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Protein

Mortality factor 4-like protein 2

Gene

Morf4l2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the MSIN3A complex which acts to repress transcription by deacetylation of nucleosomal histones (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator

Keywords - Biological processi

DNA damage, DNA repair, Growth regulation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Mortality factor 4-like protein 2
Alternative name(s):
Liver regeneration-related protein LRRG00119
MORF-related gene X protein
Transcription factor-like protein MRGX
Gene namesi
Name:Morf4l2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi1359471. Morf4l2.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000887701 – 288Mortality factor 4-like protein 2Add BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei71PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6QI89.
PRIDEiQ6QI89.

PTM databases

PhosphoSitePlusiQ6QI89.

Expressioni

Gene expression databases

BgeeiENSRNOG00000002389.
GenevisibleiQ6QI89. RN.

Interactioni

Subunit structurei

Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41 and VPS72/YL1. The NuA4 complex interacts with MYC and the adenovirus E1A protein. MORF4L1 may also participate in the formation of NuA4 related complexes which lack the KAT5/TIP60 catalytic subunit, but which include the SWI/SNF related protein SRCAP. Component of the MSIN3A histone deacetylase complex, which includes SIN3A, HDAC2, ARID4B, MORF4L1, RBBP4/RbAp48, and RBBP7/RbAp46. Interacts with MRFAP1 and RB1. May also interact with one or more as yet undefined members of the TLE (transducin-like enhancer of split) family of transcriptional repressors (By similarity).By similarity

Protein-protein interaction databases

IntActiQ6QI89. 1 interactor.
MINTiMINT-7138743.
STRINGi10116.ENSRNOP00000003247.

Structurei

3D structure databases

ProteinModelPortaliQ6QI89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini117 – 288MRGPROSITE-ProRule annotationAdd BLAST172

Sequence similaritiesi

Contains 1 MRG domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3001. Eukaryota.
ENOG410XR9F. LUCA.
GeneTreeiENSGT00530000063018.
HOGENOMiHOG000190863.
HOVERGENiHBG052487.
InParanoidiQ6QI89.
KOiK11342.
OMAiETGTESH.
OrthoDBiEOG091G0J32.
PhylomeDBiQ6QI89.
TreeFamiTF323400.

Family and domain databases

InterProiIPR008676. MRG.
IPR026541. MRG_dom.
[Graphical view]
PANTHERiPTHR10880. PTHR10880. 1 hit.
PfamiPF05712. MRG. 1 hit.
[Graphical view]
PIRSFiPIRSF038133. HAT_Nua4_EAF3/MRG15. 1 hit.
PROSITEiPS51640. MRG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6QI89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSRKQASQT RGQQSAEEDN FKKPTRSNMQ RSKMRGAASG KKSAGSQPKN
60 70 80 90 100
LDPALPGRWG GRSAENPPSG SVRKTRKNKQ KTPGNGDGGS TSEVPQPPRK
110 120 130 140 150
KRARADPTVE SEEAFKSRME VKVKIPEELK PWLVEDWDLV TRQKQLFQLP
160 170 180 190 200
AKKNVDAILE EYANCKKSQG NVDNKEYAVN EVVGGIKEYF NVMLGTQLLY
210 220 230 240 250
KFERPQYAEI LLAHPDAPMS QIYGAPHLLR LFVRIGAMLA YTPLDEKSLA
260 270 280
LLLGYLHDFL KYLAKNSASL FTASDYKVAS ADYHRKAL
Length:288
Mass (Da):32,214
Last modified:July 5, 2004 - v1
Checksum:i25C3B5D3C9E6FE42
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY539870 mRNA. Translation: AAS66210.1.
BC083606 mRNA. Translation: AAH83606.1.
RefSeqiNP_001007715.1. NM_001007714.1.
XP_006257357.1. XM_006257295.2.
XP_006257358.1. XM_006257296.3.
XP_006257359.1. XM_006257297.2.
XP_017457558.1. XM_017602069.1.
UniGeneiRn.6961.

Genome annotation databases

EnsembliENSRNOT00000003247; ENSRNOP00000003247; ENSRNOG00000002389.
GeneIDi317413.
KEGGirno:317413.
UCSCiRGD:1359471. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY539870 mRNA. Translation: AAS66210.1.
BC083606 mRNA. Translation: AAH83606.1.
RefSeqiNP_001007715.1. NM_001007714.1.
XP_006257357.1. XM_006257295.2.
XP_006257358.1. XM_006257296.3.
XP_006257359.1. XM_006257297.2.
XP_017457558.1. XM_017602069.1.
UniGeneiRn.6961.

3D structure databases

ProteinModelPortaliQ6QI89.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ6QI89. 1 interactor.
MINTiMINT-7138743.
STRINGi10116.ENSRNOP00000003247.

PTM databases

PhosphoSitePlusiQ6QI89.

Proteomic databases

PaxDbiQ6QI89.
PRIDEiQ6QI89.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000003247; ENSRNOP00000003247; ENSRNOG00000002389.
GeneIDi317413.
KEGGirno:317413.
UCSCiRGD:1359471. rat.

Organism-specific databases

CTDi9643.
RGDi1359471. Morf4l2.

Phylogenomic databases

eggNOGiKOG3001. Eukaryota.
ENOG410XR9F. LUCA.
GeneTreeiENSGT00530000063018.
HOGENOMiHOG000190863.
HOVERGENiHBG052487.
InParanoidiQ6QI89.
KOiK11342.
OMAiETGTESH.
OrthoDBiEOG091G0J32.
PhylomeDBiQ6QI89.
TreeFamiTF323400.

Miscellaneous databases

PROiQ6QI89.

Gene expression databases

BgeeiENSRNOG00000002389.
GenevisibleiQ6QI89. RN.

Family and domain databases

InterProiIPR008676. MRG.
IPR026541. MRG_dom.
[Graphical view]
PANTHERiPTHR10880. PTHR10880. 1 hit.
PfamiPF05712. MRG. 1 hit.
[Graphical view]
PIRSFiPIRSF038133. HAT_Nua4_EAF3/MRG15. 1 hit.
PROSITEiPS51640. MRG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMO4L2_RAT
AccessioniPrimary (citable) accession number: Q6QI89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 15, 2005
Last sequence update: July 5, 2004
Last modified: November 30, 2016
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.