Q6QI25 (ORML3_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ORM1-like protein 3

Alternative name(s):
Liver regeneration-related protein LRRGT00183

Gene names

Name:

Ormdl3

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	153 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling By similarity.
Subunit structure	Interacts with SPTLC1 By similarity.
Subcellular location	Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the ORM family.
Sequence caution	The sequence AAS66274.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	ceramide metabolic process Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	SPOTS complex Inferred from sequence or structural similarity. Source: UniProtKB integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 153	153	ORM1-like protein 3		PRO_0000215642
Regions
	Transmembrane	22 – 42	21	Helical; Potential
	Transmembrane	43 – 63	21	Helical; Potential
	Transmembrane	95 – 117	23	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q6QI25 [UniParc]. Last modified November 8, 2005. Version 2. Checksum: E37EB8D0EC58BB2D	FASTA	153	17,463
	10 20 30 40 50 60 MNVGTAHSEV NPNTRVMNSR GIWLSYVLAI GLLHVVLLSI PFVSVPVVWT LTNLIHNLGM 70 80 90 100 110 120 YIFLHTVKGT PFETPDQGKA RLLTHWEQMD YGVQFTASRK FLTITPIVLY FLTSFYTKYD 130 140 150 QVHFILNTVS LMSVLIPKLP QLHGVRIFGI NKY

References

[1]

"Liver regeneration after PH." Xu C.S., Zhang L., Chang C.F., Han H.P., Wang G.P., Chai L.Q., Yuan J.Y., Yang K.J., Zhao L.F., Ma H., Wang L., Wang S.F., Xing X.K., Shen G.M., Shi J.B., Rahman S., Wang Q.N., Zhang J.B. Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY539934 mRNA. Translation: AAS66274.1. Different initiation.
IPI	IPI00421400.
RefSeq	NP_001041362.1. NM_001047897.1.
UniGene	Rn.202345.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000046432.
Proteomic databases
PaxDb	Q6QI25.
PRIDE	Q6QI25.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000049621; ENSRNOP00000046432; ENSRNOG00000030445.
GeneID	360618.
KEGG	rno:360618.
UCSC	RGD:1560577. rat.
Organism-specific databases
CTD	94103.
RGD	1560577. Ormdl3.
Phylogenomic databases
eggNOG	COG5081.
GeneTree	ENSGT00390000015817.
HOGENOM	HOG000192741.
HOVERGEN	HBG080033.
InParanoid	Q6QI25.
OMA	TRKFLTA.
OrthoDB	EOG4X0MTM.
Gene expression databases
Genevestigator	Q6QI25.
GermOnline	ENSRNOG00000030445. Rattus norvegicus.
Family and domain databases
InterPro	IPR007203. ORMDL. [Graphical view]
PANTHER	PTHR12665. PTHR12665. 1 hit.
Pfam	PF04061. ORMDL. 1 hit. [Graphical view]
PIRSF	PIRSF018147. ORMDL. 1 hit.
ProtoNet	Search...
Other
NextBio	673473.

Entry information

Entry name

ORML3_RAT

Accession

Primary (citable) accession number: Q6QI25

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 8, 2005
Last sequence update:	November 8, 2005
Last modified:	April 3, 2013
This is version 66 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program