Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

ORM1-like protein 3

Gene

Ormdl3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling (By similarity).By similarity

GO - Biological processi

  1. cellular sphingolipid homeostasis Source: InterPro
  2. ceramide metabolic process Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
ORM1-like protein 3
Alternative name(s):
Liver regeneration-related protein LRRGT00183
Gene namesi
Name:Ormdl3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi1560577. Ormdl3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei22 – 4221HelicalSequence AnalysisAdd
BLAST
Transmembranei43 – 6321HelicalSequence AnalysisAdd
BLAST
Transmembranei95 – 11723HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. SPOTS complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 153153ORM1-like protein 3PRO_0000215642Add
BLAST

Proteomic databases

PaxDbiQ6QI25.
PRIDEiQ6QI25.

Expressioni

Gene expression databases

GenevestigatoriQ6QI25.

Interactioni

Subunit structurei

Interacts with SPTLC1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000046432.

Family & Domainsi

Sequence similaritiesi

Belongs to the ORM family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5081.
HOGENOMiHOG000192741.
HOVERGENiHBG080033.
InParanoidiQ6QI25.
OrthoDBiEOG7N8ZX8.
PhylomeDBiQ6QI25.
TreeFamiTF323369.

Family and domain databases

InterProiIPR007203. ORMDL.
IPR029883. ORML3.
[Graphical view]
PANTHERiPTHR12665. PTHR12665. 1 hit.
PTHR12665:SF11. PTHR12665:SF11. 1 hit.
PfamiPF04061. ORMDL. 1 hit.
[Graphical view]
PIRSFiPIRSF018147. ORMDL. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6QI25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVGTAHSEV NPNTRVMNSR GIWLSYVLAI GLLHVVLLSI PFVSVPVVWT
60 70 80 90 100
LTNLIHNLGM YIFLHTVKGT PFETPDQGKA RLLTHWEQMD YGVQFTASRK
110 120 130 140 150
FLTITPIVLY FLTSFYTKYD QVHFILNTVS LMSVLIPKLP QLHGVRIFGI

NKY
Length:153
Mass (Da):17,463
Last modified:November 8, 2005 - v2
Checksum:iE37EB8D0EC58BB2D
GO

Sequence cautioni

The sequence AAS66274.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY539934 mRNA. Translation: AAS66274.1. Different initiation.
RefSeqiNP_001041362.1. NM_001047897.1.
XP_006247407.1. XM_006247345.1.
XP_006247408.1. XM_006247346.1.
UniGeneiRn.202345.

Genome annotation databases

GeneIDi360618.
KEGGirno:360618.
UCSCiRGD:1560577. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY539934 mRNA. Translation: AAS66274.1. Different initiation.
RefSeqiNP_001041362.1. NM_001047897.1.
XP_006247407.1. XM_006247345.1.
XP_006247408.1. XM_006247346.1.
UniGeneiRn.202345.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000046432.

Proteomic databases

PaxDbiQ6QI25.
PRIDEiQ6QI25.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi360618.
KEGGirno:360618.
UCSCiRGD:1560577. rat.

Organism-specific databases

CTDi94103.
RGDi1560577. Ormdl3.

Phylogenomic databases

eggNOGiCOG5081.
HOGENOMiHOG000192741.
HOVERGENiHBG080033.
InParanoidiQ6QI25.
OrthoDBiEOG7N8ZX8.
PhylomeDBiQ6QI25.
TreeFamiTF323369.

Miscellaneous databases

NextBioi673473.
PROiQ6QI25.

Gene expression databases

GenevestigatoriQ6QI25.

Family and domain databases

InterProiIPR007203. ORMDL.
IPR029883. ORML3.
[Graphical view]
PANTHERiPTHR12665. PTHR12665. 1 hit.
PTHR12665:SF11. PTHR12665:SF11. 1 hit.
PfamiPF04061. ORMDL. 1 hit.
[Graphical view]
PIRSFiPIRSF018147. ORMDL. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Liver regeneration after PH."
    Xu C.S., Zhang L., Chang C.F., Han H.P., Wang G.P., Chai L.Q., Yuan J.Y., Yang K.J., Zhao L.F., Ma H., Wang L., Wang S.F., Xing X.K., Shen G.M., Shi J.B., Rahman S., Wang Q.N., Zhang J.B.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiORML3_RAT
AccessioniPrimary (citable) accession number: Q6QI25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: March 4, 2015
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.