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Q6QIY3

- SCNAA_MOUSE

UniProt

Q6QIY3 - SCNAA_MOUSE

Protein

Sodium channel protein type 10 subunit alpha

Gene

Scn10a

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (21 Dec 2004)
      Previous versions | rss
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    Functioni

    Tetrodotoxin-resistant channel that mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which sodium ions may pass in accordance with their electrochemical gradient. Plays a role in neuropathic pain mechanisms.1 Publication

    GO - Molecular functioni

    1. voltage-gated sodium channel activity Source: MGI

    GO - Biological processi

    1. cardiac conduction Source: MGI
    2. membrane depolarization during action potential Source: RefGenome
    3. neuronal action potential Source: RefGenome
    4. regulation of atrial cardiac muscle cell membrane depolarization Source: MGI
    5. sensory perception of pain Source: InterPro
    6. sodium ion transmembrane transport Source: GOC
    7. sodium ion transport Source: MGI

    Keywords - Molecular functioni

    Ion channel, Sodium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Sodium transport, Transport

    Keywords - Ligandi

    Sodium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sodium channel protein type 10 subunit alpha
    Alternative name(s):
    Peripheral nerve sodium channel 3
    Short name:
    PN3
    Sensory neuron sodium channel
    Sodium channel protein type X subunit alpha
    Voltage-gated sodium channel subunit alpha Nav1.8
    Gene namesi
    Name:Scn10a
    Synonyms:Sns
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:108029. Scn10a.

    Subcellular locationi

    Membrane By similarity; Multi-pass membrane protein By similarity
    Note: It can be translocated to the extracellular membrane through association with S100A10.By similarity

    GO - Cellular componenti

    1. axon Source: MGI
    2. C-fiber Source: MGI
    3. plasma membrane Source: MGI
    4. voltage-gated sodium channel complex Source: InterPro

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi861 – 8611Q → E: Sensitive to inhibition by some components of the venom of Centruroides sculpturatus. 1 Publication
    Mutagenesisi1922 – 19221Y → A: No regulation by NEDD4L. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 19581958Sodium channel protein type 10 subunit alphaPRO_0000048508Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi279 – 2791N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi288 – 2881N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi311 – 3111N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi334 – 3341N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1323 – 13231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1329 – 13291N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1337 – 13371N-linked (GlcNAc...)Sequence Analysis
    Modified residuei1452 – 14521Phosphoserine; by PKCBy similarity
    Glycosylationi1500 – 15001N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1687 – 16871N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    Ubiquitinated by NEDD4L; which promotes its endocytosis.Curated
    Phosphorylation at Ser-1452 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.By similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiQ6QIY3.
    PRIDEiQ6QIY3.

    PTM databases

    PhosphoSiteiQ6QIY3.

    Expressioni

    Tissue specificityi

    Expressed in dorsal root ganglion and trigeminal ganglion.

    Gene expression databases

    BgeeiQ6QIY3.
    CleanExiMM_SCN10A.
    GenevestigatoriQ6QIY3.

    Interactioni

    Subunit structurei

    The channel consists of an ion conducting pore forming alpha-subunit regulated by one or more associated auxiliary subunits SCN1B, SCN2B and SCN3B; electrophysiological properties may vary depending on the type of the associated beta subunits. Found in a number of complexes with PRX, DYNLT1 and PDZD2. Interacts with proteins such as FSTL1, PRX, DYNLT1, PDZD2, S100A10 and many others By similarity. Interacts with NEDD4 and NEDD4L.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi203097. 2 interactions.
    STRINGi10090.ENSMUSP00000081845.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6QIY3.
    SMRiQ6QIY3. Positions 156-268, 667-890, 1149-1420, 1470-1872.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei126 – 14924Helical; Name=S1 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei155 – 17420Helical; Name=S2 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei188 – 20619Helical; Name=S3 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei213 – 23220Helical; Voltage-sensor; Name=S4 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei249 – 27224Helical; Name=S5 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei373 – 39826Helical; Name=S6 of repeat ISequence AnalysisAdd
    BLAST
    Transmembranei659 – 68325Helical; Name=S1 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei695 – 71824Helical; Name=S2 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei727 – 74620Helical; Name=S3 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei753 – 77220Helical; Voltage-sensor; Name=S4 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei789 – 80921Helical; Name=S5 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei864 – 88926Helical; Name=S6 of repeat IISequence AnalysisAdd
    BLAST
    Transmembranei1149 – 117224Helical; Name=S1 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1186 – 121126Helical; Name=S2 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1218 – 123922Helical; Name=S3 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1244 – 126522Helical; Voltage-sensor; Name=S4 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1285 – 131228Helical; Name=S5 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1393 – 141927Helical; Name=S6 of repeat IIISequence AnalysisAdd
    BLAST
    Transmembranei1473 – 149624Helical; Name=S1 of repeat IVSequence AnalysisAdd
    BLAST
    Transmembranei1508 – 153124Helical; Name=S2 of repeat IVSequence AnalysisAdd
    BLAST
    Transmembranei1538 – 156124Helical; Name=S3 of repeat IVSequence AnalysisAdd
    BLAST
    Transmembranei1574 – 159522Helical; Voltage-sensor; Name=S4 of repeat IVSequence AnalysisAdd
    BLAST
    Transmembranei1611 – 163323Helical; Name=S5 of repeat IVSequence AnalysisAdd
    BLAST
    Transmembranei1699 – 172325Helical; Name=S6 of repeat IVSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati125 – 399275IAdd
    BLAST
    Repeati658 – 890233IIAdd
    BLAST
    Repeati1148 – 1420273IIIAdd
    BLAST
    Repeati1472 – 1724253IVAdd
    BLAST
    Domaini1852 – 188130IQAdd
    BLAST

