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Protein

Zinc transporter 3

Gene

Slc30a3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in accumulation of zinc in synaptic vesicles.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processIon transport, Transport, Zinc transport
LigandZinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc transporter 3
Short name:
ZnT-3
Alternative name(s):
Solute carrier family 30 member 3
Gene namesi
Name:Slc30a3
Synonyms:Znt3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 6

Organism-specific databases

RGDi1359689 Slc30a3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 75CytoplasmicSequence analysisAdd BLAST75
Transmembranei76 – 96HelicalSequence analysisAdd BLAST21
Topological domaini97 – 105ExtracellularSequence analysis9
Transmembranei106 – 126HelicalSequence analysisAdd BLAST21
Topological domaini127 – 145CytoplasmicSequence analysisAdd BLAST19
Transmembranei146 – 166HelicalSequence analysisAdd BLAST21
Topological domaini167 – 177ExtracellularSequence analysisAdd BLAST11
Transmembranei178 – 198HelicalSequence analysisAdd BLAST21
Topological domaini199 – 235CytoplasmicSequence analysisAdd BLAST37
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 263ExtracellularSequence analysis7
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Topological domaini285 – 388CytoplasmicSequence analysisAdd BLAST104

Keywords - Cellular componenti

Cell junction, Cytoplasmic vesicle, Endosome, Lysosome, Membrane, Synapse, Synaptosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003570451 – 388Zinc transporter 3Add BLAST388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei63PhosphoserineCombined sources1
Modified residuei66PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6QIX3
PRIDEiQ6QIX3

PTM databases

iPTMnetiQ6QIX3
PhosphoSitePlusiQ6QIX3

Expressioni

Gene expression databases

BgeeiENSRNOG00000006204
GenevisibleiQ6QIX3 RN

Interactioni

Protein-protein interaction databases

IntActiQ6QIX3, 1 interactor
STRINGi10116.ENSRNOP00000008126

Structurei

3D structure databases

ProteinModelPortaliQ6QIX3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1482 Eukaryota
COG1230 LUCA
GeneTreeiENSGT00550000074381
HOGENOMiHOG000079023
HOVERGENiHBG003345
InParanoidiQ6QIX3
KOiK14690
OMAiAQCLRCR
OrthoDBiEOG091G07UN
PhylomeDBiQ6QIX3
TreeFamiTF313382

Family and domain databases

Gene3Di1.20.1510.10, 1 hit
InterProiView protein in InterPro
IPR002524 Cation_efflux
IPR036837 Cation_efflux_CTD_sf
IPR027469 Cation_efflux_TMD_sf
PfamiView protein in Pfam
PF01545 Cation_efflux, 1 hit
SUPFAMiSSF160240 SSF160240, 1 hit
SSF161111 SSF161111, 1 hit
TIGRFAMsiTIGR01297 CDF, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q6QIX3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEPSPASGGS ETTRLVSPRD RSSAGGGLRL KSLFTEPSEP LPEGPKLEGM
60 70 80 90 100
AFHHCHKNRV SQSGLSPERA QARRQLYAAC VVCFIFMAGE VVGGYLAHSL
110 120 130 140 150
AIMTDAAHLL ADIGSMMASL FSLWLSTRPA TRTMTFGWHR SETLGALASV
160 170 180 190 200
VSLWIVTGIL LYLAFLRLLH SDYHIEAGAM LLTASIAVCA NMIMAFVLHQ
210 220 230 240 250
TGAPHSHGPR GAEYAPLEEG HGHPLSLGNT SVRAAFVHVL GDLLQSLGVL
260 270 280 290 300
AASILIYFKP QYKVADPIST FLFSICALGS TAPTLRDVLL VLMEGAPRSV
310 320 330 340 350
EFEPVRDTLL SVPGVRATHD LHLWALTLTY HVASAHLAID STADPEAILA
360 370 380
EASSRLYSRF GFSSCTLQVE KYRSEMAHCL RCREPPKA
Length:388
Mass (Da):41,898
Last modified:July 5, 2004 - v1
Checksum:i767F8165AF1533F7
GO
Isoform 2 (identifier: Q6QIX3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: Missing.

Note: No experimental confirmation available.
Show »
Length:339
Mass (Da):36,850
Checksum:i559E395B9AFFE869
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0360431 – 49Missing in isoform 2. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY538655 mRNA Translation: AAS46250.1
CH473947 Genomic DNA Translation: EDM02934.1
BC086513 mRNA Translation: AAH86513.1
RefSeqiNP_001013261.1, NM_001013243.1 [Q6QIX3-1]
XP_008762748.1, XM_008764526.2 [Q6QIX3-2]
XP_008762749.1, XM_008764527.2 [Q6QIX3-2]
XP_008762750.1, XM_008764528.1 [Q6QIX3-2]
UniGeneiRn.9297

Genome annotation databases

EnsembliENSRNOT00000008126; ENSRNOP00000008126; ENSRNOG00000006204 [Q6QIX3-1]
GeneIDi366568
KEGGirno:366568

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiZNT3_RAT
AccessioniPrimary (citable) accession number: Q6QIX3
Secondary accession number(s): Q5RJT1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: July 5, 2004
Last modified: May 23, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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