP LAVAGGPRKT APVNALVSHL 200
    LVVEPEKLYA MPDPAGPDGH LPAVATLCDL FDREIVVTIS WAKSIPGFSS 250
    LSLSDQMSVL QSVWMEVLVL GVAQRSLPLQ DELAFAEDLV LDEEGARAAG 300
    LGELGAVLLQ LVRRLQALRL EREEYVLLKA LALANSDSVH IEDAEAVEQL 350
    REALHEALLE YEAGRAGPGG GAERRRAGRL LLTLPLLRQT AGKVLAHFYG 400
    VKLEGKVPMH KLFLEMLEAM MD 422
    Length:422
    Mass (Da):45,457
    Last modified:July 5, 2004 - v1
    Checksum:i2739152CA0B355F4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY533243 mRNA. Translation: AAS20260.1.
    RefSeqiNP_001002936.1. NM_001002936.1.
    UniGeneiCfa.3916.

    Genome annotation databases

    GeneIDi403169.
    KEGGicfa:403169.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY533243 mRNA. Translation: AAS20260.1 .
    RefSeqi NP_001002936.1. NM_001002936.1.
    UniGenei Cfa.3916.

    3D structure databases

    ProteinModelPortali Q6QMY5.
    SMRi Q6QMY5. Positions 73-162, 191-420.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9615.ENSCAFP00000021334.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 403169.
    KEGGi cfa:403169.

    Organism-specific databases

    CTDi 2101.

    Phylogenomic databases

    eggNOGi NOG282629.
    HOGENOMi HOG000233467.
    HOVERGENi HBG108344.
    InParanoidi Q6QMY5.
    KOi K08552.

    Miscellaneous databases

    NextBioi 20816913.

    Family and domain databases

    Gene3Di 1.10.565.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR027289. Oest-rel_rcp.
    IPR024178. Oest_rcpt/oest-rel_rcp.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF002527. ER-like_NR. 1 hit.
    PIRSF500939. ERR1-2-3. 1 hit.
    PRINTSi PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTi SM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 2 hits.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Dog estrogen related receptor alpha (Estrra) mRNA."
      Lu P., Colitz C.
      Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiERR1_CANFA
    AccessioniPrimary (citable) accession number: Q6QMY5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 76 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3