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Protein

Zinc transporter 3

Gene

Slc30a3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in accumulation of zinc in synaptic vesicles.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ion transport, Transport, Zinc transport

Keywords - Ligandi

Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 3
Short name:
ZnT-3
Alternative name(s):
Solute carrier family 30 member 3
Gene namesi
Name:Slc30a3
Synonyms:Znt3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1359689. Slc30a3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7575CytoplasmicSequence analysisAdd
BLAST
Transmembranei76 – 9621HelicalSequence analysisAdd
BLAST
Topological domaini97 – 1059ExtracellularSequence analysis
Transmembranei106 – 12621HelicalSequence analysisAdd
BLAST
Topological domaini127 – 14519CytoplasmicSequence analysisAdd
BLAST
Transmembranei146 – 16621HelicalSequence analysisAdd
BLAST
Topological domaini167 – 17711ExtracellularSequence analysisAdd
BLAST
Transmembranei178 – 19821HelicalSequence analysisAdd
BLAST
Topological domaini199 – 23537CytoplasmicSequence analysisAdd
BLAST
Transmembranei236 – 25621HelicalSequence analysisAdd
BLAST
Topological domaini257 – 2637ExtracellularSequence analysis
Transmembranei264 – 28421HelicalSequence analysisAdd
BLAST
Topological domaini285 – 388104CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Endosome, Lysosome, Membrane, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 388388Zinc transporter 3PRO_0000357045Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei63 – 631PhosphoserineCombined sources
Modified residuei66 – 661PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6QIX3.
PRIDEiQ6QIX3.

PTM databases

iPTMnetiQ6QIX3.

Expressioni

Gene expression databases

GenevisibleiQ6QIX3. RN.

Interactioni

Protein-protein interaction databases

IntActiQ6QIX3. 1 interaction.
STRINGi10116.ENSRNOP00000008126.

Structurei

3D structure databases

ProteinModelPortaliQ6QIX3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1482. Eukaryota.
COG1230. LUCA.
GeneTreeiENSGT00550000074381.
HOGENOMiHOG000079023.
HOVERGENiHBG003345.
InParanoidiQ6QIX3.
KOiK14690.
OMAiAQCLRCR.
OrthoDBiEOG7S4X68.
PhylomeDBiQ6QIX3.
TreeFamiTF313382.

Family and domain databases

Gene3Di1.20.1510.10. 1 hit.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 1 hit.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6QIX3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPSPASGGS ETTRLVSPRD RSSAGGGLRL KSLFTEPSEP LPEGPKLEGM
60 70 80 90 100
AFHHCHKNRV SQSGLSPERA QARRQLYAAC VVCFIFMAGE VVGGYLAHSL
110 120 130 140 150
AIMTDAAHLL ADIGSMMASL FSLWLSTRPA TRTMTFGWHR SETLGALASV
160 170 180 190 200
VSLWIVTGIL LYLAFLRLLH SDYHIEAGAM LLTASIAVCA NMIMAFVLHQ
210 220 230 240 250
TGAPHSHGPR GAEYAPLEEG HGHPLSLGNT SVRAAFVHVL GDLLQSLGVL
260 270 280 290 300
AASILIYFKP QYKVADPIST FLFSICALGS TAPTLRDVLL VLMEGAPRSV
310 320 330 340 350
EFEPVRDTLL SVPGVRATHD LHLWALTLTY HVASAHLAID STADPEAILA
360 370 380
EASSRLYSRF GFSSCTLQVE KYRSEMAHCL RCREPPKA
Length:388
Mass (Da):41,898
Last modified:July 5, 2004 - v1
Checksum:i767F8165AF1533F7
GO
Isoform 2 (identifier: Q6QIX3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: Missing.

Note: No experimental confirmation available.
Show »
Length:339
Mass (Da):36,850
Checksum:i559E395B9AFFE869
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4949Missing in isoform 2. 1 PublicationVSP_036043Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY538655 mRNA. Translation: AAS46250.1.
CH473947 Genomic DNA. Translation: EDM02934.1.
BC086513 mRNA. Translation: AAH86513.1.
RefSeqiNP_001013261.1. NM_001013243.1. [Q6QIX3-1]
XP_008762748.1. XM_008764526.1. [Q6QIX3-2]
XP_008762749.1. XM_008764527.1. [Q6QIX3-2]
XP_008762750.1. XM_008764528.1. [Q6QIX3-2]
XP_008762751.1. XM_008764529.1. [Q6QIX3-2]
UniGeneiRn.9297.

Genome annotation databases

EnsembliENSRNOT00000008126; ENSRNOP00000008126; ENSRNOG00000006204. [Q6QIX3-1]
GeneIDi366568.
KEGGirno:366568.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY538655 mRNA. Translation: AAS46250.1.
CH473947 Genomic DNA. Translation: EDM02934.1.
BC086513 mRNA. Translation: AAH86513.1.
RefSeqiNP_001013261.1. NM_001013243.1. [Q6QIX3-1]
XP_008762748.1. XM_008764526.1. [Q6QIX3-2]
XP_008762749.1. XM_008764527.1. [Q6QIX3-2]
XP_008762750.1. XM_008764528.1. [Q6QIX3-2]
XP_008762751.1. XM_008764529.1. [Q6QIX3-2]
UniGeneiRn.9297.

3D structure databases

ProteinModelPortaliQ6QIX3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6QIX3. 1 interaction.
STRINGi10116.ENSRNOP00000008126.

PTM databases

iPTMnetiQ6QIX3.

Proteomic databases

PaxDbiQ6QIX3.
PRIDEiQ6QIX3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000008126; ENSRNOP00000008126; ENSRNOG00000006204. [Q6QIX3-1]
GeneIDi366568.
KEGGirno:366568.

Organism-specific databases

CTDi7781.
RGDi1359689. Slc30a3.

Phylogenomic databases

eggNOGiKOG1482. Eukaryota.
COG1230. LUCA.
GeneTreeiENSGT00550000074381.
HOGENOMiHOG000079023.
HOVERGENiHBG003345.
InParanoidiQ6QIX3.
KOiK14690.
OMAiAQCLRCR.
OrthoDBiEOG7S4X68.
PhylomeDBiQ6QIX3.
TreeFamiTF313382.

Miscellaneous databases

PROiQ6QIX3.

Gene expression databases

GenevisibleiQ6QIX3. RN.

Family and domain databases

Gene3Di1.20.1510.10. 1 hit.
InterProiIPR002524. Cation_efflux.
IPR027469. Cation_efflux_TMD.
[Graphical view]
PANTHERiPTHR11562. PTHR11562. 1 hit.
PfamiPF01545. Cation_efflux. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01297. CDF. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cowie T.F., Kanellakis S., Masters C.L., Bush A.I.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: Sprague-Dawley.
  2. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (JUN-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis.
  4. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-63 AND SER-66, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZNT3_RAT
AccessioniPrimary (citable) accession number: Q6QIX3
Secondary accession number(s): Q5RJT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.