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Protein

ORM1-like protein 3

Gene

Ormdl3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling (By similarity).By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
ORM1-like protein 3
Alternative name(s):
Liver regeneration-related protein LRRGT00183
Gene namesi
Name:Ormdl3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1560577. Ormdl3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Transmembranei95 – 117HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002156421 – 153ORM1-like protein 3Add BLAST153

Proteomic databases

PaxDbiQ6QI25.
PRIDEiQ6QI25.

Interactioni

Subunit structurei

Interacts with SPTLC1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000046432.

Family & Domainsi

Sequence similaritiesi

Belongs to the ORM family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3319. Eukaryota.
COG5081. LUCA.
HOGENOMiHOG000192741.
HOVERGENiHBG080033.
InParanoidiQ6QI25.
PhylomeDBiQ6QI25.
TreeFamiTF323369.

Family and domain databases

InterProiView protein in InterPro
IPR007203. ORMDL.
IPR029883. ORML3.
PANTHERiPTHR12665. PTHR12665. 1 hit.
PTHR12665:SF11. PTHR12665:SF11. 1 hit.
PfamiView protein in Pfam
PF04061. ORMDL. 1 hit.
PIRSFiPIRSF018147. ORMDL. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6QI25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVGTAHSEV NPNTRVMNSR GIWLSYVLAI GLLHVVLLSI PFVSVPVVWT
60 70 80 90 100
LTNLIHNLGM YIFLHTVKGT PFETPDQGKA RLLTHWEQMD YGVQFTASRK
110 120 130 140 150
FLTITPIVLY FLTSFYTKYD QVHFILNTVS LMSVLIPKLP QLHGVRIFGI

NKY
Length:153
Mass (Da):17,463
Last modified:November 8, 2005 - v2
Checksum:iE37EB8D0EC58BB2D
GO

Sequence cautioni

Q6QI25: The sequence AAS66274 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY539934 mRNA. Translation: AAS66274.1. Different initiation.
RefSeqiNP_001041362.1. NM_001047897.1.
XP_006247407.1. XM_006247345.1.
XP_006247408.1. XM_006247346.1.
UniGeneiRn.202345.

Genome annotation databases

GeneIDi360618.
KEGGirno:360618.
UCSCiRGD:1560577. rat.

Similar proteinsi

Entry informationi

Entry nameiORML3_RAT
AccessioniPrimary (citable) accession number: Q6QI25
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: October 25, 2017
This is version 86 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families