    Domaini

    The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.

    Sequence similaritiesi

    Contains 1 IQ domain.Curated

    Keywords - Domaini

    Repeat, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1226.
    HOGENOMiHOG000231755.
    HOVERGENiHBG053100.
    InParanoidiQ6QIY3.
    KOiK04842.
    PhylomeDBiQ6QIY3.

    Family and domain databases

    Gene3Di1.20.120.350. 4 hits.
    InterProiIPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR028809. Na_channel_a10su.
    IPR001696. Na_channel_asu.
    IPR010526. Na_trans_assoc.
    [Graphical view]
    PANTHERiPTHR10037:SF23. PTHR10037:SF23. 1 hit.
    PfamiPF00520. Ion_trans. 4 hits.
    PF06512. Na_trans_assoc. 1 hit.
    [Graphical view]
    PRINTSiPR00170. NACHANNEL.
    SMARTiSM00015. IQ. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q6QIY3-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEFPFGSVGT TNFRRFTPES LAEIEKQIAA HRAAKKGRPK QRGQKDKSEK     50
    PRPQLDLKAC NQLPRFYGEL PAELVGEPLE DLDPFYSTHR TFIVLDKSRT 100
    ISRFSATWAL WLFSPFNLIR RTAIKVSVHS WFSIFITVTI LVNCVCMTRT 150
    DLPEKLEYAF TVVYTFEALI KILARGFCLN EFTYLRDPWN WLDFSVITLA 200
    YVGAAIDLRG ISGLRTFRVL RALKTVSVIP GLKVIVGALI HSVRKLADVT 250
    ILTVFCLSVF ALVGLQLFKG NLKNKCIKNG TDPHKADNLS SEMAGDIFIK 300
    PGTTDPLLCG NGSDAGHCPN DYVCRKTSDN PDFNYTSFDS FAWAFLSLFR 350
    LMTQDSWERL YQQTLRASGK MYMVFFVLVI FLGSFYLVNL ILAVVTMAYE 400
    EQSQATIAEI EAKEKKFKEA LEVLQKEQEV LAALGIDTTS LYSHNGSPLA 450
    PKNANERRPR VKSRMSEGST DDNRSLQSDP YNQRRMSFLG LSSGRRRASH 500
    SSVFHFRAPS QDVSFPDGIL DDGVFHGDQE SRRSSILLGR GAGQAGPLPR 550
    SPLPQSPNPG PRRGEEGQRG VPTGELATGA PEGPALDAAG QKNFLSADYL 600
    NEPFRAQRAM SVVSIMTSVI EELEESKLKC PPCLISLAQK YLIWECCPKW 650
    KKFKMVLFEL VTDPFAELTI TLCIVVNTVF MAMEHYPMTD AFDAMLQAGN 700
    IVFTVFFTME MAFKIIAFDP YYYFQKKWNI FDCVIVTVSL LELSTSKKGS 750
    LSVLRTFRLL RVFKLAKSWP TLNMLIKIIG NSVGALGNLT FILAIIVFIF 800
    ALVGKQLLSE NYGCRRDGIS VWNGERLRWH MCDFFHSFLV VFRILCGEWI 850
    ENMWVCMEVS QDYICLTLFL TVMVLGNLVV LNLFIALLLN SFSADNLTAP 900
    EDDGEVNNLQ VALARIQVFG HRASRAITSY IRSHCRLRWP KVETQLGMKP 950
    PLTSCKAENH IATDAVNAAV GNLAKPALGG PKENHGDFIT DPNVWVSVPI 1000
    AEGESDLDEL EEDVEHASQS SWQEESPKGQ QELLQQVQKC EDHQAARSPP 1050
    SGMSSEDLAP YLGERWQREE SPRVPAEGVD DTSSSEGSTV DCPDPEEILR 1100
    KIPELAEELD EPDDCFPEGC TRRCPCCKVN TSKFPWATGW QVRKTCYRIV 1150
    EHSWFESFII FMILLSSGAL AFEDNYLEEK PRVKSVLEYT DRVFTFIFVF 1200
    EMLLKWVAYG FKKYFTNAWC WLDFLIVNIS LTSLIAKILE YSDVASIKAL 1250
    RTLRALRPLR ALSRFEGMRV VVDALVGAIP SIMNVLLVCL IFWLIFSIMG 1300
    VNLFAGKFSR CVDTRSNPFS VVNSTFVTNK SDCYNQNNTG HFFWVNVKVN 1350
    FDNVAMGYLA LLQVATFKGW MDIMYAAVDS RDINSQPNWE ESLYMYLYFV 1400
    VFIIFGGFFT LNLFVGVIID NFNQQKKKLG GQDIFMTEEQ KKYYNAMKKL 1450
    GSKKPQKPIP RPLNKYQGFV FDIVTRQAFD IIIMALICLN MITMMVETDN 1500
    QSEEKTKVLG RINQFFVAVF TGECVMKMFA LRQYYFTNGW NVFDFIVVIL 1550
    SISSLLFSAI LSSLESYFSP TLLRVIRLAR IGRILRLIRA AKGIRTLLFA 1600
    LMMSLPALFN IGLLLFLVMF IYSIFGMASF ANVIDEAGID DMFNFKTFGN 1650
    SMLCLFQITT SAGWDGLLSP ILNTGPPYCD PNRPNSNGSK GNCGSPAVGI 1700
    LFFTTYIIIS FLIVVNMYIA VILENFNVAT EESTEPLSED DFDMFYETWE 1750
    KFDPEATQFI AFSALSDFAD TLSGPLRIPK PNQNILIQMD LPLVPGDKIH 1800
    CLDILFAFTK NVLGESGELD SLKTNMEEKF MATNLSKASY EPIATTLRCK 1850
    QEDISATIIQ KAYRNYMLQR SLMLSNPLHV PRAEEDGVSL PREGYVTFMA 1900
    NDNGGLPDKS ETASATSFPP SYDSVTRGLS DRANISTSSS MQNEDEVTAK 1950
    EGKSPGPQ 1958
    Length:1,958
    Mass (Da):220,552
    Last modified:December 21, 2004 - v2
    Checksum:i24830634E86490FF
    GO
    Isoform 2 (identifier: Q6QIY3-2) [UniParc]FASTAAdd to Basket

