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Q6QIR3

- Q6QIR3_HUMAN

UniProt

Q6QIR3 - Q6QIR3_HUMAN

Protein
Submitted name:

CD45

Gene

PTPRC

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 4 out of 5- Protein predictedi
  1. Functioni

    GO - Molecular functioni

    1. heparin binding Source: Ensembl

    GO - Biological processi

    1. activation of MAPK activity Source: Ensembl
    2. B cell differentiation Source: Ensembl
    3. B cell proliferation Source: Ensembl
    4. B cell receptor signaling pathway Source: Ensembl
    5. defense response to virus Source: Ensembl
    6. heterotypic cell-cell adhesion Source: Ensembl
    7. leukocyte cell-cell adhesion Source: Ensembl
    8. negative regulation of cytokine-mediated signaling pathway Source: Ensembl
    9. negative regulation of peptidyl-tyrosine phosphorylation Source: Ensembl
    10. negative regulation of protein autophosphorylation Source: Ensembl
    11. negative regulation of T cell mediated cytotoxicity Source: Ensembl
    12. negative thymic T cell selection Source: Ensembl
    13. positive regulation of alpha-beta T cell proliferation Source: Ensembl
    14. positive regulation of antigen receptor-mediated signaling pathway Source: Ensembl
    15. positive regulation of B cell proliferation Source: Ensembl
    16. positive regulation of extrinsic apoptotic signaling pathway Source: Ensembl
    17. positive regulation of gamma-delta T cell differentiation Source: Ensembl
    18. positive regulation of humoral immune response mediated by circulating immunoglobulin Source: Ensembl
    19. positive regulation of isotype switching to IgG isotypes Source: Ensembl
    20. positive regulation of T cell mediated cytotoxicity Source: Ensembl
    21. positive thymic T cell selection Source: Ensembl
    22. protein dephosphorylation Source: Ensembl
    23. regulation of B cell differentiation Source: Ensembl
    24. regulation of B cell receptor signaling pathway Source: Ensembl
    25. regulation of cell cycle Source: Ensembl
    26. release of sequestered calcium ion into cytosol Source: Ensembl
    27. response to gamma radiation Source: Ensembl
    28. T cell proliferation Source: Ensembl

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    CD45Imported
    Gene namesi
    Name:PTPRCImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: Ensembl
    2. focal adhesion Source: Ensembl
    3. integral component of plasma membrane Source: Ensembl

    Expressioni

    Gene expression databases

    ArrayExpressiQ6QIR3.
    BgeeiQ6QIR3.

    Interactioni

    Family & Domainsi

    Family and domain databases

    InterProiIPR024739. PTP_recept_N.
    [Graphical view]
    PfamiPF12453. PTP_N. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q6QIR3-1 [UniParc]FASTAAdd to Basket

    « Hide

    LTTAKMPSVP LSSDPLPTHT TAFSPASTFE RENDFSETTT SLSPDNTSTQ   50
    VSPDSLDNAS AFNTT 65
    Length:65
    Mass (Da):6,865
    Last modified:July 5, 2004 - v1
    Checksum:i1216ED6678E8EC88
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei65 – 651Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY539659 Genomic DNA. Translation: AAS46962.1.
    UniGeneiHs.654514.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY539659 Genomic DNA. Translation: AAS46962.1 .
    UniGenei Hs.654514.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Chemistry

    BindingDBi Q6QIR3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    ChiTaRSi PTPRC. human.

    Gene expression databases

    ArrayExpressi Q6QIR3.
    Bgeei Q6QIR3.

    Family and domain databases

    InterProi IPR024739. PTP_recept_N.
    [Graphical view ]
    Pfami PF12453. PTP_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Rapid evolution by positive Darwinian selection in the extracellular domain of the abundant lymphocyte protein CD45 in primates."
      Filip L.C., Mundy N.I.
      Mol. Biol. Evol. 21:1504-1511(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ6QIR3_HUMAN
    AccessioniPrimary (citable) accession number: Q6QIR3
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 47 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.