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Q6QHT9

- CP19A_ANGJA

UniProt

Q6QHT9 - CP19A_ANGJA

Protein

Aromatase

Gene

cyp19a1

Organism
Anguilla japonica (Japanese eel)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 54 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    Catalyzes the formation of aromatic C18 estrogens from C19 androgens.1 Publication

    Catalytic activityi

    Testosterone + 3 O2 + 3 reduced flavoproteins = 17-beta-estradiol + formate + 4 H2O + 3 oxidized flavoproteins.
    Androst-4-ene-3,17-dione + 3 O2 + 3 reduced flavoproteins = estrone + formate + 4 H2O + 3 oxidized flavoproteins.

    Cofactori

    Heme group.By similarity

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. monooxygenase activity Source: UniProtKB-KW
    4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aromatase (EC:1.14.14.14)
    Alternative name(s):
    CYPXIX
    Cytochrome P-450AROM
    Cytochrome P450 19A1
    Estrogen synthase
    Gene namesi
    Name:cyp19a1
    Synonyms:cyp19
    OrganismiAnguilla japonica (Japanese eel)
    Taxonomic identifieri7937 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiAnguilliformesAnguillidaeAnguilla

    Subcellular locationi

    GO - Cellular componenti

    1. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 511511AromatasePRO_0000051966Add
    BLAST

    Expressioni

    Tissue specificityi

    Expressed in ovary. It is also found in the brain, but not in the spleen, head kidney, kidney or liver.1 Publication

    Structurei

    3D structure databases

    ProteinModelPortaliQ6QHT9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Phylogenomic databases

    HOVERGENiHBG050750.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q6QHT9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKHLEEIVME ALMPASRNAT QTAGRVVSGA TAALLSGATA ALLLLLCALL    50
    AAWSRSDKSS VPGPPFYMGI GPLLSYFRFI WTGIGTASNY YNERYGDIVR 100
    VWINGEETII LSRSSAVYQV LRKPQYTSRF GSKQGLRCIG MHERGIIFNN 150
    NIELWKKVRT YFAKALTGPG LQRTVAICVA STDSHLDQLE ELTDLSGQVD 200
    ILNLLRCTIV DISNQMFLRV PLNEKELLVK IQKYFEAWQT VLIRPDFLFK 250
    FEWMYKEHKE AAHELHEAME ILVEKKRKAL EEAEKLDDAD FATDLIFAQN 300
    HGELSAENVQ QCILEMIIAA PDTMSISLFF MLMLLKQNPE VEQEILKELD 350
    TVIGDKKAEN SNLQHLIIME SFINESLRYH PVVDFTMRKS LEDDVIEGYK 400
    VFKGTNIILN VGRMHKCEFF SKPNEFSLEN FEKTVPNRFF QPFGSGPRSC 450
    VGKHISMVMM KAILATLLSR YTMCPRDGRT LNNIRKTNNL SQQLAEKDSE 500
    LTMMFTPRRR Q 511
    Length:511
    Mass (Da):58,308
    Last modified:July 5, 2004 - v1
    Checksum:iEAB2203A8A48D8C5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY540622 mRNA. Translation: AAS47028.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY540622 mRNA. Translation: AAS47028.1 .

    3D structure databases

    ProteinModelPortali Q6QHT9.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG050750.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a cDNA encoding P-450 aromatase (CYP19) from Japanese eel ovary and its expression in ovarian follicles during induced ovarian development."
      Ijiri S., Kazeto Y., Lokman P.M., Adachi S., Yamauchi K.
      Gen. Comp. Endocrinol. 130:193-203(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
      Tissue: Ovary.

    Entry informationi

    Entry nameiCP19A_ANGJA
    AccessioniPrimary (citable) accession number: Q6QHT9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2005
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 54 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3