##gff-version 3 Q6QIY3 UniProtKB Chain 1 1958 . . . ID=PRO_0000048508;Note=Sodium channel protein type 10 subunit alpha Q6QIY3 UniProtKB Topological domain 1 125 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6QIY3 UniProtKB Transmembrane 126 149 . . . Note=Helical%3B Name%3DS1 of repeat I;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6QIY3 UniProtKB Topological domain 150 154 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6QIY3 UniProtKB Transmembrane 155 174 . . . Note=Helical%3B Name%3DS2 of repeat I;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6QIY3 UniProtKB Topological domain 175 187 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6QIY3 UniProtKB Transmembrane 188 206 . . . Note=Helical%3B Name%3DS3 of repeat I;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6QIY3 UniProtKB Topological domain 207 212 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6QIY3 UniProtKB Transmembrane 213 232 . . . Note=Helical%3B Voltage-sensor%3B Name%3DS4 of repeat I;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6QIY3 UniProtKB Topological domain 233 248 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6QIY3 UniProtKB Transmembrane 249 272 . . . Note=Helical%3B Name%3DS5 of repeat I;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6QIY3 UniProtKB Topological domain 273 340 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6QIY3 UniProtKB Intramembrane 341 365 . . . Note=Pore-forming;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 Q6QIY3 UniProtKB Topological domain 366 372 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6QIY3 UniProtKB Transmembrane 373 398 . . . Note=Helical%3B Name%3DS6 of repeat I;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6QIY3 UniProtKB Topological domain 399 658 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6QIY3 UniProtKB Transmembrane 659 683 . . . Note=Helical%3B Name%3DS1 of repeat II;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6QIY3 UniProtKB Topological domain 684 694 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6QIY3 UniProtKB Transmembrane 695 718 . . . Note=Helical%3B Name%3DS2 of repeat II;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6QIY3 UniProtKB Topological domain 719 726 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6QIY3 UniProtKB Transmembrane 727 746 . . . Note=Helical%3B Name%3DS3 of repeat II;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6QIY3 UniProtKB Topological domain 747 752 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6QIY3 UniProtKB Transmembrane 753 772 . . . Note=Helical%3B Voltage-sensor%3B Name%3DS4 of repeat II;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6QIY3 UniProtKB Topological domain 773 788 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6QIY3 UniProtKB Transmembrane 789 809 . . . Note=Helical%3B Name%3DS5 of repeat II;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6QIY3 UniProtKB Topological domain 810 833 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6QIY3 UniProtKB Intramembrane 834 854 . . . Note=Pore-forming;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 Q6QIY3 UniProtKB Topological domain 855 863 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6QIY3 UniProtKB Transmembrane 864 889 . . . Note=Helical%3B Name%3DS6 of repeat II;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6QIY3 UniProtKB Topological domain 890 1148 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6QIY3 UniProtKB Transmembrane 1149 1172 . . . Note=Helical%3B Name%3DS1 of repeat III;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6QIY3 UniProtKB Topological domain 1173 1185 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6QIY3 UniProtKB Transmembrane 1186 1211 . . . Note=Helical%3B Name%3DS2 of repeat III;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6QIY3 UniProtKB Topological domain 1212 1217 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6QIY3 UniProtKB Transmembrane 1218 1239 . . . Note=Helical%3B Name%3DS3 of repeat III;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6QIY3 UniProtKB Topological domain 1240 1243 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6QIY3 UniProtKB Transmembrane 1244 1265 . . . Note=Helical%3B Voltage-sensor%3B Name%3DS4 of repeat III;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6QIY3 UniProtKB Topological domain 1266 1284 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6QIY3 UniProtKB Transmembrane 1285 1312 . . . Note=Helical%3B Name%3DS5 of repeat III;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6QIY3 UniProtKB Topological domain 1313 1354 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6QIY3 UniProtKB Intramembrane 1355 1376 . . . Note=Pore-forming;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 Q6QIY3 UniProtKB Topological domain 1377 1392 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6QIY3 UniProtKB Transmembrane 1393 1419 . . . Note=Helical%3B Name%3DS6 of repeat III;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6QIY3 UniProtKB Topological domain 1420 1472 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6QIY3 UniProtKB Transmembrane 1473 1496 . . . Note=Helical%3B Name%3DS1 of repeat IV;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6QIY3 UniProtKB Topological domain 1497 