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Protein

Steroid receptor RNA activator 1

Gene

Sra1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.By similarity1 Publication

GO - Molecular functioni

  • ligand-dependent nuclear receptor binding Source: RGD
  • ligand-dependent nuclear receptor transcription coactivator activity Source: RGD
  • transcription coactivator activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Receptor, Ribonucleoprotein

Keywords - Biological processi

Apoptosis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Steroid receptor RNA activator 1
Alternative name(s):
Steroid receptor RNA activator protein
Short name:
SRAP
Gene namesi
Name:Sra1Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621148. Sra1.

Subcellular locationi

  • Nucleus By similarity
  • Cytoplasm By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 231231Steroid receptor RNA activator 1PRO_0000234107Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei60 – 601PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ6QGW5.
PRIDEiQ6QGW5.

PTM databases

iPTMnetiQ6QGW5.
PhosphoSiteiQ6QGW5.

Expressioni

Tissue specificityi

Expressed in various prostate cancer cell lines.1 Publication

Interactioni

Subunit structurei

SRA1 RNA exists in a ribonucleoprotein complex containing NCOA1. The RNA also forms a complex with PUS1 and RARG in the nucleus. Interacts with AR.By similarity1 Publication

GO - Molecular functioni

  • ligand-dependent nuclear receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024671.

Structurei

3D structure databases

ProteinModelPortaliQ6QGW5.
SMRiQ6QGW5. Positions 99-206.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi56 – 10146Pro-richSequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the SRA1 family.Curated

Phylogenomic databases

eggNOGiENOG410IK8X. Eukaryota.
ENOG4112996. LUCA.
HOGENOMiHOG000127508.
HOVERGENiHBG061820.
InParanoidiQ6QGW5.
PhylomeDBiQ6QGW5.

Family and domain databases

InterProiIPR009917. SRA1-protein/COPII_Sec31.
[Graphical view]
PfamiPF07304. SRA1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 11 Publication (identifier: Q6QGW5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTCCPAGGAE VEMAELYVKP GNKERGWNDP PQFSYGLQTQ TGGTKRTPLT
60 70 80 90 100
KRVAAPQDGS PRAPETSGPP PVDHPPPSSK ASRPPPMGSC PASGVDPPSS
110 120 130 140 150
PVIESETLIE DVLRPLEQAL EDCRGHTKQV CDDISRRLAL LHEQWDGGKL
160 170 180 190 200
SVPVKKRMAL LVQELLHHQW DTADDIHRSL MVDHVTEVSQ WMVGVKRLIA
210 220 230
EKRSLSSEEN KEEKSTVAPE NQTIPGFQPS S
Length:231
Mass (Da):25,263
Last modified:July 5, 2004 - v1
Checksum:iDCE58E85424B7EBA
GO
Isoform 21 Publication (identifier: Q6QGW5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-86: Missing.

Show »
Length:145
Mass (Da):16,216
Checksum:iA493FB22F19EB962
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti128 – 1281K → KK in AAO45011 (PubMed:12350225).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 8686Missing in isoform 2. 1 PublicationVSP_052034Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY026354 mRNA. Translation: AAO45011.1.
AY542868 mRNA. Translation: AAS48375.1.
RefSeqiNP_899158.3. NM_183329.3.
UniGeneiRn.29904.

Genome annotation databases

GeneIDi252891.
KEGGirno:252891.
UCSCiRGD:621148. rat. [Q6QGW5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY026354 mRNA. Translation: AAO45011.1.
AY542868 mRNA. Translation: AAS48375.1.
RefSeqiNP_899158.3. NM_183329.3.
UniGeneiRn.29904.

3D structure databases

ProteinModelPortaliQ6QGW5.
SMRiQ6QGW5. Positions 99-206.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024671.

PTM databases

iPTMnetiQ6QGW5.
PhosphoSiteiQ6QGW5.

Proteomic databases

PaxDbiQ6QGW5.
PRIDEiQ6QGW5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi252891.
KEGGirno:252891.
UCSCiRGD:621148. rat. [Q6QGW5-1]

Organism-specific databases

CTDi10011.
RGDi621148. Sra1.

Phylogenomic databases

eggNOGiENOG410IK8X. Eukaryota.
ENOG4112996. LUCA.
HOGENOMiHOG000127508.
HOVERGENiHBG061820.
InParanoidiQ6QGW5.
PhylomeDBiQ6QGW5.

Miscellaneous databases

PROiQ6QGW5.

Family and domain databases

InterProiIPR009917. SRA1-protein/COPII_Sec31.
[Graphical view]
PfamiPF07304. SRA1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSRA1_RAT
AccessioniPrimary (citable) accession number: Q6QGW5
Secondary accession number(s): Q811X7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: July 5, 2004
Last modified: July 6, 2016
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Appears to be the first example of a new class of functional RNAs also able to encode a protein. Rat SRAP1 may act as a protein rather than an RNA transcript.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.