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Protein

Envelope glycoprotein gp160

Gene

env

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

Escorts unspliced or incompletely spliced viral pre-mRNAs (late transcripts) out of the nucleus of infected cells. These pre-mRNAs carry a recognition sequence called Rev responsive element (RRE) located in the env gene, that is not present in fully spliced viral mRNAs (early transcripts). This function is essential since most viral proteins are translated from unspliced or partially spliced pre-mRNAs which cannot exit the nucleus by the pathway used by fully processed cellular mRNAs.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-bindingSAAS annotation
Biological processApoptosisUniRule annotationSAAS annotation, Fusion of virus membrane with host membraneUniRule annotationSAAS annotation, Host-virus interaction, mRNA transportSAAS annotation, Transport, Viral attachment to host cellUniRule annotationSAAS annotation, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein gp160UniRule annotation
Cleaved into the following 2 chains:
Surface protein gp120UniRule annotation
Short name:
SUUniRule annotation
Alternative name(s):
Glycoprotein 120UniRule annotation
Short name:
gp120UniRule annotation
Transmembrane protein gp41UniRule annotation
Short name:
TMUniRule annotation
Gene namesi
Name:envImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

  • Host cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation
  • Host cytoplasm SAAS annotation
  • Host endosome membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation
  • Host nucleushost nucleolus SAAS annotation
  • Virion membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei514 – 540HelicalUniRule annotationAdd BLAST27
Transmembranei681 – 708HelicalUniRule annotationAdd BLAST28

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membraneUniRule annotationSAAS annotation, Host cytoplasmSAAS annotation, Host endosomeUniRule annotationSAAS annotation, Host membrane, Host nucleusSAAS annotation, Membrane, Viral envelope proteinUniRule annotationSAAS annotationImported, Virion

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1293311.

PTM / Processingi

Keywords - PTMi

Cleavage on pair of basic residuesUniRule annotation, Disulfide bondSAAS annotation

Interactioni

Subunit structurei

Homomultimer; when bound to the RRE. Multimeric assembly is essential for activity.SAAS annotation
The mature envelope protein (Env) consists of a homotrimer of non-covalently associated gp120-gp41 heterodimers. The resulting complex protrudes from the virus surface as a spike.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ6QLK5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 513GP120InterPro annotationAdd BLAST481
Domaini533 – 720GP41InterPro annotationAdd BLAST188

Domaini

The 17 amino acids long immunosuppressive region is present in many retroviral envelope proteins. Synthetic peptides derived from this relatively conserved sequence inhibit immune function in vitro and in vivo.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Family and domain databases

CDDicd09909. HIV-1-like_HR1-HR2. 1 hit.
InterProiView protein in InterPro
IPR000328. GP41-like.
IPR000777. HIV1_GP160.
IPR000625. REV_protein.
PfamiView protein in Pfam
PF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
PF00424. REV. 1 hit.
SUPFAMiSSF56502. SSF56502. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q6QLK5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVKGIRRNY QHLWRWGTML LGMLMICSAK EQLWVTAYYG VPVWKEATTT
60 70 80 90 100
LFCASDAKAY DTEVHNVWAT HACVPTDPNP REVVMGNVTE EFNIWNNSMV
110 120 130 140 150
EQMHEDIISL WDESLKPCVK LTPLCVTFNC TNYNGTRNGT TTEPPEVKNC
160 170 180 190 200
TTKETGIKNC SFNIATSGVE DRFKKEYALL YTADIVQIDN SSINYTLIGC
210 220 230 240 250
NTSVITQACP KVSFEPIPIH YCAPAGFAIL KCNNKTFNGK GPCTNVSTVQ
260 270 280 290 300
CTHGIRPVVS TQLLLNGSLA EEVVIRSDNF SDNAKTIIVQ LKDPVVINCT
310 320 330 340 350
RPNNNTRKGI RIGPGRTFYT TERIIGDIRQ AHCNISRTQW NNTLRLIAAK
360 370 380 390 400
LKKQFNNKTI IFRNSSGGDP EIVMHSFNCG GEFFYCNTTQ LFNSTWVHNN
410 420 430 440 450
TWVHNNTGND TEEGTITLPC RIKQIINMWQ EVGKAMYAPP IKGQIRCSSN
460 470 480 490 500
ITGLILTRDG GNTSSNNETF RPGGGDMRDN WRSELYKYKV VKIEPLGVAP
510 520 530 540 550
TKARRRVVQR EKRAVGMLGA MFLGFLGAAG STMGAASLAL TVQARQVVSG
560 570 580 590 600
IVQQQNNLLR AIEAQQHLLQ LTVWGIKQLQ ARVLAVERYL GDQQLLGIWG
610 620 630 640 650
CSGKLICTTA VPWNDSWSNK SLKYIWDNMT WMQWEKEIDI HVDTIYQLLE
660 670 680 690 700
ASQYQQEKNE KDLLELDKWE SLWNWFDITN WLWYIKIFIM IVGGLIGLRI
710 720 730 740 750
VFTVLSIVNR VRQGYSPLSL QTRLPTQRGP DRPEGIEEEG GERQRHIRSI
760 770 780 790 800
SEWILNNYPG RPAEPVPLQL PPLERLTLDC NEDCGTSGTQ GVGSPQVFVE
810
SPPVLESGTK EECC
Length:814
Mass (Da):91,786
Last modified:July 5, 2004 - v1
Checksum:i8AAB45F6CA6953A1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY535434 Genomic RNA. Translation: AAS58777.1.

Similar proteinsi

Entry informationi

Entry nameiQ6QLK5_9HIV1
AccessioniPrimary (citable) accession number: Q6QLK5
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: August 30, 2017
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation