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Q6QIY3

- SCNAA_MOUSE

UniProt

Q6QIY3 - SCNAA_MOUSE

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Protein

Sodium channel protein type 10 subunit alpha

Gene
Scn10a, Sns
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.1 Publication

GO - Molecular functioni

  1. voltage-gated sodium channel activity Source: MGI

GO - Biological processi

  1. cardiac conduction Source: MGI
  2. membrane depolarization during action potential Source: RefGenome
  3. neuronal action potential Source: RefGenome
  4. regulation of atrial cardiac muscle cell membrane depolarization Source: MGI
  5. sensory perception of pain Source: InterPro
  6. sodium ion transmembrane transport Source: GOC
  7. sodium ion transport Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Sodium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium channel protein type 10 subunit alpha
Alternative name(s):
Peripheral nerve sodium channel 3
Short name:
PN3
Sensory neuron sodium channel
Sodium channel protein type X subunit alpha
Voltage-gated sodium channel subunit alpha Nav1.8
Gene namesi
Name:Scn10a
Synonyms:Sns
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Unplaced

Organism-specific databases

MGIiMGI:108029. Scn10a.

Subcellular locationi

Membrane; Multi-pass membrane protein By similarity
Note: It can be translocated to the extracellular membrane through association with S100A10 By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei126 – 14924Helical; Name=S1 of repeat I; Reviewed predictionAdd
BLAST
Transmembranei155 – 17420Helical; Name=S2 of repeat I; Reviewed predictionAdd
BLAST
Transmembranei188 – 20619Helical; Name=S3 of repeat I; Reviewed predictionAdd
BLAST
Transmembranei213 – 23220Helical; Voltage-sensor; Name=S4 of repeat I; Reviewed predictionAdd
BLAST
Transmembranei249 – 27224Helical; Name=S5 of repeat I; Reviewed predictionAdd
BLAST
Transmembranei373 – 39826Helical; Name=S6 of repeat I; Reviewed predictionAdd
BLAST
Transmembranei659 – 68325Helical; Name=S1 of repeat II; Reviewed predictionAdd
BLAST
Transmembranei695 – 71824Helical; Name=S2 of repeat II; Reviewed predictionAdd
BLAST
Transmembranei727 – 74620Helical; Name=S3 of repeat II; Reviewed predictionAdd
BLAST
Transmembranei753 – 77220Helical; Voltage-sensor; Name=S4 of repeat II; Reviewed predictionAdd
BLAST
Transmembranei789 – 80921Helical; Name=S5 of repeat II; Reviewed predictionAdd
BLAST
Transmembranei864 – 88926Helical; Name=S6 of repeat II; Reviewed predictionAdd
BLAST
Transmembranei1149 – 117224Helical; Name=S1 of repeat III; Reviewed predictionAdd
BLAST
Transmembranei1186 – 121126Helical; Name=S2 of repeat III; Reviewed predictionAdd
BLAST
Transmembranei1218 – 123922Helical; Name=S3 of repeat III; Reviewed predictionAdd
BLAST
Transmembranei1244 – 126522Helical; Voltage-sensor; Name=S4 of repeat III; Reviewed predictionAdd
BLAST
Transmembranei1285 – 131228Helical; Name=S5 of repeat III; Reviewed predictionAdd
BLAST
Transmembranei1393 – 141927Helical; Name=S6 of repeat III; Reviewed predictionAdd
BLAST
Transmembranei1473 – 149624Helical; Name=S1 of repeat IV; Reviewed predictionAdd
BLAST
Transmembranei1508 – 153124Helical; Name=S2 of repeat IV; Reviewed predictionAdd
BLAST
Transmembranei1538 – 156124Helical; Name=S3 of repeat IV; Reviewed predictionAdd
BLAST
Transmembranei1574 – 159522Helical; Voltage-sensor; Name=S4 of repeat IV; Reviewed predictionAdd
BLAST
Transmembranei1611 – 163323Helical; Name=S5 of repeat IV; Reviewed predictionAdd
BLAST
Transmembranei1699 – 172325Helical; Name=S6 of repeat IV; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. axon Source: MGI
  2. C-fiber Source: MGI
  3. plasma membrane Source: MGI
  4. voltage-gated sodium channel complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi861 – 8611Q → E: Sensitive to inhibition by some components of the venom of Centruroides sculpturatus. 1 Publication
Mutagenesisi1922 – 19221Y → A: No regulation by NEDD4L. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 19581958Sodium channel protein type 10 subunit alphaPRO_0000048508Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi279 – 2791N-linked (GlcNAc...) Reviewed prediction
Glycosylationi288 – 2881N-linked (GlcNAc...) Reviewed prediction
Glycosylationi311 – 3111N-linked (GlcNAc...) Reviewed prediction
Glycosylationi334 – 3341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1323 – 13231N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1329 – 13291N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1337 – 13371N-linked (GlcNAc...) Reviewed prediction
Modified residuei1452 – 14521Phosphoserine; by PKC By similarity
Glycosylationi1500 – 15001N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1687 – 16871N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Ubiquitinated by NEDD4L; which promotes its endocytosis Inferred.1 Publication
Phosphorylation at Ser-1452 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents By similarity.

