Q6QHF1 (Q6QHF1_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
TNF receptor superfamily, member 1A EMBL AAS48428.1

Gene names

Name:

Tnfrsf1a MGI 1314884

Organism

Mus musculus (Mouse) EMBL AAS48428.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	440 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Molecular function	Receptor EMBL AAS48428.1
Gene Ontology (GO)
Biological_process	cellular response to estradiol stimulus Inferred from electronic annotation. Source: Compara cellular response to mechanical stimulus Inferred from electronic annotation. Source: Compara defense response to bacterium Inferred from mutant phenotype PubMed 9324362. Source: MGI diterpenoid metabolic process Inferred from electronic annotation. Source: Compara flavonoid metabolic process Inferred from electronic annotation. Source: Compara inflammatory response Inferred from mutant phenotype PubMed 9551933PubMed 9843922. Source: MGI negative regulation of gene expression Inferred from electronic annotation. Source: Compara negative regulation of inflammatory response Inferred from electronic annotation. Source: Compara negative regulation of interleukin-6 production Inferred from electronic annotation. Source: Compara positive regulation of I-kappaB kinase/NF-kappaB cascade Inferred from electronic annotation. Source: Compara positive regulation of angiogenesis Inferred from electronic annotation. Source: Compara positive regulation of inflammatory response Inferred from mutant phenotype PubMed 11588035. Source: MGI positive regulation of protein import into nucleus, translocation Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from mutant phenotype PubMed 11588035. Source: MGI positive regulation of tumor necrosis factor production Inferred from electronic annotation. Source: Compara positive regulation of tyrosine phosphorylation of Stat1 protein Inferred from electronic annotation. Source: Compara prostaglandin metabolic process Traceable author statement PubMed 8387893. Source: MGI protein heterooligomerization Inferred from electronic annotation. Source: Compara regulation of apoptotic process Inferred from electronic annotation. Source: Compara response to alkaloid Inferred from electronic annotation. Source: Compara response to amino acid stimulus Inferred from electronic annotation. Source: Compara response to ethanol Inferred from electronic annotation. Source: Compara response to hypoxia Inferred from electronic annotation. Source: Compara response to lipopolysaccharide Inferred from electronic annotation. Source: Compara tetrapyrrole metabolic process Inferred from electronic annotation. Source: Compara
Cellular_component	axon Inferred from electronic annotation. Source: Compara cell surface Inferred from electronic annotation. Source: Compara extracellular space Inferred from electronic annotation. Source: Compara membrane raft Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: Compara plasma membrane Traceable author statement PubMed 9551933. Source: MGI protein complex Inferred from electronic annotation. Source: Compara
Molecular_function	tumor necrosis factor-activated receptor activity Inferred from mutant phenotype PubMed 11588035. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	1	1	EMBL AAS48428.1
	Non-terminal residue	440	1	EMBL AAS48428.1

Sequences

	Sequence		Length	Mass (Da)
	Q6QHF1 [UniParc]. Last modified July 5, 2004. Version 1. Checksum: 580A2D2E334612A3	FASTA	440	48,632
	10 20 30 40 50 60 PGLLLSLVLL ALLMGIHPSG VTGLVPSLGD REKRDSLCPQ GKYVHSKNNS ICCTKCHKGT 70 80 90 100 110 120 YLVSDCPSPG RDTVCRECEK GTFTASQNYL RQCLSCKTCR KEMSQVEISP CQADKDTVCG 130 140 150 160 170 180 CKENQFQRYL SETHFQCVDC SPCFNGTVTI PCKETQNTVC NCHAGFFLRE SECVPCSHCK 190 200 210 220 230 240 KNEECMKLCL PPPLANVTNP QDSGTAVLLP LVILLGLCLL SFIFISLMCR YPRWRPEVYS 250 260 270 280 290 300 IICRDPVPVK EEKAGKPLTP APSPAFSPTS GFNPTLGFST PGFSSPVSST PISPIFGPSN 310 320 330 340 350 360 WHFMPPVSEV VPTQGADPLL YESLCSVPAP TSVQKWEDSA HPQRPDNADL AILYAVVDGV 370 380 390 400 410 420 PPARWKEFMR FMGLSEHEIE RLEMQNGRCL REAQYSMLEA WRRRTPRHED TLEVVGLVLS 430 440 KMNLAGCLEN ILEALRNPAP

References

[1]	"Sequencing of the tnfrsf1a gene in SPRET/Ei, C57BL/6JIco and DBA/2CrlBr." Staelens J., Wielockx B., Puimege L., Vandenabeele A., Libert C. Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: DBA/2CrlBr EMBL AAS48428.1. Tissue: Liver EMBL AAS48428.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY541589 mRNA. Translation: AAS48428.1.
IPI	IPI00317228.
UniGene	Mm.1258. Mm.474976.
3D structure databases
ProteinModelPortal	Q6QHF1.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000032491. Q6QHF1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:1314884. Tnfrsf1a.
Phylogenomic databases
HOVERGEN	HBG058842.
InParanoid	Q6QHF1.
Gene expression databases
ArrayExpress	Q6QHF1.
Bgee	Q6QHF1.
Genevestigator	Q6QHF1.
Family and domain databases
Gene3D	1.10.533.10. 1 hit.
InterPro	IPR011029. DEATH-like_dom. IPR000488. Death_domain. IPR001368. TNFR/NGFR_Cys_rich_reg. IPR020419. TNFR_1A. [Graphical view]
Pfam	PF00531. Death. 1 hit. PF00020. TNFR_c6. 3 hits. [Graphical view]
PRINTS	PR01918. TNFACTORR1A.
SMART	SM00005. DEATH. 1 hit. SM00208. TNFR. 4 hits. [Graphical view]
SUPFAM	SSF47986. DEATH_like. 1 hit.
PROSITE	PS50017. DEATH_DOMAIN. 1 hit. PS00652. TNFR_NGFR_1. 3 hits. PS50050. TNFR_NGFR_2. 3 hits. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

Q6QHF1_MOUSE

Accession

Primary (citable) accession number: Q6QHF1

Entry history

Integrated into UniProtKB/TrEMBL:	July 5, 2004
Last sequence update:	July 5, 2004
Last modified:	April 3, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)