Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

CD45

Gene

PTPRC

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 4 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

  1. heparin binding Source: Ensembl
  2. protein tyrosine phosphatase activity Source: Ensembl

GO - Biological processi

  1. activation of MAPK activity Source: Ensembl
  2. B cell differentiation Source: Ensembl
  3. B cell proliferation Source: Ensembl
  4. B cell receptor signaling pathway Source: Ensembl
  5. defense response to virus Source: Ensembl
  6. heterotypic cell-cell adhesion Source: Ensembl
  7. leukocyte cell-cell adhesion Source: Ensembl
  8. negative regulation of cytokine-mediated signaling pathway Source: Ensembl
  9. negative regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
  10. negative regulation of protein autophosphorylation Source: Ensembl
  11. negative regulation of T cell mediated cytotoxicity Source: Ensembl
  12. negative thymic T cell selection Source: Ensembl
  13. positive regulation of alpha-beta T cell proliferation Source: Ensembl
  14. positive regulation of antigen receptor-mediated signaling pathway Source: Ensembl
  15. positive regulation of B cell proliferation Source: Ensembl
  16. positive regulation of extrinsic apoptotic signaling pathway Source: Ensembl
  17. positive regulation of gamma-delta T cell differentiation Source: Ensembl
  18. positive regulation of humoral immune response mediated by circulating immunoglobulin Source: Ensembl
  19. positive regulation of isotype switching to IgG isotypes Source: Ensembl
  20. positive regulation of T cell mediated cytotoxicity Source: Ensembl
  21. positive thymic T cell selection Source: Ensembl
  22. regulation of B cell differentiation Source: Ensembl
  23. regulation of B cell receptor signaling pathway Source: Ensembl
  24. regulation of cell cycle Source: Ensembl
  25. release of sequestered calcium ion into cytosol Source: Ensembl
  26. response to gamma radiation Source: Ensembl
  27. T cell proliferation Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
CD45Imported
Gene namesi
Name:PTPRCImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: Ensembl
  2. focal adhesion Source: Ensembl
  3. integral component of plasma membrane Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ6QIR3.
ExpressionAtlasiQ6QIR3. baseline and differential.

Interactioni

Family & Domainsi

Family and domain databases

InterProiIPR024739. PTP_recept_N.
[Graphical view]
PfamiPF12453. PTP_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q6QIR3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
LTTAKMPSVP LSSDPLPTHT TAFSPASTFE RENDFSETTT SLSPDNTSTQ
60
VSPDSLDNAS AFNTT
Length:65
Mass (Da):6,865
Last modified:July 5, 2004 - v1
Checksum:i1216ED6678E8EC88
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei65 – 651Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY539659 Genomic DNA. Translation: AAS46962.1.
UniGeneiHs.654514.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY539659 Genomic DNA. Translation: AAS46962.1.
UniGeneiHs.654514.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Chemistry

BindingDBiQ6QIR3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

ChiTaRSiPTPRC. human.

Gene expression databases

BgeeiQ6QIR3.
ExpressionAtlasiQ6QIR3. baseline and differential.

Family and domain databases

InterProiIPR024739. PTP_recept_N.
[Graphical view]
PfamiPF12453. PTP_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Rapid evolution by positive Darwinian selection in the extracellular domain of the abundant lymphocyte protein CD45 in primates."
    Filip L.C., Mundy N.I.
    Mol. Biol. Evol. 21:1504-1511(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ6QIR3_HUMAN
AccessioniPrimary (citable) accession number: Q6QIR3
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.