Keywords - PTMi

Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ6QIY3.
PRIDEiQ6QIY3.

PTM databases

PhosphoSiteiQ6QIY3.

Expressioni

Tissue specificityi

Expressed in dorsal root ganglion and trigeminal ganglion.

Gene expression databases

BgeeiQ6QIY3.
CleanExiMM_SCN10A.
GenevestigatoriQ6QIY3.

Interactioni

Subunit structurei

The channel consists of an ion conducting pore forming alpha-subunit regulated by one or more associated auxiliary subunits SCN1B, SCN2B and SCN3B; electrophysiological properties may vary depending on the type of the associated beta subunits. Found in a number of complexes with PRX, DYNLT1 and PDZD2. Interacts with proteins such as FSTL1, PRX, DYNLT1, PDZD2, S100A10 and many others By similarity. Interacts with NEDD4 and NEDD4L.1 Publication

Protein-protein interaction databases

BioGridi203097. 2 interactions.
STRINGi10090.ENSMUSP00000081845.

Structurei

3D structure databases

ProteinModelPortaliQ6QIY3.
SMRiQ6QIY3. Positions 156-268, 667-890, 1149-1420, 1470-1872.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati125 – 399275IAdd
BLAST
Repeati658 – 890233IIAdd
BLAST
Repeati1148 – 1420273IIIAdd
BLAST
Repeati1472 – 1724253IVAdd
BLAST
Domaini1852 – 188130IQAdd
BLAST

Domaini

The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.

Sequence similaritiesi

Contains 1 IQ domain.

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1226.
HOGENOMiHOG000231755.
HOVERGENiHBG053100.
InParanoidiQ6QIY3.
KOiK04842.
PhylomeDBiQ6QIY3.

