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Protein

N-alpha-acetyltransferase 25, NatB auxiliary subunit

Gene

Naa25

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp-Glu. May play a role in normal cell-cycle progression.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
N-alpha-acetyltransferase 25, NatB auxiliary subunit
Alternative name(s):
Liver regeneration-related protein LRRGT00164
Mitochondrial distribution and morphology protein 20
N-terminal acetyltransferase B complex subunit MDM20
Short name:
NatB complex subunit MDM20
N-terminal acetyltransferase B complex subunit NAA25
Gene namesi
Name:Naa25
Synonyms:Mdm20
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 12

Organism-specific databases

RGDi1305685. Naa25.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 970970N-alpha-acetyltransferase 25, NatB auxiliary subunitPRO_0000294339Add
BLAST

Proteomic databases

PaxDbiQ6QI44.
PRIDEiQ6QI44.

Expressioni

Gene expression databases

ExpressionAtlasiQ6QI44. baseline and differential.
GenevisibleiQ6QI44. RN.

Interactioni

Subunit structurei

Component of the N-terminal acetyltransferase B (NatB) complex which is composed of NAA20 and NAA25.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000049175.

Structurei

3D structure databases

ProteinModelPortaliQ6QI44.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati11 – 4434TPR 1Add
BLAST
Repeati45 – 7834TPR 2Add
BLAST
Repeati79 – 11234TPR 3Add
BLAST
Repeati114 – 14633TPR 4Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi871 – 8777Poly-Lys

Sequence similaritiesi

Belongs to the MDM20/NAA25 family.Curated
Contains 4 TPR repeats.Curated

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiKOG2053. Eukaryota.
ENOG410XRXD. LUCA.
GeneTreeiENSGT00390000003496.
InParanoidiQ6QI44.
KOiK17973.
OMAiEKDIQYP.
OrthoDBiEOG75F4CR.
PhylomeDBiQ6QI44.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR019183. N-acetylTrfase_B_cplx_non-cat.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF09797. NatB_MDM20. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6QI44-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATRGHVQDP NDRRLRPIYD YLDNGNNKMA IQQADKLLKK HRDLHCAKVL
60 70 80 90 100
KAIGLQRTGR QEEAFTLAQE VAALEPTDDN SLQALTILYR EMHRPELVTK
110 120 130 140 150
LYEAAVKKVP NSEEYHSHLF MAYARVGEYK KMQQAGMALY KIVPKNPYYF
160 170 180 190 200
WSVMSLIMQS ISARDENLSK TMFLPLAERM VEKMVKEDKI EAEAEVELYY
210 220 230 240 250
MILERLGKYQ EALDVIRGKL GEKLTSEIQS RENKCMAMYK KLSKWPECNA
260 270 280 290 300
LSRRLLLKNS DDWQFYLTYF DSVFRLIEEA WTPPAEGEHS LEGEVHCSAE
310 320 330 340 350
DAVKFIEDRI TEASQSSRHV RGPHLAKLEL IRRLRSQGCN DEFRLGDPEE
360 370 380 390 400
LMFQYFKKFG DKPCCFTDLK VFVDLLPAAQ CTQFINQLLG VVPLSTPTED
410 420 430 440 450
KLALPADIRG LQQHLCVVQL TRLLGLYHSM DKNQKLDVVR ELMLRYQHGL
460 470 480 490 500
EFGRSCLKTE LQFSDYYCLL AVHVLIDIWR EAGEETAVWQ ALTLLEEGLT
510 520 530 540 550
HSPSNAQFKL LLVRIYCVLG AFEPVVDLYS SLDAKHIQHD TIGYLLTRYA
560 570 580 590 600
ASLGQYAAAS QSCNFALRFF HSNQKDTSEY IIQAYKYGAF EKIPEFIAFR
610 620 630 640 650
NRLNNSLHFA QVRTERMLLD LLLEANISTS LAESIKSMNL RPEEDDVPWE
660 670 680 690 700
DLRDNRDLDV FFSWDPKDRN VSEEHKKLSL EEETMWLRIR SLTLRLISAL
710 720 730 740 750
PSLTHPVEPR NSEKTSENGV SSRVDVLRLL LQQLEVAVET GKRFIEKEIQ
760 770 780 790 800
YPFLGPVPTR MGRFFSSGCC QCQVHSFHLV SDVYELDTSG LEGTVDIQER
810 820 830 840 850
IENSLASLLE LLKGVFSTCK GDLLEVKDGN VKTQPAVLEN LVFFVETISI
860 870 880 890 900
VLWVSSYCES VLRPYKLNIQ KKKKKKKETS IVMPPIFTSF QDYVTGLQTV
910 920 930 940 950
ISNAVDHIKG LEAHLIALKL EELTLEDTSI SPVNLSNCHV LSVRRRDPGS
960 970
YWKLGAVEPM CADVCPSVQI
Length:970
Mass (Da):111,258
Last modified:July 5, 2004 - v1
Checksum:iE55DA4DFBD2B88B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY539915 mRNA. Translation: AAS66255.1.
RefSeqiNP_001041365.1. NM_001047900.1.
UniGeneiRn.202650.

Genome annotation databases

EnsembliENSRNOT00000048984; ENSRNOP00000049175; ENSRNOG00000001350.
GeneIDi360811.
KEGGirno:360811.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY539915 mRNA. Translation: AAS66255.1.
RefSeqiNP_001041365.1. NM_001047900.1.
UniGeneiRn.202650.

3D structure databases

ProteinModelPortaliQ6QI44.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000049175.

Proteomic databases

PaxDbiQ6QI44.
PRIDEiQ6QI44.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000048984; ENSRNOP00000049175; ENSRNOG00000001350.
GeneIDi360811.
KEGGirno:360811.

Organism-specific databases

CTDi80018.
RGDi1305685. Naa25.

Phylogenomic databases

eggNOGiKOG2053. Eukaryota.
ENOG410XRXD. LUCA.
GeneTreeiENSGT00390000003496.
InParanoidiQ6QI44.
KOiK17973.
OMAiEKDIQYP.
OrthoDBiEOG75F4CR.
PhylomeDBiQ6QI44.

Miscellaneous databases

NextBioi674177.
PROiQ6QI44.

Gene expression databases

ExpressionAtlasiQ6QI44. baseline and differential.
GenevisibleiQ6QI44. RN.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR019183. N-acetylTrfase_B_cplx_non-cat.
IPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PfamiPF09797. NatB_MDM20. 1 hit.
[Graphical view]
SUPFAMiSSF48452. SSF48452. 1 hit.
PROSITEiPS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Liver regeneration after PH."
    Xu C.S., Zhang L., Chang C.F., Han H.P., Wang G.P., Chai L.Q., Yuan J.Y., Yang K.J., Zhao L.F., Ma H., Wang L., Wang S.F., Xing X.K., Shen G.M., Shi J.B., Rahman S., Wang Q.N., Zhang J.B.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiNAA25_RAT
AccessioniPrimary (citable) accession number: Q6QI44
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 5, 2004
Last modified: May 11, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.