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Protein

Aromatase

Gene

cyp19a1

Organism
Anguilla japonica (Japanese eel)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the formation of aromatic C18 estrogens from C19 androgens.1 Publication

Catalytic activityi

Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

Cofactori

hemeBy similarity

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. monooxygenase activity Source: UniProtKB-KW
  4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Aromatase (EC:1.14.14.14)
Alternative name(s):
CYPXIX
Cytochrome P-450AROM
Cytochrome P450 19A1
Estrogen synthase
Gene namesi
Name:cyp19a1
Synonyms:cyp19
OrganismiAnguilla japonica (Japanese eel)
Taxonomic identifieri7937 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiAnguilliformesAnguillidaeAnguilla

Subcellular locationi

GO - Cellular componenti

  1. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 511511AromatasePRO_0000051966Add
BLAST

Expressioni

Tissue specificityi

Expressed in ovary. It is also found in the brain, but not in the spleen, head kidney, kidney or liver.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ6QHT9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOVERGENiHBG050750.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q6QHT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKHLEEIVME ALMPASRNAT QTAGRVVSGA TAALLSGATA ALLLLLCALL
60 70 80 90 100
AAWSRSDKSS VPGPPFYMGI GPLLSYFRFI WTGIGTASNY YNERYGDIVR
110 120 130 140 150
VWINGEETII LSRSSAVYQV LRKPQYTSRF GSKQGLRCIG MHERGIIFNN
160 170 180 190 200
NIELWKKVRT YFAKALTGPG LQRTVAICVA STDSHLDQLE ELTDLSGQVD
210 220 230 240 250
ILNLLRCTIV DISNQMFLRV PLNEKELLVK IQKYFEAWQT VLIRPDFLFK
260 270 280 290 300
FEWMYKEHKE AAHELHEAME ILVEKKRKAL EEAEKLDDAD FATDLIFAQN
310 320 330 340 350
HGELSAENVQ QCILEMIIAA PDTMSISLFF MLMLLKQNPE VEQEILKELD
360 370 380 390 400
TVIGDKKAEN SNLQHLIIME SFINESLRYH PVVDFTMRKS LEDDVIEGYK
410 420 430 440 450
VFKGTNIILN VGRMHKCEFF SKPNEFSLEN FEKTVPNRFF QPFGSGPRSC
460 470 480 490 500
VGKHISMVMM KAILATLLSR YTMCPRDGRT LNNIRKTNNL SQQLAEKDSE
510
LTMMFTPRRR Q
Length:511
Mass (Da):58,308
Last modified:July 5, 2004 - v1
Checksum:iEAB2203A8A48D8C5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY540622 mRNA. Translation: AAS47028.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY540622 mRNA. Translation: AAS47028.1.

3D structure databases

ProteinModelPortaliQ6QHT9.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG050750.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Characterization of a cDNA encoding P-450 aromatase (CYP19) from Japanese eel ovary and its expression in ovarian follicles during induced ovarian development."
    Ijiri S., Kazeto Y., Lokman P.M., Adachi S., Yamauchi K.
    Gen. Comp. Endocrinol. 130:193-203(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
    Tissue: Ovary.

Entry informationi

Entry nameiCP19A_ANGJA
AccessioniPrimary (citable) accession number: Q6QHT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2005
Last sequence update: July 5, 2004
Last modified: January 7, 2015
This is version 57 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.