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Protein
Submitted name:

TNF receptor superfamily, member 1A

Gene

Tnfrsf1a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. tumor necrosis factor-activated receptor activity Source: MGI

GO - Biological processi

  1. cell surface receptor signaling pathway Source: MGI
  2. cellular response to estradiol stimulus Source: Ensembl
  3. cellular response to mechanical stimulus Source: Ensembl
  4. cytokine-mediated signaling pathway Source: MGI
  5. defense response Source: MGI
  6. defense response to bacterium Source: MGI
  7. inflammatory response Source: MGI
  8. intrinsic apoptotic signaling pathway in response to DNA damage Source: MGI
  9. negative regulation of apoptotic process Source: Ensembl
  10. negative regulation of gene expression Source: Ensembl
  11. negative regulation of inflammatory response Source: MGI
  12. negative regulation of interleukin-6 production Source: Ensembl
  13. positive regulation of angiogenesis Source: Ensembl
  14. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: Ensembl
  15. positive regulation of inflammatory response Source: MGI
  16. positive regulation of neuron apoptotic process Source: Ensembl
  17. positive regulation of protein import into nucleus, translocation Source: Ensembl
  18. positive regulation of transcription from RNA polymerase II promoter Source: MGI
  19. positive regulation of tumor necrosis factor production Source: Ensembl
  20. positive regulation of tyrosine phosphorylation of Stat1 protein Source: MGI
  21. prostaglandin metabolic process Source: MGI
  22. protein heterooligomerization Source: Ensembl
  23. response to alkaloid Source: Ensembl
  24. response to amino acid Source: Ensembl
  25. response to ethanol Source: Ensembl
  26. response to hypoxia Source: Ensembl
  27. response to lipopolysaccharide Source: Ensembl
  28. response to wounding Source: Ensembl
  29. tetrapyrrole metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

ReceptorImported

Names & Taxonomyi

Protein namesi
Submitted name:
TNF receptor superfamily, member 1AImported
Gene namesi
Name:Tnfrsf1aImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:1314884. Tnfrsf1a.

Subcellular locationi

GO - Cellular componenti

  1. axon Source: Ensembl
  2. cell surface Source: Ensembl
  3. cytosol Source: Ensembl
  4. extracellular space Source: MGI
  5. Golgi membrane Source: MGI
  6. membrane raft Source: MGI
  7. mitochondrion Source: Ensembl
  8. nucleus Source: Ensembl
  9. plasma membrane Source: MGI
  10. receptor complex Source: MGI
  11. synapse Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ6QHF1.
ExpressionAtlasiQ6QHF1. baseline and differential.
GenevestigatoriQ6QHF1.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032491.

Structurei

3D structure databases

ProteinModelPortaliQ6QHF1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG058842.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020419. TNFR_1A.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF00020. TNFR_c6. 3 hits.
[Graphical view]
PRINTSiPR01918. TNFACTORR1A.
SMARTiSM00005. DEATH. 1 hit.
SM00208. TNFR. 4 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 3 hits.
PS50050. TNFR_NGFR_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Fragment.

Q6QHF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
PGLLLSLVLL ALLMGIHPSG VTGLVPSLGD REKRDSLCPQ GKYVHSKNNS
60 70 80 90 100
ICCTKCHKGT YLVSDCPSPG RDTVCRECEK GTFTASQNYL RQCLSCKTCR
110 120 130 140 150
KEMSQVEISP CQADKDTVCG CKENQFQRYL SETHFQCVDC SPCFNGTVTI
160 170 180 190 200
PCKETQNTVC NCHAGFFLRE SECVPCSHCK KNEECMKLCL PPPLANVTNP
210 220 230 240 250
QDSGTAVLLP LVILLGLCLL SFIFISLMCR YPRWRPEVYS IICRDPVPVK
260 270 280 290 300
EEKAGKPLTP APSPAFSPTS GFNPTLGFST PGFSSPVSST PISPIFGPSN
310 320 330 340 350
WHFMPPVSEV VPTQGADPLL YESLCSVPAP TSVQKWEDSA HPQRPDNADL
360 370 380 390 400
AILYAVVDGV PPARWKEFMR FMGLSEHEIE RLEMQNGRCL REAQYSMLEA
410 420 430 440
WRRRTPRHED TLEVVGLVLS KMNLAGCLEN ILEALRNPAP
Length:440
Mass (Da):48,632
Last modified:July 5, 2004 - v1
Checksum:i580A2D2E334612A3
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei440 – 4401Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY541589 mRNA. Translation: AAS48428.1.
UniGeneiMm.1258.
Mm.474976.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY541589 mRNA. Translation: AAS48428.1.
UniGeneiMm.1258.
Mm.474976.

3D structure databases

ProteinModelPortaliQ6QHF1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032491.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1314884. Tnfrsf1a.

Phylogenomic databases

HOVERGENiHBG058842.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiQ6QHF1.
ExpressionAtlasiQ6QHF1. baseline and differential.
GenevestigatoriQ6QHF1.

Family and domain databases

Gene3Di1.10.533.10. 1 hit.
InterProiIPR011029. DEATH-like_dom.
IPR000488. Death_domain.
IPR001368. TNFR/NGFR_Cys_rich_reg.
IPR020419. TNFR_1A.
[Graphical view]
PfamiPF00531. Death. 1 hit.
PF00020. TNFR_c6. 3 hits.
[Graphical view]
PRINTSiPR01918. TNFACTORR1A.
SMARTiSM00005. DEATH. 1 hit.
SM00208. TNFR. 4 hits.
[Graphical view]
SUPFAMiSSF47986. SSF47986. 1 hit.
PROSITEiPS50017. DEATH_DOMAIN. 1 hit.
PS00652. TNFR_NGFR_1. 3 hits.
PS50050. TNFR_NGFR_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Sequencing of the tnfrsf1a gene in SPRET/Ei, C57BL/6JIco and DBA/2CrlBr."
    Staelens J., Wielockx B., Puimege L., Vandenabeele A., Libert C.
    Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: DBA/2CrlBrImported.
    Tissue: LiverImported.

Entry informationi

Entry nameiQ6QHF1_MOUSE
AccessioniPrimary (citable) accession number: Q6QHF1
Entry historyi
Integrated into UniProtKB/TrEMBL: July 5, 2004
Last sequence update: July 5, 2004
Last modified: February 4, 2015
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.