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Q6QI25 (ORML3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ORM1-like protein 3
Alternative name(s):
Liver regeneration-related protein LRRGT00183
Gene names
Name:Ormdl3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length153 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling By similarity.

Subunit structure

Interacts with SPTLC1 By similarity.

Subcellular location

Endoplasmic reticulum membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the ORM family.

Sequence caution

The sequence AAS66274.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 153153ORM1-like protein 3
PRO_0000215642

Regions

Transmembrane22 – 4221Helical; Potential
Transmembrane43 – 6321Helical; Potential
Transmembrane95 – 11723Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
Q6QI25 [UniParc].

Last modified November 8, 2005. Version 2.
Checksum: E37EB8D0EC58BB2D

FASTA15317,463
        10         20         30         40         50         60 
MNVGTAHSEV NPNTRVMNSR GIWLSYVLAI GLLHVVLLSI PFVSVPVVWT LTNLIHNLGM 

        70         80         90        100        110        120 
YIFLHTVKGT PFETPDQGKA RLLTHWEQMD YGVQFTASRK FLTITPIVLY FLTSFYTKYD 

       130        140        150 
QVHFILNTVS LMSVLIPKLP QLHGVRIFGI NKY 

« Hide

References

[1]"Liver regeneration after PH."
Xu C.S., Zhang L., Chang C.F., Han H.P., Wang G.P., Chai L.Q., Yuan J.Y., Yang K.J., Zhao L.F., Ma H., Wang L., Wang S.F., Xing X.K., Shen G.M., Shi J.B., Rahman S., Wang Q.N., Zhang J.B.
Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY539934 mRNA. Translation: AAS66274.1. Different initiation.
RefSeqNP_001041362.1. NM_001047897.1.
XP_006247407.1. XM_006247345.1.
XP_006247408.1. XM_006247346.1.
UniGeneRn.202345.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000046432.

Proteomic databases

PaxDbQ6QI25.
PRIDEQ6QI25.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000049621; ENSRNOP00000046432; ENSRNOG00000030445.
GeneID360618.
KEGGrno:360618.
UCSCRGD:1560577. rat.

Organism-specific databases

CTD94103.
RGD1560577. Ormdl3.

Phylogenomic databases

eggNOGCOG5081.
GeneTreeENSGT00390000015817.
HOGENOMHOG000192741.
HOVERGENHBG080033.
InParanoidQ6QI25.
OrthoDBEOG7N8ZX8.
PhylomeDBQ6QI25.
TreeFamTF323369.

Gene expression databases

GenevestigatorQ6QI25.

Family and domain databases

InterProIPR007203. ORMDL.
[Graphical view]
PANTHERPTHR12665. PTHR12665. 1 hit.
PfamPF04061. ORMDL. 1 hit.
[Graphical view]
PIRSFPIRSF018147. ORMDL. 1 hit.
ProtoNetSearch...

Other

NextBio673473.
PROQ6QI25.

Entry information

Entry nameORML3_RAT
AccessionPrimary (citable) accession number: Q6QI25
Entry history
Integrated into UniProtKB/Swiss-Prot: November 8, 2005
Last sequence update: November 8, 2005
Last modified: April 16, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families