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Q6QHT9 (CP19A_ANGJA) Reviewed, UniProtKB/Swiss-Prot

Last modified January 22, 2014. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aromatase

EC=1.14.14.14
Alternative name(s):
CYPXIX
Cytochrome P-450AROM
Cytochrome P450 19A1
Estrogen synthase
Gene names
Name:cyp19a1
Synonyms:cyp19
OrganismAnguilla japonica (Japanese eel)
Taxonomic identifier7937 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiAnguilliformesAnguillidaeAnguilla

Protein attributes

Sequence length511 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the formation of aromatic C18 estrogens from C19 androgens. Ref.1

Catalytic activity

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.

Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactor

Heme group By similarity.

Subcellular location

Membrane; Peripheral membrane protein.

Tissue specificity

Expressed in ovary. It is also found in the brain, but not in the spleen, head kidney, kidney or liver. Ref.1

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 511511Aromatase
PRO_0000051966

Sequences

Sequence LengthMass (Da)Tools
Q6QHT9 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: EAB2203A8A48D8C5

FASTA51158,308
        10         20         30         40         50         60 
MKHLEEIVME ALMPASRNAT QTAGRVVSGA TAALLSGATA ALLLLLCALL AAWSRSDKSS 

        70         80         90        100        110        120 
VPGPPFYMGI GPLLSYFRFI WTGIGTASNY YNERYGDIVR VWINGEETII LSRSSAVYQV 

       130        140        150        160        170        180 
LRKPQYTSRF GSKQGLRCIG MHERGIIFNN NIELWKKVRT YFAKALTGPG LQRTVAICVA 

       190        200        210        220        230        240 
STDSHLDQLE ELTDLSGQVD ILNLLRCTIV DISNQMFLRV PLNEKELLVK IQKYFEAWQT 

       250        260        270        280        290        300 
VLIRPDFLFK FEWMYKEHKE AAHELHEAME ILVEKKRKAL EEAEKLDDAD FATDLIFAQN 

       310        320        330        340        350        360 
HGELSAENVQ QCILEMIIAA PDTMSISLFF MLMLLKQNPE VEQEILKELD TVIGDKKAEN 

       370        380        390        400        410        420 
SNLQHLIIME SFINESLRYH PVVDFTMRKS LEDDVIEGYK VFKGTNIILN VGRMHKCEFF 

       430        440        450        460        470        480 
SKPNEFSLEN FEKTVPNRFF QPFGSGPRSC VGKHISMVMM KAILATLLSR YTMCPRDGRT 

       490        500        510 
LNNIRKTNNL SQQLAEKDSE LTMMFTPRRR Q 

« Hide

References

[1]"Characterization of a cDNA encoding P-450 aromatase (CYP19) from Japanese eel ovary and its expression in ovarian follicles during induced ovarian development."
Ijiri S., Kazeto Y., Lokman P.M., Adachi S., Yamauchi K.
Gen. Comp. Endocrinol. 130:193-203(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
Tissue: Ovary.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY540622 mRNA. Translation: AAS47028.1.

3D structure databases

ProteinModelPortalQ6QHT9.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG050750.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. SSF48264. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCP19A_ANGJA
AccessionPrimary (citable) accession number: Q6QHT9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: July 5, 2004
Last modified: January 22, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families