Family and domain databases

Gene3Di1.20.120.350. 4 hits.
InterProiIPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR028809. Na_channel_a10su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view]
PANTHERiPTHR10037:SF23. PTHR10037:SF23. 1 hit.
PfamiPF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view]
PRINTSiPR00170. NACHANNEL.
SMARTiSM00015. IQ. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q6QIY3-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEFPFGSVGT TNFRRFTPES LAEIEKQIAA HRAAKKGRPK QRGQKDKSEK     50
PRPQLDLKAC NQLPRFYGEL PAELVGEPLE DLDPFYSTHR TFIVLDKSRT 100
ISRFSATWAL WLFSPFNLIR RTAIKVSVHS WFSIFITVTI LVNCVCMTRT 150
DLPEKLEYAF TVVYTFEALI KILARGFCLN EFTYLRDPWN WLDFSVITLA 200
YVGAAIDLRG ISGLRTFRVL RALKTVSVIP GLKVIVGALI HSVRKLADVT 250
ILTVFCLSVF ALVGLQLFKG NLKNKCIKNG TDPHKADNLS SEMAGDIFIK 300
PGTTDPLLCG NGSDAGHCPN DYVCRKTSDN PDFNYTSFDS FAWAFLSLFR 350
LMTQDSWERL YQQTLRASGK MYMVFFVLVI FLGSFYLVNL ILAVVTMAYE 400
EQSQATIAEI EAKEKKFKEA LEVLQKEQEV LAALGIDTTS LYSHNGSPLA 450
PKNANERRPR VKSRMSEGST DDNRSLQSDP YNQRRMSFLG LSSGRRRASH 500
SSVFHFRAPS QDVSFPDGIL DDGVFHGDQE SRRSSILLGR GAGQAGPLPR 550
SPLPQSPNPG PRRGEEGQRG VPTGELATGA PEGPALDAAG QKNFLSADYL 600
NEPFRAQRAM SVVSIMTSVI EELEESKLKC PPCLISLAQK YLIWECCPKW 650
KKFKMVLFEL VTDPFAELTI TLCIVVNTVF MAMEHYPMTD AFDAMLQAGN 700
IVFTVFFTME MAFKIIAFDP YYYFQKKWNI FDCVIVTVSL LELSTSKKGS 750
LSVLRTFRLL RVFKLAKSWP TLNMLIKIIG NSVGALGNLT FILAIIVFIF 800
ALVGKQLLSE NYGCRRDGIS VWNGERLRWH MCDFFHSFLV VFRILCGEWI 850
ENMWVCMEVS QDYICLTLFL TVMVLGNLVV LNLFIALLLN SFSADNLTAP 900
EDDGEVNNLQ VALARIQVFG HRASRAITSY IRSHCRLRWP KVETQLGMKP 950
PLTSCKAENH IATDAVNAAV GNLAKPALGG PKENHGDFIT DPNVWVSVPI 1000
AEGESDLDEL EEDVEHASQS SWQEESPKGQ QELLQQVQKC EDHQAARSPP 1050
SGMSSEDLAP YLGERWQREE SPRVPAEGVD DTSSSEGSTV DCPDPEEILR 1100
KIPELAEELD EPDDCFPEGC TRRCPCCKVN TSKFPWATGW QVRKTCYRIV 1150
EHSWFESFII FMILLSSGAL AFEDNYLEEK PRVKSVLEYT DRVFTFIFVF 1200
EMLLKWVAYG FKKYFTNAWC WLDFLIVNIS LTSLIAKILE YSDVASIKAL 1250
RTLRALRPLR ALSRFEGMRV VVDALVGAIP SIMNVLLVCL IFWLIFSIMG 1300
VNLFAGKFSR CVDTRSNPFS VVNSTFVTNK SDCYNQNNTG HFFWVNVKVN 1350
FDNVAMGYLA LLQVATFKGW MDIMYAAVDS RDINSQPNWE ESLYMYLYFV 1400
VFIIFGGFFT LNLFVGVIID NFNQQKKKLG GQDIFMTEEQ KKYYNAMKKL 1450
GSKKPQKPIP RPLNKYQGFV FDIVTRQAFD IIIMALICLN MITMMVETDN 1500
QSEEKTKVLG RINQFFVAVF TGECVMKMFA LRQYYFTNGW NVFDFIVVIL 1550
SISSLLFSAI LSSLESYFSP TLLRVIRLAR IGRILRLIRA AKGIRTLLFA 1600
LMMSLPALFN IGLLLFLVMF IYSIFGMASF ANVIDEAGID DMFNFKTFGN 1650
SMLCLFQITT SAGWDGLLSP ILNTGPPYCD PNRPNSNGSK GNCGSPAVGI 1700
LFFTTYIIIS FLIVVNMYIA VILENFNVAT EESTEPLSED DFDMFYETWE 1750
KFDPEATQFI AFSALSDFAD TLSGPLRIPK PNQNILIQMD LPLVPGDKIH 1800
CLDILFAFTK NVLGESGELD SLKTNMEEKF MATNLSKASY EPIATTLRCK 1850
QEDISATIIQ KAYRNYMLQR SLMLSNPLHV PRAEEDGVSL PREGYVTFMA 1900
NDNGGLPDKS ETASATSFPP SYDSVTRGLS DRANISTSSS MQNEDEVTAK 1950
EGKSPGPQ 1958
Length:1,958
Mass (Da):220,552
Last modified:December 21, 2004 - v2
Checksum:i24830634E86490FF
GO
Isoform 2 (identifier: Q6QIY3-2) [UniParc]FASTAAdd to Basket

Also known as: Nav1.8c

The sequence of this isoform differs from the canonical sequence as follows:
     1030-1030: Missing.

Show »
Length:1,957
Mass (Da):220,424
Checksum:i23426D535A65601D
GO
Isoform 3 (identifier: Q6QIY3-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1435: Missing.

Show »
Length:523
Mass (Da):58,512
Checksum:iD9DB3D0D96A3C622
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 14351435Missing in isoform 3. VSP_012256Add
BLAST
Alternative sequencei1030 – 10301Missing in isoform 2. VSP_012257

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ622906 Genomic DNA. Translation: CAF22039.1.
AJ623269 mRNA. Translation: CAF25039.1.
AJ623270 mRNA. Translation: CAF25040.1.
L42342 mRNA. Translation: AAA68000.1.
AY538273 mRNA. Translation: AAS45602.1.
CCDSiCCDS57716.1. [Q6QIY3-1]
RefSeqiNP_033160.2. NM_009134.3. [Q6QIY3-2]
XP_006512052.1. XM_006511989.1. [Q6QIY3-1]
XP_006512053.1. XM_006511990.1. [Q6QIY3-1]
XP_006512054.1. XM_006511991.1. [Q6QIY3-1]
UniGeneiMm.247042.
Mm.455125.
Mm.489505.

