Reviewed, UniProtKB/Swiss-Prot Q6QHT9 (CP19A_ANGJA)

Names and origin

Protein names

Recommended name:
    Cytochrome P450 19A1
    EC=1.14.14.1
Alternative name(s):
    CYPXIX
    Aromatase
    Estrogen synthase
    Cytochrome P-450AROM

Gene names

Name:	cyp19a1
Synonyms:	cyp19

Organism

Anguilla japonica (Japanese eel)

Taxonomic identifier

7937 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Anguilliformes › Anguillidae › Anguilla

Protein attributes

Sequence length	511 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the formation of aromatic C18 estrogens from C19 androgens. Ref.1
Catalytic activity	RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.
Cofactor	Heme group By similarity.
Subcellular location	Membrane; Peripheral membrane protein.
Tissue specificity	Expressed in ovary. It is also found in the brain, but not in the spleen, head kidney, kidney or liver. Ref.1
Sequence similarities	Belongs to the cytochrome P450 family.

Ontologies

Keywords
Cellular component	Membrane
Ligand	Heme Iron Metal-binding
Molecular function	Monooxygenase Oxidoreductase
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	aromatase activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro heme binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 511	511	Cytochrome P450 19A1		PRO_0000051966

Sequences

	Sequence		Length	Mass (Da)
	Q6QHT9-1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: EAB2203A8A48D8C5	FASTA	511	58,308
	10 20 30 40 50 60 MKHLEEIVME ALMPASRNAT QTAGRVVSGA TAALLSGATA ALLLLLCALL AAWSRSDKSS 70 80 90 100 110 120 VPGPPFYMGI GPLLSYFRFI WTGIGTASNY YNERYGDIVR VWINGEETII LSRSSAVYQV 130 140 150 160 170 180 LRKPQYTSRF GSKQGLRCIG MHERGIIFNN NIELWKKVRT YFAKALTGPG LQRTVAICVA 190 200 210 220 230 240 STDSHLDQLE ELTDLSGQVD ILNLLRCTIV DISNQMFLRV PLNEKELLVK IQKYFEAWQT 250 260 270 280 290 300 VLIRPDFLFK FEWMYKEHKE AAHELHEAME ILVEKKRKAL EEAEKLDDAD FATDLIFAQN 310 320 330 340 350 360 HGELSAENVQ QCILEMIIAA PDTMSISLFF MLMLLKQNPE VEQEILKELD TVIGDKKAEN 370 380 390 400 410 420 SNLQHLIIME SFINESLRYH PVVDFTMRKS LEDDVIEGYK VFKGTNIILN VGRMHKCEFF 430 440 450 460 470 480 SKPNEFSLEN FEKTVPNRFF QPFGSGPRSC VGKHISMVMM KAILATLLSR YTMCPRDGRT 490 500 510 LNNIRKTNNL SQQLAEKDSE LTMMFTPRRR Q

References

[1]

"Characterization of a cDNA encoding P-450 aromatase (CYP19) from Japanese eel ovary and its expression in ovarian follicles during induced ovarian development." Ijiri S., Kazeto Y., Lokman P.M., Adachi S., Yamauchi K. Gen. Comp. Endocrinol. 130:193-203(2003) [PubMed: 12568797] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY. Tissue: Ovary.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY540622 mRNA. Translation: AAS47028.1.
3D structure databases
SMR	Q6QHT9. Positions 62-509.
ModBase	Search...
Phylogenomic databases
HOVERGEN	Q6QHT9.
Enzyme and pathway databases
BRENDA	1.14.14.1. 190648.
Family and domain databases
InterPro	IPR001128. Cyt_P450. IPR017973. Cyt_P450_C. IPR017972. Cyt_P450_CS. IPR002401. Cyt_P450_E_grp-I. [Graphical view]
Gene3D	G3DSA:1.10.630.10. Cyt_P450. 1 hit.
PANTHER	PTHR19383. Cyt_P450. 1 hit.
Pfam	PF00067. p450. 1 hit. [Graphical view]
PRINTS	PR00463. EP450I. PR00385. P450.
PROSITE	PS00086. CYTOCHROME_P450. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CP19A_ANGJA

Accession

Primary (citable) accession number: Q6QHT9

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 24, 2005
Last sequence update:	July 5, 2004
Last modified:	February 9, 2010
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)