Q6QIR3 (Q6QIR3_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
CD45 EMBL AAS46962.1

Gene names

Name:

PTPRC EMBL AAS46962.1

Organism

Homo sapiens (Human) EMBL AAS46962.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	65 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

Ontologies

Gene Ontology (GO)
Biological_process	B cell differentiation Inferred from electronic annotation. Source: Compara B cell proliferation Inferred from electronic annotation. Source: Compara B cell receptor signaling pathway Inferred from electronic annotation. Source: Compara T cell proliferation Inferred from electronic annotation. Source: Compara activation of MAPK activity Inferred from electronic annotation. Source: Compara defense response to virus Inferred from electronic annotation. Source: Compara heterotypic cell-cell adhesion Inferred from electronic annotation. Source: Compara leukocyte cell-cell adhesion Inferred from electronic annotation. Source: Compara negative regulation of T cell mediated cytotoxicity Inferred from electronic annotation. Source: Compara negative regulation of cytokine-mediated signaling pathway Inferred from electronic annotation. Source: Compara negative regulation of peptidyl-tyrosine phosphorylation Inferred from electronic annotation. Source: Compara negative regulation of protein autophosphorylation Inferred from electronic annotation. Source: Compara negative thymic T cell selection Inferred from electronic annotation. Source: Compara positive regulation of B cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of T cell mediated cytotoxicity Inferred from electronic annotation. Source: Compara positive regulation of alpha-beta T cell proliferation Inferred from electronic annotation. Source: Compara positive regulation of antigen receptor-mediated signaling pathway Inferred from electronic annotation. Source: Compara positive regulation of apoptotic process Inferred from electronic annotation. Source: Compara positive regulation of gamma-delta T cell differentiation Inferred from electronic annotation. Source: Compara positive regulation of humoral immune response mediated by circulating immunoglobulin Inferred from electronic annotation. Source: Compara positive regulation of isotype switching to IgG isotypes Inferred from electronic annotation. Source: Compara positive thymic T cell selection Inferred from electronic annotation. Source: Compara protein dephosphorylation Inferred from electronic annotation. Source: Compara regulation of B cell differentiation Inferred from electronic annotation. Source: Compara regulation of B cell receptor signaling pathway Inferred from electronic annotation. Source: Compara regulation of cell cycle Inferred from electronic annotation. Source: Compara release of sequestered calcium ion into cytosol Inferred from electronic annotation. Source: Compara response to gamma radiation Inferred from electronic annotation. Source: Compara
Cellular_component	external side of plasma membrane Inferred from electronic annotation. Source: Compara focal adhesion Inferred from electronic annotation. Source: Compara integral to plasma membrane Inferred from electronic annotation. Source: Compara
Molecular_function	heparin binding Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAS46962.1
	Non-terminal residue	65	1	EMBL AAS46962.1

Sequences

	Sequence		Length	Mass (Da)
	Q6QIR3 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 1216ED6678E8EC88	FASTA	65	6,865
	10 20 30 40 50 60 LTTAKMPSVP LSSDPLPTHT TAFSPASTFE RENDFSETTT SLSPDNTSTQ VSPDSLDNAS AFNTT

References

[1]	"Rapid evolution by positive Darwinian selection in the extracellular domain of the abundant lymphocyte protein CD45 in primates." Filip L.C., Mundy N.I. Mol. Biol. Evol. 21:1504-1511(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY539659 Genomic DNA. Translation: AAS46962.1.
IPI	IPI01010697.
UniGene	Hs.654514.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q6QIR3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Gene expression databases
ArrayExpress	Q6QIR3.
Bgee	Q6QIR3.
Family and domain databases
InterPro	IPR024739. PTP_recept_N. [Graphical view]
Pfam	PF12453. PTP_N. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q6QIR3.
ChiTaRS	PTPRC. human.

Entry information

Entry name

Q6QIR3_HUMAN

Accession

Primary (citable) accession number: Q6QIR3

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	March 6, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.