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Q6QHF1

- Q6QHF1_MOUSE

UniProt

Q6QHF1 - Q6QHF1_MOUSE

Protein
Submitted name:

TNF receptor superfamily, member 1A

Gene

Tnfrsf1a

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (05 Jul 2004)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: MGI
    2. tumor necrosis factor-activated receptor activity Source: MGI

    GO - Biological processi

    1. cell surface receptor signaling pathway Source: MGI
    2. cellular response to estradiol stimulus Source: Ensembl
    3. cellular response to mechanical stimulus Source: Ensembl
    4. cytokine-mediated signaling pathway Source: MGI
    5. defense response Source: MGI
    6. defense response to bacterium Source: MGI
    7. inflammatory response Source: MGI
    8. intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
    9. negative regulation of apoptotic process Source: Ensembl
    10. negative regulation of gene expression Source: Ensembl
    11. negative regulation of inflammatory response Source: Ensembl
    12. negative regulation of interleukin-6 production Source: Ensembl
    13. positive regulation of angiogenesis Source: Ensembl
    14. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
    15. positive regulation of inflammatory response Source: MGI
    16. positive regulation of protein import into nucleus, translocation Source: Ensembl
    17. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    18. positive regulation of tumor necrosis factor production Source: Ensembl
    19. positive regulation of tyrosine phosphorylation of Stat1 protein Source: Ensembl
    20. prostaglandin metabolic process Source: MGI
    21. protein heterooligomerization Source: Ensembl
    22. response to alkaloid Source: Ensembl
    23. response to amino acid Source: Ensembl
    24. response to ethanol Source: Ensembl
    25. response to hypoxia Source: Ensembl
    26. response to lipopolysaccharide Source: Ensembl
    27. tetrapyrrole metabolic process Source: Ensembl

    Keywords - Molecular functioni

    ReceptorImported

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    TNF receptor superfamily, member 1AImported
    Gene namesi
    Name:Tnfrsf1aImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:1314884. Tnfrsf1a.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: Ensembl
    2. cell surface Source: Ensembl
    3. extracellular space Source: Ensembl
    4. Golgi membrane Source: Ensembl
    5. membrane raft Source: Ensembl
    6. nucleus Source: Ensembl
    7. plasma membrane Source: MGI
    8. receptor complex Source: MGI

    Expressioni

    Gene expression databases

    ArrayExpressiQ6QHF1.
    BgeeiQ6QHF1.
    GenevestigatoriQ6QHF1.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000032491.

    Structurei

    3D structure databases

    ProteinModelPortaliQ6QHF1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Phylogenomic databases

    HOVERGENiHBG058842.
    InParanoidiQ6QHF1.

    Family and domain databases

    Gene3Di1.10.533.10. 1 hit.
    InterProiIPR011029. DEATH-like_dom.
    IPR000488. Death_domain.
    IPR001368. TNFR/NGFR_Cys_rich_reg.
    IPR020419. TNFR_1A.
    [Graphical view]
    PfamiPF00531. Death. 1 hit.
    PF00020. TNFR_c6. 3 hits.
    [Graphical view]
    PRINTSiPR01918. TNFACTORR1A.
    SMARTiSM00005. DEATH. 1 hit.
    SM00208. TNFR. 4 hits.
    [Graphical view]
    SUPFAMiSSF47986. SSF47986. 1 hit.
    PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
    PS00652. TNFR_NGFR_1. 3 hits.
    PS50050. TNFR_NGFR_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q6QHF1-1 [UniParc]FASTAAdd to Basket

    « Hide

    PGLLLSLVLL ALLMGIHPSG VTGLVPSLGD REKRDSLCPQ GKYVHSKNNS    50
    ICCTKCHKGT YLVSDCPSPG RDTVCRECEK GTFTASQNYL RQCLSCKTCR 100
    KEMSQVEISP CQADKDTVCG CKENQFQRYL SETHFQCVDC SPCFNGTVTI 150
    PCKETQNTVC NCHAGFFLRE SECVPCSHCK KNEECMKLCL PPPLANVTNP 200
    QDSGTAVLLP LVILLGLCLL SFIFISLMCR YPRWRPEVYS IICRDPVPVK 250
    EEKAGKPLTP APSPAFSPTS GFNPTLGFST PGFSSPVSST PISPIFGPSN 300
    WHFMPPVSEV VPTQGADPLL YESLCSVPAP TSVQKWEDSA HPQRPDNADL 350
    AILYAVVDGV PPARWKEFMR FMGLSEHEIE RLEMQNGRCL REAQYSMLEA 400
    WRRRTPRHED TLEVVGLVLS KMNLAGCLEN ILEALRNPAP 440
    Length:440
    Mass (Da):48,632
    Last modified:July 5, 2004 - v1
    Checksum:i580A2D2E334612A3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11Imported
    Non-terminal residuei440 – 4401Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY541589 mRNA. Translation: AAS48428.1.
    UniGeneiMm.1258.
    Mm.474976.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY541589 mRNA. Translation: AAS48428.1 .
    UniGenei Mm.1258.
    Mm.474976.

    3D structure databases

    ProteinModelPortali Q6QHF1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000032491.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:1314884. Tnfrsf1a.

    Phylogenomic databases

    HOVERGENi HBG058842.
    InParanoidi Q6QHF1.

    Miscellaneous databases

    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q6QHF1.
    Bgeei Q6QHF1.
    Genevestigatori Q6QHF1.

    Family and domain databases

    Gene3Di 1.10.533.10. 1 hit.
    InterProi IPR011029. DEATH-like_dom.
    IPR000488. Death_domain.
    IPR001368. TNFR/NGFR_Cys_rich_reg.
    IPR020419. TNFR_1A.
    [Graphical view ]
    Pfami PF00531. Death. 1 hit.
    PF00020. TNFR_c6. 3 hits.
    [Graphical view ]
    PRINTSi PR01918. TNFACTORR1A.
    SMARTi SM00005. DEATH. 1 hit.
    SM00208. TNFR. 4 hits.
    [Graphical view ]
    SUPFAMi SSF47986. SSF47986. 1 hit.
    PROSITEi PS50017. DEATH_DOMAIN. 1 hit.
    PS00652. TNFR_NGFR_1. 3 hits.
    PS50050. TNFR_NGFR_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequencing of the tnfrsf1a gene in SPRET/Ei, C57BL/6JIco and DBA/2CrlBr."
      Staelens J., Wielockx B., Puimege L., Vandenabeele A., Libert C.
      Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: DBA/2CrlBrImported.
      Tissue: LiverImported.

    Entry informationi

    Entry nameiQ6QHF1_MOUSE
    AccessioniPrimary (citable) accession number: Q6QHF1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: July 5, 2004
    Last sequence update: July 5, 2004
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)