1507 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6QIY3 UniProtKB Transmembrane 1508 1531 . . . Note=Helical%3B Name%3DS2 of repeat IV;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6QIY3 UniProtKB Topological domain 1532 1537 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6QIY3 UniProtKB Transmembrane 1538 1561 . . . Note=Helical%3B Name%3DS3 of repeat IV;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6QIY3 UniProtKB Topological domain 1562 1573 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6QIY3 UniProtKB Transmembrane 1574 1595 . . . Note=Helical%3B Voltage-sensor%3B Name%3DS4 of repeat IV;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6QIY3 UniProtKB Topological domain 1596 1610 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6QIY3 UniProtKB Transmembrane 1611 1633 . . . Note=Helical%3B Name%3DS5 of repeat IV;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6QIY3 UniProtKB Topological domain 1634 1647 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6QIY3 UniProtKB Intramembrane 1648 1670 . . . Note=Pore-forming;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 Q6QIY3 UniProtKB Topological domain 1671 1698 . . . Note=Extracellular;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6QIY3 UniProtKB Transmembrane 1699 1723 . . . Note=Helical%3B Name%3DS6 of repeat IV;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6QIY3 UniProtKB Topological domain 1724 1958 . . . Note=Cytoplasmic;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6QIY3 UniProtKB Repeat 116 404 . . . Note=I;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6QIY3 UniProtKB Repeat 646 910 . . . Note=II;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6QIY3 UniProtKB Repeat 1141 1450 . . . Note=III;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6QIY3 UniProtKB Repeat 1459 1758 . . . Note=IV;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6QIY3 UniProtKB Domain 1852 1881 . . . Note=IQ Q6QIY3 UniProtKB Region 27 54 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6QIY3 UniProtKB Region 444 483 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6QIY3 UniProtKB Region 539 583 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6QIY3 UniProtKB Region 1006 1094 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6QIY3 UniProtKB Region 1901 1958 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6QIY3 UniProtKB Compositional bias 455 469 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6QIY3 UniProtKB Compositional bias 1020 1042 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6QIY3 UniProtKB Compositional bias 1062 1076 . . . Note=Basic and acidic residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6QIY3 UniProtKB Compositional bias 1907 1945 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q6QIY3 UniProtKB Modified residue 440 440 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q14524 Q6QIY3 UniProtKB Modified residue 443 443 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q14524 Q6QIY3 UniProtKB Modified residue 466 466 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q14524 Q6QIY3 UniProtKB Modified residue 478 478 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q14524 Q6QIY3 UniProtKB Modified residue 611 611 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q14524 Q6QIY3 UniProtKB Modified residue 614 614 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q14524 Q6QIY3 UniProtKB Modified residue 1452 1452 . . . Note=Phosphoserine%3B by PKC;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:Q14524 Q6QIY3 UniProtKB Glycosylation 279 279 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6QIY3 UniProtKB Glycosylation 288 288 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6QIY3 UniProtKB Glycosylation 311 311 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6QIY3 UniProtKB Glycosylation 334 334 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6QIY3 UniProtKB Glycosylation 1323 1323 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6QIY3 UniProtKB Glycosylation 1329 1329 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6QIY3 UniProtKB Glycosylation 1337 1337 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6QIY3 UniProtKB Glycosylation 1500 1500 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6QIY3 UniProtKB Glycosylation 1687 1687 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q6QIY3 UniProtKB Disulfide bond 276 318 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 Q6QIY3 UniProtKB Disulfide bond 856 865 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:D0E0C2 Q6QIY3 UniProtKB Alternative sequence 1 1435 . . . ID=VSP_012256;Note=In isoform 3. Missing;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q6QIY3 UniProtKB Alternative sequence 1030 1030 . . . ID=VSP_012257;Note=In isoform 2. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15047701;Dbxref=PMID:15047701 Q6QIY3 UniProtKB Mutagenesis 861 861 . . . Note=Sensitive to inhibition by some components of the venom of Centruroides sculpturatus. Q->E;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:24159039;Dbxref=PMID:24159039 Q6QIY3 UniProtKB Mutagenesis 1922 1922 . . . Note=No regulation by NEDD4L. Y->A;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:15123669;Dbxref=PMID:15123669