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Protein

Corticosteroid 11-beta-dehydrogenase isozyme 1

Gene

HSD11B1

Organism
Cavia porcellus (Guinea pig)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).By similarity1 Publication

Catalytic activityi

An 11-beta-hydroxysteroid + NADP+ = an 11-oxosteroid + NADPH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei170SubstrateBy similarity1
Active sitei183Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi41 – 67NADP3 PublicationsAdd BLAST27
Nucleotide bindingi92 – 93NADP3 Publications2
Nucleotide bindingi119 – 123NADP3 Publications5
Nucleotide bindingi183 – 187NADP3 Publications5
Nucleotide bindingi218 – 222NADP3 Publications5

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processLipid metabolism, Steroid metabolism
LigandNADP

Enzyme and pathway databases

BRENDAi1.1.1.146 1225
1.1.1.B40 1225
SABIO-RKiQ6QLL4

Names & Taxonomyi

Protein namesi
Recommended name:
Corticosteroid 11-beta-dehydrogenase isozyme 1 (EC:1.1.1.146)
Alternative name(s):
11-beta-hydroxysteroid dehydrogenase 1
Short name:
11-DH
Short name:
11-beta-HSD1
Gene namesi
Name:HSD11B1
OrganismiCavia porcellus (Guinea pig)
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricomorphaCaviidaeCavia
Proteomesi
  • UP000005447 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 7CytoplasmicSequence analysis7
Transmembranei8 – 24Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST17
Topological domaini25 – 300LumenalSequence analysisAdd BLAST276

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000546181 – 300Corticosteroid 11-beta-dehydrogenase isozyme 1Add BLAST300

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi207N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ6QLL4

Expressioni

Tissue specificityi

Widely expressed at low levels. Highest expression in liver.1 Publication

Gene expression databases

BgeeiENSCPOG00000005596

Interactioni

Subunit structurei

Homodimer.3 Publications

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000005042

Structurei

Secondary structure

1300
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi29 – 32Combined sources4
Beta strandi36 – 41Combined sources6
Helixi45 – 56Combined sources12
Beta strandi60 – 66Combined sources7
Helixi68 – 81Combined sources14
Beta strandi84 – 90Combined sources7
Helixi96 – 110Combined sources15
Beta strandi114 – 118Combined sources5
Helixi133 – 143Combined sources11
Helixi145 – 161Combined sources17
Beta strandi164 – 170Combined sources7
Helixi171 – 173Combined sources3
Helixi181 – 203Combined sources23
Beta strandi209 – 215Combined sources7
Helixi221 – 227Combined sources7
Turni228 – 230Combined sources3
Helixi238 – 250Combined sources13
Beta strandi254 – 260Combined sources7
Helixi264 – 268Combined sources5
Helixi271 – 281Combined sources11
Helixi286 – 290Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1XSEX-ray2.50A/B24-297[»]
3DWFX-ray2.20A/B/C/D24-299[»]
3G49X-ray2.50A/B/C/D24-300[»]
3LZ6X-ray1.84A/B/C/D26-288[»]
ProteinModelPortaliQ6QLL4
SMRiQ6QLL4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ6QLL4

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1205 Eukaryota
COG1028 LUCA
GeneTreeiENSGT00880000138008
HOGENOMiHOG000010276
HOVERGENiHBG005481
InParanoidiQ6QLL4
OMAiIGREMAY
OrthoDBiEOG091G0H0R
TreeFamiTF329114

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

Q6QLL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFLKKYLLT ILMVFLAYYY YSANEKFRPE MLQGKKVIVT GASKGIGREI
60 70 80 90 100
AYHLAKMGAH VVVTARSKEA LQKVVARCLE LGAASAHYIA GSMEDMTFAE
110 120 130 140 150
EFVAEAGNLM GGLDMLILNH VLYNRLTFFH GEIDNVRKSM EVNFHSFVVL
160 170 180 190 200
SVAAMPMLMQ SQGSIAVVSS VAGKITYPLI APYSASKFAL DGFFSTLRSE
210 220 230 240 250
FLVNKVNVSI TLCILGLIDT ETAIKATSGI YLGPASPKEE CALEIIKGTA
260 270 280 290 300
LRQDEMYYVG SRWVPYLLGN PGRKIMEFLS AAEYNWDNVL SNEKLYGRWA
Length:300
Mass (Da):33,226
Last modified:January 23, 2007 - v3
Checksum:i8D8A9725F7A6D912
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti22S → P in AAF01249 (PubMed:10699594).Curated1
Sequence conflicti103V → A in AAF01249 (PubMed:10699594).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188005 mRNA Translation: AAF01249.1
AY535424 mRNA Translation: AAS47491.1
RefSeqiNP_001166328.1, NM_001172857.1
XP_013012714.1, XM_013157260.1

Genome annotation databases

EnsembliENSCPOT00000005656; ENSCPOP00000005042; ENSCPOG00000005596
GeneIDi100135542

Similar proteinsi

Entry informationi

Entry nameiDHI1_CAVPO
AccessioniPrimary (citable) accession number: Q6QLL4
Secondary accession number(s): Q9QZE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 104 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

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