Q6QMG6 (Q6QMG6_RAT) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Multidrug resistance-associated protein 4 EMBL AAS78928.1

Gene names

Name:

Abcc4 EMBL AAS78928.1 RGD 620266

Organism

Rattus norvegicus (Rat) EMBL AAS78928.1

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	1325 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the ABC transporter superfamily. RuleBase RU000684 Contains 2 ABC transmembrane type-1 domains. SAAS SAAS001140

Ontologies

Keywords
Domain	Repeat SAAS SAAS001140
Ligand	ATP-binding RuleBase RU000684 Nucleotide-binding
Gene Ontology (GO)
Biological_process	ATP catabolic process Inferred from electronic annotation. Source: GOC positive regulation of smooth muscle cell proliferation Inferred from mutant phenotype PubMed 18636120. Source: RGD response to drug Inferred from expression pattern Ref.1. Source: RGD response to organic cyclic compound Inferred from expression pattern Ref.1. Source: RGD response to organic nitrogen Inferred from expression pattern PubMed 18418891. Source: RGD
Cellular_component	basolateral plasma membrane Inferred from direct assay PubMed 18619525. Source: RGD integral to membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of substances Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q6QMG6 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 0C292662629C20BC	FASTA	1,325	148,865
	10 20 30 40 50 60 MLPVHTEVKP NPLQDANLCS RLFFWWLNPL FKAGHKRRLE EDDMFSVLPE DRSKHLGEEL 70 80 90 100 110 120 QGYWDKEVLR AKKDARKPSL TKAIVKCYWK SYLILGIFTL IEETTRVVQP IFLGKIIDYF 130 140 150 160 170 180 EKYDSDDSAA LHTAYGYAAV LSLCTLILAI LHHLYFYHVQ CAGMRIRVAM CHMIYRKALR 190 200 210 220 230 240 LSNSAMGKTT TGQIVNLLSN DVNKFDQVTI FLHFLWAGPL QAIGVTILLW VEIGISCLAG 250 260 270 280 290 300 LAILVILLPL QSCIGKLFSS LRSKTAAFTD ARFRTMNEVI TGMRIIKMYA WEKSFADLIT 310 320 330 340 350 360 NLRKKEISKI LGSSYLRGMN MASFFIANKV ILFVTFTTYV LLGNKITSSH VFVAMTLYGA 370 380 390 400 410 420 VRLTVTLFFP SAIERVSEAV VSVRRIKNFL LLDELPERKA QEPSDGKAIV HVQDFTAFWD 430 440 450 460 470 480 KALDTPTLQG LSFTARPGEL LAVVGPVGAG KSSLLSAVLG ELPPTSGLVS VHGRIAYVSQ 490 500 510 520 530 540 QPWVFSGTVR SNILFGRKYE KERYEKVIKA CALKKDLQLL EDGDLTVIGD RGATLSGGQK 550 560 570 580 590 600 ARVNLARAVY QDADIYLLDD PLSAVDAEVG KHLFQLCICQ TLHEKITILV THQLQYLKAA 610 620 630 640 650 660 SHILILKDGE MVQKGTYTEF LKSGVDFGSL LKKENEEAEP SPVPGTPTLR NRTFSEASIW 670 680 690 700 710 720 SQQSSRPSLK DGVPDAQDAE NTQAAQPEES RSEGRIGFKA YKNYFSAGAS WFFIIFLVLL 730 740 750 760 770 780 NLMGQVFYVL QDWWLSHWAN RQGALNDTKN ANGNVTGTLD LSWYLGIYTG LTAVTVLFGI 790 800 810 820 830 840 ARSLLVFYVL VNASQTLHNR MFESILKAPV LFFDRNPIGR ILNRFSKDIG HMDDLLPLTF 850 860 870 880 890 900 LDFIQTLLLV VSVIAVAAAV IPWILIPLVP LSIIFVVLRR YFLETSRDVK RLESTTRSPV 910 920 930 940 950 960 FSHLSSSLQG LWTIRAYKAE ERCQELFDAH QDLHSEAWFL FLTTSRWFAV RLDAICAVFV 970 980 990 1000 1010 1020 IVVAFGSLVL AKTLDAGQVG LALSYSLTLM GMFQWSVRQS AEVENMMISV ERVIEYTDLE 1030 1040 1050 1060 1070 1080 KEAPWECRKR PPPGWPHEGV IVFDNVNFTY SLDGPLVLKH LTALIKSREK VGIVGRTGAG 1090 1100 1110 1120 1130 1140 KSSLISALFR LSEPEGKIWI DKILTTEIGL HDLRKKMSII PQEPVLFTGT MRKNLDPFNE 1150 1160 1170 1180 1190 1200 HSDEELWKAL EEVQLKEAIE DLPGKMDTEL AESGSNFSVG QRQLVCLARA ILKKNRILII 1210 1220 1230 1240 1250 1260 DEATANVDPR TDELIQQKIR EKFAQCTVLT IAHRLNTIID SDKIMVLDSG RLREYDEPYV 1270 1280 1290 1300 1310 1320 LLQNPESLFY KMVQQLGKGE AAALTETAKQ VYFRRNYPDI AFSSPAVMST SNGQPSALTI FETAL

References

[1]	"Rat multidrug resistance protein 4 (Mrp4, Abcc4): molecular cloning, organ distribution, postnatal renal expression, and chemical inducibility." Chen C., Klaassen C.D. Biochem. Biophys. Res. Commun. 317:46-53(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: Sprague-Dawley EMBL AAS78928.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY533524 mRNA. Translation: AAS78928.1.
IPI	IPI00421457.
RefSeq	NP_596902.1. NM_133411.1.
UniGene	Rn.13195.
3D structure databases
ProteinModelPortal	Q6QMG6.
ModBase	Search...
PTM databases
PhosphoSite	Q6QMG6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	170924.
KEGG	rno:170924.
Organism-specific databases
CTD	10257.
RGD	620266. Abcc4.
Phylogenomic databases
HOVERGEN	HBG108314.
KO	K05673.
Gene expression databases
Genevestigator	Q6QMG6.
Family and domain databases
InterPro	IPR003593. AAA+_ATPase. IPR003439. ABC_transporter-like. IPR017871. ABC_transporter_CS. IPR017940. ABC_transporter_type1. IPR001140. ABC_transptr_TM_dom. IPR011527. ABC_transptrTM_dom_typ1. IPR027417. P-loop_NTPase. [Graphical view]
Pfam	PF00664. ABC_membrane. 2 hits. PF00005. ABC_tran. 2 hits. [Graphical view]
SMART	SM00382. AAA. 2 hits. [Graphical view]
SUPFAM	SSF90123. ABC_TM_1. 2 hits. SSF52540. SSF52540. 2 hits.
PROSITE	PS50929. ABC_TM1F. 2 hits. PS00211. ABC_TRANSPORTER_1. 2 hits. PS50893. ABC_TRANSPORTER_2. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	621431.

Entry information

Entry name

Q6QMG6_RAT

Accession

Primary (citable) accession number: Q6QMG6

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	May 29, 2013
This is version 72 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)