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Q6QI25

- ORML3_RAT

UniProt

Q6QI25 - ORML3_RAT

Protein

ORM1-like protein 3

Gene

Ormdl3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling By similarity.By similarity

    GO - Biological processi

    1. ceramide metabolic process Source: UniProtKB

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ORM1-like protein 3
    Alternative name(s):
    Liver regeneration-related protein LRRGT00183
    Gene namesi
    Name:Ormdl3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 10

    Organism-specific databases

    RGDi1560577. Ormdl3.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB
    2. integral component of membrane Source: UniProtKB-KW
    3. SPOTS complex Source: UniProtKB

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 153153ORM1-like protein 3PRO_0000215642Add
    BLAST

    Proteomic databases

    PaxDbiQ6QI25.
    PRIDEiQ6QI25.

    Expressioni

    Gene expression databases

    GenevestigatoriQ6QI25.

    Interactioni

    Subunit structurei

    Interacts with SPTLC1.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000046432.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei22 – 4221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei43 – 6321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei95 – 11723HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ORM family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5081.
    GeneTreeiENSGT00390000015817.
    HOGENOMiHOG000192741.
    HOVERGENiHBG080033.
    InParanoidiQ6QI25.
    OrthoDBiEOG7N8ZX8.
    PhylomeDBiQ6QI25.
    TreeFamiTF323369.

    Family and domain databases

    InterProiIPR007203. ORMDL.
    [Graphical view]
    PANTHERiPTHR12665. PTHR12665. 1 hit.
    PfamiPF04061. ORMDL. 1 hit.
    [Graphical view]
    PIRSFiPIRSF018147. ORMDL. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q6QI25-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNVGTAHSEV NPNTRVMNSR GIWLSYVLAI GLLHVVLLSI PFVSVPVVWT    50
    LTNLIHNLGM YIFLHTVKGT PFETPDQGKA RLLTHWEQMD YGVQFTASRK 100
    FLTITPIVLY FLTSFYTKYD QVHFILNTVS LMSVLIPKLP QLHGVRIFGI 150
    NKY 153
    Length:153
    Mass (Da):17,463
    Last modified:November 8, 2005 - v2
    Checksum:iE37EB8D0EC58BB2D
    GO

    Sequence cautioni

    The sequence AAS66274.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY539934 mRNA. Translation: AAS66274.1. Different initiation.
    RefSeqiNP_001041362.1. NM_001047897.1.
    XP_006247407.1. XM_006247345.1.
    XP_006247408.1. XM_006247346.1.
    UniGeneiRn.202345.

    Genome annotation databases

    EnsembliENSRNOT00000049621; ENSRNOP00000046432; ENSRNOG00000030445.
    GeneIDi360618.
    KEGGirno:360618.
    UCSCiRGD:1560577. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY539934 mRNA. Translation: AAS66274.1 . Different initiation.
    RefSeqi NP_001041362.1. NM_001047897.1.
    XP_006247407.1. XM_006247345.1.
    XP_006247408.1. XM_006247346.1.
    UniGenei Rn.202345.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000046432.

    Proteomic databases

    PaxDbi Q6QI25.
    PRIDEi Q6QI25.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000049621 ; ENSRNOP00000046432 ; ENSRNOG00000030445 .
    GeneIDi 360618.
    KEGGi rno:360618.
    UCSCi RGD:1560577. rat.

    Organism-specific databases

    CTDi 94103.
    RGDi 1560577. Ormdl3.

    Phylogenomic databases

    eggNOGi COG5081.
    GeneTreei ENSGT00390000015817.
    HOGENOMi HOG000192741.
    HOVERGENi HBG080033.
    InParanoidi Q6QI25.
    OrthoDBi EOG7N8ZX8.
    PhylomeDBi Q6QI25.
    TreeFami TF323369.

    Miscellaneous databases

    NextBioi 673473.
    PROi Q6QI25.

    Gene expression databases

    Genevestigatori Q6QI25.

    Family and domain databases

    InterProi IPR007203. ORMDL.
    [Graphical view ]
    PANTHERi PTHR12665. PTHR12665. 1 hit.
    Pfami PF04061. ORMDL. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF018147. ORMDL. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Liver regeneration after PH."
      Xu C.S., Zhang L., Chang C.F., Han H.P., Wang G.P., Chai L.Q., Yuan J.Y., Yang K.J., Zhao L.F., Ma H., Wang L., Wang S.F., Xing X.K., Shen G.M., Shi J.B., Rahman S., Wang Q.N., Zhang J.B.
      Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiORML3_RAT
    AccessioniPrimary (citable) accession number: Q6QI25
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2005
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 74 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3