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Q6QI25

- ORML3_RAT

UniProt

Q6QI25 - ORML3_RAT

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Protein

ORM1-like protein 3

Gene

Ormdl3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling (By similarity).By similarity

GO - Biological processi

  1. ceramide metabolic process Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
ORM1-like protein 3
Alternative name(s):
Liver regeneration-related protein LRRGT00183
Gene namesi
Name:Ormdl3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi1560577. Ormdl3.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB
  2. integral component of membrane Source: UniProtKB-KW
  3. SPOTS complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 153153ORM1-like protein 3PRO_0000215642Add
BLAST

Proteomic databases

PaxDbiQ6QI25.
PRIDEiQ6QI25.

Expressioni

Gene expression databases

GenevestigatoriQ6QI25.

Interactioni

Subunit structurei

Interacts with SPTLC1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000046432.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei22 – 4221HelicalSequence AnalysisAdd
BLAST
Transmembranei43 – 6321HelicalSequence AnalysisAdd
BLAST
Transmembranei95 – 11723HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the ORM family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5081.
GeneTreeiENSGT00390000015817.
HOGENOMiHOG000192741.
HOVERGENiHBG080033.
InParanoidiQ6QI25.
OrthoDBiEOG7N8ZX8.
PhylomeDBiQ6QI25.
TreeFamiTF323369.

Family and domain databases

InterProiIPR007203. ORMDL.
[Graphical view]
PANTHERiPTHR12665. PTHR12665. 1 hit.
PfamiPF04061. ORMDL. 1 hit.
[Graphical view]
PIRSFiPIRSF018147. ORMDL. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6QI25-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNVGTAHSEV NPNTRVMNSR GIWLSYVLAI GLLHVVLLSI PFVSVPVVWT
60 70 80 90 100
LTNLIHNLGM YIFLHTVKGT PFETPDQGKA RLLTHWEQMD YGVQFTASRK
110 120 130 140 150
FLTITPIVLY FLTSFYTKYD QVHFILNTVS LMSVLIPKLP QLHGVRIFGI

NKY
Length:153
Mass (Da):17,463
Last modified:November 8, 2005 - v2
Checksum:iE37EB8D0EC58BB2D
GO

Sequence cautioni

The sequence AAS66274.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY539934 mRNA. Translation: AAS66274.1. Different initiation.
RefSeqiNP_001041362.1. NM_001047897.1.
XP_006247407.1. XM_006247345.1.
XP_006247408.1. XM_006247346.1.
UniGeneiRn.202345.

Genome annotation databases

EnsembliENSRNOT00000049621; ENSRNOP00000046432; ENSRNOG00000030445.
GeneIDi360618.
KEGGirno:360618.
UCSCiRGD:1560577. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY539934 mRNA. Translation: AAS66274.1 . Different initiation.
RefSeqi NP_001041362.1. NM_001047897.1.
XP_006247407.1. XM_006247345.1.
XP_006247408.1. XM_006247346.1.
UniGenei Rn.202345.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000046432.

Proteomic databases

PaxDbi Q6QI25.
PRIDEi Q6QI25.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000049621 ; ENSRNOP00000046432 ; ENSRNOG00000030445 .
GeneIDi 360618.
KEGGi rno:360618.
UCSCi RGD:1560577. rat.

Organism-specific databases

CTDi 94103.
RGDi 1560577. Ormdl3.

Phylogenomic databases

eggNOGi COG5081.
GeneTreei ENSGT00390000015817.
HOGENOMi HOG000192741.
HOVERGENi HBG080033.
InParanoidi Q6QI25.
OrthoDBi EOG7N8ZX8.
PhylomeDBi Q6QI25.
TreeFami TF323369.

Miscellaneous databases

NextBioi 673473.
PROi Q6QI25.

Gene expression databases

Genevestigatori Q6QI25.

Family and domain databases

InterProi IPR007203. ORMDL.
[Graphical view ]
PANTHERi PTHR12665. PTHR12665. 1 hit.
Pfami PF04061. ORMDL. 1 hit.
[Graphical view ]
PIRSFi PIRSF018147. ORMDL. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Liver regeneration after PH."
    Xu C.S., Zhang L., Chang C.F., Han H.P., Wang G.P., Chai L.Q., Yuan J.Y., Yang K.J., Zhao L.F., Ma H., Wang L., Wang S.F., Xing X.K., Shen G.M., Shi J.B., Rahman S., Wang Q.N., Zhang J.B.
    Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiORML3_RAT
AccessioniPrimary (citable) accession number: Q6QI25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: October 1, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3