    Also known as: Nav1.8c

    The sequence of this isoform differs from the canonical sequence as follows:
         1030-1030: Missing.

    Show »
    Length:1,957
    Mass (Da):220,424
    Checksum:i23426D535A65601D
    GO
    Isoform 3 (identifier: Q6QIY3-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1435: Missing.

    Show »
    Length:523
    Mass (Da):58,512
    Checksum:iD9DB3D0D96A3C622
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 14351435Missing in isoform 3. CuratedVSP_012256Add
    BLAST
    Alternative sequencei1030 – 10301Missing in isoform 2. 1 PublicationVSP_012257

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ622906 Genomic DNA. Translation: CAF22039.1.
    AJ623269 mRNA. Translation: CAF25039.1.
    AJ623270 mRNA. Translation: CAF25040.1.
    L42342 mRNA. Translation: AAA68000.1.
    AY538273 mRNA. Translation: AAS45602.1.
    CCDSiCCDS57716.1. [Q6QIY3-1]
    RefSeqiNP_033160.2. NM_009134.3. [Q6QIY3-2]
    XP_006512052.1. XM_006511989.1. [Q6QIY3-1]
    XP_006512053.1. XM_006511990.1. [Q6QIY3-1]
    XP_006512054.1. XM_006511991.1. [Q6QIY3-1]
    UniGeneiMm.247042.
    Mm.455125.
    Mm.489505.

    Genome annotation databases

    GeneIDi20264.
    KEGGimmu:20264.
    UCSCiuc009sbf.2. mouse. [Q6QIY3-3]
    uc009sbg.3. mouse. [Q6QIY3-2]
    uc009sbh.3. mouse. [Q6QIY3-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AJ622906 Genomic DNA. Translation: CAF22039.1 .
    AJ623269 mRNA. Translation: CAF25039.1 .
    AJ623270 mRNA. Translation: CAF25040.1 .
    L42342 mRNA. Translation: AAA68000.1 .
    AY538273 mRNA. Translation: AAS45602.1 .
    CCDSi CCDS57716.1. [Q6QIY3-1 ]
    RefSeqi NP_033160.2. NM_009134.3. [Q6QIY3-2 ]
    XP_006512052.1. XM_006511989.1. [Q6QIY3-1 ]
    XP_006512053.1. XM_006511990.1. [Q6QIY3-1 ]
    XP_006512054.1. XM_006511991.1. [Q6QIY3-1 ]
    UniGenei Mm.247042.
    Mm.455125.
    Mm.489505.