Genome annotation databases

GeneIDi20264.
KEGGimmu:20264.
UCSCiuc009sbf.2. mouse. [Q6QIY3-3]
uc009sbg.3. mouse. [Q6QIY3-2]
uc009sbh.3. mouse. [Q6QIY3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AJ622906 Genomic DNA. Translation: CAF22039.1 .
AJ623269 mRNA. Translation: CAF25039.1 .
AJ623270 mRNA. Translation: CAF25040.1 .
L42342 mRNA. Translation: AAA68000.1 .
AY538273 mRNA. Translation: AAS45602.1 .
CCDSi CCDS57716.1. [Q6QIY3-1 ]
RefSeqi NP_033160.2. NM_009134.3. [Q6QIY3-2 ]
XP_006512052.1. XM_006511989.1. [Q6QIY3-1 ]
XP_006512053.1. XM_006511990.1. [Q6QIY3-1 ]
XP_006512054.1. XM_006511991.1. [Q6QIY3-1 ]
UniGenei Mm.247042.
Mm.455125.
Mm.489505.

3D structure databases

ProteinModelPortali Q6QIY3.
SMRi Q6QIY3. Positions 156-268, 667-890, 1149-1420, 1470-1872.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 203097. 2 interactions.
STRINGi 10090.ENSMUSP00000081845.

Chemistry

BindingDBi Q6QIY3.
ChEMBLi CHEMBL5158.

PTM databases

PhosphoSitei Q6QIY3.

Proteomic databases

PaxDbi Q6QIY3.
PRIDEi Q6QIY3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 20264.
KEGGi mmu:20264.
UCSCi uc009sbf.2. mouse. [Q6QIY3-3 ]
uc009sbg.3. mouse. [Q6QIY3-2 ]
uc009sbh.3. mouse. [Q6QIY3-1 ]

Organism-specific databases

CTDi 6336.
MGIi MGI:108029. Scn10a.

Phylogenomic databases

eggNOGi COG1226.
HOGENOMi HOG000231755.
HOVERGENi HBG053100.
InParanoidi Q6QIY3.
KOi K04842.
PhylomeDBi Q6QIY3.

Miscellaneous databases

NextBioi 297931.
PROi Q6QIY3.
SOURCEi Search...

Gene expression databases

Bgeei Q6QIY3.
CleanExi MM_SCN10A.
Genevestigatori Q6QIY3.

Family and domain databases

Gene3Di 1.20.120.350. 4 hits.
InterProi IPR027359. Channel_four-helix_dom.
IPR005821. Ion_trans_dom.
IPR000048. IQ_motif_EF-hand-BS.
IPR028809. Na_channel_a10su.
IPR001696. Na_channel_asu.
IPR010526. Na_trans_assoc.
[Graphical view ]
PANTHERi PTHR10037:SF23. PTHR10037:SF23. 1 hit.
Pfami PF00520. Ion_trans. 4 hits.
PF06512. Na_trans_assoc. 1 hit.
[Graphical view ]
PRINTSi PR00170. NACHANNEL.
SMARTi SM00015. IQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Novel isoforms of the sodium channels Nav1.8 and Nav1.5 are produced by a conserved mechanism in mouse and rat."
    Kerr N.C.H., Holmes F.E., Wynick D.
    J. Biol. Chem. 279:24826-24833(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 943-1090 (ISOFORMS 1 AND 2).
    Strain: 129P2.
    Tissue: Spinal ganglion and Trigeminal ganglion.
  2. "Mouse sodium channel clone BC in pSB+."
    Jover E., Shah V.
    Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 3).
    Strain: C3H.
  3. "cDNA cloning of the mouse sensory neuron specific sodium channel Nav1.8 (Scn10a)."
    Puhl H.L. III, King M.M., Ikeda S.R.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2).
    Strain: CD-1.
    Tissue: Spinal ganglion.
  4. "Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2."
    Fotia A.B., Ekberg J., Adams D.J., Cook D.I., Poronnik P., Kumar S.
    J. Biol. Chem. 279:28930-28935(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH NEDD4 AND NEDD4L, PROBABLE UBIQUITINATION, MUTAGENESIS OF TYR-1922.
  5. "Voltage-gated sodium channel in grasshopper mice defends against bark scorpion toxin."
    Rowe A.H., Xiao Y., Rowe M.P., Cummins T.R., Zakon H.H.
    Science 342:441-446(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTAGENESIS OF GLN-861.

Entry informationi

Entry nameiSCNAA_MOUSE
AccessioniPrimary (citable) accession number: Q6QIY3
Secondary accession number(s): Q62243
, Q6EWG7, Q6KCH7, Q703F9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: December 21, 2004
Last modified: September 3, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Mus musculus is sensitive to the pain-inducing components of the bark scorpion (Centruroides sculpturatus) venom while Onychomys torridus is not. Gln-861 may account for the difference between both rodents and its replacement by a glutamate, the corresponding amino acid found in the Onychomys torridus ortholog, allows inhibition of Snc10a by the venom, which in turn, inhibits sodium currents, blocks action potential propagation and may induce analgesia (1 Publication).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi