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Protein

ORM1-like protein 3

Gene

Ormdl3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
ORM1-like protein 3
Alternative name(s):
Liver regeneration-related protein LRRGT00183
Gene namesi
Name:Ormdl3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1560577. Ormdl3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
Transmembranei43 – 63HelicalSequence analysisAdd BLAST21
Transmembranei95 – 117HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002156421 – 153ORM1-like protein 3Add BLAST153

Proteomic databases

PaxDbiQ6QI25.
PRIDEiQ6QI25.

Expressioni

Gene expression databases

BgeeiENSRNOG00000030445.

Interactioni

Subunit structurei

Interacts with SPTLC1.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000046432.

Family & Domainsi

Sequence similaritiesi

Belongs to the ORM family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3319. Eukaryota.
COG5081. LUCA.
HOGENOMiHOG000192741.
HOVERGENiHBG080033.
InParanoidiQ6QI25.
PhylomeDBiQ6QI25.
TreeFamiTF323369.

Family and domain databases

InterProiIPR007203. ORMDL.
IPR029883. ORML3.
[Graphical view]
PANTHERiPTHR12665. PTHR12665. 1 hit.
PTHR12665:SF11. PTHR12665:SF11. 1 hit.
PfamiPF04061. ORMDL. 1 hit.
[Graphical view]
PIRSFiPIRSF018147. ORMDL. 1 hit.

Sequencei

Sequence statusi: Complete.

Q6QI25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVGTAHSEV NPNTRVMNSR GIWLSYVLAI GLLHVVLLSI PFVSVPVVWT
60 70 80 90 100
LTNLIHNLGM YIFLHTVKGT PFETPDQGKA RLLTHWEQMD YGVQFTASRK
110 120 130 140 150
FLTITPIVLY FLTSFYTKYD QVHFILNTVS LMSVLIPKLP QLHGVRIFGI

NKY
Length:153
Mass (Da):17,463
Last modified:November 8, 2005 - v2
Checksum:iE37EB8D0EC58BB2D
GO

Sequence cautioni

The sequence AAS66274 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY539934 mRNA. Translation: AAS66274.1. Different initiation.
RefSeqiNP_001041362.1. NM_001047897.1.
XP_006247407.1. XM_006247345.1.
XP_006247408.1. XM_006247346.1.
UniGeneiRn.202345.

Genome annotation databases

GeneIDi360618.
KEGGirno:360618.
UCSCiRGD:1560577. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY539934 mRNA. Translation: AAS66274.1. Different initiation.
RefSeqiNP_001041362.1. NM_001047897.1.
XP_006247407.1. XM_006247345.1.
XP_006247408.1. XM_006247346.1.
UniGeneiRn.202345.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000046432.

Proteomic databases

PaxDbiQ6QI25.
PRIDEiQ6QI25.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi360618.
KEGGirno:360618.
UCSCiRGD:1560577. rat.

Organism-specific databases

CTDi94103.
RGDi1560577. Ormdl3.

Phylogenomic databases

eggNOGiKOG3319. Eukaryota.
COG5081. LUCA.
HOGENOMiHOG000192741.
HOVERGENiHBG080033.
InParanoidiQ6QI25.
PhylomeDBiQ6QI25.
TreeFamiTF323369.

Miscellaneous databases

PROiQ6QI25.

Gene expression databases

BgeeiENSRNOG00000030445.

Family and domain databases

InterProiIPR007203. ORMDL.
IPR029883. ORML3.
[Graphical view]
PANTHERiPTHR12665. PTHR12665. 1 hit.
PTHR12665:SF11. PTHR12665:SF11. 1 hit.
PfamiPF04061. ORMDL. 1 hit.
[Graphical view]
PIRSFiPIRSF018147. ORMDL. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiORML3_RAT
AccessioniPrimary (citable) accession number: Q6QI25
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: September 7, 2016
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.