    3D structure databases

    ProteinModelPortali Q6QIY3.
    SMRi Q6QIY3. Positions 156-268, 667-890, 1149-1420, 1470-1872.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 203097. 2 interactions.
    STRINGi 10090.ENSMUSP00000081845.

    Chemistry

    BindingDBi Q6QIY3.
    ChEMBLi CHEMBL5158.

    PTM databases

    PhosphoSitei Q6QIY3.

    Proteomic databases

    PaxDbi Q6QIY3.
    PRIDEi Q6QIY3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 20264.
    KEGGi mmu:20264.
    UCSCi uc009sbf.2. mouse. [Q6QIY3-3 ]
    uc009sbg.3. mouse. [Q6QIY3-2 ]
    uc009sbh.3. mouse. [Q6QIY3-1 ]

    Organism-specific databases

    CTDi 6336.
    MGIi MGI:108029. Scn10a.

    Phylogenomic databases

    eggNOGi COG1226.
    HOGENOMi HOG000231755.
    HOVERGENi HBG053100.
    InParanoidi Q6QIY3.
    KOi K04842.
    PhylomeDBi Q6QIY3.

    Miscellaneous databases

    NextBioi 297931.
    PROi Q6QIY3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q6QIY3.
    CleanExi MM_SCN10A.
    Genevestigatori Q6QIY3.

    Family and domain databases

    Gene3Di 1.20.120.350. 4 hits.
    InterProi IPR027359. Channel_four-helix_dom.
    IPR005821. Ion_trans_dom.
    IPR000048. IQ_motif_EF-hand-BS.
    IPR028809. Na_channel_a10su.
    IPR001696. Na_channel_asu.
    IPR010526. Na_trans_assoc.
    [Graphical view ]
    PANTHERi PTHR10037:SF23. PTHR10037:SF23. 1 hit.
    Pfami PF00520. Ion_trans. 4 hits.
    PF06512. Na_trans_assoc. 1 hit.
    [Graphical view ]
    PRINTSi PR00170. NACHANNEL.
    SMARTi SM00015. IQ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Novel isoforms of the sodium channels Nav1.8 and Nav1.5 are produced by a conserved mechanism in mouse and rat."
      Kerr N.C.H., Holmes F.E., Wynick D.
      J. Biol. Chem. 279:24826-24833(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 943-1090 (ISOFORMS 1 AND 2).
      Strain: 129P2.
      Tissue: Spinal ganglion and Trigeminal ganglion.
    2. "Mouse sodium channel clone BC in pSB+."
      Jover E., Shah V.
      Submitted (JUN-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 3).
      Strain: C3H.
    3. "cDNA cloning of the mouse sensory neuron specific sodium channel Nav1.8 (Scn10a)."
      Puhl H.L. III, King M.M., Ikeda S.R.
      Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2).
      Strain: CD-1.
      Tissue: Spinal ganglion.
    4. "Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2."
      Fotia A.B., Ekberg J., Adams D.J., Cook D.I., Poronnik P., Kumar S.
      J. Biol. Chem. 279:28930-28935(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NEDD4 AND NEDD4L, PROBABLE UBIQUITINATION, MUTAGENESIS OF TYR-1922.
    5. "Voltage-gated sodium channel in grasshopper mice defends against bark scorpion toxin."
      Rowe A.H., Xiao Y., Rowe M.P., Cummins T.R., Zakon H.H.
      Science 342:441-446(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MUTAGENESIS OF GLN-861.

    Entry informationi

    Entry nameiSCNAA_MOUSE
    AccessioniPrimary (citable) accession number: Q6QIY3
    Secondary accession number(s): Q62243
    , Q6EWG7, Q6KCH7, Q703F9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 21, 2004
    Last sequence update: December 21, 2004
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Mus musculus is sensitive to the pain-inducing components of the bark scorpion (Centruroides sculpturatus) venom while Onychomys torridus is not. Gln-861 may account for the difference between both rodents and its replacement by a glutamate, the corresponding amino acid found in the Onychomys torridus ortholog, allows inhibition of Snc10a by the venom, which in turn, inhibits sodium currents, blocks action potential propagation and may induce analgesia (PubMed:24159039).1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3