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Protein
Submitted name:

TNF receptor superfamily, member 1A

Gene

Tnfrsf1a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
TNF receptor superfamily, member 1AImported
Gene namesi
Name:Tnfrsf1aImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1314884. Tnfrsf1a.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei207 – 229HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500427865924 – 440Sequence analysisAdd BLAST417

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi53 ↔ 66PROSITE-ProRule annotation
Disulfide bondi78 ↔ 93PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

Proteomic databases

PaxDbiQ6QHF1.

Expressioni

Gene expression databases

BgeeiENSMUSG00000030341.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032491.

Structurei

3D structure databases

ProteinModelPortaliQ6QHF1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini37 – 75TNFR-CysInterPro annotationAdd BLAST39
Repeati37 – 75TNFR-CysPROSITE-ProRule annotationAdd BLAST39
Domaini77 – 119TNFR-CysInterPro annotationAdd BLAST43
Repeati77 – 119TNFR-CysPROSITE-ProRule annotationAdd BLAST43
Domaini120 – 160TNFR-CysInterPro annotationAdd BLAST41
Repeati120 – 160TNFR-CysPROSITE-ProRule annotationAdd BLAST41
Domaini350 – 435DeathInterPro annotationAdd BLAST86

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IXBX. Eukaryota.
ENOG4111YG2. LUCA.
HOVERGENiHBG058842.

Family and domain databases

CDDicd08313. Death_TNFR1. 1 hit.
cd10576. TNFRSF1A. 1 hit.
InterProiView protein in InterPro
IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020419. TNFR_1A.
IPR033994. TNFRSF1A_death.
IPR033993. TNFRSF1A_N.
PfamiView protein in Pfam
PF00531. Death. 1 hit.
PF00020. TNFR_c6. 3 hits.
PRINTSiPR01918. TNFACTORR1A.
SMARTiView protein in SMART
SM00005. DEATH. 1 hit.
SM00208. TNFR. 4 hits.
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiView protein in PROSITE
PS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 3 hits.

Sequencei

Sequence statusi: Fragment.

Q6QHF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PGLLLSLVLL ALLMGIHPSG VTGLVPSLGD REKRDSLCPQ GKYVHSKNNS
60 70 80 90 100
ICCTKCHKGT YLVSDCPSPG RDTVCRECEK GTFTASQNYL RQCLSCKTCR
110 120 130 140 150
KEMSQVEISP CQADKDTVCG CKENQFQRYL SETHFQCVDC SPCFNGTVTI
160 170 180 190 200
PCKETQNTVC NCHAGFFLRE SECVPCSHCK KNEECMKLCL PPPLANVTNP
210 220 230 240 250
QDSGTAVLLP LVILLGLCLL SFIFISLMCR YPRWRPEVYS IICRDPVPVK
260 270 280 290 300
EEKAGKPLTP APSPAFSPTS GFNPTLGFST PGFSSPVSST PISPIFGPSN
310 320 330 340 350
WHFMPPVSEV VPTQGADPLL YESLCSVPAP TSVQKWEDSA HPQRPDNADL
360 370 380 390 400
AILYAVVDGV PPARWKEFMR FMGLSEHEIE RLEMQNGRCL REAQYSMLEA
410 420 430 440
WRRRTPRHED TLEVVGLVLS KMNLAGCLEN ILEALRNPAP
Length:440
Mass (Da):48,632
Last modified:July 5, 2004 - v1
Checksum:i580A2D2E334612A3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei440Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY541589 mRNA. Translation: AAS48428.1.
UniGeneiMm.1258.
Mm.474976.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY541589 mRNA. Translation: AAS48428.1.
UniGeneiMm.1258.
Mm.474976.

3D structure databases

ProteinModelPortaliQ6QHF1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032491.

Proteomic databases

PaxDbiQ6QHF1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1314884. Tnfrsf1a.

Phylogenomic databases

eggNOGiENOG410IXBX. Eukaryota.
ENOG4111YG2. LUCA.
HOVERGENiHBG058842.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000030341.

Family and domain databases

CDDicd08313. Death_TNFR1. 1 hit.
cd10576. TNFRSF1A. 1 hit.
InterProiView protein in InterPro
IPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020419. TNFR_1A.
IPR033994. TNFRSF1A_death.
IPR033993. TNFRSF1A_N.
PfamiView protein in Pfam
PF00531. Death. 1 hit.
PF00020. TNFR_c6. 3 hits.
PRINTSiPR01918. TNFACTORR1A.
SMARTiView protein in SMART
SM00005. DEATH. 1 hit.
SM00208. TNFR. 4 hits.
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiView protein in PROSITE
PS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 2 hits.
PS50050. TNFR_NGFR_2. 3 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiQ6QHF1_MOUSE
AccessioniPrimary (citable) accession number: Q6QHF1
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: May 10, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.