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Q6QHF1 (Q6QHF1_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein names
Gene names
Name:Tnfrsf1a MGI 1314884
OrganismMus musculus (Mouse) EMBL AAS48428.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length440 AA.
Sequence statusFragment.
Protein existenceEvidence at transcript level

Ontologies

Keywords
   Molecular functionReceptor EMBL AAS48428.1
Gene Ontology (GO)
   Biological_processcell surface receptor signaling pathway

Inferred from mutant phenotype PubMed 9551933. Source: MGI

cellular response to estradiol stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to mechanical stimulus

Inferred from electronic annotation. Source: Ensembl

cytokine-mediated signaling pathway

Inferred from mutant phenotype PubMed 11588035. Source: MGI

defense response

Inferred from mutant phenotype PubMed 8387893. Source: MGI

defense response to bacterium

Inferred from mutant phenotype PubMed 9324362. Source: MGI

inflammatory response

Inferred from mutant phenotype PubMed 9551933PubMed 9843922. Source: MGI

intrinsic apoptotic signaling pathway in response to DNA damage

Inferred from mutant phenotype PubMed 17242187. Source: MGI

negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of gene expression

Inferred from electronic annotation. Source: Ensembl

negative regulation of inflammatory response

Inferred from electronic annotation. Source: Ensembl

negative regulation of interleukin-6 production

Inferred from electronic annotation. Source: Ensembl

positive regulation of I-kappaB kinase/NF-kappaB signaling

Inferred from electronic annotation. Source: Ensembl

positive regulation of angiogenesis

Inferred from electronic annotation. Source: Ensembl

positive regulation of inflammatory response

Inferred from mutant phenotype PubMed 11588035. Source: MGI

positive regulation of protein import into nucleus, translocation

Inferred from electronic annotation. Source: Ensembl

positive regulation of transcription from RNA polymerase II promoter

Inferred from mutant phenotype PubMed 11588035. Source: MGI

positive regulation of tumor necrosis factor production

Inferred from electronic annotation. Source: Ensembl

positive regulation of tyrosine phosphorylation of Stat1 protein

Inferred from electronic annotation. Source: Ensembl

prostaglandin metabolic process

Traceable author statement PubMed 8387893. Source: MGI

protein heterooligomerization

Inferred from electronic annotation. Source: Ensembl

response to alkaloid

Inferred from electronic annotation. Source: Ensembl

response to amino acid

Inferred from electronic annotation. Source: Ensembl

response to ethanol

Inferred from electronic annotation. Source: Ensembl

response to hypoxia

Inferred from electronic annotation. Source: Ensembl

response to lipopolysaccharide

Inferred from electronic annotation. Source: Ensembl

tetrapyrrole metabolic process

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentGolgi membrane

Inferred from electronic annotation. Source: Ensembl

axon

Inferred from electronic annotation. Source: Ensembl

cell surface

Inferred from electronic annotation. Source: Ensembl

extracellular space

Inferred from electronic annotation. Source: Ensembl

membrane raft

Inferred from electronic annotation. Source: Ensembl

nucleus

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Traceable author statement PubMed 9551933. Source: MGI

receptor complex

Inferred from sequence orthology PubMed 23382219. Source: MGI

   Molecular_functiontumor necrosis factor-activated receptor activity

Inferred from mutant phenotype PubMed 11588035. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL AAS48428.1
Non-terminal residue4401 EMBL AAS48428.1

Sequences

Sequence LengthMass (Da)Tools
Q6QHF1 [UniParc].

Last modified July 5, 2004. Version 1.
Checksum: 580A2D2E334612A3

FASTA44048,632
        10         20         30         40         50         60 
PGLLLSLVLL ALLMGIHPSG VTGLVPSLGD REKRDSLCPQ GKYVHSKNNS ICCTKCHKGT 

        70         80         90        100        110        120 
YLVSDCPSPG RDTVCRECEK GTFTASQNYL RQCLSCKTCR KEMSQVEISP CQADKDTVCG 

       130        140        150        160        170        180 
CKENQFQRYL SETHFQCVDC SPCFNGTVTI PCKETQNTVC NCHAGFFLRE SECVPCSHCK 

       190        200        210        220        230        240 
KNEECMKLCL PPPLANVTNP QDSGTAVLLP LVILLGLCLL SFIFISLMCR YPRWRPEVYS 

       250        260        270        280        290        300 
IICRDPVPVK EEKAGKPLTP APSPAFSPTS GFNPTLGFST PGFSSPVSST PISPIFGPSN 

       310        320        330        340        350        360 
WHFMPPVSEV VPTQGADPLL YESLCSVPAP TSVQKWEDSA HPQRPDNADL AILYAVVDGV 

       370        380        390        400        410        420 
PPARWKEFMR FMGLSEHEIE RLEMQNGRCL REAQYSMLEA WRRRTPRHED TLEVVGLVLS 

       430        440 
KMNLAGCLEN ILEALRNPAP 

« Hide

References

[1]"Sequencing of the tnfrsf1a gene in SPRET/Ei, C57BL/6JIco and DBA/2CrlBr."
Staelens J., Wielockx B., Puimege L., Vandenabeele A., Libert C.
Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE.
Strain: DBA/2CrlBr EMBL AAS48428.1.
Tissue: Liver EMBL AAS48428.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY541589 mRNA. Translation: AAS48428.1.
UniGeneMm.1258.
Mm.474976.

3D structure databases

ProteinModelPortalQ6QHF1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000032491.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:1314884. Tnfrsf1a.

Phylogenomic databases

HOVERGENHBG058842.
InParanoidQ6QHF1.

Gene expression databases

ArrayExpressQ6QHF1.
BgeeQ6QHF1.
GenevestigatorQ6QHF1.

Family and domain databases

Gene3D1.10.533.10. 1 hit.
InterProIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020419. TNFR_1A.
[Graphical view]
PfamPF00531. Death. 1 hit.
PF00020. TNFR_c6. 3 hits.
[Graphical view]
PRINTSPR01918. TNFACTORR1A.
SMARTSM00005. DEATH. 1 hit.
SM00208. TNFR. 4 hits.
[Graphical view]
SUPFAMSSF47986. SSF47986. 1 hit.
PROSITEPS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 3 hits.
PS50050. TNFR_NGFR_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameQ6QHF1_MOUSE
AccessionPrimary (citable) accession number: Q6QHF1
Entry history
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: April 16, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)